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FR2166316A1 - 7-acylcephalosporins - prepd via a silylated inter - Google Patents

7-acylcephalosporins - prepd via a silylated inter

Info

Publication number
FR2166316A1
FR2166316A1 FR7200514A FR7200514A FR2166316A1 FR 2166316 A1 FR2166316 A1 FR 2166316A1 FR 7200514 A FR7200514 A FR 7200514A FR 7200514 A FR7200514 A FR 7200514A FR 2166316 A1 FR2166316 A1 FR 2166316A1
Authority
FR
France
Prior art keywords
alkyl
aryl
hal
prepd
inter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7200514A
Other languages
French (fr)
Other versions
FR2166316B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to FR7200514A priority Critical patent/FR2166316A1/en
Publication of FR2166316A1 publication Critical patent/FR2166316A1/en
Application granted granted Critical
Publication of FR2166316B1 publication Critical patent/FR2166316B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06—Acylation of 7-aminocephalosporanic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Cephalosporin antibiotics of formula (I): where R = H, MeCO2, O alkyl or -SR7; R7 = alkyl, aryl or a heterocyclic residue, R1 and R2 = H, alkyl, aryl, aralkyl, O-aryl, cycloalkyl, or a heterocyclic, residue or R1 and R2 tog. form a ring, R3 = H, hal, OH, NH2, NH alkyl, N3, O alkyl, S alkyl, benzyloxycarbonyl, benzhydroxycarbonyl, beta-haloethoxycarbonyl, CHal3CH2OCO-, or alkylOCO, and n = 0 or 1, are prepd by reacting a 7-aminocephalosporanic acid with R4R5R6SiX and a t.amine, where R4 and R5 = alkyl, opt. substd by hal, aryl, or O-alkyl, O-alkyl opt. substd by hal or aryl, aryl, O aryl, or hal; R6 = O-alkyl opt. substd. by hal or aryl or O-aryl; and X = hal., condensing the inter. with R1(CR2R3)nCOZ and a base, where Z is a labile residue e.g. hal or O-acyl and solvolysing to remove the silyl gp.
FR7200514A 1972-01-07 1972-01-07 7-acylcephalosporins - prepd via a silylated inter Granted FR2166316A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7200514A FR2166316A1 (en) 1972-01-07 1972-01-07 7-acylcephalosporins - prepd via a silylated inter

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7200514A FR2166316A1 (en) 1972-01-07 1972-01-07 7-acylcephalosporins - prepd via a silylated inter

Publications (2)

Publication Number Publication Date
FR2166316A1 true FR2166316A1 (en) 1973-08-17
FR2166316B1 FR2166316B1 (en) 1977-10-28

Family

ID=9091611

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7200514A Granted FR2166316A1 (en) 1972-01-07 1972-01-07 7-acylcephalosporins - prepd via a silylated inter

Country Status (1)

Country Link
FR (1) FR2166316A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2349589A1 (en) * 1976-04-27 1977-11-25 Bristol Myers Co PROCESS FOR PREPARING A CEPHALOSPORIN AND PRODUCT OBTAINED
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2349589A1 (en) * 1976-04-27 1977-11-25 Bristol Myers Co PROCESS FOR PREPARING A CEPHALOSPORIN AND PRODUCT OBTAINED
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
US6664420B2 (en) * 2000-08-09 2003-12-16 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
US6855826B2 (en) * 2000-08-09 2005-02-15 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
US7041829B2 (en) 2000-08-09 2006-05-09 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
US7132537B2 (en) 2000-08-09 2006-11-07 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
US7211667B2 (en) 2000-08-09 2007-05-01 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
US7619097B2 (en) * 2000-08-09 2009-11-17 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
US7795450B2 (en) 2000-08-09 2010-09-14 Magnesium Diagnostics, Inc. Antagonist of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
US7982048B2 (en) 2000-08-09 2011-07-19 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
US8129545B2 (en) 2000-08-09 2012-03-06 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states

Also Published As

Publication number Publication date
FR2166316B1 (en) 1977-10-28

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Legal Events

Date Code Title Description
ST Notification of lapse