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FR2357563A1 - Nouvelles 7h-pyrrolo(3,2-f) quinazoline-1,3-diamines substituees en position 7, leur procede de preparation et medicament les contenant - Google Patents

Nouvelles 7h-pyrrolo(3,2-f) quinazoline-1,3-diamines substituees en position 7, leur procede de preparation et medicament les contenant

Info

Publication number
FR2357563A1
FR2357563A1 FR7721232A FR7721232A FR2357563A1 FR 2357563 A1 FR2357563 A1 FR 2357563A1 FR 7721232 A FR7721232 A FR 7721232A FR 7721232 A FR7721232 A FR 7721232A FR 2357563 A1 FR2357563 A1 FR 2357563A1
Authority
FR
France
Prior art keywords
quinazoline
pyrrolo
preparation
new
product containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7721232A
Other languages
English (en)
Other versions
FR2357563B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of FR2357563A1 publication Critical patent/FR2357563A1/fr
Application granted granted Critical
Publication of FR2357563B1 publication Critical patent/FR2357563B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne de nouvelles 7H-pyrrolo-Ø3,2-fõ-quinazoline- 1,3-diamines substituées en position 7; elle concerne également des composés intermédiaires utilisés dans leur préparation Elle concerne en outre un procédé à plusieurs variantes pour la préparation de ces nouveaux composés. Les composés de l'invention sont doués d'activité biologique, notamment d'activité antibactérienne. Ils peuvent être incorporés à ce titre dans des compositions pharmaceutiques.
FR7721232A 1976-07-09 1977-07-08 Nouvelles 7h-pyrrolo(3,2-f) quinazoline-1,3-diamines substituees en position 7, leur procede de preparation et medicament les contenant Granted FR2357563A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70400276A 1976-07-09 1976-07-09
US70400176A 1976-07-09 1976-07-09
GB5382176 1976-12-23
US78498777A 1977-04-06 1977-04-06

Publications (2)

Publication Number Publication Date
FR2357563A1 true FR2357563A1 (fr) 1978-02-03
FR2357563B1 FR2357563B1 (fr) 1983-03-11

Family

ID=27449036

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7721232A Granted FR2357563A1 (fr) 1976-07-09 1977-07-08 Nouvelles 7h-pyrrolo(3,2-f) quinazoline-1,3-diamines substituees en position 7, leur procede de preparation et medicament les contenant

Country Status (13)

Country Link
JP (1) JPS539796A (fr)
AU (1) AU507828B2 (fr)
BE (1) BE856647A (fr)
CA (1) CA1093555A (fr)
CH (1) CH634069A5 (fr)
DE (1) DE2731039A1 (fr)
DK (1) DK309977A (fr)
FR (1) FR2357563A1 (fr)
IE (1) IE45427B1 (fr)
IN (1) IN147488B (fr)
MX (1) MX5133E (fr)
NL (1) NL7707658A (fr)
PH (1) PH13539A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0639075A4 (fr) * 1990-11-14 1993-09-29 Chiron Corp Inhibition specifique de la dihydrofolate reductase et composes prevus a cet effet.

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100810468B1 (ko) * 2001-10-10 2008-03-07 씨제이제일제당 (주) 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난1ｈ-인돌 유도체
US7262297B2 (en) * 2003-05-15 2007-08-28 Hoffmann-La Roche Inc. Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors
US11077109B2 (en) * 2017-08-01 2021-08-03 The Trustees Of Princeton University Compounds having antibacterial activity and methods of use

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0639075A4 (fr) * 1990-11-14 1993-09-29 Chiron Corp Inhibition specifique de la dihydrofolate reductase et composes prevus a cet effet.
EP0639075A1 (fr) * 1990-11-14 1995-02-22 Chiron Corporation Inhibition specifique de la dihydrofolate reductase et composes prevus a cet effet

Also Published As

Publication number Publication date
FR2357563B1 (fr) 1983-03-11
JPS539796A (en) 1978-01-28
CA1093555A (fr) 1981-01-13
NL7707658A (nl) 1978-01-11
AU2668777A (en) 1979-01-04
IE45427B1 (en) 1982-08-25
JPS6254111B2 (fr) 1987-11-13
DE2731039A1 (de) 1978-01-19
CH634069A5 (en) 1983-01-14
MX5133E (es) 1983-03-28
AU507828B2 (en) 1980-02-28
BE856647A (fr) 1978-01-09
PH13539A (en) 1980-06-26
DK309977A (da) 1978-01-10
IN147488B (fr) 1980-03-15
IE45427L (en) 1978-10-06

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Legal Events

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