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FR2150216A1 - 17-vinylidene steroids - inters for progesterone derivs - Google Patents

17-vinylidene steroids - inters for progesterone derivs

Info

Publication number
FR2150216A1
FR2150216A1 FR7130457A FR7130457A FR2150216A1 FR 2150216 A1 FR2150216 A1 FR 2150216A1 FR 7130457 A FR7130457 A FR 7130457A FR 7130457 A FR7130457 A FR 7130457A FR 2150216 A1 FR2150216 A1 FR 2150216A1
Authority
FR
France
Prior art keywords
vinylidene
steroids
steroid
inters
derivs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7130457A
Other languages
French (fr)
Other versions
FR2150216B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Palo Alto LLC
Original Assignee
Roche Palo Alto LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Priority to FR7130457A priority Critical patent/FR2150216A1/en
Publication of FR2150216A1 publication Critical patent/FR2150216A1/en
Application granted granted Critical
Publication of FR2150216B1 publication Critical patent/FR2150216B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Steroids of the formula: (where A = A, B and C rings of a steroid molecule; R = H, OH or acyloxy; R1 = H or acyl), are prepd. by reacting a 17 alpha-ethynyl-17 beta-acyloxy estrane or androstane steroid with Zn in an ethylene glycol ether to give the corresp. 17 vinylidene steroid which is oxidised with OsO4, OsO4, H2O2 mixture, a percarboxylic acid, phenyliodoso acerate or morpholine. The prodts. have progestational, and antiinflammatory activity and the intermediate vinylidene cpds. are antandrogenic.
FR7130457A 1971-08-20 1971-08-20 17-vinylidene steroids - inters for progesterone derivs Granted FR2150216A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7130457A FR2150216A1 (en) 1971-08-20 1971-08-20 17-vinylidene steroids - inters for progesterone derivs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7130457A FR2150216A1 (en) 1971-08-20 1971-08-20 17-vinylidene steroids - inters for progesterone derivs

Publications (2)

Publication Number Publication Date
FR2150216A1 true FR2150216A1 (en) 1973-04-06
FR2150216B1 FR2150216B1 (en) 1974-10-18

Family

ID=9082096

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7130457A Granted FR2150216A1 (en) 1971-08-20 1971-08-20 17-vinylidene steroids - inters for progesterone derivs

Country Status (1)

Country Link
FR (1) FR2150216A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351997A1 (en) * 1975-11-17 1977-12-16 Upjohn Co PROCESS FOR THE PREPARATION OF CORTICOSTEROIDS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351997A1 (en) * 1975-11-17 1977-12-16 Upjohn Co PROCESS FOR THE PREPARATION OF CORTICOSTEROIDS

Also Published As

Publication number Publication date
FR2150216B1 (en) 1974-10-18

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Legal Events

Date Code Title Description
ST Notification of lapse