FR22C1013I1 - DIHYDRONAPHTYRIDINES AND RELATED COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES - Google Patents
DIHYDRONAPHTYRIDINES AND RELATED COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASESInfo
- Publication number
- FR22C1013I1 FR22C1013I1 FR22C1013C FR22C1013I1 FR 22C1013 I1 FR22C1013 I1 FR 22C1013I1 FR 22C1013 C FR22C1013 C FR 22C1013C FR 22C1013 I1 FR22C1013 I1 FR 22C1013I1
- Authority
- FR
- France
- Prior art keywords
- dihydronaphtyridines
- treatment
- kinase inhibitors
- compounds useful
- related compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2012/041378 WO2013184119A1 (en) | 2012-06-07 | 2012-06-07 | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| EP17208408.9A EP3366293B1 (en) | 2012-06-07 | 2012-06-07 | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR22C1013I1 true FR22C1013I1 (en) | 2022-06-17 |
| FR22C1013I2 FR22C1013I2 (en) | 2022-12-30 |
Family
ID=49712374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR22C1013C Active FR22C1013I2 (en) | 2012-06-07 | 2022-04-07 | DIHYDRONAPHTYRIDINES AND RELATED COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES |
Country Status (27)
| Country | Link |
|---|---|
| EP (3) | EP3722296A3 (en) |
| JP (1) | JP5883195B2 (en) |
| KR (1) | KR101652229B1 (en) |
| CN (3) | CN104902895B (en) |
| AU (1) | AU2012327210B2 (en) |
| BR (1) | BR112014030577B1 (en) |
| CA (1) | CA2875970C (en) |
| CY (1) | CY1123377T1 (en) |
| DK (2) | DK3366293T3 (en) |
| ES (2) | ES2663605T3 (en) |
| FR (1) | FR22C1013I2 (en) |
| HK (1) | HK1209345A1 (en) |
| HR (1) | HRP20200864T1 (en) |
| HU (2) | HUE049958T2 (en) |
| IL (1) | IL236110A (en) |
| LT (2) | LT3366293T (en) |
| MX (2) | MX2014015024A (en) |
| NO (1) | NO2022010I1 (en) |
| PH (2) | PH12018502294B1 (en) |
| PL (1) | PL3366293T3 (en) |
| PT (2) | PT3366293T (en) |
| RS (1) | RS60406B1 (en) |
| RU (1) | RU2664055C2 (en) |
| SG (1) | SG11201408133TA (en) |
| SI (1) | SI3366293T1 (en) |
| SM (1) | SMT202000302T1 (en) |
| WO (1) | WO2013184119A1 (en) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| AR095464A1 (en) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | HETEROARILO COMPOUNDS AND USES OF THE SAME |
| CA2907243C (en) | 2013-03-15 | 2021-12-28 | Celgene Avilomics Research, Inc. | Substituted dihydropyrimidopyrimidinone compounds and pharmaceutical compositions thereof use fgfr4 inhibitor |
| BR112015022191A8 (en) | 2013-03-15 | 2018-01-23 | Celgene Avilomics Res Inc | heteroaryl compounds and uses thereof |
| HRP20211801T1 (en) * | 2016-01-11 | 2022-03-04 | Merck Patent Gmbh | Quinolin-2-one derivatives |
| BR112019025346A2 (en) * | 2017-05-30 | 2020-06-30 | Deciphera Pharmaceuticals, Inc. | use of 1- [4-bromo-5- [1-ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl] -2-fluorophenyl] -3- phenylurea and analogs for the treatment of cancers associated with genetic abnormalities in the platelet-derived growth factor alpha receptor |
| WO2019056990A1 (en) * | 2017-09-20 | 2019-03-28 | 浙江海正药业股份有限公司 | 1,2-dihydro-1,6-naphthyridine derivative, preparation method therefor, and application thereof in medicine |
| CN111818915B (en) | 2018-01-31 | 2024-05-24 | 德西费拉制药有限责任公司 | Combination therapy for the treatment of gastrointestinal stromal tumors |
| EP3746060A1 (en) | 2018-01-31 | 2020-12-09 | Deciphera Pharmaceuticals, LLC | Combination therapy for the treatment of mastocytosis |
| US20220144825A1 (en) * | 2019-03-11 | 2022-05-12 | Teva Pharmaceuticals International Gmbh | Solid state forms of ripretinib |
| CA3138300A1 (en) | 2019-05-03 | 2020-11-12 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
| CN114615982A (en) | 2019-08-12 | 2022-06-10 | 德西费拉制药有限责任公司 | Ripoctinib for treating gastrointestinal stromal tumor |
| WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| NZ788005A (en) | 2019-10-24 | 2024-10-25 | Kinnate Biopharma Inc | Inhibitors of raf kinases |
| AU2020419197B2 (en) | 2019-12-30 | 2023-08-31 | Deciphera Pharmaceuticals, Llc | Amorphous kinase inhibitor formulations and methods of use thereof |
| IL293864A (en) | 2019-12-30 | 2022-08-01 | Deciphera Pharmaceuticals Llc | Preparations of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3- phenylurea |
| KR102535840B1 (en) * | 2020-07-31 | 2023-05-23 | (주)파로스아이바이오 | Use of 2,3,5-Substituted Thiophene Compound for Prevention, Improvement or Treatment of Gastrointestinal Stromal Tumor |
| WO2022060996A1 (en) | 2020-09-18 | 2022-03-24 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
| WO2022081469A1 (en) | 2020-10-12 | 2022-04-21 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
| CN112625038A (en) * | 2020-12-31 | 2021-04-09 | 武汉九州钰民医药科技有限公司 | Method for preparing Ripoctinib |
| WO2022162690A1 (en) * | 2021-01-28 | 2022-08-04 | Dr. Reddy's Laboratories Limited | Process for the preparation of ripretinib and solid state forms thereof |
| TW202308645A (en) | 2021-04-23 | 2023-03-01 | 美商奇奈特生物製藥公司 | Treatment of cancer with a raf inhibitor |
| WO2023122322A1 (en) * | 2021-12-24 | 2023-06-29 | Teva Pharmaceuticals International Gmbh | Improved processes for the preparation of ripretinib |
| CN114213411B (en) * | 2022-01-24 | 2023-06-30 | 成都伊诺达博医药科技有限公司 | Synthesis method of rapatinib |
| US11814384B2 (en) | 2022-02-03 | 2023-11-14 | Kinnate Biopharma Inc. | Inhibtors of Raf kinases |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7449582B2 (en) * | 2003-10-08 | 2008-11-11 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| DE102006030524A1 (en) * | 2006-07-01 | 2008-01-03 | Koch Transporttechnik Gmbh | Method for removing loose coal from corrugated surfaces of long narrow coal cake comprises moving the loose coal from peaks into troughs and holding on the coal cake |
| US8188113B2 (en) * | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| CN101516379A (en) * | 2006-09-14 | 2009-08-26 | 迪赛孚尔制药有限公司 | Kinase inhibitors useful for the treatment of proliferative diseases |
| EA200900573A1 (en) * | 2006-10-20 | 2009-10-30 | АйАрЭм ЭлЭлСи | COMPOSITIONS AND METHODS FOR MODULATION OF C-KIT AND PDGFR RECEPTORS |
| ES2383331T3 (en) * | 2008-02-22 | 2012-06-20 | Irm Llc | Heterocyclic compounds and compositions as inhibitors of C-KIT and PDGFR INHIBITORS kinases |
-
2012
- 2012-06-07 HU HUE17208408A patent/HUE049958T2/en unknown
- 2012-06-07 DK DK17208408.9T patent/DK3366293T3/en active
- 2012-06-07 EP EP20161887.3A patent/EP3722296A3/en active Pending
- 2012-06-07 PH PH1/2018/502294A patent/PH12018502294B1/en unknown
- 2012-06-07 CN CN201280075113.7A patent/CN104902895B/en active Active
- 2012-06-07 SI SI201231785T patent/SI3366293T1/en unknown
- 2012-06-07 MX MX2014015024A patent/MX2014015024A/en active IP Right Grant
- 2012-06-07 LT LTEP17208408.9T patent/LT3366293T/en unknown
- 2012-06-07 SM SM20200302T patent/SMT202000302T1/en unknown
- 2012-06-07 DK DK12878321.4T patent/DK2858646T3/en active
- 2012-06-07 CN CN201910368783.1A patent/CN110433162A/en active Pending
- 2012-06-07 PL PL17208408T patent/PL3366293T3/en unknown
- 2012-06-07 MX MX2020005712A patent/MX2020005712A/en unknown
- 2012-06-07 CN CN201910368784.6A patent/CN110403938A/en active Pending
- 2012-06-07 PT PT172084089T patent/PT3366293T/en unknown
- 2012-06-07 EP EP17208408.9A patent/EP3366293B1/en active Active
- 2012-06-07 PT PT128783214T patent/PT2858646T/en unknown
- 2012-06-07 RU RU2014153920A patent/RU2664055C2/en active
- 2012-06-07 WO PCT/US2012/041378 patent/WO2013184119A1/en active Application Filing
- 2012-06-07 KR KR1020157000365A patent/KR101652229B1/en active IP Right Grant
- 2012-06-07 ES ES12878321.4T patent/ES2663605T3/en active Active
- 2012-06-07 EP EP12878321.4A patent/EP2858646B1/en active Active
- 2012-06-07 RS RS20200633A patent/RS60406B1/en unknown
- 2012-06-07 SG SG11201408133TA patent/SG11201408133TA/en unknown
- 2012-06-07 ES ES17208408T patent/ES2797252T3/en active Active
- 2012-06-07 JP JP2015515992A patent/JP5883195B2/en active Active
- 2012-06-07 CA CA2875970A patent/CA2875970C/en active Active
- 2012-06-07 BR BR112014030577-3A patent/BR112014030577B1/en active IP Right Grant
- 2012-06-07 AU AU2012327210A patent/AU2012327210B2/en active Active
-
2014
- 2014-12-07 IL IL236110A patent/IL236110A/en active IP Right Grant
- 2014-12-09 PH PH12014502757A patent/PH12014502757A1/en unknown
-
2015
- 2015-10-15 HK HK15110134.9A patent/HK1209345A1/en unknown
-
2020
- 2020-05-29 HR HRP20200864TT patent/HRP20200864T1/en unknown
- 2020-06-10 CY CY20201100530T patent/CY1123377T1/en unknown
-
2022
- 2022-04-07 FR FR22C1013C patent/FR22C1013I2/en active Active
- 2022-04-07 NO NO2022010C patent/NO2022010I1/en unknown
- 2022-05-03 LT LTPA2022008C patent/LTPA2022008I1/lt unknown
- 2022-05-09 HU HUS2200017C patent/HUS2200017I1/en unknown
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