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FR2447378A1 - Antihypertensive and vasodilating 4,7-di:methoxy benzofuran(s) - prepd. from phenyl piperazine(s) and epoxy or halo alkoxy benzofuran(s) - Google Patents

Antihypertensive and vasodilating 4,7-di:methoxy benzofuran(s) - prepd. from phenyl piperazine(s) and epoxy or halo alkoxy benzofuran(s)

Info

Publication number
FR2447378A1
FR2447378A1 FR7901608A FR7901608A FR2447378A1 FR 2447378 A1 FR2447378 A1 FR 2447378A1 FR 7901608 A FR7901608 A FR 7901608A FR 7901608 A FR7901608 A FR 7901608A FR 2447378 A1 FR2447378 A1 FR 2447378A1
Authority
FR
France
Prior art keywords
benzofuran
vasodilating
prepd
antihypertensive
epoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7901608A
Other languages
French (fr)
Inventor
G Bourgery
A Lacour
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7901608A priority Critical patent/FR2447378A1/en
Publication of FR2447378A1 publication Critical patent/FR2447378A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

derivs. of formula (I) are new: In (I) (i) A is -CH2CHOHCH2-; in which case R is acetyl R1 is H and R2 is 2-CH3, 2-F, 2-OCH3, or R1=R2=CH3; or R is acetamido, R1 is H, R2 is H, 4-F or 2-OCH3; or R = N-methyl carbomoylamino; R1 is H, R2 is 2-CH3, or (ii) A is ethylene; R = acetamido, R1 is H, R2 is 2-OCH3, or (iii) A is -CH2CH2CH2-R is acetyl, R1 is H, R2 is H or 2-CH3; or R is 1-hydroxyethyl, R1 is H, R2 is H or 2-CH3, or R = N-methylcarbamoylamino, R1 is H, R2 is CH3. (I) and antihypertensives, and some cpds. are peripheral vasodilators.
FR7901608A 1979-01-23 1979-01-23 Antihypertensive and vasodilating 4,7-di:methoxy benzofuran(s) - prepd. from phenyl piperazine(s) and epoxy or halo alkoxy benzofuran(s) Withdrawn FR2447378A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7901608A FR2447378A1 (en) 1979-01-23 1979-01-23 Antihypertensive and vasodilating 4,7-di:methoxy benzofuran(s) - prepd. from phenyl piperazine(s) and epoxy or halo alkoxy benzofuran(s)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7901608A FR2447378A1 (en) 1979-01-23 1979-01-23 Antihypertensive and vasodilating 4,7-di:methoxy benzofuran(s) - prepd. from phenyl piperazine(s) and epoxy or halo alkoxy benzofuran(s)

Publications (1)

Publication Number Publication Date
FR2447378A1 true FR2447378A1 (en) 1980-08-22

Family

ID=9221072

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7901608A Withdrawn FR2447378A1 (en) 1979-01-23 1979-01-23 Antihypertensive and vasodilating 4,7-di:methoxy benzofuran(s) - prepd. from phenyl piperazine(s) and epoxy or halo alkoxy benzofuran(s)

Country Status (1)

Country Link
FR (1) FR2447378A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0156331A2 (en) * 1984-03-27 1985-10-02 Kaken Pharmaceutical Co., Ltd. Benzofuran derivatives, processes for preparing the same and antihypertensive agents containing the same
EP0303920A1 (en) * 1987-08-20 1989-02-22 BASF Aktiengesellschaft Benzofuran derivatives and therapeutic agents containing them
US4917989A (en) * 1987-05-19 1990-04-17 Basf Aktiengesellschaft Optical recording medium which has a reflector layer containing a silicon-phthalocyanine derivative
WO2008040057A1 (en) * 2006-10-04 2008-04-10 Bionomics Limited Novel benzofuran potassium channel blockers and uses thereof
US7897764B2 (en) * 2007-06-08 2011-03-01 National Health Research Institutes Thiourea derivatives
US7985763B2 (en) 2007-04-10 2011-07-26 National Health Research Institutes Hepatitis C virus inhibitors
US8198284B2 (en) 2008-04-30 2012-06-12 National Health Research Institutes Treatment of neurodegenerative disorders with thiourea compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2730593A1 (en) * 1976-07-12 1978-01-19 Delalande Sa NEW AMINO-ALCOXYBENZOFURANS, METHOD FOR MANUFACTURING THE SAME PHARMACEUTICAL PRODUCTS THEREOF

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2730593A1 (en) * 1976-07-12 1978-01-19 Delalande Sa NEW AMINO-ALCOXYBENZOFURANS, METHOD FOR MANUFACTURING THE SAME PHARMACEUTICAL PRODUCTS THEREOF

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0156331A2 (en) * 1984-03-27 1985-10-02 Kaken Pharmaceutical Co., Ltd. Benzofuran derivatives, processes for preparing the same and antihypertensive agents containing the same
EP0156331A3 (en) * 1984-03-27 1986-08-20 Kaken Pharmaceutical Co., Ltd. Benzuforan derivatives, processes for preparing the same and antihypertensive agents containing the same
US4917989A (en) * 1987-05-19 1990-04-17 Basf Aktiengesellschaft Optical recording medium which has a reflector layer containing a silicon-phthalocyanine derivative
EP0303920A1 (en) * 1987-08-20 1989-02-22 BASF Aktiengesellschaft Benzofuran derivatives and therapeutic agents containing them
WO2008040057A1 (en) * 2006-10-04 2008-04-10 Bionomics Limited Novel benzofuran potassium channel blockers and uses thereof
AU2007304880B2 (en) * 2006-10-04 2012-10-11 Bionomics Limited Novel benzofuran potassium channel blockers and uses thereof
AU2007304880B9 (en) * 2006-10-04 2012-11-08 Bionomics Limited Novel benzofuran potassium channel blockers and uses thereof
US7985763B2 (en) 2007-04-10 2011-07-26 National Health Research Institutes Hepatitis C virus inhibitors
US7897764B2 (en) * 2007-06-08 2011-03-01 National Health Research Institutes Thiourea derivatives
US8198284B2 (en) 2008-04-30 2012-06-12 National Health Research Institutes Treatment of neurodegenerative disorders with thiourea compounds

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