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FR2340932A1 - PROLINE DERIVATIVES AND RELATED COMPOUNDS USEFUL FOR REDUCING BLOOD TENSION - Google Patents

PROLINE DERIVATIVES AND RELATED COMPOUNDS USEFUL FOR REDUCING BLOOD TENSION

Info

Publication number
FR2340932A1
FR2340932A1 FR7704122A FR7704122A FR2340932A1 FR 2340932 A1 FR2340932 A1 FR 2340932A1 FR 7704122 A FR7704122 A FR 7704122A FR 7704122 A FR7704122 A FR 7704122A FR 2340932 A1 FR2340932 A1 FR 2340932A1
Authority
FR
France
Prior art keywords
compounds useful
related compounds
reducing blood
proline derivatives
blood tension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7704122A
Other languages
French (fr)
Other versions
FR2340932B1 (en
Inventor
Miguel Angel Ondetti
David Wayne Cushman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/657,792 external-priority patent/US4046889A/en
Priority claimed from US05/751,851 external-priority patent/US4105776A/en
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2340932A1 publication Critical patent/FR2340932A1/en
Application granted granted Critical
Publication of FR2340932B1 publication Critical patent/FR2340932B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7704122A 1976-02-13 1977-02-14 PROLINE DERIVATIVES AND RELATED COMPOUNDS USEFUL FOR REDUCING BLOOD TENSION Granted FR2340932A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/657,792 US4046889A (en) 1976-02-13 1976-02-13 Azetidine-2-carboxylic acid derivatives
US69843276A 1976-06-21 1976-06-21
US05/751,851 US4105776A (en) 1976-06-21 1976-12-22 Proline derivatives and related compounds

Publications (2)

Publication Number Publication Date
FR2340932A1 true FR2340932A1 (en) 1977-09-09
FR2340932B1 FR2340932B1 (en) 1981-02-06

Family

ID=27417986

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7704122A Granted FR2340932A1 (en) 1976-02-13 1977-02-14 PROLINE DERIVATIVES AND RELATED COMPOUNDS USEFUL FOR REDUCING BLOOD TENSION

Country Status (31)

Country Link
JP (1) JPS604815B2 (en)
AR (4) AR222445A1 (en)
AT (1) AT365569B (en)
AU (1) AU509899B2 (en)
BG (3) BG37075A3 (en)
CA (1) CA1101864A (en)
CH (3) CH622503A5 (en)
DD (1) DD129442B3 (en)
DE (2) DE2703828C2 (en)
DK (1) DK157487C (en)
ES (5) ES455803A1 (en)
FI (1) FI66596C (en)
FR (1) FR2340932A1 (en)
GB (1) GB1576161A (en)
GR (1) GR69811B (en)
HK (1) HK20281A (en)
HU (1) HU181965B (en)
IE (1) IE44707B1 (en)
IL (1) IL51297A (en)
IT (1) IT1062293B (en)
KE (1) KE3136A (en)
MY (2) MY8200075A (en)
NL (1) NL168509C (en)
NO (1) NO146985C (en)
NZ (1) NZ183130A (en)
PH (1) PH12970A (en)
PL (1) PL118161B1 (en)
RO (1) RO69941A (en)
SE (2) SE423812B (en)
SU (1) SU747422A3 (en)
YU (1) YU40664B (en)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2372817A1 (en) * 1976-12-03 1978-06-30 Squibb & Sons Inc DERIVATIVES OF THIAZOLIDINECARBOXYLIC ACIDS AND RELATED ACIDS, USEFUL AS ANTI-HYPERTENSION AGENTS
FR2377374A1 (en) * 1977-01-17 1978-08-11 Squibb & Sons Inc ACYL DERIVATIVES OF AMINO ACIDS AND THEIR USE AS MEDICINAL PRODUCTS
FR2412537A1 (en) * 1977-12-22 1979-07-20 Science Union & Cie NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION
FR2413089A1 (en) * 1977-12-27 1979-07-27 Squibb & Sons Inc HYPERTENSION TREATMENT COMPOSITION
FR2417499A1 (en) * 1978-02-21 1979-09-14 Squibb & Sons Inc MERCAPTOACYLAMINO-HALOGEN ACIDS AND THEIR THERAPEUTIC USE
FR2417500A1 (en) * 1978-02-15 1979-09-14 Squibb & Sons Inc DERIVATIVES OF CYCLIC DEHYDROGENIC AMINO ACIDS AND THEIR THERAPEUTIC USE
FR2422651A1 (en) * 1978-04-14 1979-11-09 Squibb & Sons Inc PYRROLIDINECARBOXALDEHYDE AND PIPERIDINECARBOXALDEHYDE DERIVATIVES FOR THERAPEUTIC USE
FR2432019A1 (en) * 1978-07-27 1980-02-22 Squibb & Sons Inc THIOPROPANOYLAMINO-ACIDS AND THEIR THERAPEUTIC USE
FR2443460A1 (en) * 1978-12-08 1980-07-04 Squibb & Sons Inc MERCAPTOACYL DERIVATIVES OF 4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC ACIDS AND 1,4,5,6-TETRAHYDROPYRIDINE-2-CARBOXYLIC ACIDS, USEFUL AS HYDROGENANTS
FR2445324A1 (en) * 1978-12-30 1980-07-25 Santen Pharmaceutical Co Ltd NOVEL DISULFIDE DERIVATIVES CONTAINING A PYRROLIDINE OR THIAZOLIDINE CYCLE USEFUL AS ANTIHYPERTENSORS AND FOR PREVENTING AND TREATING DIABETES COMPLICATIONS AND METHODS FOR THEIR PREPARATION
FR2446281A1 (en) * 1979-01-15 1980-08-08 Squibb & Sons Inc MERCAPTOACYL HYDROXY PROLINES CARBAMATES, WITH ANTIHYPERTENSIVE ACTION
FR2450824A1 (en) * 1979-03-08 1980-10-03 Squibb & Sons Inc NEW ACID DERIVATIVES 1- (O-MERCAPTOACYL) -5-PYRAZOLIDINONE-3-CARBOXYLICS, USEFUL IN PARTICULAR AS HYPOTENSION AGENTS
FR2468589A1 (en) * 1979-05-18 1981-05-08 Squibb & Sons Inc AMINOACYLATED MERCAPTOACYL AMINO ACID DERIVATIVES WITH ANTIHYPERTENSIVE ACTION
FR2471975A1 (en) * 1979-12-13 1981-06-26 Kanegafuchi Chemical Ind PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-MERCAPTOALCANOYLAMINOACIDES
EP0031104A1 (en) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them
FR2473517A1 (en) * 1979-12-10 1981-07-17 Squibb & Sons Inc ANTI-HYPERTENSIVE ACID MERCAPTOACYL AMINO ACID CARBOTHIOIC ACID DERIVATIVES AND PROCESS FOR THEIR PREPARATION
FR2478632A1 (en) * 1980-03-21 1981-09-25 Squibb & Sons Inc MERCOPTOACYLATED DERIVATIVES OF PROLINE AND PIPECOLIC ACID WITH CETONIC FUNCTION WITH ANTI-HYPERTENSIVE ACTION
FR2567881A1 (en) * 1984-07-23 1986-01-24 Boryung Pharm PROCESS FOR THE PRODUCTION OF A PYRROLIDINE DERIVATIVE
FR2574792A1 (en) * 1984-12-19 1986-06-20 Boryung Pharm PROCESS FOR THE PREPARATION OF PYRROLIDINE DERIVATIVES
FR2577222A1 (en) * 1985-02-11 1986-08-14 Boryung Pharm PROCESS FOR THE PREPARATION OF 1- (3-MERCAPTO-25-METHYLPROPIONYL) -PYRROLIDINE- (25) -CARBOXYLIC ACID
EP0427435A1 (en) * 1989-11-06 1991-05-15 E.R. Squibb & Sons, Inc. Process for direct isolation of captopril
WO1994004128A2 (en) * 1992-08-26 1994-03-03 Beiersdorf Ag Use of radical catchers as immunomodulating agents in cosmetic and dermatological compositions
WO1994004129A3 (en) * 1992-08-26 1994-05-26 Beiersdorf Ag Cosmetic and dermatological sunscreen compositions containing thiols and/or thiol derivates

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053651A (en) 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
CA1144930A (en) * 1978-08-11 1983-04-19 Miguel A. Ondetti Mercaptoacyl derivatives of substituted prolines
NZ190995A (en) * 1978-09-05 1982-03-09 American Cyanamid Co Substituted omega propionyl or butyryl l-prolines and pharmaceutical compositions
NL7809120A (en) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES.
NL7809121A (en) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw OPTICALLY ACTIVE DERIVATIVES OF MERCAPTO-ISO BUTIC ACID.
GR73585B (en) * 1978-09-11 1984-03-26 Univ Miami
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
JPS5540622A (en) * 1978-09-14 1980-03-22 Santen Pharmaceut Co Ltd Hypotensive agent
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
US4410542A (en) 1978-12-30 1983-10-18 Santen Pharmaceutical Co., Ltd. Disulfide compounds
US4461896A (en) * 1979-02-07 1984-07-24 Norwich Eaton Pharmaceuticals, Inc. 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
US4234489A (en) * 1979-06-25 1980-11-18 E. R. Squibb & Sons, Inc. Pyroglutamic acid derivatives and analogs
JPS5629403U (en) * 1979-08-13 1981-03-20
DE2937779A1 (en) * 1979-09-19 1981-04-09 Hoechst Ag, 6000 Frankfurt AMINO ACID DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
DE3011239A1 (en) * 1980-03-22 1981-10-01 C.H. Boehringer Sohn, 6507 Ingelheim SUBSTITUTED ALKYLTHIOACYLAMINO ACIDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS
SE8203245L (en) * 1981-05-27 1982-11-28 Crc Ricerca Chim PROCEDURE FOR ENANTIOSELECTIVE PREPARATION OF N-SUBSTITUTED PROLINE DERIVATIVES
JPH06740B2 (en) * 1984-08-16 1994-01-05 三菱レイヨン株式会社 Process for producing optically active carboxylic acid amide
HU196369B (en) * 1984-10-18 1988-11-28 Egyt Gyogyszervegyeszeti Gyar New process for producing n-acylized l-prolin derivatives
AT395012B (en) * 1986-06-27 1992-08-25 Richter Gedeon Vegyeszet METHOD FOR PRODUCING N- (1 (S) | THOXYCARBONYL-3-PHENYL-PROPYL) - (S) -ALANYL- (S) PROLIN AND ITS ACID ADDITION SALTS
JP2863534B2 (en) * 1988-10-24 1999-03-03 マリオン ラボラトリーズ，インコーポレイティド Pharmaceutical composition
IT1266570B1 (en) * 1993-07-30 1997-01-09 Zambon Spa DERIVATIVES OF PROPANAMIDE N-ETEROARYL SUBSTITUTES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
GB9704522D0 (en) * 1997-03-05 1997-04-23 Smithkline Beecham Plc Compounds
ES2182203T3 (en) 1997-10-31 2003-03-01 Hoffmann La Roche DERIVATIVES OF D-PROLINA.
EP1421063A1 (en) * 2001-08-07 2004-05-26 Sunesis Pharmaceuticals, Inc. Disulfide and thiosulfonate ligands and libraries comprising these ligands
CN100361971C (en) * 2005-09-19 2008-01-16 华中师范大学 Double functional group L-proline derivative with adjustable catalytic activity and its prepn
DK2328619T3 (en) 2008-08-22 2017-03-13 Baxalta GmbH POLYMER BENZYL CARBONATE DERIVATES
CN105732579A (en) 2012-04-27 2016-07-06 陶氏益农公司 Pesticidal Compositions And Processes Related Thereto

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* Cited by examiner, † Cited by third party
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CA946836A (en) * 1970-03-18 1974-05-07 Miguel A. Ondetti Enzyme inhibitor

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2372817A1 (en) * 1976-12-03 1978-06-30 Squibb & Sons Inc DERIVATIVES OF THIAZOLIDINECARBOXYLIC ACIDS AND RELATED ACIDS, USEFUL AS ANTI-HYPERTENSION AGENTS
FR2377374A1 (en) * 1977-01-17 1978-08-11 Squibb & Sons Inc ACYL DERIVATIVES OF AMINO ACIDS AND THEIR USE AS MEDICINAL PRODUCTS
FR2412537A1 (en) * 1977-12-22 1979-07-20 Science Union & Cie NEW SUBSTITUTE THIOBUTYRAMIDES, THEIR METHODS OF OBTAINING AND THEIR PHARMACEUTICAL APPLICATION
FR2413089A1 (en) * 1977-12-27 1979-07-27 Squibb & Sons Inc HYPERTENSION TREATMENT COMPOSITION
FR2417500A1 (en) * 1978-02-15 1979-09-14 Squibb & Sons Inc DERIVATIVES OF CYCLIC DEHYDROGENIC AMINO ACIDS AND THEIR THERAPEUTIC USE
FR2417499A1 (en) * 1978-02-21 1979-09-14 Squibb & Sons Inc MERCAPTOACYLAMINO-HALOGEN ACIDS AND THEIR THERAPEUTIC USE
FR2422651A1 (en) * 1978-04-14 1979-11-09 Squibb & Sons Inc PYRROLIDINECARBOXALDEHYDE AND PIPERIDINECARBOXALDEHYDE DERIVATIVES FOR THERAPEUTIC USE
FR2432019A1 (en) * 1978-07-27 1980-02-22 Squibb & Sons Inc THIOPROPANOYLAMINO-ACIDS AND THEIR THERAPEUTIC USE
FR2443460A1 (en) * 1978-12-08 1980-07-04 Squibb & Sons Inc MERCAPTOACYL DERIVATIVES OF 4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC ACIDS AND 1,4,5,6-TETRAHYDROPYRIDINE-2-CARBOXYLIC ACIDS, USEFUL AS HYDROGENANTS
FR2445324A1 (en) * 1978-12-30 1980-07-25 Santen Pharmaceutical Co Ltd NOVEL DISULFIDE DERIVATIVES CONTAINING A PYRROLIDINE OR THIAZOLIDINE CYCLE USEFUL AS ANTIHYPERTENSORS AND FOR PREVENTING AND TREATING DIABETES COMPLICATIONS AND METHODS FOR THEIR PREPARATION
FR2446281A1 (en) * 1979-01-15 1980-08-08 Squibb & Sons Inc MERCAPTOACYL HYDROXY PROLINES CARBAMATES, WITH ANTIHYPERTENSIVE ACTION
FR2450824A1 (en) * 1979-03-08 1980-10-03 Squibb & Sons Inc NEW ACID DERIVATIVES 1- (O-MERCAPTOACYL) -5-PYRAZOLIDINONE-3-CARBOXYLICS, USEFUL IN PARTICULAR AS HYPOTENSION AGENTS
FR2468589A1 (en) * 1979-05-18 1981-05-08 Squibb & Sons Inc AMINOACYLATED MERCAPTOACYL AMINO ACID DERIVATIVES WITH ANTIHYPERTENSIVE ACTION
FR2473517A1 (en) * 1979-12-10 1981-07-17 Squibb & Sons Inc ANTI-HYPERTENSIVE ACID MERCAPTOACYL AMINO ACID CARBOTHIOIC ACID DERIVATIVES AND PROCESS FOR THEIR PREPARATION
FR2471975A1 (en) * 1979-12-13 1981-06-26 Kanegafuchi Chemical Ind PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-MERCAPTOALCANOYLAMINOACIDES
EP0031104A1 (en) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them
FR2478632A1 (en) * 1980-03-21 1981-09-25 Squibb & Sons Inc MERCOPTOACYLATED DERIVATIVES OF PROLINE AND PIPECOLIC ACID WITH CETONIC FUNCTION WITH ANTI-HYPERTENSIVE ACTION
FR2567881A1 (en) * 1984-07-23 1986-01-24 Boryung Pharm PROCESS FOR THE PRODUCTION OF A PYRROLIDINE DERIVATIVE
FR2574792A1 (en) * 1984-12-19 1986-06-20 Boryung Pharm PROCESS FOR THE PREPARATION OF PYRROLIDINE DERIVATIVES
FR2577222A1 (en) * 1985-02-11 1986-08-14 Boryung Pharm PROCESS FOR THE PREPARATION OF 1- (3-MERCAPTO-25-METHYLPROPIONYL) -PYRROLIDINE- (25) -CARBOXYLIC ACID
EP0427435A1 (en) * 1989-11-06 1991-05-15 E.R. Squibb & Sons, Inc. Process for direct isolation of captopril
WO1994004128A2 (en) * 1992-08-26 1994-03-03 Beiersdorf Ag Use of radical catchers as immunomodulating agents in cosmetic and dermatological compositions
WO1994004129A3 (en) * 1992-08-26 1994-05-26 Beiersdorf Ag Cosmetic and dermatological sunscreen compositions containing thiols and/or thiol derivates
WO1994004128A3 (en) * 1992-08-26 1994-07-07 Beiersdorf Ag Use of radical catchers as immunomodulating agents in cosmetic and dermatological compositions
AU690075B2 (en) * 1992-08-26 1998-04-23 Beiersdorf Aktiengesellschaft Use of radical catchers as immunomodulating agents in cosmetic and dermatological compositions

Also Published As

Publication number Publication date
DE2703828A1 (en) 1977-08-18
BG37375A3 (en) 1985-05-15
AR222783A1 (en) 1981-06-30
CH624931A5 (en) 1981-08-31
DK59677A (en) 1977-08-14
NL7701457A (en) 1977-08-16
DE2703828C2 (en) 1984-06-20
NO146985B (en) 1982-10-04
NO770464L (en) 1977-08-16
SE8104660L (en) 1981-08-03
IE44707B1 (en) 1982-03-10
IT1062293B (en) 1984-05-23
YU33177A (en) 1983-01-21
SE7701561L (en) 1977-09-23
FI66596B (en) 1984-07-31
IL51297A0 (en) 1977-03-31
GR69811B (en) 1982-07-13
IL51297A (en) 1980-03-31
HK20281A (en) 1981-05-22
NL168509C (en) 1982-04-16
JPS604815B2 (en) 1985-02-06
NO146985C (en) 1983-01-12
CH622503A5 (en) 1981-04-15
PL195965A1 (en) 1978-02-27
AU509899B2 (en) 1980-05-29
ES467052A1 (en) 1978-11-01
BG37075A3 (en) 1985-03-15
SE426697B (en) 1983-02-07
DE2759862C2 (en) 1989-12-07
IE44707L (en) 1977-08-13
BG37074A3 (en) 1985-03-15
PH12970A (en) 1979-10-24
ES467050A1 (en) 1978-11-01
RO69941A (en) 1980-05-15
AR226290A1 (en) 1982-06-30
ATA98977A (en) 1981-06-15
SE423812B (en) 1982-06-07
DK157487B (en) 1990-01-15
CH624932A5 (en) 1981-08-31
ES455803A1 (en) 1978-06-16
JPS52116457A (en) 1977-09-29
DD129442A5 (en) 1978-01-18
AT365569B (en) 1982-01-25
DD129442B3 (en) 1990-01-10
FR2340932B1 (en) 1981-02-06
MY102705A (en) 1992-09-30
NZ183130A (en) 1979-08-31
GB1576161A (en) 1980-10-01
AU2134777A (en) 1978-07-20
KE3136A (en) 1981-07-03
AR222445A1 (en) 1981-05-29
MY8200075A (en) 1982-12-31
ES467051A1 (en) 1978-11-01
FI770437A (en) 1977-08-14
SU747422A3 (en) 1980-07-23
DK157487C (en) 1990-06-11
YU40664B (en) 1986-04-30
HU181965B (en) 1983-11-28
ES467053A1 (en) 1978-11-01
PL118161B1 (en) 1981-09-30
AR214649A1 (en) 1979-07-13
FI66596C (en) 1987-03-18
CA1101864A (en) 1981-05-26

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