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FR2405256A1 - Cerebral and peripheral vasodilator (-)-vincamine prepn. - by oxidative transposition of (-)-vincadifformine acid addn. salt with hydrogen peroxide and soluble metal salt - Google Patents

Cerebral and peripheral vasodilator (-)-vincamine prepn. - by oxidative transposition of (-)-vincadifformine acid addn. salt with hydrogen peroxide and soluble metal salt

Info

Publication number
FR2405256A1
FR2405256A1 FR7828448A FR7828448A FR2405256A1 FR 2405256 A1 FR2405256 A1 FR 2405256A1 FR 7828448 A FR7828448 A FR 7828448A FR 7828448 A FR7828448 A FR 7828448A FR 2405256 A1 FR2405256 A1 FR 2405256A1
Authority
FR
France
Prior art keywords
salt
vincadifformine
vincamine
prepn
transposition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7828448A
Other languages
French (fr)
Other versions
FR2405256B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of FR2405256A1 publication Critical patent/FR2405256A1/en
Application granted granted Critical
Publication of FR2405256B1 publication Critical patent/FR2405256B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Process for the preparation of (-)-vincamine (I) by oxidational transportation of a (-)-vincadifformine acid addition salt (II) using H2O2 in the presence of a soluble metal salt of a hydrated oxide of vanadium, chromium, molybdenum or tungsten. Pref. the soluble salt is an alkali metal, alkaline earth metal or ammonium salt, esp. Na or NH4 molybdate or tungstate. Process gives improved yield (60-70%) with reduced quantities of 16-epivincamine (2 10%) by product.
FR7828448A 1977-10-08 1978-10-05 Cerebral and peripheral vasodilator (-)-vincamine prepn. - by oxidative transposition of (-)-vincadifformine acid addn. salt with hydrogen peroxide and soluble metal salt Granted FR2405256A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2745415A DE2745415C2 (en) 1977-10-08 1977-10-08 Process for the preparation of (-) - vincamine

Publications (2)

Publication Number Publication Date
FR2405256A1 true FR2405256A1 (en) 1979-05-04
FR2405256B1 FR2405256B1 (en) 1981-05-29

Family

ID=6021035

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7828448A Granted FR2405256A1 (en) 1977-10-08 1978-10-05 Cerebral and peripheral vasodilator (-)-vincamine prepn. - by oxidative transposition of (-)-vincadifformine acid addn. salt with hydrogen peroxide and soluble metal salt

Country Status (6)

Country Link
BE (1) BE870978A (en)
DE (1) DE2745415C2 (en)
FR (1) FR2405256A1 (en)
HU (1) HU181410B (en)
IT (1) IT1099764B (en)
ZA (1) ZA785651B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1141285B (en) * 1980-04-17 1986-10-01 Inverni Della Beffa Spa PROCEDURE FOR THE PREPARATION, OF VINCAMIN AND RELATED ALCALOIDS
CH646166A5 (en) * 1980-09-30 1984-11-15 Linnea Sa PARTIAL SYNTHESIS PROCEDURE OF VINCAMINE AND RELATED INDOLIC ALCALOIDS.
HU185255B (en) * 1981-04-23 1984-12-28 Richter Gedeon Vegyeszet New process preparing compounds with eburnane skeleton by means of the oxidative transformation of tabersonine or dihydrotabersonine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2123521A1 (en) * 1971-01-29 1972-09-08 Richter Gedeon Vegyeszet Vincamine prepn - by epimerisation of 16-epi-vincamine
FR2281371A1 (en) * 1974-08-09 1976-03-05 Buskine Sa PROCESS FOR THE PREPARATION OF VINCAMINE AND OTHER INDOLIC ALKALOIDS
FR2332280A1 (en) * 1975-11-20 1977-06-17 Kunesch Nicole Vincamine and (16)-epivincamine prepn. - from tabersonine salt by hydrogenating and oxidative rearrangement

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE837049A (en) * 1975-12-24 1976-04-16 PROCESS FOR PREPARING NATURAL VINCAMINE FROM TABERSONIN

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2123521A1 (en) * 1971-01-29 1972-09-08 Richter Gedeon Vegyeszet Vincamine prepn - by epimerisation of 16-epi-vincamine
FR2281371A1 (en) * 1974-08-09 1976-03-05 Buskine Sa PROCESS FOR THE PREPARATION OF VINCAMINE AND OTHER INDOLIC ALKALOIDS
FR2332280A1 (en) * 1975-11-20 1977-06-17 Kunesch Nicole Vincamine and (16)-epivincamine prepn. - from tabersonine salt by hydrogenating and oxidative rearrangement

Also Published As

Publication number Publication date
FR2405256B1 (en) 1981-05-29
BE870978A (en) 1979-04-03
DE2745415A1 (en) 1979-04-12
IT1099764B (en) 1985-09-28
HU181410B (en) 1983-07-28
DE2745415C2 (en) 1983-06-23
ZA785651B (en) 1979-10-31
IT7828469A0 (en) 1978-10-05

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse