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FR2178754A1 - 2-amino-6-phenoxymethyl - dihydrooxazines - analgesics, hypotensives, diuretics, etc - Google Patents

2-amino-6-phenoxymethyl - dihydrooxazines - analgesics, hypotensives, diuretics, etc

Info

Publication number
FR2178754A1
FR2178754A1 FR7211946A FR7211946A FR2178754A1 FR 2178754 A1 FR2178754 A1 FR 2178754A1 FR 7211946 A FR7211946 A FR 7211946A FR 7211946 A FR7211946 A FR 7211946A FR 2178754 A1 FR2178754 A1 FR 2178754A1
Authority
FR
France
Prior art keywords
dihydrooxazines
hypotensives
phenoxymethyl
diuretics
analgesics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7211946A
Other languages
French (fr)
Other versions
FR2178754B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7211946A priority Critical patent/FR2178754A1/en
Publication of FR2178754A1 publication Critical patent/FR2178754A1/en
Application granted granted Critical
Publication of FR2178754B1 publication Critical patent/FR2178754B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds. of formula (I) (where R = Straight or branched alkyl or cycloalkyl of 1-6C or phenyl), are prepd. by cyclisation in a suitable solvent of a N-(4-phenoxy-3-X-butyl)-N'-R- urea (where X = Cl when R = alkyl or cycloalkyl, and X = OH, when R = phenyl). The cpds. (I) show analgesic, antiinflammatory, vasodilatory, hypotensive, sedative, bronchodilatory spasmolytic, atropinic diuretic and antihistaminic activities.
FR7211946A 1972-04-05 1972-04-05 2-amino-6-phenoxymethyl - dihydrooxazines - analgesics, hypotensives, diuretics, etc Granted FR2178754A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7211946A FR2178754A1 (en) 1972-04-05 1972-04-05 2-amino-6-phenoxymethyl - dihydrooxazines - analgesics, hypotensives, diuretics, etc

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7211946A FR2178754A1 (en) 1972-04-05 1972-04-05 2-amino-6-phenoxymethyl - dihydrooxazines - analgesics, hypotensives, diuretics, etc

Publications (2)

Publication Number Publication Date
FR2178754A1 true FR2178754A1 (en) 1973-11-16
FR2178754B1 FR2178754B1 (en) 1976-07-02

Family

ID=9096367

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7211946A Granted FR2178754A1 (en) 1972-04-05 1972-04-05 2-amino-6-phenoxymethyl - dihydrooxazines - analgesics, hypotensives, diuretics, etc

Country Status (1)

Country Link
FR (1) FR2178754A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1485790A (en) * 1965-06-03 1967-06-23 Hoechst Ag Benzothiazines and benzoxazines
FR1558915A (en) * 1967-05-05 1969-03-07

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1485790A (en) * 1965-06-03 1967-06-23 Hoechst Ag Benzothiazines and benzoxazines
FR1558915A (en) * 1967-05-05 1969-03-07

Also Published As

Publication number Publication date
FR2178754B1 (en) 1976-07-02

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Legal Events

Date Code Title Description
ST Notification of lapse