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FR2368282A1 - Adjuvant immunologique constitue par le p-amino-phenyl de n-acetyl-muramyl-l-alanyl-d-isoglutamine - Google Patents

Adjuvant immunologique constitue par le p-amino-phenyl de n-acetyl-muramyl-l-alanyl-d-isoglutamine

Info

Publication number
FR2368282A1
FR2368282A1 FR7631935A FR7631935A FR2368282A1 FR 2368282 A1 FR2368282 A1 FR 2368282A1 FR 7631935 A FR7631935 A FR 7631935A FR 7631935 A FR7631935 A FR 7631935A FR 2368282 A1 FR2368282 A1 FR 2368282A1
Authority
FR
France
Prior art keywords
isoglutamine
alanyl
phenyl
amino
muramyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7631935A
Other languages
English (en)
Other versions
FR2368282B1 (fr
Inventor
Marcel Derrien
Derrien Edgar Lederer Francoise Audibert Louis Chedid Jean Choay Et Pierre Lefrancier Marcel
Edgar Lederer
Francoise Audibert
Louis Chedid
Jean Choay
Pierre Lefrancier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR7631935A priority Critical patent/FR2368282A1/fr
Priority to CH1280977A priority patent/CH626629A5/fr
Priority to DE19772747379 priority patent/DE2747379A1/de
Priority to GB43832/77A priority patent/GB1590659A/en
Priority to JP12588277A priority patent/JPS5353628A/ja
Priority to US05/845,105 priority patent/US4185089A/en
Publication of FR2368282A1 publication Critical patent/FR2368282A1/fr
Application granted granted Critical
Publication of FR2368282B1 publication Critical patent/FR2368282B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention est relative à un nouvel agent adjuvant immunologique soluble dans l'eau. L'agent adjuvant est le 2-(p-amino-phényl-2-acétamido-2-déoxy-3-0-D-glucopyranosyl)-D-propio-nyl-L-alanyl-D-isoglutamine qui, dans sa forme glucoside, répond à la formule :
FR7631935A 1976-10-22 1976-10-22 Adjuvant immunologique constitue par le p-amino-phenyl de n-acetyl-muramyl-l-alanyl-d-isoglutamine Granted FR2368282A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR7631935A FR2368282A1 (fr) 1976-10-22 1976-10-22 Adjuvant immunologique constitue par le p-amino-phenyl de n-acetyl-muramyl-l-alanyl-d-isoglutamine
CH1280977A CH626629A5 (fr) 1976-10-22 1977-10-20
DE19772747379 DE2747379A1 (de) 1976-10-22 1977-10-21 P-amino-phenyl-n-acetyl-muramyl-l- alanyl-d-isoglutamin, verfahren zu dessen herstellung und diese verbindung enthaltende arzneimittel
GB43832/77A GB1590659A (en) 1976-10-22 1977-10-21 Immunological adjuvant constituted by the p-aminophenyl derivative of n-acetylmuramyl-l-alanyl-d-isoglutamine
JP12588277A JPS5353628A (en) 1976-10-22 1977-10-21 Nnacetyllmuramyllllalanylldd isogultamine ppaminophenyl derivatives* and immunological adjant containing said compound and process for preparation thereof
US05/845,105 US4185089A (en) 1976-10-22 1977-10-25 Immunological adjuvant constituted by the p-amino-phenyl derivative of N-acetyl-muramyl-L-alanyl-D-isoglutamine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7631935A FR2368282A1 (fr) 1976-10-22 1976-10-22 Adjuvant immunologique constitue par le p-amino-phenyl de n-acetyl-muramyl-l-alanyl-d-isoglutamine

Publications (2)

Publication Number Publication Date
FR2368282A1 true FR2368282A1 (fr) 1978-05-19
FR2368282B1 FR2368282B1 (fr) 1980-10-17

Family

ID=9179110

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7631935A Granted FR2368282A1 (fr) 1976-10-22 1976-10-22 Adjuvant immunologique constitue par le p-amino-phenyl de n-acetyl-muramyl-l-alanyl-d-isoglutamine

Country Status (6)

Country Link
US (1) US4185089A (fr)
JP (1) JPS5353628A (fr)
CH (1) CH626629A5 (fr)
DE (1) DE2747379A1 (fr)
FR (1) FR2368282A1 (fr)
GB (1) GB1590659A (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006068A2 (fr) * 1978-06-05 1979-12-12 ANVAR Agence Nationale de Valorisation de la Recherche Composés du type muramyl-peptide et médicaments les contenant
WO1997010259A1 (fr) * 1995-09-11 1997-03-20 Bezrukov, Mikhail Vasilievich Procede d'obtention de peptides muramiques
EP1326873A1 (fr) * 2000-10-17 2003-07-16 Alchemia Pty Ltd Banques combinatoires de monosaccharides

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377570A (en) * 1979-01-29 1983-03-22 Merck & Co., Inc. Immunologically active dipeptidyl saccharides and methods of preparation
FR2449697A1 (fr) 1979-02-20 1980-09-19 Anvar Nouveaux muramyl-peptides substitues sur un azote peptidique et medicaments les contenant
FI75578C (fi) * 1979-07-25 1988-07-11 Ciba Geigy Ag Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4770874A (en) * 1983-08-22 1988-09-13 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4772466A (en) * 1983-08-22 1988-09-20 Syntex (U.S.A.) Inc. Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4933179A (en) * 1983-08-22 1990-06-12 Syntex (U.S.A.) Inc. Feline leukemia virus antigen vaccines
US5554372A (en) * 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
US5149529A (en) * 1988-04-08 1992-09-22 Board Of Trustees Of Leland Chiron Corporation Compositions and treatment for herpes simplex
US4950645A (en) * 1988-07-08 1990-08-21 Immunotherapeutics, Inc. Composition for macrophage activation
US5416070A (en) * 1988-07-08 1995-05-16 Immunotherapeutics, Inc. Composition for macrophage activation
US6156319A (en) 1994-07-25 2000-12-05 The Trustees Of The University Of Pennsylvania Soluble herpesvirus glycoprotein complex vaccine
AU2004262506A1 (en) 2003-02-28 2005-02-17 National Institutes Of Health Compositions, methods and kits relating to poxvirus subunit vaccines
AU2005330703A1 (en) * 2004-07-19 2006-10-26 Baylor College Of Medicine Modulation of cytokine signaling regulators and applications for immunotherapy
JP2008542405A (ja) 2005-06-08 2008-11-27 ニューバイオメッド ピーアイケイエイ プライベート リミテッド ポリイノシン酸‐ポリシチジル酸に基づくアジュバント
US7868159B2 (en) * 2005-06-23 2011-01-11 Baylor College Of Medicine Modulation of negative immune regulators and applications for immunotherapy
US20070166800A1 (en) * 2006-01-13 2007-07-19 Haixiang Lin Immunogenic substances comprising a polyinosinic acid-polycytidilic acid based adjuvant
US20070166239A1 (en) * 2006-01-13 2007-07-19 Haixiang Lin Mucosal immunogenic substances comprising a polyinosinic acid - polycytidilic acid based adjuvant
CN101678082B (zh) 2007-03-26 2013-06-19 再生医药有限公司 使用cxcl9和抗cxcl9抗体促进骨髓保护和再生的方法
JP2011505144A (ja) * 2007-11-30 2011-02-24 ベイラー カレッジ オブ メディシン 樹状細胞ワクチン組成物およびその使用
US9808504B2 (en) 2009-09-22 2017-11-07 Yale University Immunogenic epitopes as targets for universal cancer vaccines
KR101955365B1 (ko) 2011-07-12 2019-03-07 필라델피아 헬스 앤드 에듀케이션 코포레이션 디/비/에이 드렉셀 유니버시티 컬리지 오브 메디슨 신규한 클로스트리듐 디피실(Clostridium Difficile) DNA 백신
WO2015116178A1 (fr) 2014-01-31 2015-08-06 Thomas Jefferson University Protéines de fusion pour la modulation des lymphocytes t régulateurs et effecteurs
US9834610B2 (en) 2013-01-31 2017-12-05 Thomas Jefferson University Fusion proteins for modulating regulatory and effector T cells
RU2678981C2 (ru) 2014-12-23 2019-02-05 Йишенг Байофарма (Сингапур) Пте Лтд Композиция от бешенства, содержащая адъювант pika
US10610564B2 (en) 2015-02-26 2020-04-07 Stc.Unm IRGM and precision autophagy controls for antimicrobial and inflammatory disease states and methods of detection of autophagy
WO2020140007A1 (fr) 2018-12-28 2020-07-02 University Of Rochester Thérapie génique pour mutations dominantes best1

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082736A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof
US4082735A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006068A2 (fr) * 1978-06-05 1979-12-12 ANVAR Agence Nationale de Valorisation de la Recherche Composés du type muramyl-peptide et médicaments les contenant
EP0006068A3 (en) * 1978-06-05 1980-01-09 Anvar Agence Nationale De Valorisation De La Recherche Compounds of the muramyl-peptide type and medicines containing them
WO1997010259A1 (fr) * 1995-09-11 1997-03-20 Bezrukov, Mikhail Vasilievich Procede d'obtention de peptides muramiques
EP1326873A1 (fr) * 2000-10-17 2003-07-16 Alchemia Pty Ltd Banques combinatoires de monosaccharides
EP1326873A4 (fr) * 2000-10-17 2007-12-19 Alchemia Pty Ltd Banques combinatoires de monosaccharides
US7417129B2 (en) 2000-10-17 2008-08-26 Alchemia Pty Ltd Combinatorial libraries of monosaccharides
US8093227B2 (en) 2000-10-17 2012-01-10 Alchemia Pty Ltd Monosaccharide compounds and methods therefor

Also Published As

Publication number Publication date
JPS5353628A (en) 1978-05-16
FR2368282B1 (fr) 1980-10-17
CH626629A5 (fr) 1981-11-30
DE2747379A1 (de) 1978-04-27
US4185089A (en) 1980-01-22
GB1590659A (en) 1981-06-03
JPS6126800B2 (fr) 1986-06-21

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