FR2288527A2 - Oil-free adjuvant compsns causing no hypersensitisation - contg N-acetyl-muramyl-L-alanyl-D-isoglutamine pref in aq soln - Google Patents
Oil-free adjuvant compsns causing no hypersensitisation - contg N-acetyl-muramyl-L-alanyl-D-isoglutamine pref in aq solnInfo
- Publication number
- FR2288527A2 FR2288527A2 FR7529624A FR7529624A FR2288527A2 FR 2288527 A2 FR2288527 A2 FR 2288527A2 FR 7529624 A FR7529624 A FR 7529624A FR 7529624 A FR7529624 A FR 7529624A FR 2288527 A2 FR2288527 A2 FR 2288527A2
- Authority
- FR
- France
- Prior art keywords
- oil
- compsns
- isoglutamine
- alanyl
- contg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Novel oil-free adjuvant compsns. contain N-acetylmuramyl-L-alanyl-D-isoglutamine (I) as active principle together with a pharmaceutically acceptable vehicle, prefd. being sterile injectable aaq. solns. of (I). Also claimed are lyophilised (I) prepns. suitable for preparing such solns. (I) has high non-specific adjuvant activity in aq. soln. and in physiological lquids (unlike prior art non-specific adjuants), and also does not induce host sensitisation to (I) or other adjuvants prefd. from mycobacteria. Compared with the use of (I) in water-oil emulsions as in the parent patent, difficulties due to the non-metabolisable nature of the oil and harmfulness of emulsion stabilisers are avoided. The compsns. increase the effectiveness of bacterial or viral vaccines, and are esp. for increasing the immunity of human or animal hosts to bacterial or viral infections, tumour antigens, protozoal antigens etc. They are also useful for making sera contg. antibodies active towards these antigents.
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL48325A IL48325A (en) | 1974-10-22 | 1975-10-20 | Immunological-free adjuvant compositions containing n-acetyl muramyl-alanyl-d-isoglutamine or n-acetyl-muramyl-l-alanyl-d-glutamicn acid |
NL7512326A NL7512326A (en) | 1974-10-22 | 1975-10-21 | METHOD OF PREPARING A MEDICINAL PRODUCT. |
DE19752547104 DE2547104A1 (en) | 1974-10-22 | 1975-10-21 | OIL-FREE ADJUVANCES CONTAINING N-ACETYL-MURAMYL-L-ALANYL-D-GLUTAMIC ACID |
NL7512325A NL7512325A (en) | 1974-10-22 | 1975-10-21 | METHOD OF PREPARING A MEDICINAL PRODUCT. |
GB43079/75A GB1531244A (en) | 1974-10-22 | 1975-10-21 | Oil-free adjuvant composition |
GB43080/75A GB1531014A (en) | 1974-10-22 | 1975-10-21 | Oil-free adjuvant composition |
DE19752547105 DE2547105A1 (en) | 1974-10-22 | 1975-10-21 | N-ACETYL-MURAMYL-L-ALANYL-D-ISOGLUTAMINE CONTAINING OIL-FREE ADJUVANCES |
US05/624,994 US4158052A (en) | 1974-10-22 | 1975-10-22 | Oil-free adjuvant compositions containing N-acetyl-muramyl-L-alanyl-D-isoglutamine |
AU85917/75A AU503714B2 (en) | 1974-10-22 | 1975-10-22 | Oil-free adjuvant composition |
US05/625,195 US4172125A (en) | 1974-10-22 | 1975-10-23 | Oil-free adjuvant compositions containing N-acetyl-muramyl-L-alanyl-D-glutamic acid and method of use |
CA240,142A CA1060796A (en) | 1975-09-26 | 1975-11-20 | Oil-free adjuvant composition containing muramyl dipeptide |
CA240,116A CA1060795A (en) | 1975-09-26 | 1975-11-20 | Oil-free adjuvant composition containing muramyl dipeptide |
JP51113813A JPS5244223A (en) | 1975-09-26 | 1976-09-24 | Oillfree composition including nnacetyllmuramyllllalanyllddisoglutamine |
JP51113812A JPS5241211A (en) | 1975-09-26 | 1976-09-24 | Oillfree composition including nnacetyllmuramyllllalanyllddisoglutamine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/516,991 US4186194A (en) | 1973-10-23 | 1974-10-22 | Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2288527A2 true FR2288527A2 (en) | 1976-05-21 |
FR2288527B2 FR2288527B2 (en) | 1979-09-14 |
Family
ID=24057920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7529624A Granted FR2288527A2 (en) | 1974-10-22 | 1975-09-26 | Oil-free adjuvant compsns causing no hypersensitisation - contg N-acetyl-muramyl-L-alanyl-D-isoglutamine pref in aq soln |
Country Status (3)
Country | Link |
---|---|
BE (2) | BE834754R (en) |
FR (1) | FR2288527A2 (en) |
ZA (2) | ZA756661B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2533827A1 (en) * | 1982-09-30 | 1984-04-06 | Anvar | Composition possessing immunoregulatory properties, in particular of non-specific immunological adjuvants, based on muramyl peptide and an aluminium derivative |
US4652449A (en) * | 1982-07-05 | 1987-03-24 | Centre National De La Recherche Scientifique (Cnrs) | Encapsulating biological active substances into erythrocytes |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4397844A (en) * | 1978-02-24 | 1983-08-09 | Ciba-Geigy Corporation | Antigen derivatives and processes for their preparation |
FR2428050A1 (en) * | 1978-06-05 | 1980-01-04 | Anvar | OLIGOMERS OF MURAMYL-PEPTIDE COMPOUNDS AND DRUGS CONTAINING THEM |
US4368190A (en) | 1980-04-17 | 1983-01-11 | Merck & Co., Inc. | Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation |
US4310514A (en) | 1980-05-05 | 1982-01-12 | Merck & Co., Inc. | Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation |
US4315913A (en) | 1980-06-09 | 1982-02-16 | Merck & Co. Inc. | Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2160326A1 (en) * | 1971-11-19 | 1973-06-29 | Anvar | |
DE2450355A1 (en) * | 1973-10-23 | 1975-05-28 | Anvar | ADJUVANCES FORMED FROM N-ACYL-MURAMIC ACID DERIVATIVES AND VACCINES CONTAINING THEM |
-
1975
- 1975-09-26 FR FR7529624A patent/FR2288527A2/en active Granted
- 1975-10-22 ZA ZA756661A patent/ZA756661B/en unknown
- 1975-10-22 BE BE161150A patent/BE834754R/en not_active IP Right Cessation
- 1975-10-22 BE BE161149A patent/BE834753R/en not_active IP Right Cessation
- 1975-10-22 ZA ZA756660A patent/ZA756660B/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2160326A1 (en) * | 1971-11-19 | 1973-06-29 | Anvar | |
DE2450355A1 (en) * | 1973-10-23 | 1975-05-28 | Anvar | ADJUVANCES FORMED FROM N-ACYL-MURAMIC ACID DERIVATIVES AND VACCINES CONTAINING THEM |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4652449A (en) * | 1982-07-05 | 1987-03-24 | Centre National De La Recherche Scientifique (Cnrs) | Encapsulating biological active substances into erythrocytes |
US4752586A (en) * | 1982-07-05 | 1988-06-21 | Centre National De La Recherche Scientifique | Apparatus for encapsulating biological active substances into erythrocytes |
FR2533827A1 (en) * | 1982-09-30 | 1984-04-06 | Anvar | Composition possessing immunoregulatory properties, in particular of non-specific immunological adjuvants, based on muramyl peptide and an aluminium derivative |
Also Published As
Publication number | Publication date |
---|---|
BE834754R (en) | 1976-02-16 |
FR2288527B2 (en) | 1979-09-14 |
ZA756660B (en) | 1976-11-24 |
BE834753R (en) | 1976-02-16 |
ZA756661B (en) | 1976-11-24 |
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