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FR2302093A1 - Nouveaux esters alkyliques - Google Patents

Nouveaux esters alkyliques

Info

Publication number
FR2302093A1
FR2302093A1 FR7605383A FR7605383A FR2302093A1 FR 2302093 A1 FR2302093 A1 FR 2302093A1 FR 7605383 A FR7605383 A FR 7605383A FR 7605383 A FR7605383 A FR 7605383A FR 2302093 A1 FR2302093 A1 FR 2302093A1
Authority
FR
France
Prior art keywords
alkyl esters
new alkyl
new
esters
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7605383A
Other languages
English (en)
Other versions
FR2302093B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of FR2302093A1 publication Critical patent/FR2302093A1/fr
Application granted granted Critical
Publication of FR2302093B1 publication Critical patent/FR2302093B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR7605383A 1975-02-26 1976-02-26 Nouveaux esters alkyliques Granted FR2302093A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752508181 DE2508181A1 (de) 1975-02-26 1975-02-26 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
FR2302093A1 true FR2302093A1 (fr) 1976-09-24
FR2302093B1 FR2302093B1 (fr) 1979-09-21

Family

ID=5939797

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7605383A Granted FR2302093A1 (fr) 1975-02-26 1976-02-26 Nouveaux esters alkyliques

Country Status (27)

Country Link
US (1) US4044141A (fr)
JP (1) JPS6025424B2 (fr)
AT (1) AT351024B (fr)
BE (1) BE838924A (fr)
CA (1) CA1069902A (fr)
CH (1) CH622506A5 (fr)
CS (1) CS188994B2 (fr)
DD (1) DD125483A5 (fr)
DE (1) DE2508181A1 (fr)
DK (1) DK78876A (fr)
ES (1) ES445508A1 (fr)
FI (1) FI61483C (fr)
FR (1) FR2302093A1 (fr)
GB (1) GB1477114A (fr)
HU (1) HU171717B (fr)
IE (1) IE42643B1 (fr)
IL (1) IL49095A (fr)
IN (1) IN142197B (fr)
LU (1) LU74424A1 (fr)
NL (1) NL7601823A (fr)
NO (1) NO146393C (fr)
PL (1) PL100906B1 (fr)
PT (1) PT64840B (fr)
RO (1) RO68479A (fr)
SE (1) SE7602317L (fr)
SU (1) SU574150A3 (fr)
ZA (1) ZA761118B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984002132A1 (fr) * 1982-11-24 1984-06-07 Cermol Sa Nouveaux esters de 1,4-dihydropyridines et leurs procedes de preparation et medicaments contenant lesdits esters
EP0191448A2 (fr) * 1985-02-11 1986-08-20 Syntex (U.S.A.) Inc. Dihydropyridines antihypertensives
EP0330470A2 (fr) * 1988-02-24 1989-08-30 Ajinomoto Co., Inc. Dérivés de 1,4-dihydropyridine utiles contre les cellules tumorales
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2747513A1 (de) * 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen
DE2837477A1 (de) * 1978-08-28 1980-03-13 Bayer Ag Sila-substituierte 1,4-dihydropyridin- derivate
DE2841667A1 (de) * 1978-09-25 1980-04-10 Bayer Ag Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
BE886259A (fr) * 1979-11-23 1981-05-20 Sandoz Sa Nouveaux medicament a base de derives de la 1,4-dihydropyridine, pour le traitement de l'insuffisance cerebrovasculaire ou a action spamolytique
DE3018259A1 (de) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JPS57171968A (en) * 1981-04-17 1982-10-22 Kyowa Hakko Kogyo Co Ltd 1,4-dihydropyridine derivative
JPS57200364A (en) * 1981-06-04 1982-12-08 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its salt
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US5137889A (en) * 1983-12-02 1992-08-11 Otsuka Pharmaceutical Co., Ltd. Dihydropyridine derivatives and process for preparing the same
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
DE4342196A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Neue 4-Phenyl-substituierte 1,4-Dihydropyridine
JPS60248693A (ja) * 1984-04-19 1985-12-09 Nippon Shinyaku Co Ltd ピリジン誘導体及び製法
US4672068A (en) * 1984-05-04 1987-06-09 Fujirebio Kabushiki Kaisha Antihypertensive 1,4-dihydropyridines having a conjugated ester
DE3424342A1 (de) * 1984-07-03 1986-01-09 Bayer Ag, 5090 Leverkusen 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridin-3,5-dicarbonsaeure-isopropyl-(2-(3-trifluormethylphenoxy)-ethyl)-ester, mehrere verfahren zu seiner herstellung sowie seine verwendung in arzneimitteln
JPS6143165A (ja) * 1984-08-07 1986-03-01 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体の製造法
US4994476A (en) * 1984-10-31 1991-02-19 Bristol-Myers Company Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties
US4757071A (en) * 1984-12-14 1988-07-12 Nisshin Flour Milling Co., Ltd. 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases
US4595690A (en) * 1985-02-11 1986-06-17 Syntex (U.S.A.) Inc. Antihypertensive dihydropyridine derivatives
US4593033A (en) * 1985-04-24 1986-06-03 Merck & Co., Inc. Substituted indeno[2,1-c] pyridines useful as calcium channel blockers
US4605660A (en) * 1985-06-03 1986-08-12 Merck & Co., Inc. Indeno[2,1-c]pyridine compounds, and their use as calcium channel blockers
US4670443A (en) * 1985-07-02 1987-06-02 Merck & Co., Inc. Benzo(f)isoquinoline compounds useful as calcium entry blockers
US4788203A (en) * 1985-11-26 1988-11-29 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders
US4721708A (en) * 1985-11-26 1988-01-26 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds and cardiovascular use
DE3601196A1 (de) * 1986-01-17 1987-07-23 Merck Patent Gmbh 1,4-dihydropyridine
DK114587A (da) * 1986-03-12 1987-09-13 Byk Gulden Lomberg Chem Fab Monocycliske esterderivater
US4761420A (en) * 1986-06-13 1988-08-02 Laboratoires Syntex S.A. Antihypertensive dihydropyridine derivatives
JPH0688973B2 (ja) * 1987-03-12 1994-11-09 京都薬品工業株式会社 １，４−ジヒドロピリジン誘導体
AU2673588A (en) * 1987-12-11 1989-06-15 Laboratoires Syntex 1,4-dihydropyridine derivatives as neuroprotective compounds
KR940003492B1 (ko) * 1988-10-27 1994-04-23 주식회사 유한양행 1,4-디하이드로피리딘유도체 및 그의 제조방법
JPH01151557A (ja) * 1988-11-15 1989-06-14 Otsuka Pharmaceut Co Ltd 降圧剤
DE4125271A1 (de) * 1991-07-31 1993-02-11 Bayer Ag Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester
GB9119983D0 (en) * 1991-09-19 1991-11-06 Erba Carlo Spa Dihydropyridine derivatives useful in antitumor therapy
EE03192B1 (et) * 1993-12-10 1999-06-15 Bayer Aktiengesellschaft Isopropüül-(2-metoksüetüül)-4-(2-kloro-3-tsüanofenüül)-1,4-dihüdro-2,6-dimetüülpüri diin-3,5-dikarboksülaat, selle enantiomeerid ja vaheühend, meetodid nimetatud ühendite valmistamiseks ja kasutamine
DE4342193A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Arylsubstituierte Alkoxycarbonyl-1,4-dihydropyridin-5-carbonsäureester
SE9600086D0 (sv) * 1996-01-10 1996-01-10 Astra Ab New manufacturing process
CN106380405B (zh) * 2016-08-24 2019-01-29 郑州瑞康制药有限公司 一种2-(3-硝基亚苄基)乙酰乙酸异丙酯的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL77955C (fr) * 1948-11-17
FR2182983A1 (fr) * 1972-04-18 1973-12-14 Bayer Ag

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3996234A (en) * 1972-04-18 1976-12-07 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
JPS5649909B2 (fr) 1973-05-02 1981-11-25

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL77955C (fr) * 1948-11-17
FR2182983A1 (fr) * 1972-04-18 1973-12-14 Bayer Ag

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984002132A1 (fr) * 1982-11-24 1984-06-07 Cermol Sa Nouveaux esters de 1,4-dihydropyridines et leurs procedes de preparation et medicaments contenant lesdits esters
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
EP0191448A2 (fr) * 1985-02-11 1986-08-20 Syntex (U.S.A.) Inc. Dihydropyridines antihypertensives
EP0191448A3 (fr) * 1985-02-11 1987-08-19 Syntex (U.S.A.) Inc. Dihydropyridines antihypertensives
EP0330470A2 (fr) * 1988-02-24 1989-08-30 Ajinomoto Co., Inc. Dérivés de 1,4-dihydropyridine utiles contre les cellules tumorales
EP0330470A3 (fr) * 1988-02-24 1992-01-02 Ajinomoto Co., Inc. Dérivés de 1,4-dihydropyridine utiles contre les cellules tumorales
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells

Also Published As

Publication number Publication date
BE838924A (fr) 1976-08-25
ATA132976A (de) 1978-12-15
ZA761118B (en) 1977-02-23
SE7602317L (sv) 1976-08-27
AT351024B (de) 1979-07-10
JPS51108075A (fr) 1976-09-25
GB1477114A (en) 1977-06-22
PT64840B (fr) 1977-06-07
NL7601823A (nl) 1976-08-30
IL49095A (en) 1979-12-30
FI760475A (fr) 1976-08-27
FI61483B (fi) 1982-04-30
RO68479A (fr) 1981-01-30
LU74424A1 (fr) 1977-01-07
NO146393B (no) 1982-06-14
CH622506A5 (fr) 1981-04-15
IL49095A0 (en) 1976-04-30
SU574150A3 (ru) 1977-09-25
IE42643B1 (en) 1980-09-24
IE42643L (en) 1976-08-26
DK78876A (da) 1976-08-27
AU1143876A (en) 1977-09-01
US4044141A (en) 1977-08-23
FR2302093B1 (fr) 1979-09-21
FI61483C (fi) 1982-08-10
DE2508181A1 (de) 1976-09-09
PT64840A (fr) 1976-03-01
ES445508A1 (es) 1977-11-16
NO760470L (fr) 1976-08-27
NO146393C (no) 1982-09-22
CS188994B2 (en) 1979-03-30
DE2508181C2 (fr) 1988-12-01
CA1069902A (fr) 1980-01-15
PL100906B1 (pl) 1978-11-30
DD125483A5 (fr) 1977-04-20
IN142197B (fr) 1977-06-11
JPS6025424B2 (ja) 1985-06-18
HU171717B (hu) 1978-03-28

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Legal Events

Date Code Title Description
ST Notification of lapse