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FR2265403A1 - Growth-hormone inhibiting tetradecapeptide solns - for injection, with prolonged action by forming a complex with e.g. heavy metal salts - Google Patents

Growth-hormone inhibiting tetradecapeptide solns - for injection, with prolonged action by forming a complex with e.g. heavy metal salts

Info

Publication number
FR2265403A1
FR2265403A1 FR7510079A FR7510079A FR2265403A1 FR 2265403 A1 FR2265403 A1 FR 2265403A1 FR 7510079 A FR7510079 A FR 7510079A FR 7510079 A FR7510079 A FR 7510079A FR 2265403 A1 FR2265403 A1 FR 2265403A1
Authority
FR
France
Prior art keywords
complex
injection
phe
growth
tetradecapeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7510079A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2265403A1 publication Critical patent/FR2265403A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Aq. compsns. for injection, having a prolonged duration of action, contain the peptide of formula (I) H.Ala.Gly.Cys.Lys.Asn.Phe.Phe.Trp.Lys.Thr.Phe.Thr.Ser.Cys.OH (I) in the form of a complex produced by adding an inorg. salt (esp. halides, phosphates, pyro-phosphates or polyphosphates) of Ca, Co, Mg, Mn, Al or Zn; and/or a polymer such as polyoxygelatine, polyvinyl-pyrrolidone, carboxymethyl-cellulose or sulphnoc acid or phosphoric acid esters of alginic acid, dextran, polyphenols or polyalcohols. Esp. pref. is the addition of polyphloretin phosphate to (I). (I) inhibits are secretion of growth hormone but the action is short-lived when (I) is used as such. As a complex its activity persists for many hours. The compsns. are used for treating diabetes mellitus, acromegalia, and angiopathia and as diagnostic reagents.
FR7510079A 1974-04-02 1975-04-01 Growth-hormone inhibiting tetradecapeptide solns - for injection, with prolonged action by forming a complex with e.g. heavy metal salts Withdrawn FR2265403A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH457474 1974-04-02

Publications (1)

Publication Number Publication Date
FR2265403A1 true FR2265403A1 (en) 1975-10-24

Family

ID=4278626

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7510079A Withdrawn FR2265403A1 (en) 1974-04-02 1975-04-01 Growth-hormone inhibiting tetradecapeptide solns - for injection, with prolonged action by forming a complex with e.g. heavy metal salts

Country Status (2)

Country Link
DE (1) DE2512943A1 (en)
FR (1) FR2265403A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187361A2 (en) * 1985-01-05 1986-07-16 Hoechst Aktiengesellschaft Sustained-release compositions, process for preparing them and suitable compositions for medical or veterinary use
EP0193917A2 (en) * 1985-03-06 1986-09-10 American Cyanamid Company Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration
US5456922A (en) * 1985-03-06 1995-10-10 American Cyanamid Company Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration of growth hormone

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187361A2 (en) * 1985-01-05 1986-07-16 Hoechst Aktiengesellschaft Sustained-release compositions, process for preparing them and suitable compositions for medical or veterinary use
EP0187361A3 (en) * 1985-01-05 1987-10-21 Hoechst Aktiengesellschaft Sustained-release compositions, process for preparing them and suitable compositions for medical or veterinary use
EP0193917A2 (en) * 1985-03-06 1986-09-10 American Cyanamid Company Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration
EP0193917A3 (en) * 1985-03-06 1987-09-23 American Cyanamid Company Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration
US5456922A (en) * 1985-03-06 1995-10-10 American Cyanamid Company Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration of growth hormone

Also Published As

Publication number Publication date
DE2512943A1 (en) 1975-10-16

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Legal Events

Date Code Title Description
RE Withdrawal of published application