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FR2387234A1 - CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS - Google Patents

CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS

Info

Publication number
FR2387234A1
FR2387234A1 FR7811069A FR7811069A FR2387234A1 FR 2387234 A1 FR2387234 A1 FR 2387234A1 FR 7811069 A FR7811069 A FR 7811069A FR 7811069 A FR7811069 A FR 7811069A FR 2387234 A1 FR2387234 A1 FR 2387234A1
Authority
FR
France
Prior art keywords
preparation process
therapeutic applications
cephalosporin derivatives
derivatives
cephalosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7811069A
Other languages
French (fr)
Other versions
FR2387234B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of FR2387234A1 publication Critical patent/FR2387234A1/en
Application granted granted Critical
Publication of FR2387234B1 publication Critical patent/FR2387234B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne de nouveaux dérivés de céphème, répondant à la formule générale :The invention relates to novel cephem derivatives, corresponding to the general formula:

FR7811069A 1977-04-15 1978-04-14 CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS Expired FR2387234B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2716677A DE2716677C2 (en) 1977-04-15 1977-04-15 Cephem derivatives and processes for their preparation

Publications (2)

Publication Number Publication Date
FR2387234A1 true FR2387234A1 (en) 1978-11-10
FR2387234B1 FR2387234B1 (en) 1985-09-13

Family

ID=6006350

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7811069A Expired FR2387234B1 (en) 1977-04-15 1978-04-14 CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS

Country Status (30)

Country Link
US (1) US4399131A (en)
JP (1) JPS6052756B2 (en)
AT (1) AT367426B (en)
AU (1) AU526333B2 (en)
BE (1) BE866038A (en)
CA (1) CA1161836A (en)
CH (1) CH643558A5 (en)
CS (1) CS208748B2 (en)
DD (1) DD138423A5 (en)
DE (1) DE2716677C2 (en)
DK (1) DK163244C (en)
ES (3) ES468666A1 (en)
FI (1) FI66188C (en)
FR (1) FR2387234B1 (en)
GB (1) GB1603212A (en)
GR (1) GR71190B (en)
HK (1) HK28983A (en)
HU (1) HU184145B (en)
IE (1) IE46535B1 (en)
IL (1) IL54503A0 (en)
IT (1) IT1095578B (en)
LU (1) LU79439A1 (en)
NL (1) NL7804019A (en)
NO (1) NO781322L (en)
NZ (1) NZ186968A (en)
OA (1) OA05939A (en)
PT (1) PT67906B (en)
SE (1) SE447384B (en)
YU (1) YU87378A (en)
ZA (1) ZA782168B (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2465737A1 (en) * 1979-04-12 1981-03-27 Squibb & Sons Inc 7- (2- (2-AMINO-4-THIAZOLYL) -2 - ((1-CARBOXY-1,1-DIALKYL) ALKOXYIMINO) ACETAMIDO) CEPHEM SULFOXYDES WITH ANTIBACTERIAL ACTION
FR2465738A1 (en) * 1979-09-19 1981-03-27 Squibb & Sons Inc AMINOTHIAZOLYL UREIDO CEPHALOSPORIN SULFOXIDES WITH ANTIBACTERIAL ACTION, AND METHOD AND INTERMEDIATES FOR PREPARING SAME
EP0043756A1 (en) * 1980-06-30 1982-01-13 Sanofi S.A. 1,2,4-Triazinylthiomethyl-3-cephem sulfoxides, process for their preparation and pharmaceutical compositions containing them
EP0045937A2 (en) * 1980-08-11 1982-02-17 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
EP0047491A2 (en) * 1980-09-08 1982-03-17 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
FR2501209A1 (en) * 1981-03-03 1982-09-10 Sanofi Sa NOVEL DERIVATIVES OF CEPHALOSPORINS AND ANTIBIOTIC DRUGS CONTAINING SAID DERIVATIVES
EP0064740A2 (en) * 1981-05-12 1982-11-17 Hoechst Aktiengesellschaft Cephalosporin derivatives, and process for their preparation
EP0080944A1 (en) * 1981-12-01 1983-06-08 Sanofi S.A. Cephalosporin derivatives substituted in position 3 with a thiomethylheterocyclic group, process for their preparation and pharmaceutical compositions containing them
EP0088853A1 (en) * 1981-11-16 1983-09-21 Sanofi S.A. Derivatives of pyridinium thiomethyl cephalosporins, process for their preparation and pharmaceutical compositions containing them
US4603129A (en) * 1980-02-23 1986-07-29 Hoechst Aktiengesellschaft Cephalosporin derivatives
EP0214029A1 (en) 1985-08-09 1987-03-11 Roussel-Uclaf 1-Dethia-2-thia cephalosporanic-acid derivatives, process for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them
EP0099297B1 (en) * 1982-07-13 1988-04-06 Sanofi S.A. Cephalosporin derivatives, process for their preparation and antibiotic medicaments containing them
EP0334281A2 (en) * 1988-03-22 1989-09-27 Hoechst Aktiengesellschaft Cephalosporin derivatives and process for their preparation
EP0447118A2 (en) * 1990-03-16 1991-09-18 ZENECA Pharma S.A. 3-tetrazolylthiomethyl cephalosporin antibiotics

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878514A (en) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY
BE878433A (en) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID DERIVATIVES 3,7-DISUBSTITUTED, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY
US4496562A (en) * 1977-03-14 1985-01-29 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted-3-cephem-4-carboxylic acid esters
US4409217A (en) * 1977-03-14 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
ZA781502B (en) * 1977-03-14 1979-09-26 Fujisawa Pharmaceutical Co New cephem and cepham compounds and processes for preparation thereof
FR2410655A1 (en) * 1977-12-05 1979-06-29 Roussel Uclaf NEW OXIMES DERIVED FROM 3-SUBSTITUTE 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2432521A1 (en) * 1978-03-31 1980-02-29 Roussel Uclaf NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS
FR2421907A1 (en) * 1978-04-07 1979-11-02 Roussel Uclaf NEW CEPHALOSPORINS DERIVED FROM 7- / 2- (2-AMINO 4-THIAZOLYL) 2- (CARBOXYMETHOXYIMINO / ACETAMIDO 3-SUBSTITUTE CEPHALOSPORANIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
AR229883A1 (en) 1978-05-26 1983-12-30 Glaxo Group Ltd PROCEDURE FOR THE PREPARATION OF ANTIBIOTIC (6R, 7R) -7 - ((Z) -2- (2-AMINOTIAZOL-4-IL) -2- (2-CARBOXIPROP-2-OXIIMINO) -ACETAMIDO) -3- (1 -PIRIDINOMETIL) -CEF-3-EM-4-CARBOXYLATE
DE2822861A1 (en) * 1978-05-26 1979-11-29 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4331666A (en) 1979-05-11 1982-05-25 Farmitalia Carlo Erba S.P.A. 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid
US4271157A (en) 1980-02-28 1981-06-02 E. R. Squibb & Sons, Inc. Imidazole derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
US4409215A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
US4349672A (en) * 1979-11-29 1982-09-14 Hoffmann-La Roche Inc. Cephalosporin derivatives
FR2476087A1 (en) * 1980-02-18 1981-08-21 Roussel Uclaf NOVEL OXIMES DERIVED FROM 3-ALKYLOXY OR 3-ALKYL-THIOMETHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS
US4252802A (en) 1980-03-13 1981-02-24 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
FR2479229B1 (en) * 1980-03-26 1986-01-17 Clin Midy NOVEL CEPHALOSPORIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS FOR USE AS ANTIBIOTICS CONTAINING SAID DERIVATIVES
IT1141286B (en) * 1980-04-17 1986-10-01 Dob Far Spa ESTERS OF DESACETOXY Cephalosporins THEIR SALTS AND PROCEDURES FOR THEIR OBTAINING
JPS5756486A (en) * 1980-08-11 1982-04-05 Fujisawa Pharmaceut Co Ltd Novel cephem compound or its salt, their preparation and prophylactic or remedy for microbism containing the same as active ingredient
JPS6011917B2 (en) * 1981-04-09 1985-03-28 山之内製薬株式会社 Novel cephalosporin compounds
JPS5849382A (en) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd Beta-lactam compound
EP0187355A1 (en) 1981-09-23 1986-07-16 E.R. Squibb & Sons, Inc. Process for preparing beta-lactam antibiotics
JPS5862181A (en) * 1981-10-07 1983-04-13 Dai Ichi Seiyaku Co Ltd Cephalosporin derivative
PH19163A (en) * 1982-04-06 1986-01-16 Daiichi Seiyaku Co Cephalosporin derivatives
US4500526A (en) * 1982-06-28 1985-02-19 Bristol-Myers Company Cephalosporin derivatives
EP0098161A3 (en) * 1982-06-30 1985-04-24 Glaxo Group Limited Cephalosporin compounds
US4616081A (en) * 1982-07-07 1986-10-07 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compounds
US4459405A (en) * 1982-11-16 1984-07-10 Eli Lilly And Company Desacetylcephalosporin sulfones
US4477660A (en) * 1982-11-16 1984-10-16 Eli Lilly And Company 7-(S)-Acylaminocephalosporin sulfones and process
US4608373A (en) * 1982-12-13 1986-08-26 Yamanouchi Pharmaceutical Co., Ltd. Cephem compounds
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US5132301A (en) * 1983-05-02 1992-07-21 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
FR2546520B1 (en) * 1983-05-27 1985-08-30 Sanofi Sa NOVEL ANTIBIOTIC COMPOUNDS DERIVED FROM CEPHALOSPORINS
DE150507T1 (en) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo CEPHALOSPORINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS.
JPS60142987A (en) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd Cephalosporin derivative
KR920004820B1 (en) * 1984-02-23 1992-06-18 메이지제과 주식회사 Process for preparing novel cephalosporin derivatives
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
US4684722A (en) * 1986-01-06 1987-08-04 E. R. Squibb & Sons, Inc. Monosulfactams
US5147871A (en) * 1986-07-03 1992-09-15 Hoffmann La-Roche, Inc. Anti-bacterial cephalosporin compounds
ZA874696B (en) 1986-07-03 1988-01-04 F. Hoffmann-La Roche & Co. Aktiengesellschaft Acyl derivatives
JPS63132893A (en) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd Novel cephalosporin derivative, production thereof and antibacterial agent containing said derivative as active ingredient
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US5428163A (en) * 1986-12-31 1995-06-27 Mills; Randell L. Prodrugs for selective drug delivery
CS273349B2 (en) * 1988-03-31 1991-03-12 Hoffmann La Roche Method of cephalosporin's new derivatives production
US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
DK0449515T3 (en) * 1990-03-24 1995-10-16 Lucky Ltd New Cephalosporin Intermediates and Processes for Preparation of Intermediates and End Products thereof
JPH0626344U (en) * 1992-08-27 1994-04-08 武盛 豊永 Soft touch phone
US5811419A (en) * 1996-01-16 1998-09-22 Hoffmann-La Roche Inc. Isooxacephem-derivatives
DE19607960A1 (en) * 1996-03-01 1997-09-04 Hoechst Schering Agrevo Gmbh Process for the preparation of ketone oxime ether by boronic acid coupling
US5883247A (en) * 1996-06-10 1999-03-16 Hoffmann-La Roche Inc. Preparation of cephem and isooxacephem derivatives
WO2001095944A2 (en) * 2000-06-12 2001-12-20 Mills Randell L Photocleavable prodrugs for selective drug delivery
US20050080260A1 (en) * 2003-04-22 2005-04-14 Mills Randell L. Preparation of prodrugs for selective drug delivery
BRPI0413908A (en) * 2003-08-25 2006-10-24 Revaax Pharmaceuticals Llc neurotherapeutic pharmaceutical formulation in oral dosage form, compound, and method of treating a behavioral disorder or a cognitive disorder
US7908037B2 (en) * 2009-03-27 2011-03-15 General Electric Company Pre-programmed energy management ballast or driver
WO2016030534A1 (en) 2014-08-29 2016-03-03 Tes Pharma S.R.L. INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE

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FR2192805A1 (en) * 1972-07-18 1974-02-15 Gist Brocades Nv

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Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2465737A1 (en) * 1979-04-12 1981-03-27 Squibb & Sons Inc 7- (2- (2-AMINO-4-THIAZOLYL) -2 - ((1-CARBOXY-1,1-DIALKYL) ALKOXYIMINO) ACETAMIDO) CEPHEM SULFOXYDES WITH ANTIBACTERIAL ACTION
FR2465738A1 (en) * 1979-09-19 1981-03-27 Squibb & Sons Inc AMINOTHIAZOLYL UREIDO CEPHALOSPORIN SULFOXIDES WITH ANTIBACTERIAL ACTION, AND METHOD AND INTERMEDIATES FOR PREPARING SAME
US4603129A (en) * 1980-02-23 1986-07-29 Hoechst Aktiengesellschaft Cephalosporin derivatives
EP0043756A1 (en) * 1980-06-30 1982-01-13 Sanofi S.A. 1,2,4-Triazinylthiomethyl-3-cephem sulfoxides, process for their preparation and pharmaceutical compositions containing them
EP0045937A2 (en) * 1980-08-11 1982-02-17 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
EP0045937A3 (en) * 1980-08-11 1982-10-13 Fujisawa Pharmaceutical Co. Ltd. New cephem compounds and processes for preparation thereof
EP0047491A3 (en) * 1980-09-08 1983-03-16 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
EP0047491A2 (en) * 1980-09-08 1982-03-17 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
FR2501209A1 (en) * 1981-03-03 1982-09-10 Sanofi Sa NOVEL DERIVATIVES OF CEPHALOSPORINS AND ANTIBIOTIC DRUGS CONTAINING SAID DERIVATIVES
FR2515654A1 (en) * 1981-05-12 1983-05-06 Hoechst Ag CEPHALOSPORINE DERIVATIVES AS INTERMEDIATE PRODUCTS FOR PREPARING PRODUCTS WITH THERAPEUTIC ACTIVITY
FR2511682A1 (en) * 1981-05-12 1983-02-25 Hoechst Ag CEPHALOSPORINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
EP0064740A3 (en) * 1981-05-12 1983-11-23 Hoechst Aktiengesellschaft Cephalosporin derivatives, and process for their preparation
EP0064740A2 (en) * 1981-05-12 1982-11-17 Hoechst Aktiengesellschaft Cephalosporin derivatives, and process for their preparation
EP0088853A1 (en) * 1981-11-16 1983-09-21 Sanofi S.A. Derivatives of pyridinium thiomethyl cephalosporins, process for their preparation and pharmaceutical compositions containing them
EP0080944A1 (en) * 1981-12-01 1983-06-08 Sanofi S.A. Cephalosporin derivatives substituted in position 3 with a thiomethylheterocyclic group, process for their preparation and pharmaceutical compositions containing them
EP0099297B1 (en) * 1982-07-13 1988-04-06 Sanofi S.A. Cephalosporin derivatives, process for their preparation and antibiotic medicaments containing them
EP0214029A1 (en) 1985-08-09 1987-03-11 Roussel-Uclaf 1-Dethia-2-thia cephalosporanic-acid derivatives, process for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them
EP0334281A2 (en) * 1988-03-22 1989-09-27 Hoechst Aktiengesellschaft Cephalosporin derivatives and process for their preparation
EP0334281A3 (en) * 1988-03-22 1991-08-28 Hoechst Aktiengesellschaft Cephalosporin derivatives and process for their preparation
EP0447118A2 (en) * 1990-03-16 1991-09-18 ZENECA Pharma S.A. 3-tetrazolylthiomethyl cephalosporin antibiotics
EP0447118A3 (en) * 1990-03-16 1992-06-03 I.C.I.- Pharma 3-tetrazolylthiomethyl cephalosporin antibiotics

Also Published As

Publication number Publication date
DK163244C (en) 1992-06-29
LU79439A1 (en) 1978-11-28
AU3507178A (en) 1979-10-18
US4399131A (en) 1983-08-16
SE447384B (en) 1986-11-10
ES468666A1 (en) 1980-12-16
NZ186968A (en) 1981-04-24
CH643558A5 (en) 1984-06-15
PT67906A (en) 1978-05-01
NO781322L (en) 1978-10-17
DE2716677A1 (en) 1978-10-26
ZA782168B (en) 1979-03-28
IE780736L (en) 1978-10-15
OA05939A (en) 1981-06-30
AU526333B2 (en) 1983-01-06
FI781131A (en) 1978-10-16
PT67906B (en) 1994-01-14
YU87378A (en) 1983-01-21
CS208748B2 (en) 1981-09-15
JPS6052756B2 (en) 1985-11-21
FI66188C (en) 1984-09-10
SE7804185L (en) 1978-10-16
JPS53130691A (en) 1978-11-14
BE866038A (en) 1978-10-17
AT367426B (en) 1982-07-12
ES477153A1 (en) 1979-07-01
FI66188B (en) 1984-05-31
NL7804019A (en) 1978-10-17
DK163244B (en) 1992-02-10
IE46535B1 (en) 1983-07-13
FR2387234B1 (en) 1985-09-13
IT1095578B (en) 1985-08-10
DE2716677C2 (en) 1985-10-10
IT7822244A0 (en) 1978-04-12
DK162878A (en) 1978-10-16
HU184145B (en) 1984-07-30
CA1161836A (en) 1984-02-07
GB1603212A (en) 1981-11-18
HK28983A (en) 1983-08-26
ATA263278A (en) 1981-11-15
ES477154A1 (en) 1979-12-01
GR71190B (en) 1983-04-11
DD138423A5 (en) 1979-10-31
IL54503A0 (en) 1978-07-31

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