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FR2272684A1 - Antibiotic-unsaturated acid compsns. - having a synergistic effect against gram positive and negative bacteria - Google Patents

Antibiotic-unsaturated acid compsns. - having a synergistic effect against gram positive and negative bacteria

Info

Publication number
FR2272684A1
FR2272684A1 FR7500325A FR7500325A FR2272684A1 FR 2272684 A1 FR2272684 A1 FR 2272684A1 FR 7500325 A FR7500325 A FR 7500325A FR 7500325 A FR7500325 A FR 7500325A FR 2272684 A1 FR2272684 A1 FR 2272684A1
Authority
FR
France
Prior art keywords
antibiotic
acid
compsns
synergistic effect
unsaturated acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7500325A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ITO SHOJIRO JA
Original Assignee
ITO SHOJIRO JA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ITO SHOJIRO JA filed Critical ITO SHOJIRO JA
Priority to FR7500325A priority Critical patent/FR2272684A1/en
Publication of FR2272684A1 publication Critical patent/FR2272684A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The antimicrobial activity of an antibiotic is increased by adding to the antibiotic an unsatd. fatty acid having a chain length between 14 and 22C atoms or a salt of such an acid. Pharmaceutical compsns. contng. such mixtures are also new. The synergistic effect between the antibiotic and the acid, makes the compsns. effective against resistant strains. Suitable antibiotics include penicillins, cephalosporins, macrolides, chloramphenicol, tetracyclines, streptomycin, colistin, bleomycin, chromomycin A3, and 5-fluorouracil. The acid is pref. of formula CnH2n-aCOOR where R = H, Na or K, n = 13-21 (13 & 21 excluded) and a is 1, 3, 5 or 7, typically palmito-oleic, oleic, arachidonic, linolenic or linoleinic acids. The amount of acid added depends upon the activity of the antibiotic, for example for 20 units of penicillin, 0.015 mg. of unsaturated acid, such as linolenic acid is used.
FR7500325A 1975-01-07 1975-01-07 Antibiotic-unsaturated acid compsns. - having a synergistic effect against gram positive and negative bacteria Withdrawn FR2272684A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7500325A FR2272684A1 (en) 1975-01-07 1975-01-07 Antibiotic-unsaturated acid compsns. - having a synergistic effect against gram positive and negative bacteria

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7500325A FR2272684A1 (en) 1975-01-07 1975-01-07 Antibiotic-unsaturated acid compsns. - having a synergistic effect against gram positive and negative bacteria

Publications (1)

Publication Number Publication Date
FR2272684A1 true FR2272684A1 (en) 1975-12-26

Family

ID=9149470

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7500325A Withdrawn FR2272684A1 (en) 1975-01-07 1975-01-07 Antibiotic-unsaturated acid compsns. - having a synergistic effect against gram positive and negative bacteria

Country Status (1)

Country Link
FR (1) FR2272684A1 (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2374031A1 (en) * 1976-12-17 1978-07-13 Scherico Ltd NEW FORMULATIONS OF B-LACTAM ANTIBIOTICS, THEIR PREPARATION PROCESS, ANTIBIOTIC MIXTURE FOR INJECTION AS WELL AS ITS PREPARATION PROCESS
EP0003407A1 (en) * 1978-01-23 1979-08-08 Efamol Limited Pharmaceutical and dietary composition comprising gamma-linolenic acids
EP0004770A2 (en) * 1978-04-11 1979-10-17 Efamol Limited Pharmaceutical and dietary composition comprising gamma-linolenic acids
EP0007614A1 (en) * 1978-07-24 1980-02-06 Merck & Co. Inc. An antibacterial composition of thienamycin-type compound and a dipeptidase inhibitor
EP0019423A1 (en) * 1979-05-18 1980-11-26 Efamol Limited Pharmaceutical and dietary composition comprising gamma-linolenic acids
EP0028778A1 (en) * 1979-11-02 1981-05-20 Merck & Co. Inc. Antibacterial compositions comprising a beta-lactam-type compound and a 3-substituted propenoate
US4273763A (en) * 1978-01-23 1981-06-16 Efamol Limited Pharmaceutical and dietary compositions
EP0035856A2 (en) * 1980-03-07 1981-09-16 Efamol Limited Pharmaceutical and dietary compositions
US4338306A (en) * 1979-05-10 1982-07-06 Kyoto Yakuhin Kogyo Kabushiki Kaisha Adjuvant for promoting absorption of pharmacologically active substances through the rectum
US4539208A (en) * 1980-09-17 1985-09-03 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
EP1905301A2 (en) * 2006-09-27 2008-04-02 Miura Co., Ltd. Disinfectant
EP2503998A1 (en) * 2009-11-27 2012-10-03 Croda International PLC Dermatological compositions comprising a fat or oil of an essential fatty acid triglyceride

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEM. ABSTR., vol. 56, 5197d (1962), cite ACTA MICROBIOL. Acad. Sci. Hung, 8, PAGES 43 - 51 (1961) *
CHEM. ABSTR., vol. 69, 17060s, (1968), cite 'ARCH. IMMUNOL. THER. EXP., 1968, 16 (2), pages 219 - 227 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2374031A1 (en) * 1976-12-17 1978-07-13 Scherico Ltd NEW FORMULATIONS OF B-LACTAM ANTIBIOTICS, THEIR PREPARATION PROCESS, ANTIBIOTIC MIXTURE FOR INJECTION AS WELL AS ITS PREPARATION PROCESS
US4273763A (en) * 1978-01-23 1981-06-16 Efamol Limited Pharmaceutical and dietary compositions
EP0003407A1 (en) * 1978-01-23 1979-08-08 Efamol Limited Pharmaceutical and dietary composition comprising gamma-linolenic acids
US4415554A (en) * 1978-01-23 1983-11-15 Efamol Limited Treatment for menstrual disorders
US4393049A (en) * 1978-01-23 1983-07-12 Efamol Limited Treatment for obesity
US4302447A (en) * 1978-01-23 1981-11-24 Efamol Limited Pharmaceutical and dietary composition
EP0004770A3 (en) * 1978-04-11 1980-02-06 Efamol Limited Pharmaceutical and dietary composition comprising gamma-linolenic acids
EP0004770A2 (en) * 1978-04-11 1979-10-17 Efamol Limited Pharmaceutical and dietary composition comprising gamma-linolenic acids
EP0007614A1 (en) * 1978-07-24 1980-02-06 Merck & Co. Inc. An antibacterial composition of thienamycin-type compound and a dipeptidase inhibitor
US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US4338306A (en) * 1979-05-10 1982-07-06 Kyoto Yakuhin Kogyo Kabushiki Kaisha Adjuvant for promoting absorption of pharmacologically active substances through the rectum
EP0019423A1 (en) * 1979-05-18 1980-11-26 Efamol Limited Pharmaceutical and dietary composition comprising gamma-linolenic acids
EP0028778A1 (en) * 1979-11-02 1981-05-20 Merck & Co. Inc. Antibacterial compositions comprising a beta-lactam-type compound and a 3-substituted propenoate
EP0035856A2 (en) * 1980-03-07 1981-09-16 Efamol Limited Pharmaceutical and dietary compositions
EP0035856A3 (en) * 1980-03-07 1981-09-23 Efamol Limited Pharmaceutical and dietary compositions
US4539208A (en) * 1980-09-17 1985-09-03 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
EP1905301A2 (en) * 2006-09-27 2008-04-02 Miura Co., Ltd. Disinfectant
EP1905301A3 (en) * 2006-09-27 2009-11-11 Miura Co., Ltd. Disinfectant
EP2503998A1 (en) * 2009-11-27 2012-10-03 Croda International PLC Dermatological compositions comprising a fat or oil of an essential fatty acid triglyceride

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Legal Events

Date Code Title Description
ST Notification of lapse