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FR2263750A1 - N-phenyl-N-(2-aryl-6-methyl-pyrimidin-4-yl)amino acid derivs. - useful e.g. as analeptics, hypotensives, analgesics, etc. - Google Patents

N-phenyl-N-(2-aryl-6-methyl-pyrimidin-4-yl)amino acid derivs. - useful e.g. as analeptics, hypotensives, analgesics, etc.

Info

Publication number
FR2263750A1
FR2263750A1 FR7408340A FR7408340A FR2263750A1 FR 2263750 A1 FR2263750 A1 FR 2263750A1 FR 7408340 A FR7408340 A FR 7408340A FR 7408340 A FR7408340 A FR 7408340A FR 2263750 A1 FR2263750 A1 FR 2263750A1
Authority
FR
France
Prior art keywords
phenyl
hypotensives
analgesics
aryl
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7408340A
Other languages
French (fr)
Other versions
FR2263750B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7408340A priority Critical patent/FR2263750A1/en
Publication of FR2263750A1 publication Critical patent/FR2263750A1/en
Application granted granted Critical
Publication of FR2263750B1 publication Critical patent/FR2263750B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel pyrimidine derivs. of formula (I): (R = H or is not >4C alkoxy; Z = OH, is not >4C alkoxy or NHOH; Ar = phenyl opt. substd. by >=1 is not >4C alkoxy; n = 1-2) are prepd. by reacting a 2-aryl-4-chloro-6-methylpyrimidine with appropriate N-phenyl amino acid ester, then opt. converting Z. (I) are respiratory analeptics, hypotensives, antibronchoconstrictors, anticholinergics, anti-ulcer agents, analgesics and anti-inflammatories. In rats the oral LD50 is >=1400 mg/kg. (I) are administered orally at 40-300 mg/day, parenterally at 10-200 mg/day or rectally at 20-150 mg/day.
FR7408340A 1974-03-12 1974-03-12 N-phenyl-N-(2-aryl-6-methyl-pyrimidin-4-yl)amino acid derivs. - useful e.g. as analeptics, hypotensives, analgesics, etc. Granted FR2263750A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7408340A FR2263750A1 (en) 1974-03-12 1974-03-12 N-phenyl-N-(2-aryl-6-methyl-pyrimidin-4-yl)amino acid derivs. - useful e.g. as analeptics, hypotensives, analgesics, etc.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7408340A FR2263750A1 (en) 1974-03-12 1974-03-12 N-phenyl-N-(2-aryl-6-methyl-pyrimidin-4-yl)amino acid derivs. - useful e.g. as analeptics, hypotensives, analgesics, etc.

Publications (2)

Publication Number Publication Date
FR2263750A1 true FR2263750A1 (en) 1975-10-10
FR2263750B1 FR2263750B1 (en) 1977-11-04

Family

ID=9136174

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7408340A Granted FR2263750A1 (en) 1974-03-12 1974-03-12 N-phenyl-N-(2-aryl-6-methyl-pyrimidin-4-yl)amino acid derivs. - useful e.g. as analeptics, hypotensives, analgesics, etc.

Country Status (1)

Country Link
FR (1) FR2263750A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996032383A1 (en) * 1995-04-13 1996-10-17 Dainippon Pharmaceutical Co., Ltd. Acetamide derivatives, process for producing the same, and medicinal composition containing the same
EP1610774A2 (en) * 2003-04-09 2006-01-04 Exelixis, Inc. Tie-2 modulators and methods of use
US7816529B2 (en) 2003-07-02 2010-10-19 Vertex Pharmaceuticals Incorporated Pyrimidines useful as modulators of voltage-gated ion channels

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996032383A1 (en) * 1995-04-13 1996-10-17 Dainippon Pharmaceutical Co., Ltd. Acetamide derivatives, process for producing the same, and medicinal composition containing the same
CN1094929C (en) * 1995-04-13 2002-11-27 大日本制药株式会社 Acetamide derivatives, process for producing the same, and medicinal composition containing the same
EP1610774A2 (en) * 2003-04-09 2006-01-04 Exelixis, Inc. Tie-2 modulators and methods of use
EP1610774A4 (en) * 2003-04-09 2008-07-16 Exelixis Inc Tie-2 modulators and methods of use
US7816529B2 (en) 2003-07-02 2010-10-19 Vertex Pharmaceuticals Incorporated Pyrimidines useful as modulators of voltage-gated ion channels
US8324220B2 (en) 2003-07-02 2012-12-04 Vertex Pharmaceuticals Incorporated Pyrimidines useful as modulators of voltage-gated ion channels

Also Published As

Publication number Publication date
FR2263750B1 (en) 1977-11-04

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Legal Events

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