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FR2269334A1 - Anti-allergic 2-cyanoindanes and 3-cyanocoumarins - for prophylaxis and treatment of asthma, hay-fever and rhinitis - Google Patents

Anti-allergic 2-cyanoindanes and 3-cyanocoumarins - for prophylaxis and treatment of asthma, hay-fever and rhinitis

Info

Publication number
FR2269334A1
FR2269334A1 FR7513797A FR7513797A FR2269334A1 FR 2269334 A1 FR2269334 A1 FR 2269334A1 FR 7513797 A FR7513797 A FR 7513797A FR 7513797 A FR7513797 A FR 7513797A FR 2269334 A1 FR2269334 A1 FR 2269334A1
Authority
FR
France
Prior art keywords
treatment
hay
rhinitis
prophylaxis
fever
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7513797A
Other languages
French (fr)
Other versions
FR2269334B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB19721/74A external-priority patent/GB1509904A/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of FR2269334A1 publication Critical patent/FR2269334A1/en
Application granted granted Critical
Publication of FR2269334B1 publication Critical patent/FR2269334B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/67—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having two rings, e.g. tetralones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/24—Quinones containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
    • C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)

Abstract

Cpds. of formula (I) and their pharmaceutically acceptable salts, and inters. of formula (II) are new: (where R1-4 are each H, halogen, alkyl or alkoxy; or any two of R1-4 together with the C atoms to which they are bonded may form an opt. substd. carbocycle; X is a direct bond or O). (I) are used for inhibiting the effects of certain antigen-antibody reactions, e.g., in the prophylaxis and treatment of asthma, hay-fever and in treatment of rhinitis. (I) may be administered orally, by injection or by inhalation, doses being 0.1-100 mg./kg./day.
FR7513797A 1974-05-04 1975-05-02 Anti-allergic 2-cyanoindanes and 3-cyanocoumarins - for prophylaxis and treatment of asthma, hay-fever and rhinitis Granted FR2269334A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB19721/74A GB1509904A (en) 1974-05-04 1974-05-04 Nitriles derived from indane-1,3-dione and coumarin
GB4811574 1974-11-07

Publications (2)

Publication Number Publication Date
FR2269334A1 true FR2269334A1 (en) 1975-11-28
FR2269334B1 FR2269334B1 (en) 1978-10-06

Family

ID=26254216

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7513797A Granted FR2269334A1 (en) 1974-05-04 1975-05-02 Anti-allergic 2-cyanoindanes and 3-cyanocoumarins - for prophylaxis and treatment of asthma, hay-fever and rhinitis
FR7539260A Granted FR2282876A1 (en) 1974-05-04 1975-12-22 COMPOUNDS WITH ANTI-ALLERGIC ACTIVITY

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7539260A Granted FR2282876A1 (en) 1974-05-04 1975-12-22 COMPOUNDS WITH ANTI-ALLERGIC ACTIVITY

Country Status (7)

Country Link
JP (1) JPS50160254A (en)
DE (1) DE2519713A1 (en)
DK (1) DK193675A (en)
ES (3) ES437408A1 (en)
FR (2) FR2269334A1 (en)
NL (1) NL7505201A (en)
SE (1) SE7505038L (en)

Also Published As

Publication number Publication date
FR2269334B1 (en) 1978-10-06
JPS50160254A (en) 1975-12-25
SE7505038L (en) 1975-12-19
ES454325A1 (en) 1977-12-16
FR2282876B1 (en) 1980-05-16
FR2282876A1 (en) 1976-03-26
ES454326A1 (en) 1977-12-16
AU8079175A (en) 1976-11-04
NL7505201A (en) 1975-11-06
DK193675A (en) 1975-11-05
DE2519713A1 (en) 1975-11-20
ES437408A1 (en) 1977-08-01

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Legal Events

Date Code Title Description
ST Notification of lapse