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FR2054507A1 - (3 alkoxy-2-(diaryl) methyl)-propylamines cardio - vascular pharmaceuticals - Google Patents

(3 alkoxy-2-(diaryl) methyl)-propylamines cardio - vascular pharmaceuticals

Info

Publication number
FR2054507A1
FR2054507A1 FR6924645A FR6924645A FR2054507A1 FR 2054507 A1 FR2054507 A1 FR 2054507A1 FR 6924645 A FR6924645 A FR 6924645A FR 6924645 A FR6924645 A FR 6924645A FR 2054507 A1 FR2054507 A1 FR 2054507A1
Authority
FR
France
Prior art keywords
diaryl
propylamines
alkoxy
methyl
pharmaceuticals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6924645A
Other languages
French (fr)
Other versions
FR2054507B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAUVERNAY CTRE RECH
Original Assignee
MAUVERNAY CTRE RECH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MAUVERNAY CTRE RECH filed Critical MAUVERNAY CTRE RECH
Priority to FR6924645A priority Critical patent/FR2054507A1/en
Priority to JP45061100A priority patent/JPS4941428B1/ja
Priority to DE19702035535 priority patent/DE2035535A1/en
Publication of FR2054507A1 publication Critical patent/FR2054507A1/en
Application granted granted Critical
Publication of FR2054507B1 publication Critical patent/FR2054507B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/90—Xanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

3-Alkoxy-2-(diaryl)methyl -propylamines, cardiovascular pharmaceuticals Cpds. of formula (where Ar and Ar' are opt. subst aryl which may be linked in the form of polynuclear aromatic group by C-C bonds or chains containing heteroatoms and oxygen, R is aliphatic residue, aryl or arylaliphatic residue, and A is tert. amino group where N-atom may form part of heterocycle). are obtained by replacing OH-group of aminoalcohol by Cl-atom and reacting intermediate in solvent with diaryl derivative of methane that has previously been converted to sodium derivative and whose aryl residues correspond to the residues Ar and Ar' of the required product.
FR6924645A 1969-07-18 1969-07-18 (3 alkoxy-2-(diaryl) methyl)-propylamines cardio - vascular pharmaceuticals Granted FR2054507A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR6924645A FR2054507A1 (en) 1969-07-18 1969-07-18 (3 alkoxy-2-(diaryl) methyl)-propylamines cardio - vascular pharmaceuticals
JP45061100A JPS4941428B1 (en) 1969-07-18 1970-07-14
DE19702035535 DE2035535A1 (en) 1969-07-18 1970-07-17 Square bracket on 3 alkoxy 2 (diaryl) methyl square bracket on propylamine, its manufacture and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6924645A FR2054507A1 (en) 1969-07-18 1969-07-18 (3 alkoxy-2-(diaryl) methyl)-propylamines cardio - vascular pharmaceuticals

Publications (2)

Publication Number Publication Date
FR2054507A1 true FR2054507A1 (en) 1971-04-23
FR2054507B1 FR2054507B1 (en) 1973-06-08

Family

ID=9037713

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6924645A Granted FR2054507A1 (en) 1969-07-18 1969-07-18 (3 alkoxy-2-(diaryl) methyl)-propylamines cardio - vascular pharmaceuticals

Country Status (3)

Country Link
JP (1) JPS4941428B1 (en)
DE (1) DE2035535A1 (en)
FR (1) FR2054507A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629347A (en) * 1991-07-05 1997-05-13 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
US5495047A (en) * 1991-07-10 1996-02-27 Merck, Sharp & Dohme (Ltd.) Fused tricyclic compounds, pharmaceutical compositions containing them and their use in therapy
GB9211193D0 (en) * 1992-05-27 1992-07-08 Merck Sharp & Dohme Therapeutic agents
GB9300051D0 (en) * 1993-01-04 1993-03-03 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
JPS4941428B1 (en) 1974-11-08
FR2054507B1 (en) 1973-06-08
DE2035535A1 (en) 1971-01-28

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Legal Events

Date Code Title Description
ST Notification of lapse