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FR2322600A1 - Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576) - Google Patents

Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576)

Info

Publication number
FR2322600A1
FR2322600A1 FR7527160A FR7527160A FR2322600A1 FR 2322600 A1 FR2322600 A1 FR 2322600A1 FR 7527160 A FR7527160 A FR 7527160A FR 7527160 A FR7527160 A FR 7527160A FR 2322600 A1 FR2322600 A1 FR 2322600A1
Authority
FR
France
Prior art keywords
pyrrolidinone
substd
opt
alkyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7527160A
Other languages
French (fr)
Other versions
FR2322600B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AR261091A priority Critical patent/AR208414A1/en
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7527160A priority patent/FR2322600A1/en
Priority to OA55663A priority patent/OA05162A/en
Priority to NLAANVRAGE7512732,A priority patent/NL177405C/en
Priority to CA238,909A priority patent/CA1057755A/en
Priority to IE2414/75A priority patent/IE41928B1/en
Priority to JP75132198A priority patent/JPS5422996B2/ja
Priority to HU75RO868A priority patent/HU173108B/en
Priority to DD189261A priority patent/DD122684A5/xx
Priority to PH17740A priority patent/PH16806A/en
Priority to AU86331/75A priority patent/AU503200B2/en
Priority to IL48423A priority patent/IL48423A/en
Priority to BE161652A priority patent/BE835325A/en
Priority to NO753713A priority patent/NO143576C/en
Priority to LU73738A priority patent/LU73738A1/xx
Priority to DK499275AA priority patent/DK141098B/en
Priority to ES442390A priority patent/ES442390A1/en
Priority to GB4610375A priority patent/GB1468497A/en
Priority to SU752186208A priority patent/SU673173A3/en
Priority to SE7512477A priority patent/SE407063B/en
Priority to CY1045A priority patent/CY1045A/en
Priority to ES442389A priority patent/ES442389A1/en
Priority to CH1437875A priority patent/CH609057A5/xx
Priority to CS757510A priority patent/CS231957B2/en
Priority to FI753127A priority patent/FI60707C/en
Priority to YU2815/75A priority patent/YU39583B/en
Priority to PL1975199797A priority patent/PL101248B1/en
Priority to AT848675A priority patent/AT343123B/en
Priority to DE2550111A priority patent/DE2550111C2/en
Priority to JP51001850A priority patent/JPS5233685A/en
Priority to AR263835A priority patent/AR208800A1/en
Priority to SU762385529A priority patent/SU604496A3/en
Publication of FR2322600A1 publication Critical patent/FR2322600A1/en
Priority to US05/790,801 priority patent/US4220646A/en
Priority to AT401977A priority patent/AT343666B/en
Priority to CS775983A priority patent/CS231958B2/en
Priority to JP12525778A priority patent/JPS5498790A/en
Priority to JP54105633A priority patent/JPS5919551B2/en
Application granted granted Critical
Publication of FR2322600B1 publication Critical patent/FR2322600B1/fr
Priority to HK193/80A priority patent/HK19380A/en
Priority to YU1921/82A priority patent/YU40087B/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Pyrrolidinone derivs. of formula (I) (where R1 and R2 are linked so as to form with the pyrroline nucleus an isoindoline, 6,7-dihydro-5H-pyrrolo 3,4-b pyrazine, 2,3,6,7-tetrahydro-5H-oxathiino 1,4 2,3-c -pyrrole or 2,3,6,7-tetrahydro-5H-dithiino 1,4 2,3-c -pyrrole nucleus; Het is 2-pyridyl, 2-quinolyl or 1,8-naphthyridin-2-yl opt. substd. by 1-3 substituents from halogenM 1-4C alkyl, 1-4C alkoxy and CN; Z is O or S; and R is H, 1-4C alkyl (opt. substd. by 1-3 halogen atoms), 2-4C alkenyl, 2-4C alkynyl, 3-6C cycloalkyl, 1-4c alkoxy, phenyl (opt. substd. by 1-3 substituents from halogen, 1-4C alkoxy, 1-4C alkyl, NO2 and CF3), phenyl-(1-4C alkyl)(opt. substd. in the phenyl residue as indicated for phenyl), or to 5- or 6- membered heterocyclyl with 1 or 2 hetero atoms selected from N, O and S; and when R1 and R2 are linked so as to form an isoindoline residue this opt. substd. by 1-4 substituents from halogen, 1-4C alkyl, 1-4C alkoxy, NO2 and CF3), e.g. 3- (4-acryloyl-1-piperazinyl)carbonyloxy -2-(7-chloro-1,8-naphthy- ridin-2-yl)-1-isoindolinone, are new cpds. (I) are tranquillisers, anticonvulsants, hypnogenic agents or hypnotics active at doses of 0.1-100 mg/kg p.o. in the mouse. Toxicity is low (mouse LD50 generally >300 mg/kg p.o.).
FR7527160A 1974-11-07 1975-09-04 Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576) Granted FR2322600A1 (en)

Priority Applications (39)

Application Number Priority Date Filing Date Title
AR261091A AR208414A1 (en) 1974-11-07 1975-01-01 PROCEDURE TO OBTAIN NEW DERIVATIVES OF ((ACIL-4PIPERAZINIL-1) CARBONYLOXI-5 PYRROLINONE-2)
FR7527160A FR2322600A1 (en) 1975-09-04 1975-09-04 Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576)
OA55663A OA05162A (en) 1974-11-07 1975-10-23 New heterocyclic compounds and their preparation.
NLAANVRAGE7512732,A NL177405C (en) 1974-11-07 1975-10-30 METHOD FOR PREPARING PHARMACEUTICAL PREPARATIONS AND METHOD FOR PREPARING MEDICINAL COMPOUNDS, SUITABLE FOR USE IN THESE PREPARATIONS.
CA238,909A CA1057755A (en) 1974-11-07 1975-11-03 Heterocyclic compounds, their preparation and compositions thereof_
JP75132198A JPS5422996B2 (en) 1974-11-07 1975-11-05
HU75RO868A HU173108B (en) 1974-11-07 1975-11-05 Process for preparing new isoindolinyl-, pyrrolopyrazinyl-, oxathiinopyrrolyl-, and dithiinopyrrolyl-oxy-carbonyl-piperazine derivatives
DD189261A DD122684A5 (en) 1974-11-07 1975-11-05
PH17740A PH16806A (en) 1974-11-07 1975-11-05 Isoindoline,pyrrolo(3,4-b)pyrazine,1,4 oxathiino(2,3-c)pyrole and 1,4-dithiino(2,3-c)pyrrole compounds
AU86331/75A AU503200B2 (en) 1974-11-07 1975-11-05 Esters of 1-acyl-piperazine-4-carboxylic acids
IL48423A IL48423A (en) 1974-11-07 1975-11-05 (4-acylpiperazin-1-yl)carbonyloxyisoindolinones,5h-pyrrolo(3,4-b)pyrazines, 5h-1,4-oxathiano(2,3-c) pyrroles, their preparation and pharmaceutical compositions containing thesame
IE2414/75A IE41928B1 (en) 1974-11-07 1975-11-05 Esters of 1-acylpiperazine-4-carboxylic acids
ES442389A ES442389A1 (en) 1974-11-07 1975-11-06 Procedure for preparing acilpiperazinoinoindolinones. (Machine-translation by Google Translate, not legally binding)
LU73738A LU73738A1 (en) 1974-11-07 1975-11-06
DK499275AA DK141098B (en) 1974-11-07 1975-11-06 Analogous process for the preparation of naphthyridine derivatives.
ES442390A ES442390A1 (en) 1974-11-07 1975-11-06 Procedure for preparing acilpiperazinoisoindolinonas. (Machine-translation by Google Translate, not legally binding)
GB4610375A GB1468497A (en) 1974-11-07 1975-11-06 Esters of 1-acylpiperazine-4-carboxylic acids
SU752186208A SU673173A3 (en) 1974-11-07 1975-11-06 Method of producing heterocyclic compounds
SE7512477A SE407063B (en) 1974-11-07 1975-11-06 ANALOGICAL PROCEDURE FOR PREPARATION OF PIPERAZINYL-CARBONYLOXI DERIVATIVES OF PYRROLE DERIVATIVES
CY1045A CY1045A (en) 1974-11-07 1975-11-06 Esters of 1-acylpiperazine-4-carbocylic acids
BE161652A BE835325A (en) 1974-11-07 1975-11-06 NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
CH1437875A CH609057A5 (en) 1974-11-07 1975-11-06
NO753713A NO143576C (en) 1974-11-07 1975-11-06 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE HETEROCYCLIC COMPOUNDS
PL1975199797A PL101248B1 (en) 1974-11-07 1975-11-07 METHOD OF MAKING NEW PYROLINE DERIVATIVES
FI753127A FI60707C (en) 1974-11-07 1975-11-07 PROCEDURE FOR FRAMSTATION OF AV 2- (1,8-NAPHTHYRIDIN-2-YL) -3- (1-PIPERAZINYL) CARBONYLOXIPYRROLER ANVAENDBARA SAOSOM LAEKEMEDEL
YU2815/75A YU39583B (en) 1974-11-07 1975-11-07 Process for obtaining new heterocyclic compounds
CS757510A CS231957B2 (en) 1974-11-07 1975-11-07 Manufacturing process of heterocyclic compounds
AT848675A AT343123B (en) 1974-11-07 1975-11-07 PROCESS FOR THE PRODUCTION OF NEW PIPERAZINE DERIVATIVES
DE2550111A DE2550111C2 (en) 1974-11-07 1975-11-07 7-chloro-1,8-naphthyridine derivatives, processes for their preparation and compositions containing them
JP51001850A JPS5233685A (en) 1975-09-04 1976-01-10 New heterocycliccompounds
AR263835A AR208800A1 (en) 1974-11-07 1976-07-02 PROCEDURE TO OBTAIN NEW DERIVATIVES OF (ACIL-4 PIPERAZINIL-1-CARBONYLOXI) -5 PYRROLINONE-2
SU762385529A SU604496A3 (en) 1974-11-07 1976-08-02 Method of obtaining heterogeneous ring compounds
US05/790,801 US4220646A (en) 1974-11-07 1977-04-25 Heterocyclic compounds
AT401977A AT343666B (en) 1974-11-07 1977-06-07 PROCESS FOR THE PRODUCTION OF NEW PIPERAZINE DERIVATIVES
CS775983A CS231958B2 (en) 1974-11-07 1977-09-14 Manufacturing process of new heteroclic compoundes
JP12525778A JPS5498790A (en) 1974-11-07 1978-10-13 Manufacture of novel heterocyclic compound
JP54105633A JPS5919551B2 (en) 1975-09-04 1979-08-21 Pyrrolo[3,4-b]pyrazine derivative
HK193/80A HK19380A (en) 1974-11-07 1980-04-10 Esters of 1-acylpiperazine-4-carboxylic acids
YU1921/82A YU40087B (en) 1974-11-07 1982-08-26 Process for obtaining new heterocyclic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7527160A FR2322600A1 (en) 1975-09-04 1975-09-04 Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576)

Publications (2)

Publication Number Publication Date
FR2322600A1 true FR2322600A1 (en) 1977-04-01
FR2322600B1 FR2322600B1 (en) 1979-09-14

Family

ID=9159630

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7527160A Granted FR2322600A1 (en) 1974-11-07 1975-09-04 Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576)

Country Status (2)

Country Link
JP (1) JPS5919551B2 (en)
FR (1) FR2322600A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2423650A1 (en) * 1973-05-15 1974-12-05 Rhone Poulenc Sa NEW NAPHTYRIDE DERIVATIVES, THEIR PRODUCTION AND COMPOSITIONS THEREOF

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2423650A1 (en) * 1973-05-15 1974-12-05 Rhone Poulenc Sa NEW NAPHTYRIDE DERIVATIVES, THEIR PRODUCTION AND COMPOSITIONS THEREOF

Also Published As

Publication number Publication date
FR2322600B1 (en) 1979-09-14
JPS5919551B2 (en) 1984-05-07
JPS5540671A (en) 1980-03-22

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