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FR2156469A1 - Tetrahydroisoquinolinoylalkoxy-7-(2-phenyl)-gamma - -benzopyrones - as spasmolytics and vascular protecting agents - Google Patents

Tetrahydroisoquinolinoylalkoxy-7-(2-phenyl)-gamma - -benzopyrones - as spasmolytics and vascular protecting agents

Info

Publication number
FR2156469A1
FR2156469A1 FR7137850A FR7137850A FR2156469A1 FR 2156469 A1 FR2156469 A1 FR 2156469A1 FR 7137850 A FR7137850 A FR 7137850A FR 7137850 A FR7137850 A FR 7137850A FR 2156469 A1 FR2156469 A1 FR 2156469A1
Authority
FR
France
Prior art keywords
gamma
phenyl
tetrahydroisoquinolinoylalkoxy
benzopyrones
spasmolytics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7137850A
Other languages
French (fr)
Other versions
FR2156469B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BLAISE ROLLAND FR
Original Assignee
BLAISE ROLLAND FR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE790074D priority Critical patent/BE790074A/en
Application filed by BLAISE ROLLAND FR filed Critical BLAISE ROLLAND FR
Priority to FR7137850A priority patent/FR2156469A1/en
Priority to CH1492172A priority patent/CH557376A/en
Priority to LU66322A priority patent/LU66322A1/xx
Priority to NL7214168A priority patent/NL7214168A/xx
Priority to JP47104548A priority patent/JPS4935630B2/ja
Priority to CA154,645A priority patent/CA982571A/en
Priority to GB4846672A priority patent/GB1378397A/en
Priority to ES408114A priority patent/ES408114A1/en
Priority to IL40640A priority patent/IL40640A/en
Priority to DE2251872A priority patent/DE2251872C3/en
Priority to US299895A priority patent/US3891651A/en
Publication of FR2156469A1 publication Critical patent/FR2156469A1/en
Application granted granted Critical
Publication of FR2156469B1 publication Critical patent/FR2156469B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. (I):- (where RN is 6,7-dimethoxy-1-(3',4'-dimethoxybenzyl) isoquinolinyl 1 n is 1-5, Y=O or H2 and R1 is H or OH, or when Y or O, R1 = - -(CH2)n-O- or when Y-O and n = 1, R1 is -O(R')-COO - B circled positive; R' = CH2 CH(Me), CH(Et), C(Me/2 and B circled positive is Na circled positive H circled positive, H3N circled positive (CH2CH2OH), H2N circled positive (CH2CH2OH)2, hN(CH2CH2OH)3 or H2N circled positive O) are prepd. by reacting RNH1v or a 7-hydroxy-2-phenyl gamma-benzopyrone (v) with X- -(CH2)n X' to give (II) or (III) then reacting the prod. with (V) or (IV) resp. (II) and (III) are also new cpds:- RN- -(CH2)n X (where X, X' = Halogen and R2 - H or OH).
FR7137850A 1971-10-21 1971-10-21 Tetrahydroisoquinolinoylalkoxy-7-(2-phenyl)-gamma - -benzopyrones - as spasmolytics and vascular protecting agents Granted FR2156469A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
BE790074D BE790074A (en) 1971-10-21 NEW COMPOUNDS DERIVED FROM TETRAHYDROISOQUINOLEIN AND GAMMA-BENZOPYRONE AND THEIR PREPARATION METHODS
FR7137850A FR2156469A1 (en) 1971-10-21 1971-10-21 Tetrahydroisoquinolinoylalkoxy-7-(2-phenyl)-gamma - -benzopyrones - as spasmolytics and vascular protecting agents
CH1492172A CH557376A (en) 1971-10-21 1972-10-12 PROCESS FOR THE PREPARATION OF NEW COMPOUNDS DERIVED FROM TETRAHYDRO-ISOQUINOLEIN AND GAMMA-BENZOPYRONE.
NL7214168A NL7214168A (en) 1971-10-21 1972-10-19
LU66322A LU66322A1 (en) 1971-10-21 1972-10-19
CA154,645A CA982571A (en) 1971-10-21 1972-10-20 Method of preparing novel compounds derived from tetrahydro-isoquinoline and gamma-benzopyrone, and compounds thus obtained
JP47104548A JPS4935630B2 (en) 1971-10-21 1972-10-20
GB4846672A GB1378397A (en) 1971-10-21 1972-10-20 Compounds derived from tetrahydroisoquinoline and gammabenzopyrone and method of preparing same
ES408114A ES408114A1 (en) 1971-10-21 1972-10-21 Compounds derived from tetrahydro-isoquinoline and gamma-benzopyrone
IL40640A IL40640A (en) 1971-10-21 1972-10-22 Compounds derived from tetrahydro-isoquinoline and gamma-benzopyrone,their preparation and pharmaceutical compositions containing them
DE2251872A DE2251872C3 (en) 1971-10-21 1972-10-23 Salts of N- [(5-carboxy-methoxy-2-phenyl-ybenzopyron-7-yl) -oxyacetyl] -tetrahydropapaverine, processes for their preparation and pharmaceuticals containing them
US299895A US3891651A (en) 1971-10-21 1972-10-24 Compounds derived from tetrahydro-isoquinoline and gamma-benzopyrone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7137850A FR2156469A1 (en) 1971-10-21 1971-10-21 Tetrahydroisoquinolinoylalkoxy-7-(2-phenyl)-gamma - -benzopyrones - as spasmolytics and vascular protecting agents

Publications (2)

Publication Number Publication Date
FR2156469A1 true FR2156469A1 (en) 1973-06-01
FR2156469B1 FR2156469B1 (en) 1974-11-15

Family

ID=9084706

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7137850A Granted FR2156469A1 (en) 1971-10-21 1971-10-21 Tetrahydroisoquinolinoylalkoxy-7-(2-phenyl)-gamma - -benzopyrones - as spasmolytics and vascular protecting agents

Country Status (1)

Country Link
FR (1) FR2156469A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024677A1 (en) * 2000-09-21 2002-03-28 Biogal Pharmaceutical Co., Ltd. N-disubstituted carbamoyloxy flavones

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860336A (en) * 1958-05-30 1961-02-01 Chemiewerk Homburg Ag N-substituted 2-phenyl-7-aminoalkoxy chromones and a process for preparing them
GB1016088A (en) * 1961-03-16 1966-01-05 Cassella Farbwerke Mainkur Ag New 7-hydroxychromone derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860336A (en) * 1958-05-30 1961-02-01 Chemiewerk Homburg Ag N-substituted 2-phenyl-7-aminoalkoxy chromones and a process for preparing them
GB1016088A (en) * 1961-03-16 1966-01-05 Cassella Farbwerke Mainkur Ag New 7-hydroxychromone derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024677A1 (en) * 2000-09-21 2002-03-28 Biogal Pharmaceutical Co., Ltd. N-disubstituted carbamoyloxy flavones
WO2002024676A1 (en) * 2000-09-21 2002-03-28 Teva Pharmaceuticals Industries, Ltd. N-disubstituted carbamoyloxy flavones
US6610738B2 (en) 2000-09-21 2003-08-26 Biogal Pharmaceutical Co., Ltd. N-disubstituted carbamoyloxy flavones

Also Published As

Publication number Publication date
FR2156469B1 (en) 1974-11-15

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Legal Events

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