FI98830B - Process for the preparation of bifunctional proteins - Google Patents

Process for the preparation of bifunctional proteins

Info

Publication number: FI98830B
Authority: FI; Finland
Prior art keywords: preparation; bifunctional proteins; bifunctional; proteins
Prior art date: 1987-04-16

Application number

FI881743A

Other languages

Finnish (fi)

Swedish (sv)

Other versions

FI881743A0 (en

FI98830C (en

FI881743A (en

Inventor

Paul Habermann

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-16

Filing date

1988-04-14

Publication date

1997-05-15

1988-04-14 Application filed by Hoechst Ag filed Critical Hoechst Ag

1988-04-14 Publication of FI881743A0 publication Critical patent/FI881743A0/en

1988-10-17 Publication of FI881743A publication Critical patent/FI881743A/en

1997-05-15 Publication of FI98830B publication Critical patent/FI98830B/en

1997-08-25 Application granted granted Critical

1997-08-25 Publication of FI98830C publication Critical patent/FI98830C/en

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FI881743A 1987-04-16 1988-04-14 Process for the preparation of bifunctional proteins FI98830C (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3712985		1987-04-16
DE19873712985 DE3712985A1 (en)	1987-04-16	1987-04-16	BIFUNCTIONAL PROTEINS

Publications (4)

Publication Number	Publication Date
FI881743A0 FI881743A0 (en)	1988-04-14
FI881743A FI881743A (en)	1988-10-17
FI98830B true FI98830B (en)	1997-05-15
FI98830C FI98830C (en)	1997-08-25

Family

ID=6325799

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI881743A FI98830C (en)	1987-04-16	1988-04-14	Process for the preparation of bifunctional proteins

Country Status (20)

Country	Link
EP (1)	EP0288809B1 (en)
JP (1)	JP2667193B2 (en)
KR (1)	KR970000187B1 (en)
AR (1)	AR242991A1 (en)
AT (1)	ATE79135T1 (en)
AU (1)	AU613022B2 (en)
CA (1)	CA1322157C (en)
DE (2)	DE3712985A1 (en)
DK (1)	DK170741B1 (en)
ES (1)	ES2033981T3 (en)
FI (1)	FI98830C (en)
GR (1)	GR3006141T3 (en)
HU (1)	HU204303B (en)
IE (1)	IE61574B1 (en)
IL (1)	IL86086A (en)
NO (1)	NO176922C (en)
NZ (1)	NZ224247A (en)
PH (1)	PH25327A (en)
PT (1)	PT87237B (en)
ZA (1)	ZA882659B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5662896A (en) *	1988-03-21	1997-09-02	Chiron Viagene, Inc.	Compositions and methods for cancer immunotherapy
US6406697B1 (en)	1989-02-23	2002-06-18	Genentech, Inc.	Hybrid immunoglobulins
US5116964A (en) *	1989-02-23	1992-05-26	Genentech, Inc.	Hybrid immunoglobulins
US5225538A (en) *	1989-02-23	1993-07-06	Genentech, Inc.	Lymphocyte homing receptor/immunoglobulin fusion proteins
WO1990012877A1 (en) *	1989-04-19	1990-11-01	Cetus Corporation	Multifunctional m-csf proteins and genes encoding therefor
US5073627A (en) *	1989-08-22	1991-12-17	Immunex Corporation	Fusion proteins comprising GM-CSF and IL-3
US5108910A (en) *	1989-08-22	1992-04-28	Immunex Corporation	DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
JP3115318B2 (en) *	1989-08-22	2000-12-04	イミュネックス・コーポレーション	Fusion protein containing GM-CSF and IL-3
US5376367A (en) *	1991-11-22	1994-12-27	Immunex Corporation	Fusion proteins comprising MGF and IL-3
US5723125A (en) *	1995-12-28	1998-03-03	Tanox Biosystems, Inc.	Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
EP1037927B1 (en)	1997-12-08	2004-05-19	Lexigen Pharmaceuticals Corp.	Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation
SK782002A3 (en)	1999-07-21	2003-08-05	Lexigen Pharm Corp	FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
ATE316982T1 (en)	1999-08-09	2006-02-15	Lexigen Pharm Corp	MULTIPLE CYTOKINE ANTIBODIES COMPLEXES
JP4553290B2 (en) *	1999-11-30	2010-09-29	塩野義製薬株式会社	Chemokine SLC-IL2 fusion protein and its gene
DE60122286T2 (en)	2000-02-11	2007-08-02	Merck Patent Gmbh	INCREASING THE CIRCULATORY HALF-TIME OF ANTIBODY-BASED FUSION PROTEINS
KR20090010127A (en)	2001-03-07	2009-01-28	메르크 파텐트 게엠베하	Expression technology for proteins containing a hybrid isotype antibody moiety
WO2002079415A2 (en)	2001-03-30	2002-10-10	Lexigen Pharmaceuticals Corp.	Reducing the immunogenicity of fusion proteins
BR0209177A (en)	2001-05-03	2004-10-05	Merck Patent Gmbh	Recombinant tumor specific antibody and use
CN102180944A (en)	2001-10-10	2011-09-14	诺和诺德公司	Remodeling and glycoconjugation of peptides
EP2354791A1 (en)	2001-12-04	2011-08-10	Merck Patent GmbH	Immunocytokines with modulated selectivity
BRPI0317376B8 (en)	2002-12-17	2021-05-25	Merck Patent Gmbh	antibody-il2 fusion protein designated as hu14.18-il2, uses thereof, vector and pharmaceutical composition
DE602004031341D1 (en)	2003-07-21	2011-03-24	Transgene Sa	MULTIFUNCTIONAL CYTOKINE
JP4842128B2 (en) *	2003-07-21	2011-12-21	トランジェーヌ、ソシエテ、アノニム	Novel multifunctional cytokine
WO2010001414A1 (en) *	2008-07-03	2010-01-07	Lupin Limited	Expression of heterologous proteins in bacterial system using a gm-csf fusion tag

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1985000817A1 (en) *	1983-08-10	1985-02-28	Amgen	Microbial expression of interleukin ii
GB8327880D0 (en) *	1983-10-18	1983-11-16	Ajinomoto Kk	Saccharomyces cerevisiae
EP0158198A1 (en) *	1984-03-29	1985-10-16	Takeda Chemical Industries, Ltd.	DNA and use thereof
WO1985004673A1 (en) *	1984-04-10	1985-10-24	Takeda Chemical Industries, Ltd.	Novel dna and its use
DE3419995A1 (en) *	1984-05-29	1985-12-05	Hoechst Ag, 6230 Frankfurt	GENE TECHNOLOGICAL METHOD FOR PRODUCING HUMAN INTERLEUKIN-2 AND MEANS FOR CARRYING OUT THIS METHOD
AU588819B2 (en) *	1984-10-29	1989-09-28	Immunex Corporation	Cloning of human granulocyte-macrophage colony stimulating factor gene
JPS61128889A (en) *	1984-11-27	1986-06-16	Green Cross Corp:The	Recombinant dna and transformant by same
JPH0646957B2 (en) *	1985-03-11	1994-06-22	武田薬品工業株式会社	Method for producing interleukin-2
WO1987002060A1 (en) *	1985-10-03	1987-04-09	Biogen N.V.	Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells
DE3541856A1 (en) *	1985-11-27	1987-06-04	Hoechst Ag	EUKARYOTIC FUSION PROTEINS, THEIR PRODUCTION AND USE, AND MEANS FOR CARRYING OUT THE PROCESS
DE3545568A1 (en) *	1985-12-21	1987-07-16	Hoechst Ag	GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE

1987
- 1987-04-16 DE DE19873712985 patent/DE3712985A1/en not_active Withdrawn
1988
- 1988-04-09 AT AT88105693T patent/ATE79135T1/en not_active IP Right Cessation
- 1988-04-09 ES ES198888105693T patent/ES2033981T3/en not_active Expired - Lifetime
- 1988-04-09 EP EP88105693A patent/EP0288809B1/en not_active Expired - Lifetime
- 1988-04-09 DE DE8888105693T patent/DE3873397D1/en not_active Expired - Fee Related
- 1988-04-14 NZ NZ224247A patent/NZ224247A/en unknown
- 1988-04-14 PT PT87237A patent/PT87237B/en active IP Right Grant
- 1988-04-14 FI FI881743A patent/FI98830C/en not_active IP Right Cessation
- 1988-04-15 HU HU881966A patent/HU204303B/en not_active IP Right Cessation
- 1988-04-15 IE IE114688A patent/IE61574B1/en not_active IP Right Cessation
- 1988-04-15 IL IL8608688A patent/IL86086A/en not_active IP Right Cessation
- 1988-04-15 ZA ZA882659A patent/ZA882659B/en unknown
- 1988-04-15 JP JP63093321A patent/JP2667193B2/en not_active Expired - Fee Related
- 1988-04-15 CA CA000564322A patent/CA1322157C/en not_active Expired - Fee Related
- 1988-04-15 AR AR88310585A patent/AR242991A1/en active
- 1988-04-15 NO NO881658A patent/NO176922C/en not_active IP Right Cessation
- 1988-04-15 AU AU14661/88A patent/AU613022B2/en not_active Ceased
- 1988-04-15 DK DK209188A patent/DK170741B1/en not_active IP Right Cessation
- 1988-04-16 KR KR1019880004345A patent/KR970000187B1/en not_active IP Right Cessation
1989
- 1989-04-14 PH PH36799A patent/PH25327A/en unknown
1992
- 1992-11-04 GR GR920402185T patent/GR3006141T3/el unknown

Also Published As

Publication number	Publication date
DK209188D0 (en)	1988-04-15
IE61574B1 (en)	1994-11-16
JP2667193B2 (en)	1997-10-27
AU1466188A (en)	1988-10-20
HUT47319A (en)	1989-02-28
EP0288809B1 (en)	1992-08-05
CA1322157C (en)	1993-09-14
PT87237A (en)	1988-05-01
JPS63301898A (en)	1988-12-08
IE881146L (en)	1988-10-16
EP0288809A1 (en)	1988-11-02
NO881658L (en)	1988-10-17
HU204303B (en)	1991-12-30
DK209188A (en)	1988-10-17
PH25327A (en)	1991-04-30
FI881743A0 (en)	1988-04-14
NZ224247A (en)	1990-04-26
PT87237B (en)	1992-07-31
NO176922C (en)	1995-06-21
AR242991A1 (en)	1993-06-30
DE3873397D1 (en)	1992-09-10
AU613022B2 (en)	1991-07-25
FI98830C (en)	1997-08-25
IL86086A0 (en)	1988-09-30
DK170741B1 (en)	1996-01-08
KR970000187B1 (en)	1997-01-06
GR3006141T3 (en)	1993-06-21
DE3712985A1 (en)	1988-11-03
NO176922B (en)	1995-03-13
FI881743A (en)	1988-10-17
ES2033981T3 (en)	1993-04-01
IL86086A (en)	1995-01-24
KR880012760A (en)	1988-11-29
NO881658D0 (en)	1988-04-15
ATE79135T1 (en)	1992-08-15
ZA882659B (en)	1988-10-14

Publication	Publication Date	Title
FI98830B (en)	1997-05-15	Process for the preparation of bifunctional proteins
FI882007A (en)	1988-10-30	Process for the preparation of steroid-5-reductase inhibitors
PT86600A (en)	1988-02-01	PROCESS FOR THE PREPARATION OF ANTICOAGULANT PEPTIDES
FI981380A (en)	1998-06-15	Process for Preparation of HCV Polypeptides
FI892058A0 (en)	1989-04-28	Process for the preparation of phenol
NO172447C (en)	1993-07-21	PROCEDURE FOR B-AVERMECTIN PREPARATION
FI881303A (en)	1988-09-21	Process for the preparation of ibuprofen
FI872769A (en)	1987-12-24	Process for the preparation of alpha-monoolefins
FI104171B (en)	1999-11-30	Process for the preparation of mono-N-alkylated polyazamacrocyclic compounds
FI93215C (en)	1995-03-10	Process for the preparation of therapeutically useful aminoalkoxyphenyl derivatives
FI880467A (en)	1988-08-05	Process for the preparation of therapeutically useful substituted 3,4-dihydro-2H-benzopyrans
FI902316A0 (en)	1990-05-09	Process for the preparation of therapeutically-substituted dihydropyrrolizine compounds
FI102270B1 (en)	1998-11-13	Process for the preparation of diets
FI895663A0 (en)	1989-11-27	Process for the preparation of chlorofluorobenzene or difluorobenzene
FI92065C (en)	1994-09-26	Process for the preparation of pharmaceutical piperidine derivatives
FI93119B (en)	1994-11-15	Process for the preparation of novel thieno-triazolo-diethepines
PT87857A (en)	1988-07-01	PROCESS FOR THE PREPARATION OF NOVEL IMMUNOSSUPRESSANT PEPTIDES
FI92188C (en)	1994-10-10	Process for the preparation of therapeutically useful phenoxyalkylpyrocatechol derivatives
FI901606A0 (en)	1990-03-30	Process for the preparation of sulfonyl derivatives of thieno-trizolidodiazepines
NO174085C (en)	1994-03-16	Process for the preparation of sucralfate preparations
FI892144A (en)	1989-11-06	Process for the preparation of 5-C-hydroxymethylaldohexose-based compounds
FI93442B (en)	1994-12-30	Process for the preparation of new cysteine derivatives
FI88294C (en)	1993-04-26	Process for the preparation of azetidinones
PT87732A (en)	1988-07-01	PROCESS FOR THE PREPARATION OF (E) - (P-FLUOROPHENETHYL) -3-FLUOROALLYLAMINE
FI903604A0 (en)	1990-07-17	New Process for Preparation of 2-Diazo-3-Trisubstituted Silyloxy-3-Butenoates

Legal Events

Date	Code	Title	Description
1988-04-14	FG	Patent granted	Owner name: HOECHST AKTIENGESELLSCHAFT
1997-04-16	BB	Publication of examined application
2004-08-31	MM	Patent lapsed	Owner name: HOECHST AKTIENGESELLSCHAFT