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FR2172948A1 - 2-arylamino-2-imidazoline derivs - with analgesic and hypotensive activity - Google Patents

2-arylamino-2-imidazoline derivs - with analgesic and hypotensive activity

Info

Publication number
FR2172948A1
FR2172948A1 FR7230915A FR7230915A FR2172948A1 FR 2172948 A1 FR2172948 A1 FR 2172948A1 FR 7230915 A FR7230915 A FR 7230915A FR 7230915 A FR7230915 A FR 7230915A FR 2172948 A1 FR2172948 A1 FR 2172948A1
Authority
FR
France
Prior art keywords
arylamino
analgesic
hypotensive activity
cpd
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7230915A
Other languages
French (fr)
Other versions
FR2172948B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of FR2172948A1 publication Critical patent/FR2172948A1/en
Application granted granted Critical
Publication of FR2172948B1 publication Critical patent/FR2172948B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Title derivatives of formula (I): (where R1 - R3 are H, F, Cl, Br, Me, Et, OMe, CF3 or CN and R4 is CH2=C(CH3) or in which R5 is H, Me or Et) and their acid addn. salts, which are useful e.g. in the treatment of migraine, are obtd. by treating a cpd. of formula (II): or its metal salt with a cpd. R4CH2-Hal (where Hal is Cl or Br) or by reacting a cpd. of formula (III): (where A is CN or a group -CY=NH in which Y is is not >4C alkoxy or alkylthio, SH or amino) with ethylenediamine or its acid addn. salt.
FR7230915A 1972-02-23 1972-08-31 2-arylamino-2-imidazoline derivs - with analgesic and hypotensive activity Granted FR2172948A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19722208434 DE2208434C2 (en) 1972-02-23 1972-02-23 Substituted 2- (N-furylmethyl-N-phenyl-amino) -2-imidazolines, their acid addition salts, processes for their preparation and compositions containing them

Publications (2)

Publication Number Publication Date
FR2172948A1 true FR2172948A1 (en) 1973-10-05
FR2172948B1 FR2172948B1 (en) 1975-11-28

Family

ID=5836781

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7230915A Granted FR2172948A1 (en) 1972-02-23 1972-08-31 2-arylamino-2-imidazoline derivs - with analgesic and hypotensive activity

Country Status (2)

Country Link
DE (1) DE2208434C2 (en)
FR (1) FR2172948A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2830278A1 (en) * 1978-07-10 1980-01-31 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF
DE2951601A1 (en) * 1979-12-21 1981-07-02 C.H. Boehringer Sohn, 6507 Ingelheim NEW SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1211341A (en) * 1955-12-19 1960-03-15 A Wander Dr Process for the preparation of 2-amino-imidazolines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759125A (en) * 1969-11-19 1971-05-18 Boehringer Sohn Ingelheim NEW N-ALLYL-2-ARYLAMINO-IMIDAZOLINES- (2) SUBSTITUTES AND METHODS FOR MAKING THEM

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1211341A (en) * 1955-12-19 1960-03-15 A Wander Dr Process for the preparation of 2-amino-imidazolines

Also Published As

Publication number Publication date
DE2208434A1 (en) 1973-08-30
FR2172948B1 (en) 1975-11-28
DE2208434C2 (en) 1982-09-16

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Legal Events

Date Code Title Description
ST Notification of lapse