FR2137713B1 - - Google Patents

Info

Publication number: FR2137713B1
Authority: FR; France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

FR7216686A

Other versions

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia and Upjohn Co

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-05-11

Filing date

1972-05-10

Publication date

1975-12-26

1972-05-10 Application filed by Upjohn Co filed Critical Upjohn Co

1972-12-29 Publication of FR2137713A1 publication Critical patent/FR2137713A1/fr

1975-12-26 Application granted granted Critical

1975-12-26 Publication of FR2137713B1 publication Critical patent/FR2137713B1/fr

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

FR7216686A 1971-05-11 1972-05-10 Expired FR2137713B1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US14241871A	1971-05-11	1971-05-11

Publications (2)

Publication Number	Publication Date
FR2137713A1 FR2137713A1 (fr)	1972-12-29
FR2137713B1 true FR2137713B1 (fr)	1975-12-26

Family

ID=22499766

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR7216686A Expired FR2137713B1 (fr)	1971-05-11	1972-05-10

Country Status (9)

Country	Link
US (2)	US3681343A (fr)
AU (1)	AU472686B2 (fr)
BE (1)	BE783273A (fr)
CH (3)	CH573942A5 (fr)
DE (1)	DE2221790A1 (fr)
FR (1)	FR2137713B1 (fr)
GB (2)	GB1380880A (fr)
NL (1)	NL7206302A (fr)
ZA (1)	ZA722560B (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4932874B1 (fr) *	1970-12-11	1974-09-03
US3946032A (en) *	1971-04-08	1976-03-23	Ciba-Geigy Corporation	Acetal derivatives of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde
CH545302A (de) *	1971-04-08	1974-01-13	Ciba Geigy Ag	Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten
US4902794A (en) *	1971-04-28	1990-02-20	The Upjohn Company	Triazolo-benzodiazepines
US4250094A (en) *	1971-04-28	1981-02-10	The Upjohn Company	1-(Aminoalkyl) substituted-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
DE2308280A1 (de) *	1971-11-15	1973-09-06	Ciba Geigy Ag	Verfahren zur herstellung von neuen diazepinderivaten
US3886174A (en) *	1971-11-22	1975-05-27	Upjohn Co	1-Substituted-6-phenyl-4H-s-triazolo{8 4,3-a{9 {8 1,4{9 benzodiazepines
CH567031A5 (fr) *	1972-05-18	1975-09-30	Ciba Geigy Ag
US3879406A (en) *	1972-07-13	1975-04-22	Hoffmann La Roche	Preparation of triazolobenzodiazepines
IE38931B1 (en) *	1973-03-09	1978-07-05	Lipha	Triazolobenzodiazepines
IE41197B1 (en)	1973-05-29	1979-11-07	Squibb & Sons Inc	4h-s-triazolo (4,3-a)(1,5)benzodiazepin-5-ones
US4213982A (en)	1973-05-29	1980-07-22	E. R. Squibb & Sons, Inc.	Novel 4H-S-triazolo[4,3-A] [1,5]benzodiazepin-5-ones
AT338799B (de) *	1974-03-02	1977-09-12	Boehringer Sohn Ingelheim	Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze
JPS5747914B2 (fr) *	1974-04-12	1982-10-13
US3910944A (en) *	1974-11-20	1975-10-07	Upjohn Co	Spiro(cyclopropane-1,4{40 -(4H)-s-triazolo-(4,3-a)(1,4)benzodiazepines)
US4044016A (en) *	1975-01-13	1977-08-23	Hoffmann-La Roche Inc.	Preparation of triazolo benzodiazepines and novel compounds
US4018788A (en) *	1975-06-16	1977-04-19	The Upjohn Company	6-(O-Halophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine
US4226772A (en) *	1976-03-15	1980-10-07	The Upjohn Company	1-[(Dialkylamino)methyl]-6-phenyl-4H-s-[4,3,-a][1,4]triazolobenzodiazepine N1 -oxide
US4009175A (en) *	1976-03-15	1977-02-22	The Upjohn Company	1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines
US4415583A (en) *	1980-03-27	1983-11-15	The Upjohn Company	Process for inducing hypnosis
US4374842A (en) *	1980-04-18	1983-02-22	Shionogi & Co., Ltd.	4,1-Benzoxazepines and compositions
US4479959A (en) *	1981-01-29	1984-10-30	The Upjohn Company	Process for inducing hypnosis
US4444781A (en) *	1981-04-06	1984-04-24	The Upjohn Company	Process for inducing hypnosis
AU2015201727B2 (en) *	2010-05-14	2018-03-08	Dana-Farber Cancer Institute, Inc.	Compositions and methods for treating neoplasia, inflammatory disease and other disorders
BR112012029005A2 (pt)	2010-05-14	2016-07-26	Dana Farber Cancer Inst Inc	composições e métodos de tratamento de neoplasia, doença inflamatória e outros distúrbios
WO2011143660A2 (fr)	2010-05-14	2011-11-17	Dana-Farber Cancer Institute, Inc.	Compositions et méthodes de traitement de la leucémie
US9301962B2 (en)	2010-05-14	2016-04-05	Baylor College Of Medicine	Male contraceptive compositions and methods of use
US9249161B2 (en)	2010-12-02	2016-02-02	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
AR084070A1 (es)	2010-12-02	2013-04-17	Constellation Pharmaceuticals Inc	Inhibidores del bromodominio y usos de los mismos
US9422292B2 (en)	2011-05-04	2016-08-23	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
EP2721031B1 (fr)	2011-06-17	2016-01-20	Constellation Pharmaceuticals, Inc.	Inhibiteurs à bromodomaine et leurs utilisations
TWI602820B (zh)	2012-06-06	2017-10-21	星宿藥物公司	溴域抑制劑及其用途
WO2013184878A1 (fr)	2012-06-06	2013-12-12	Constellation Pharmaceuticals, Inc.	Inhibiteurs de bromo-domaine de benzo [b] isoxazoloazépines et applications associées
KR20160034379A (ko)	2013-07-25	2016-03-29	다나-파버 캔서 인스티튜트 인크.	전사 인자의 억제제 및 그의 용도
MX2016005980A (es)	2013-11-08	2016-12-09	Dana Farber Cancer Inst Inc	Terapia de combinación para el cáncer usando inhibidores de la proteína bromodominio y extra-terminal.
WO2015117087A1 (fr)	2014-01-31	2015-08-06	Dana-Farber Cancer Institute, Inc.	Utilisations des dérivés de diazépane
RU2016134947A (ru)	2014-01-31	2018-03-01	Дана-Фарбер Кансер Институт, Инк.	Производные диаминопиримидин бензолсульфона и их применение
RU2722179C2 (ru)	2014-02-28	2020-05-28	Тэнша Терапеутикс, Инк.	Лечение состояний, ассоциированных с гиперинсулинемией
LT3157928T (lt)	2014-06-20	2019-05-27	Constellation Pharmaceuticals, Inc.	2-((4s)-6-(4-chlorfenil)-1-metil-4h-benzo[c]iizoksazolo[4,5-e]azepin-4-il)acetamido kristalinės formos
CA2955074A1 (fr)	2014-08-08	2016-02-11	Dana-Farber Cancer Institute, Inc.	Derives de diazepane et leurs utilisations
CA2955077A1 (fr)	2014-08-08	2016-02-11	Dana-Farber Cancer Institute, Inc.	Derives de dihydropteridinone et leurs utilisations
JP6715243B2 (ja)	2014-10-27	2020-07-01	テンシャセラピューティクス，インコーポレイテッド	ブロモドメイン阻害剤
WO2016201370A1 (fr)	2015-06-12	2016-12-15	Dana-Farber Cancer Institute, Inc.	Thérapie d'association utilisant des inhibiteurs de transcription et des inhibiteurs de kinases
JP2018526424A (ja)	2015-09-11	2018-09-13	ダナ−ファーバーキャンサーインスティテュート，インコーポレイテッド	アセトアミドチエノトリアゾロジアゼピンおよびこれらの使用
KR20180049058A (ko)	2015-09-11	2018-05-10	다나-파버 캔서 인스티튜트 인크.	시아노 티에노트리아졸로디아제핀 및 그의 용도
CN114957291A (zh)	2015-11-25	2022-08-30	达纳-法伯癌症研究所股份有限公司	二价溴结构域抑制剂及其用途
US11472806B2 (en)	2017-05-12	2022-10-18	Domain Therapeutics	Substituted heterocyclic compounds as allosteric modulators of group II metabotropic glutamate receptors
AU2021246833A1 (en) *	2020-03-31	2022-07-21	F. Hoffmann-La Roche Ag	Benzodiazepine derivatives as GABA A gamma1 PAMS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH540247A (de) *	1967-04-21	1973-09-28	Ciba Geigy Ag	Verfahren zur Herstellung von heterocyclischen, Asthylendoppelbindungen enthaltenden Verbindungen
JPS4837280B1 (fr) *	1969-03-08	1973-11-09
YU34997B (en) *	1970-03-27	1980-06-30	Hiroyuki Tawada	Process for preparing benzodiazepine derivatives

1971
- 1971-05-11 US US142418A patent/US3681343A/en not_active Expired - Lifetime
1972
- 1972-04-12 GB GB5857273A patent/GB1380880A/en not_active Expired
- 1972-04-12 GB GB1691372A patent/GB1377435A/en not_active Expired
- 1972-04-17 ZA ZA722560A patent/ZA722560B/xx unknown
- 1972-04-27 AU AU41640/72A patent/AU472686B2/en not_active Expired
- 1972-05-04 DE DE19722221790 patent/DE2221790A1/de active Pending
- 1972-05-10 CH CH1394475A patent/CH573942A5/xx not_active IP Right Cessation
- 1972-05-10 CH CH698872A patent/CH582180A5/xx not_active IP Right Cessation
- 1972-05-10 BE BE783273A patent/BE783273A/fr not_active IP Right Cessation
- 1972-05-10 CH CH1394375A patent/CH572485A5/xx not_active IP Right Cessation
- 1972-05-10 NL NL7206302A patent/NL7206302A/xx not_active Application Discontinuation
- 1972-05-10 FR FR7216686A patent/FR2137713B1/fr not_active Expired
1973
- 1973-07-13 US US37909373 patent/USRE28505E/en not_active Expired

Also Published As

Publication number	Publication date
NL7206302A (fr)	1972-11-14
AU4164072A (en)	1973-11-01
CH572485A5 (fr)	1976-02-13
ZA722560B (en)	1973-02-28
AU472686B2 (en)	1976-06-03
GB1380880A (en)	1975-01-15
CH573942A5 (fr)	1976-03-31
BE783273A (fr)	1972-11-10
CH582180A5 (fr)	1976-11-30
FR2137713A1 (fr)	1972-12-29
US3681343A (en)	1972-08-01
GB1377435A (en)	1974-12-18
DE2221790A1 (de)	1972-11-23
USRE28505E (en)	1975-08-05

Publication	Publication Date	Title
ATA136472A (fr)	1973-12-15
AU2658571A (fr)	1972-09-21
AU2691671A (fr)	1972-09-28
AU2485671A (fr)	1972-08-03
AU3005371A (fr)	1972-12-21
AU2952271A (fr)	1972-12-07
AU2941471A (fr)	1972-11-30
AU2894671A (fr)	1972-11-23
AU2742671A (fr)	1972-10-12
AU2684071A (fr)	1972-09-28
AU2564071A (fr)	1972-08-24
AU2473671A (fr)	1972-08-03
AU2907471A (fr)	1972-11-23
AU3038671A (fr)	1973-01-04
AU2486471A (fr)	1972-08-03
AU3025871A (fr)	1973-01-04
AU2503871A (fr)	1972-08-10
AU2456871A (fr)	1972-08-17
AU2577671A (fr)	1972-08-24
AU2588771A (fr)	1972-08-31
AU2654071A (fr)	1972-09-21
AU2963771A (fr)	1972-12-07
AU2669471A (fr)	1972-09-21
AU2415871A (fr)	1972-07-13
AU2684171A (fr)	1971-07-15

Legal Events

Date	Code	Title	Description
1987-03-27	ST	Notification of lapse