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FR2068423A1 - 3-phenyl-5-ethoxycarbonyl-2-oxazolidinones antiarrhythmics - Google Patents

3-phenyl-5-ethoxycarbonyl-2-oxazolidinones antiarrhythmics

Info

Publication number
FR2068423A1
FR2068423A1 FR6938134A FR6938134A FR2068423A1 FR 2068423 A1 FR2068423 A1 FR 2068423A1 FR 6938134 A FR6938134 A FR 6938134A FR 6938134 A FR6938134 A FR 6938134A FR 2068423 A1 FR2068423 A1 FR 2068423A1
Authority
FR
France
Prior art keywords
antiarrhythmics
oxazolidinones
ethoxycarbonyl
phenyl
phosgene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6938134A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR6938134A priority Critical patent/FR2068423A1/en
Publication of FR2068423A1 publication Critical patent/FR2068423A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

3-Phenyl-5-ethoxycarbonyl-2-oxazolidinones-antiarrhythmics. Oxazolidinone derivs have formula (I) where R1 and R2=1-4C aliphatic grps. or together with the C atom to which they are attached form a 5-8C cycloalkyl gp. The cpds. are prepd. from a ketone R1-CO-R2 by reaction with ethyl chloroacetate to give an alpha-carbethoxy epoxide followed by treatment with aniline and cyclisation with phosgene. In example acetaone and ethyl chloracetate were reacted together in the presence of K, tert, butoxide, the product treated with excess aniline then with phosgene to give (I) R1=R2=CH3, m.pt. 85 degrees C.
FR6938134A 1969-11-06 1969-11-06 3-phenyl-5-ethoxycarbonyl-2-oxazolidinones antiarrhythmics Withdrawn FR2068423A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR6938134A FR2068423A1 (en) 1969-11-06 1969-11-06 3-phenyl-5-ethoxycarbonyl-2-oxazolidinones antiarrhythmics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6938134A FR2068423A1 (en) 1969-11-06 1969-11-06 3-phenyl-5-ethoxycarbonyl-2-oxazolidinones antiarrhythmics

Publications (1)

Publication Number Publication Date
FR2068423A1 true FR2068423A1 (en) 1971-08-27

Family

ID=9042680

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6938134A Withdrawn FR2068423A1 (en) 1969-11-06 1969-11-06 3-phenyl-5-ethoxycarbonyl-2-oxazolidinones antiarrhythmics

Country Status (1)

Country Link
FR (1) FR2068423A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417044A2 (en) * 1989-09-07 1991-03-13 Ciba-Geigy Ag Oxazolidinones and thiones as plantgrowth regulators
EP0697408A1 (en) * 1994-08-19 1996-02-21 MERCK PATENT GmbH 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists
US7645781B2 (en) 2002-02-25 2010-01-12 Pfizer Inc N-aryl-2-oxazolidinone-5-carboxamides and their derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2437390A (en) * 1948-03-09 Z-oxazolidone compounds and proc

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2437390A (en) * 1948-03-09 Z-oxazolidone compounds and proc

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417044A2 (en) * 1989-09-07 1991-03-13 Ciba-Geigy Ag Oxazolidinones and thiones as plantgrowth regulators
EP0417044A3 (en) * 1989-09-07 1991-06-12 Ciba-Geigy Ag Oxazolidinones and thiones as plantgrowth regulators
EP0697408A1 (en) * 1994-08-19 1996-02-21 MERCK PATENT GmbH 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists
US7645781B2 (en) 2002-02-25 2010-01-12 Pfizer Inc N-aryl-2-oxazolidinone-5-carboxamides and their derivatives

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Legal Events

Date Code Title Description
ST Notification of lapse