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FR2190411A1 - Derivs of 7-hydroxy isoflavones - vascular protectors, antiphlogistics and anti-allergics, prepd from a halocarboxylic acid and a 7-hydroxy isoflavone - Google Patents

Derivs of 7-hydroxy isoflavones - vascular protectors, antiphlogistics and anti-allergics, prepd from a halocarboxylic acid and a 7-hydroxy isoflavone

Info

Publication number
FR2190411A1
FR2190411A1 FR7223188A FR7223188A FR2190411A1 FR 2190411 A1 FR2190411 A1 FR 2190411A1 FR 7223188 A FR7223188 A FR 7223188A FR 7223188 A FR7223188 A FR 7223188A FR 2190411 A1 FR2190411 A1 FR 2190411A1
Authority
FR
France
Prior art keywords
hydroxy
allergics
antiphlogistics
derivs
prepd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7223188A
Other languages
French (fr)
Other versions
FR2190411B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BLAISE ROLLAND FR
Original Assignee
BLAISE ROLLAND FR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BLAISE ROLLAND FR filed Critical BLAISE ROLLAND FR
Priority to FR7223188A priority Critical patent/FR2190411A1/en
Publication of FR2190411A1 publication Critical patent/FR2190411A1/en
Application granted granted Critical
Publication of FR2190411B1 publication Critical patent/FR2190411B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds are of formula (I) where R1 = H or -COOR4 R2 = H, OH, OCH2COOR4,OCH(CH3)COOR4 or -OC(CH3)2 COOR4 R3 = OCH2 R3=OCH2COOR4; OCH(CH3) COOR4, or -OC(CH3)2 COOR4 R4 = H,C1-C3 alkyl, Na, K or Li. In an example, 40 g 2-ethoxy-carbonyl-7-hydroxy isoflavone, 26g ethyl bromoacetate, 35.6g K2CO3, and 400 ml dry acetone were refluxed together for 5 hrs to give 48g (I) R1 = -COOC2H5, R2=H, R3=OCH2COOCH2H5, mpt 88 degrees C.
FR7223188A 1972-06-27 1972-06-27 Derivs of 7-hydroxy isoflavones - vascular protectors, antiphlogistics and anti-allergics, prepd from a halocarboxylic acid and a 7-hydroxy isoflavone Granted FR2190411A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7223188A FR2190411A1 (en) 1972-06-27 1972-06-27 Derivs of 7-hydroxy isoflavones - vascular protectors, antiphlogistics and anti-allergics, prepd from a halocarboxylic acid and a 7-hydroxy isoflavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7223188A FR2190411A1 (en) 1972-06-27 1972-06-27 Derivs of 7-hydroxy isoflavones - vascular protectors, antiphlogistics and anti-allergics, prepd from a halocarboxylic acid and a 7-hydroxy isoflavone

Publications (2)

Publication Number Publication Date
FR2190411A1 true FR2190411A1 (en) 1974-02-01
FR2190411B1 FR2190411B1 (en) 1975-06-20

Family

ID=9100891

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7223188A Granted FR2190411A1 (en) 1972-06-27 1972-06-27 Derivs of 7-hydroxy isoflavones - vascular protectors, antiphlogistics and anti-allergics, prepd from a halocarboxylic acid and a 7-hydroxy isoflavone

Country Status (1)

Country Link
FR (1) FR2190411A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146921A2 (en) * 1983-12-21 1985-07-03 Takeda Chemical Industries, Ltd. Method for treating osteoporosis
EP0146922A2 (en) * 1983-12-21 1985-07-03 Takeda Chemical Industries, Ltd. Benzopyran-4-on derivatives and their production
WO2003087083A1 (en) * 2002-04-12 2003-10-23 Biotest Laboratories, Llc 5-alkyl-7-alkylcarbonate-isoflavone ester as isoflavone prodrug
EP1368024A1 (en) * 2001-03-16 2003-12-10 Novogen Research Pty. Ltd. Treatment of restenosis
US7368434B2 (en) * 2002-06-27 2008-05-06 The Endowment For Research In Human Biology, Inc. Compounds useful for the inhibition of ALDH
US8158810B2 (en) 2006-07-27 2012-04-17 Gilead Sciences, Inc. ALDH-2 inhibitors in the treatment of addiction

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1802961A1 (en) * 1967-10-17 1969-05-22 Fisons Pharmaceuticals Ltd Chromone compounds and processes for making the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1802961A1 (en) * 1967-10-17 1969-05-22 Fisons Pharmaceuticals Ltd Chromone compounds and processes for making the same

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146921A2 (en) * 1983-12-21 1985-07-03 Takeda Chemical Industries, Ltd. Method for treating osteoporosis
EP0146922A2 (en) * 1983-12-21 1985-07-03 Takeda Chemical Industries, Ltd. Benzopyran-4-on derivatives and their production
EP0146922A3 (en) * 1983-12-21 1986-04-02 Takeda Chemical Industries, Ltd. Benzopyran-4-on derivatives and their production
EP0146921A3 (en) * 1983-12-21 1986-04-02 Takeda Chemical Industries, Ltd. Method for treating osteoporosis
EP1368024A1 (en) * 2001-03-16 2003-12-10 Novogen Research Pty. Ltd. Treatment of restenosis
EP1368024A4 (en) * 2001-03-16 2009-03-18 Novogen Res Pty Ltd Treatment of restenosis
WO2003087083A1 (en) * 2002-04-12 2003-10-23 Biotest Laboratories, Llc 5-alkyl-7-alkylcarbonate-isoflavone ester as isoflavone prodrug
US7368434B2 (en) * 2002-06-27 2008-05-06 The Endowment For Research In Human Biology, Inc. Compounds useful for the inhibition of ALDH
US8158810B2 (en) 2006-07-27 2012-04-17 Gilead Sciences, Inc. ALDH-2 inhibitors in the treatment of addiction

Also Published As

Publication number Publication date
FR2190411B1 (en) 1975-06-20

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Legal Events

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