FR2410641A1 - RACEMIC AND OPTICALLY ACTIVE FORMS OF (BIPHENYLYL-4) -2 N- (DIETHYLAMINO ALKYL) PROPIONAMIDES AND THEIR SALTS USEFUL AS SPASMOLYTIC AGENTS AND METHODS FOR PREPARATION - Google Patents
RACEMIC AND OPTICALLY ACTIVE FORMS OF (BIPHENYLYL-4) -2 N- (DIETHYLAMINO ALKYL) PROPIONAMIDES AND THEIR SALTS USEFUL AS SPASMOLYTIC AGENTS AND METHODS FOR PREPARATIONInfo
- Publication number
- FR2410641A1 FR2410641A1 FR7833889A FR7833889A FR2410641A1 FR 2410641 A1 FR2410641 A1 FR 2410641A1 FR 7833889 A FR7833889 A FR 7833889A FR 7833889 A FR7833889 A FR 7833889A FR 2410641 A1 FR2410641 A1 FR 2410641A1
- Authority
- FR
- France
- Prior art keywords
- propionamides
- biphenylyl
- racemic
- preparation
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Novel compounds useful as spasmolytic agents of the following formula: in which n is 2 or 3. In addition, salts of these novel compounds are provided which are suitable for parenteral and oral administration to animals and humans as spasmolytic agents. In compositions for oral and parenteral or rectal administration, about 5 to about 40 mg of active ingredient per dosage unit are used. The bromide and iodide salts of these novel compounds are particularly useful.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT964377A IT1090782B (en) | 1977-11-30 | 1977-11-30 | 2 4 BIPHENYLIL 2 DIETHYLAMIN ALCHYL PROPIONAMIDE ITS SALTS AND RELATED MANUFACTURING PROCEDURES |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2410641A1 true FR2410641A1 (en) | 1979-06-29 |
FR2410641B1 FR2410641B1 (en) | 1983-04-15 |
Family
ID=11132874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7833889A Granted FR2410641A1 (en) | 1977-11-30 | 1978-11-30 | RACEMIC AND OPTICALLY ACTIVE FORMS OF (BIPHENYLYL-4) -2 N- (DIETHYLAMINO ALKYL) PROPIONAMIDES AND THEIR SALTS USEFUL AS SPASMOLYTIC AGENTS AND METHODS FOR PREPARATION |
Country Status (9)
Country | Link |
---|---|
JP (1) | JPS5490157A (en) |
BE (1) | BE872403A (en) |
CA (1) | CA1118446A (en) |
CH (1) | CH637370A5 (en) |
DE (1) | DE2851416A1 (en) |
ES (1) | ES475533A1 (en) |
FR (1) | FR2410641A1 (en) |
IT (1) | IT1090782B (en) |
NL (1) | NL7811698A (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003029187A1 (en) * | 2001-09-28 | 2003-04-10 | Dompe S.P.A. | Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them |
WO2008017903A1 (en) * | 2006-08-08 | 2008-02-14 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylacetic acids with very fast skin penetration rate |
WO2008020270A1 (en) * | 2006-08-15 | 2008-02-21 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
AU2013206218A1 (en) * | 2006-08-15 | 2013-06-27 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
US9371284B2 (en) | 2007-06-04 | 2016-06-21 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses |
US9872846B2 (en) | 2006-07-09 | 2018-01-23 | Techfields Pharma Co., Ltd. | High penetration compositions and uses thereof |
US11135153B2 (en) | 2006-07-09 | 2021-10-05 | Techfields Pharma Co., Ltd. | High penetration composition and uses thereof |
US11541029B2 (en) | 2008-12-04 | 2023-01-03 | Techfields Pharma Co., Ltd. | High penetration compositions and their applications |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5940036B2 (en) * | 2013-10-08 | 2016-06-29 | テックフィールズ バイオケム カンパニー リミテッド | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin permeability |
JP6290947B2 (en) * | 2016-02-05 | 2018-03-07 | テックフィールズ バイオケム カンパニー リミテッド | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin permeability |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1584547A (en) * | 1968-06-05 | 1969-12-26 | ||
FR1593024A (en) * | 1968-09-18 | 1970-05-25 | ||
FR2119846A1 (en) * | 1970-12-28 | 1972-08-11 | Choay Sa | N,n-diethylaminoethylamide of para isobutyl phenylacetic - acid - antiinflammatory and analgesic |
FR2370723A1 (en) * | 1976-11-12 | 1978-06-09 | Upjohn Co | NEW ARYL-ACYLAMIDES N- (2-AMINOCYCLOALIPHATICS), THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM |
-
1977
- 1977-11-30 IT IT964377A patent/IT1090782B/en active
-
1978
- 1978-11-28 CH CH1216178A patent/CH637370A5/en not_active IP Right Cessation
- 1978-11-28 DE DE19782851416 patent/DE2851416A1/en active Granted
- 1978-11-29 ES ES475533A patent/ES475533A1/en not_active Expired
- 1978-11-29 NL NL7811698A patent/NL7811698A/en not_active Application Discontinuation
- 1978-11-30 FR FR7833889A patent/FR2410641A1/en active Granted
- 1978-11-30 BE BE192036A patent/BE872403A/en not_active IP Right Cessation
- 1978-11-30 CA CA000317175A patent/CA1118446A/en not_active Expired
- 1978-11-30 JP JP14730778A patent/JPS5490157A/en active Granted
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1584547A (en) * | 1968-06-05 | 1969-12-26 | ||
FR1593024A (en) * | 1968-09-18 | 1970-05-25 | ||
FR2119846A1 (en) * | 1970-12-28 | 1972-08-11 | Choay Sa | N,n-diethylaminoethylamide of para isobutyl phenylacetic - acid - antiinflammatory and analgesic |
FR2370723A1 (en) * | 1976-11-12 | 1978-06-09 | Upjohn Co | NEW ARYL-ACYLAMIDES N- (2-AMINOCYCLOALIPHATICS), THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7026510B2 (en) | 2001-09-28 | 2006-04-11 | Dompé S.p.A. | Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them |
WO2003029187A1 (en) * | 2001-09-28 | 2003-04-10 | Dompe S.P.A. | Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them |
AU2002338784B2 (en) * | 2001-09-28 | 2008-08-14 | Dompe' Farmaceutici S.P.A. | Quaternary ammonium salts of omega-aminoalkylamides of R-2-aryl-propionic acids and pharmaceutical compositions containing them |
US9872846B2 (en) | 2006-07-09 | 2018-01-23 | Techfields Pharma Co., Ltd. | High penetration compositions and uses thereof |
US11135153B2 (en) | 2006-07-09 | 2021-10-05 | Techfields Pharma Co., Ltd. | High penetration composition and uses thereof |
WO2008017903A1 (en) * | 2006-08-08 | 2008-02-14 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylacetic acids with very fast skin penetration rate |
WO2008020270A1 (en) * | 2006-08-15 | 2008-02-21 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
AU2013206218B2 (en) * | 2006-08-15 | 2016-06-30 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
AU2013206218A1 (en) * | 2006-08-15 | 2013-06-27 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
AU2006347391B2 (en) * | 2006-08-15 | 2013-03-07 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate |
US9371284B2 (en) | 2007-06-04 | 2016-06-21 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses |
US10233198B2 (en) | 2007-06-04 | 2019-03-19 | Techfields Pharma Co., Ltd. | Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses |
US11541029B2 (en) | 2008-12-04 | 2023-01-03 | Techfields Pharma Co., Ltd. | High penetration compositions and their applications |
Also Published As
Publication number | Publication date |
---|---|
DE2851416A1 (en) | 1979-05-31 |
CA1118446A (en) | 1982-02-16 |
BE872403A (en) | 1979-03-16 |
CH637370A5 (en) | 1983-07-29 |
ES475533A1 (en) | 1980-01-16 |
JPS631286B2 (en) | 1988-01-12 |
FR2410641B1 (en) | 1983-04-15 |
JPS5490157A (en) | 1979-07-17 |
NL7811698A (en) | 1979-06-01 |
IT1090782B (en) | 1985-06-26 |
DE2851416C2 (en) | 1989-02-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO154582C (en) | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE DIPHENYL-DIBUTYLPIPERAZINE CARBOXAMIDS. | |
RU93005057A (en) | PHARMACEUTICAL COMPOUNDS, THYENOBENZODIAZEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION, PHARMOCOMPOSITION AND THEIR USE | |
FI810604L (en) | FOERFARANDE FOER FRAMSTAELLNING AV INDANDERIVAT | |
FR2395256A1 (en) | PHENYLACETIC ACID DERIVATIVES THEIR METHODS OF PREPARATION AND THEIR APPLICATIONS IN THERAPEUTICS | |
MX5680E (en) | PROCEDURE FOR THE PREPARATION OF 2- (2-ALCOXIETIL) -2'-HIDROXI-6,7-BENZOMORFANOS | |
FR2410641A1 (en) | RACEMIC AND OPTICALLY ACTIVE FORMS OF (BIPHENYLYL-4) -2 N- (DIETHYLAMINO ALKYL) PROPIONAMIDES AND THEIR SALTS USEFUL AS SPASMOLYTIC AGENTS AND METHODS FOR PREPARATION | |
FR2445834A1 (en) | HETEROBICYCLIC DERIVATIVES OF UNSATURATED 7-ACYLAMIDO-3-CEPHEM-4-CARBOXYLIC ACID, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USE | |
DE3483798D1 (en) | DIHYDRODIBENZOCYCLOHEPTYLIDENETHYLAMINE DERIVATIVES. | |
FR2430418A1 (en) | HALOGENOMETHYL DERIVATIVES OF A-AMINO ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC USES | |
ATE41772T1 (en) | POLYMETHOXYBENZYL PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES. | |
SE8102220L (en) | USE OF SUBSTITUTED DERIVATIVES OF 4-PHENYL-4-OXO-2-BUTENIC ACID AS A MEDICINE | |
TR200000153T2 (en) | 6-azauracil derivatives that inhibit il-5. | |
DK160686A (en) | TRI AND TETRACYCLIC COMPOUNDS | |
FR2432520A1 (en) | NOVEL IMIDAZOQUINOXALINS AND THEIR SALTS, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
ES2183492T3 (en) | NEW NITRON DERIVATIVES, THEIR PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
DK408083A (en) | ISOQUINOLINE DERIVATIVES, THEIR PREPARATION AND USE | |
DK429480A (en) | PHOSPHONO HYDROXYDIC ACETIC ACID PROCEDURES FOR PREPARING IT AND USING IT AS A MEDICINE | |
ES2101059T3 (en) | NITROGENATED BICYCLE DERIVATIVES, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. | |
AR007052A1 (en) | A CARBOHYDRATE DERIVATIVE, ITS USE AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT | |
NO843296L (en) | PROCEDURE FOR THE PREPARATION OF BENZO ACID DERIVATIVES WITH ANTIMICROBIAL ACTIVITY | |
ATE5145T1 (en) | O-CREATINOPHOSPHATE DERIVATIVE WITH THERAPEUTIC ACTIVITIES, PROCESS FOR ITS PREPARATION AND ITS PHARMACEUTICAL COMPOSITIONS. | |
TNSN87043A1 (en) | DISSYMMETRIC DERIVATIVES OF 1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID, METHODS OF PREPARATION AND THERAPEUTIC USE | |
FR2396747A1 (en) | NEW R, S- (2- (2-HYDROXYETHYLAMINO) -1-PHENYL) -ETHYLAMINE DERIVATIVES, THEIR PHARMACEUTICALLY ACCEPTABLE ACID ADDITIONAL SALTS AND THEIR PREPARATION PROCEDURE | |
SE8005687L (en) | NEW 10-HALOGEN-E-HOMO BURNANS JUST SET FOR THEIR PREPARATION | |
ATE7224T1 (en) | PROPANOLAMINE DERIVATIVES, THEIR SALTS, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |