FR2439017A1 - Artificial cerebrospinal fluid - contg. a hexose and alkali or alkaline earth metal salts in sufficient quantity to lower the freezing point - Google Patents
Artificial cerebrospinal fluid - contg. a hexose and alkali or alkaline earth metal salts in sufficient quantity to lower the freezing pointInfo
- Publication number
- FR2439017A1 FR2439017A1 FR7829621A FR7829621A FR2439017A1 FR 2439017 A1 FR2439017 A1 FR 2439017A1 FR 7829621 A FR7829621 A FR 7829621A FR 7829621 A FR7829621 A FR 7829621A FR 2439017 A1 FR2439017 A1 FR 2439017A1
- Authority
- FR
- France
- Prior art keywords
- hexose
- alkali
- alkaline earth
- freezing point
- sufficient quantity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
An artificial cerebro-spinal fluid (I) contains 0.3-0.9 g/litre of a hexose and mineral salts in sufficient quantity to lower the freezing point, or cryoscopic DELTA t, by 0.5 to 0.7 degrees C. The hexose is pref. glucose and/or levulose and the mineral salts are alkali or alkaline earth cations with chloride, sulphate, bicarbonate or phosphate anions. The total wt. of mineral salts is 6-12 g/l. (I) is used (i) to prevent dessication of nervous tissue during surgery, (ii) as a vehicle for medicaments, which act on the cortex or marrow, (iii) for injection into the spinal cord when measuring intracranial pressure, (iv) for dialysis of human cerebro-spinal fluid during auto-immune diseases, (v) to inject cranial radiographic contrast media, and (vi) as a solvent for injectable proteins.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7829621A FR2439017A1 (en) | 1978-10-18 | 1978-10-18 | Artificial cerebrospinal fluid - contg. a hexose and alkali or alkaline earth metal salts in sufficient quantity to lower the freezing point |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7829621A FR2439017A1 (en) | 1978-10-18 | 1978-10-18 | Artificial cerebrospinal fluid - contg. a hexose and alkali or alkaline earth metal salts in sufficient quantity to lower the freezing point |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2439017A1 true FR2439017A1 (en) | 1980-05-16 |
FR2439017B1 FR2439017B1 (en) | 1982-10-22 |
Family
ID=9213876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7829621A Granted FR2439017A1 (en) | 1978-10-18 | 1978-10-18 | Artificial cerebrospinal fluid - contg. a hexose and alkali or alkaline earth metal salts in sufficient quantity to lower the freezing point |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2439017A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5308459A (en) * | 1991-03-07 | 1994-05-03 | Baxter Diagnostics Inc. | Biosynthetic cerebrospinal fluid control and method of use |
EP1875919A1 (en) * | 2005-04-19 | 2008-01-09 | Otsuka Pharmaceutical Factory, Inc. | Artificial cerebrospinal fluid |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB486880A (en) * | 1935-12-14 | 1938-06-13 | Arthur Percival Masters | Improved game apparatus |
US3067098A (en) * | 1959-11-02 | 1962-12-04 | Baxter Don Inc | Intravenous nourishment of patients |
-
1978
- 1978-10-18 FR FR7829621A patent/FR2439017A1/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB486880A (en) * | 1935-12-14 | 1938-06-13 | Arthur Percival Masters | Improved game apparatus |
US3067098A (en) * | 1959-11-02 | 1962-12-04 | Baxter Don Inc | Intravenous nourishment of patients |
Non-Patent Citations (1)
Title |
---|
CA1975 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5308459A (en) * | 1991-03-07 | 1994-05-03 | Baxter Diagnostics Inc. | Biosynthetic cerebrospinal fluid control and method of use |
EP1875919A1 (en) * | 2005-04-19 | 2008-01-09 | Otsuka Pharmaceutical Factory, Inc. | Artificial cerebrospinal fluid |
US20090092681A1 (en) * | 2005-04-19 | 2009-04-09 | Otsuka Pharmceutical Factory ,Inc. | Artificial cerebrospinal fluid |
EP1875919A4 (en) * | 2005-04-19 | 2012-09-26 | Otsuka Pharma Co Ltd | Artificial cerebrospinal fluid |
US8409624B2 (en) * | 2005-04-19 | 2013-04-02 | Otsuka Pharmaceutical Factory, Inc. | Artificial cerebrospinal fluid |
Also Published As
Publication number | Publication date |
---|---|
FR2439017B1 (en) | 1982-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |