[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

FI94357B - Förfarande för framställning av i vatten olösliga hyaluronsyragel och -membran - Google Patents

Förfarande för framställning av i vatten olösliga hyaluronsyragel och -membran Download PDF

Info

Publication number
FI94357B
FI94357B FI901330A FI901330A FI94357B FI 94357 B FI94357 B FI 94357B FI 901330 A FI901330 A FI 901330A FI 901330 A FI901330 A FI 901330A FI 94357 B FI94357 B FI 94357B
Authority
FI
Finland
Prior art keywords
water
nucleophile
gel
methyl ester
amino acid
Prior art date
Application number
FI901330A
Other languages
English (en)
Finnish (fi)
Other versions
FI94357C (sv
FI901330A0 (sv
Inventor
Raymond G Hamilton
Ellen M Fox
Raksha A Acharya
Alan E Walts
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22278122&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI94357(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of FI901330A0 publication Critical patent/FI901330A0/sv
Publication of FI94357B publication Critical patent/FI94357B/sv
Application granted granted Critical
Publication of FI94357C publication Critical patent/FI94357C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (35)

1. Förfarande för framställning av en i vatten olöslig, ej tvärbunden, biokompatibel gel, k ä n n e - 5. e c k n a t därav, att man framställer en vattenhaltig blandning omfattande 0,4 - 2,6 vikt-% hyaluronsyra (HA), aktiverar hyaluronsyran med ett aktiveringsreagens för bildande av aktiverad hyaluronsyra, och 10 omsätter den aktiverade hyaluronsyran med en nuk- leofil under förhällanden varvid bildas en i vatten olöslig, biokompatibel gel.
2. Förfarande enligt patenkrav 1, känne-t e c k n a t därav, att aktiveringen omfattar stegen 15 man sänker pH-värdet tili mellan 4,0 och 5,0 hos vattenblandningen innehällande hyaluronsyra, genom till-sättning av syra, och man bringar vattenblandningen i kontakt med aktive-ringsreagenset. 20
3. Förfarande enligt patentkrav 2, känne- t e c k n a t därav, att syran omfattar klorvätesyra.
4. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att HA och aktiveringsreagens är närvarande under aktiveringen vid ett molförhällande av 25 ätminstone 0,23 molekvivalenter aktiveringsreagens till 1 molekvivalent glukuronsyragrupper hos HA.
5. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att det aktiverade HA och nukleofi-len är närvarande vid omsättningssteget i ett molförhäll-30 ande av ätminstone 0,2 molekvivalenter nukleofil tili en molekvivalent glukuronsyragrupper hos den aktiverade HA.
6. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att aktiveringsmedlet omfattar en karbodiimid. 35
7. Förfarande enligt patentkrav 6, känne- t e c k n a t därav, att karbodiimiden omfattar 1-etyl- 94357 3-(3-dimetylaminopropyl)karbodiimid eller l-etyl-3-(3-di-metylaminopropyl)karbodiimid-metjodid.
8. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att nukleofilen omfattar en aminosy- 5 ra.
9. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att nukleofilen omfattar ett amino-syrasalt.
10. Förfarande enligt patentkrav 1, känne- 10 tecknat därav, att nukleofilen omfattar en aminosy- raester.
11. Förfarande enligt patentkrav 10, känne-tecknat därav, att aminosyraestern omfattar en me-tylester. 15
12. Förfarande enligt patentkrav 10, känne- tecknat därav, att aminosyraestern omfattar en bu-tylester.
13. Förfarande enligt patentkrav 12, känne-tecknat därav, att butylestern omfattar en t-butyl- 20 ester.
14. Förfarande enligt patentkrav 1, känne-tecknat därav, att nukleofilen omfattar en metyles-ter av en aminosyra, vilken valts bland leucin, valin, isoleucin, arginin, prolin, histidin eller fenylalanin. *25
15. Förfarande enligt patentkrav 1, känne- tecknat därav, att nukleofilen omfattar L-leucinme-tylesterhydroklorid, L-valinmetylesterhydroklorid, L-iso-leucinmetylesterhydroklorid, L-argininmetylesterhydroklo-rid, L-prolinmetylesterhydroklorid, L-histidinmetylester-30 hydroklorid, L-fenylalaninhydroklorid eller L-leucin-t-butylesterhydroklorid.
16. Förfarande enligt patentkrav 1, känne-tecknat därav, att nukleofilen omfattar en aminosy-raamid. 94357
17. Förfarande enligt patentkrav 16, känne-t e c k n a t därav, att aminosyraamiden omfattar leucin-amidhydroklorid.
18. Förfarande enligt patentkrav 1, känne- 5 tecknat därav, att nukleofilen omfattar en mono-funktionell amin.
19. Förfarande enligt patentkrav 18, känne-tecknat därav, att den monofunktionella aminen omfattar anilin. 10
20. Förfarande enligt patentkrav 1, känne- tecknat därav, att aktiveringen och omsättningen sker samtidigt.
21. Förfarande enligt patentkrav 1, känne-tecknat därav, att det ytterligare omfattar in- 15 blandning av ett detekterbart märke.
22. Förfarande enligt patentekrav 21, känne-tecknat därav, att det detekterbara märket omfattar ett färgämne som färgar aminosyror.
23. Medelst förfarandet enligt patentkrav 1 fram- 20 ställd vattenolöslig, biokompatibel gel.
24. Förfarande för framställning av en i vatten olöslig, biokompatibel film, kännetecknad därav, att man bildar en biokompatibel gel enligt patentkrav 23, •25 och torkar gelen.
25. Förfarande för framställning av en i vatten olöslig, biokompatibel film, kännetecknat därav, att man 30 bildar en biokompatibel gel enligt patentkrav 23 och komprimerar gelen under förhällanden som tilläter urvattning av gelen.
26. I vatten olöslig, biokompatibel HA omfattande 35 komposition, kännetecknad därav, att den er- 94357 hällits genom att bringa HA att reagera i en vattenhaltig blandning vid en koncentration pä 0,4 - 2,6 vikt-%, med ett aktiveringsreagens och en nukleofil under förhällanden vilka är tillräckliga för att tilläta bildning av en i 5 vatten olöslig produkt som Sr väsentligen utan tvärbind-ningar.
27. Komposition enligt patentekrav 26, känne-t e c k n a d därav, att kompositionen är väsentligen fri frän bifunktionella eller polyfunktionella nukleofiler och 10 att kompositionen är väsentligen fri frän bifunktionella eller polyfunktionella elektrofiler.
28. Komposition enligt patentkrav 26, känne-t e c k n a d därav, att den ytterligare omfattar en mo-nofunktionell nukleofil.
29. Komposition enligt patentkrav 26, känne- t e c k n a d därav, att den ytterligare omfattar en mo-nofunktionell amin.
30. Komposition enligt patentkrav 26, känne- t e c k n a d därav, att aktiveringsmedlet är en karbodi- 20 imid.
31. Komposition enligt patentkrav 30, känne-t e c k n a d därav, att karbodiimiden är l-etyl-3-(3-dimetylaminopropyl)karbodiimidhydroklorid (EDC).
32. Komposition enligt patentkrav 28, känne- *25 tecknad därav, att nukleofilen är en metylester av en aminosyra.
33. Medelst förfarandet enligt patentkrav 24 fram-ställd film.
34. Medelst förfarandet enligt patentkrav 25 fram- 30 ställd film.
35. Komposition enligt patentkrav 26, känne-tecknad därav, att den ytterligare omfattar ett detekterbart märke.
FI901330A 1987-09-18 1990-03-16 Förfarande för framställning av i vatten olösliga hyaluronsyragel och -membran FI94357C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/100,104 US4937270A (en) 1987-09-18 1987-09-18 Water insoluble derivatives of hyaluronic acid
US10010487 1987-09-18
PCT/US1988/002969 WO1989002445A1 (en) 1987-09-18 1988-08-26 Water insoluble derivatives of hyaluronic acid
US8802969 1988-08-26

Publications (3)

Publication Number Publication Date
FI901330A0 FI901330A0 (sv) 1990-03-16
FI94357B true FI94357B (sv) 1995-05-15
FI94357C FI94357C (sv) 1995-08-25

Family

ID=22278122

Family Applications (1)

Application Number Title Priority Date Filing Date
FI901330A FI94357C (sv) 1987-09-18 1990-03-16 Förfarande för framställning av i vatten olösliga hyaluronsyragel och -membran

Country Status (11)

Country Link
US (1) US4937270A (sv)
EP (1) EP0397652B1 (sv)
JP (2) JP2684208B2 (sv)
AT (1) ATE138940T1 (sv)
AU (1) AU606230B2 (sv)
CA (1) CA1332235C (sv)
DE (1) DE3855351T2 (sv)
DK (1) DK68990A (sv)
FI (1) FI94357C (sv)
NO (2) NO301770B1 (sv)
WO (1) WO1989002445A1 (sv)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3043611C2 (de) * 1980-11-19 1984-07-05 Messerschmitt-Bölkow-Blohm GmbH, 8000 München Drehpositionierbare Anlage
US6235726B1 (en) * 1987-09-18 2001-05-22 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US6030958A (en) * 1987-09-18 2000-02-29 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US6610669B1 (en) * 1987-09-18 2003-08-26 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US5527893A (en) * 1987-09-18 1996-06-18 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
EP0416250A3 (en) * 1989-08-01 1991-08-28 The Research Foundation Of State University Of New York N-acylurea and o-acylisourea derivatives of hyaluronic acid
US5356883A (en) * 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5990096A (en) * 1990-09-18 1999-11-23 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
GR920100122A (el) * 1991-04-05 1993-03-16 Ethicon Inc Πολυσακχαρίτες οι οποίοι περιέχουν καρβοξύλιο με σταυροειδείς δεσμούς δια την πρόληψιν της προσφύσεως.
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US5977088A (en) * 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5767106A (en) * 1992-02-21 1998-06-16 Hyal Pharmaceutical Corporation Treatment of disease and conditions associated with macrophage infiltration
JP3390477B2 (ja) * 1993-01-25 2003-03-24 生化学工業株式会社 薬剤組成物及びその製造法
US5616568A (en) * 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
US5585361A (en) 1994-06-07 1996-12-17 Genzyme Corporation Methods for the inhibition of platelet adherence and aggregation
US5931165A (en) * 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
US6294202B1 (en) 1994-10-06 2001-09-25 Genzyme Corporation Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers
US6063396A (en) * 1994-10-26 2000-05-16 Houston Biotechnology Incorporated Methods and compositions for the modulation of cell proliferation and wound healing
US6063116A (en) * 1994-10-26 2000-05-16 Medarex, Inc. Modulation of cell proliferation and wound healing
JPH11502431A (ja) * 1995-01-16 1999-03-02 バクスター インターナショナル インコーポレイテッド 手術後の癒着を防止するための架橋化フィブリンの自己支持シート様材料
US7883693B2 (en) * 1995-12-18 2011-02-08 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
US6833408B2 (en) * 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
ES2373200T3 (es) * 1995-12-18 2012-02-01 Angiodevice International Gmbh Composiciones de pol�?meros reticulados y métodos para su uso.
US6015828A (en) * 1996-05-31 2000-01-18 Cuppoletti; John Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases
US5791352A (en) * 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
FR2752843B1 (fr) * 1996-08-30 1998-10-16 Sod Conseils Rech Applic Copolymeres reticules a base de polymeres polycarboxyliques et leur utilisation comme support de composition pharmaceutique
US20090324721A1 (en) * 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
US7009034B2 (en) * 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US8003705B2 (en) * 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
AU4648697A (en) * 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US7192984B2 (en) * 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US20040096422A1 (en) * 1997-06-17 2004-05-20 Schwartz Herbert E. Compositions of polyacids and polyethers and methods for their use in reducing pain
US20050074495A1 (en) * 1997-06-17 2005-04-07 Fziomed, Inc. Compositions of polyacids and methods for their use in reducing adhesions
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
FR2766716B1 (fr) * 1997-08-01 2000-02-18 Cogent Sarl Prothese composite pour la prevention des adherences post-chirurgicales et son procede d'obtention
US6229009B1 (en) 1997-08-29 2001-05-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Polycarboxylic based cross-linked copolymers
JPH11189666A (ja) 1997-12-26 1999-07-13 Showa Sangyo Co Ltd 多糖類成形体に耐水性を付与する方法
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
IT1301994B1 (it) 1998-08-05 2000-07-20 Jasper Ltd Liability Co Derivati dell'acido ialuronico.
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
EP1137373A4 (en) * 1998-12-04 2004-05-19 Chandrashekhar P Pathak BIOCOMPATIBLE, CROSSLINKED POLYMERS
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
EP1162984A2 (en) 1999-03-15 2001-12-19 Trustees Of Boston University Use of cross linked polysaccharides for the inhibition of angiogenesis
CA2368162A1 (en) * 1999-03-19 2000-09-28 Robert J. Miller Surface modification of substrates
US20040048021A1 (en) * 1999-03-19 2004-03-11 Wan Barbara Y. F. Surface modification of substrates
US7083777B1 (en) * 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
WO2000059490A2 (en) * 1999-04-06 2000-10-12 Genzyme Corporation Immunomodulating composition for use especially in the treatment of inflammations, infections and surgical adhesions
FR2799196B1 (fr) 1999-10-04 2002-02-08 Sod Conseils Rech Applic Copolymeres reticules a base de copolymeres polycarboxyliques non reticules
US7582311B1 (en) 1999-10-15 2009-09-01 Genentech, Inc. Injection vehicle for polymer-based formulations
US7651703B2 (en) 1999-10-15 2010-01-26 Genentech, Inc. Injection vehicle for polymer-based formulations
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6521223B1 (en) 2000-02-14 2003-02-18 Genzyme Corporation Single phase gels for the prevention of adhesions
US6749865B2 (en) 2000-02-15 2004-06-15 Genzyme Corporation Modification of biopolymers for improved drug delivery
DE60138020D1 (de) * 2000-04-28 2009-04-30 Fziomed Inc Haemostatische zusammenstellung von polysäuren und polyalkylenoxyden und deren verwendungsmethoden
KR100375299B1 (ko) * 2000-10-10 2003-03-10 주식회사 엘지생명과학 히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
US6710162B2 (en) 2001-02-16 2004-03-23 Genzyme Corporation Method of drying a material having a cohesive phase
US6620927B2 (en) * 2001-02-22 2003-09-16 Anika Therapeutics, Inc. Thiol-modified hyaluronan
ITTS20010013A1 (it) * 2001-06-04 2002-12-04 Ct Ricerche Poly Tec H A R L S Nuovi derivati di ialuronano.
US20030114061A1 (en) * 2001-12-13 2003-06-19 Kazuhisa Matsuda Adhesion preventive membrane, method of producing a collagen single strand, collagen nonwoven fabric and method and apparatus for producing the same
WO2003057274A2 (en) * 2001-12-28 2003-07-17 Genzyme Corporation Bioresorbable foam packing device and use thereof
US20030229333A1 (en) * 2002-02-22 2003-12-11 Control Delivery Systems, Inc. Methods for treating otic disorders
TWI261485B (en) * 2002-04-05 2006-09-01 Hamamatsu Photonics Kk X-ray tube adjustment device, X-ray tube adjustment system and method of adjusting X-ray tube
BR0309890A (pt) * 2002-05-09 2005-05-10 Medigenes Composição farmacêutica contendo plasma sanguìneo, ou soro sanguìneo utilizada no tratamento de lesões, bem como seu método e processo de aplicação
US7299805B2 (en) 2002-06-07 2007-11-27 Marctec, Llc Scaffold and method for implanting cells
TWI251596B (en) * 2002-12-31 2006-03-21 Ind Tech Res Inst Method for producing a double-crosslinked hyaluronate material
WO2004063181A1 (en) * 2003-01-03 2004-07-29 Genzyme Corporation Urea derivatives and their use as anti-inflammatory agents
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8137688B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8138265B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
CA2520865A1 (en) * 2003-03-31 2004-10-21 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
AU2004251040A1 (en) * 2003-05-15 2005-01-06 University Of Utah Research Foundation Anti-adhesion composites and methods os use thereof
JP4511470B2 (ja) * 2003-10-29 2010-07-28 帝人株式会社 ヒアルロン酸化合物、そのハイドロゲルおよび関節軟骨損傷治療用材料
US8124120B2 (en) * 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
CN1930190B (zh) 2004-01-07 2011-04-20 生化学工业株式会社 透明质酸衍生物及含有其的药剂
EP1731180B1 (en) * 2004-03-31 2017-10-11 Nipro Corporation Antiadhesive kit, process for producing the same and method of adhesion prevention
CA2563347C (en) 2004-04-20 2014-01-14 Genzyme Corporation Surgical mesh-like implant
CN104174071A (zh) 2004-04-28 2014-12-03 安希奥设备国际有限责任公司 用于形成交联生物材料的组合物和系统及关联的制备方法与用途
ITMI20041373A1 (it) 2004-07-09 2004-10-09 Lima Lto S P A N-metil-ammidi di carbossimetilcellulosa acido alginico o carbossimetalamido
US7858107B2 (en) * 2004-09-10 2010-12-28 Medtronic Xomed, Inc. Flexible bioresorbable hemostatic packing and stent having a preselectable in-vivo residence time
EP1796602A4 (en) 2004-09-17 2016-10-19 Angiotech Pharm Inc MULTIFUNCTIONAL COMPOUNDS FOR PRODUCING NETWORKED BIOMATERIALS AND MANUFACTURING AND USE METHOD THEREFOR
ITPD20050056A1 (it) 2005-03-02 2006-09-03 Fidia Farmaceutici Derivati ammidici del'acido ialuronico in osteoartrosi
RU2283848C1 (ru) * 2005-06-16 2006-09-20 Институт нефтехимии и катализа РАН Республика Башкортостан Способ получения конъюгатов альгиновой кислоты
US7323184B2 (en) * 2005-08-22 2008-01-29 Healagenics, Inc. Compositions and methods for the treatment of wounds and the reduction of scar formation
US8206726B2 (en) 2006-02-06 2012-06-26 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US10092524B2 (en) 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US9308068B2 (en) 2007-12-03 2016-04-12 Sofradim Production Implant for parastomal hernia
ES2585483T3 (es) 2008-02-13 2016-10-06 The Cleveland Clinic Foundation Mejora molecular de la matriz extracelular y métodos de uso
US8668863B2 (en) 2008-02-26 2014-03-11 Board Of Regents, The University Of Texas System Dendritic macroporous hydrogels prepared by crystal templating
US8410180B2 (en) 2008-04-30 2013-04-02 The Cleveland Clinic Foundation Methods to treat urinary incontinence
US9242026B2 (en) 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
CZ301555B6 (cs) 2008-11-06 2010-04-14 Cpn S. R. O. Zpusob prípravy DTPA sítovaných derivátu kyseliny hyaluronové a jejich modifikace
FR2949688B1 (fr) 2009-09-04 2012-08-24 Sofradim Production Tissu avec picots revetu d'une couche microporeuse bioresorbable
JP6042815B2 (ja) 2010-10-08 2016-12-14 ザ ボード オブ リージェンツ オブ ザ ユニバーシティ オブ テキサス システム 生物医学的応用のためのアルギン酸塩及びヒアルロン酸を用いる抗癒着性バリア膜
US8946194B2 (en) 2010-10-08 2015-02-03 Board Of Regents, University Of Texas System One-step processing of hydrogels for mechanically robust and chemically desired features
ES2635087T3 (es) * 2011-03-03 2017-10-02 Chugai Seiyaku Kabushiki Kaisha Derivado de ácido hialurónico modificado con ácido amino-carboxilico
FR2972626B1 (fr) 2011-03-16 2014-04-11 Sofradim Production Prothese comprenant un tricot tridimensionnel et ajoure
EP2731617A4 (en) 2011-07-12 2015-07-01 Brigham & Womens Hospital LIPID-CONTAINING PSA COMPOSITIONS, METHODS OF ISOLATION AND METHODS OF USING SAME
FR2977789B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
FR2977790B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
CA2849052C (en) 2011-09-30 2019-11-05 Sofradim Production Reversible stiffening of light weight mesh
KR101428145B1 (ko) * 2011-11-24 2014-08-08 (주)아모레퍼시픽 수불용성 겔 조성물 및 그 제조방법
FR2985271B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Tricot a picots
FR2985170B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Prothese pour hernie inguinale
FR2988585B1 (fr) 2012-03-28 2015-04-03 Cousin Biotech Plaque viscerale destinee a la coelioscopie
FR2994185B1 (fr) 2012-08-02 2015-07-31 Sofradim Production Procede de preparation d’une couche poreuse a base de chitosane
FR2995788B1 (fr) 2012-09-25 2014-09-26 Sofradim Production Patch hemostatique et procede de preparation
FR2995778B1 (fr) 2012-09-25 2015-06-26 Sofradim Production Prothese de renfort de la paroi abdominale et procede de fabrication
FR2995779B1 (fr) 2012-09-25 2015-09-25 Sofradim Production Prothese comprenant un treillis et un moyen de consolidation
AU2013322268B2 (en) 2012-09-28 2017-08-31 Sofradim Production Packaging for a hernia repair device
WO2014093489A2 (en) 2012-12-11 2014-06-19 Board Of Regents, The University Of Texas System Hydrogel membrane for adhesion prevention
US11565027B2 (en) 2012-12-11 2023-01-31 Board Of Regents, The University Of Texas System Hydrogel membrane for adhesion prevention
EP2934595A1 (en) * 2012-12-19 2015-10-28 University of Geneva Hyaluronic acid - antioxidant conjugates and their uses
FR3006578B1 (fr) 2013-06-07 2015-05-29 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
FR3006581B1 (fr) 2013-06-07 2016-07-22 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
CN103724454B (zh) * 2013-12-03 2017-04-12 江南大学 一种透明质酸接枝聚合物囊泡的制备方法
EP3000433B1 (en) 2014-09-29 2022-09-21 Sofradim Production Device for introducing a prosthesis for hernia treatment into an incision and flexible textile based prosthesis
EP3000432B1 (en) 2014-09-29 2022-05-04 Sofradim Production Textile-based prosthesis for treatment of inguinal hernia
EP3029189B1 (en) 2014-12-05 2021-08-11 Sofradim Production Prosthetic porous knit, method of making same and hernia prosthesis
EP3059255B1 (en) 2015-02-17 2020-05-13 Sofradim Production Method for preparing a chitosan-based matrix comprising a fiber reinforcement member
EP3085337B1 (en) 2015-04-24 2022-09-14 Sofradim Production Prosthesis for supporting a breast structure
EP3106185B1 (en) 2015-06-19 2018-04-25 Sofradim Production Synthetic prosthesis comprising a knit and a non porous film and method for forming same
EP3337321A4 (en) 2015-08-19 2019-07-17 President and Fellows of Harvard College LIPIDED PSA COMPOSITIONS AND METHOD
CN105381501A (zh) * 2015-12-15 2016-03-09 日照天一生物医疗科技有限公司 可降解生物复合止血膜及其制备方法
EP3195830B1 (en) 2016-01-25 2020-11-18 Sofradim Production Prosthesis for hernia repair
CA3030974A1 (en) 2016-07-15 2018-01-18 President And Fellows Of Harvard College Glycolipid compositions and methods of use
EP3312325B1 (en) 2016-10-21 2021-09-22 Sofradim Production Method for forming a mesh having a barbed suture attached thereto and the mesh thus obtained
CZ2016826A3 (cs) * 2016-12-22 2018-07-04 Contipro A.S. Léčivý prostředek s nosičem na bázi hyaluronanu a/nebo jeho derivátů, způsob výroby a použití
WO2018165327A1 (en) 2017-03-08 2018-09-13 Alafair Biosciences, Inc. Hydrogel medium for the storage and preservation of tissue
KR102715397B1 (ko) 2017-03-22 2024-10-10 아센디스 파마 에이에스 히드로겔 가교된 히알루론산 전구약물 조성물 및 방법
EP3398554A1 (en) 2017-05-02 2018-11-07 Sofradim Production Prosthesis for inguinal hernia repair
EP3653171B1 (en) 2018-11-16 2024-08-21 Sofradim Production Implants suitable for soft tissue repair
US12064330B2 (en) 2020-04-28 2024-08-20 Covidien Lp Implantable prothesis for minimally invasive hernia repair
WO2023030435A1 (en) 2021-09-01 2023-03-09 Shanghai Qisheng Biological Preparation Co., Ltd. Cartilage regeneration using injectable, in situ polymerizable collagen compositions containing chondrocytes or stem cells

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1238043A (en) * 1983-12-15 1988-06-14 Endre A. Balazs Water insoluble preparations of hyaluronic acid and processes therefor
SE442820B (sv) * 1984-06-08 1986-02-03 Pharmacia Ab Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut
SE456346B (sv) * 1984-07-23 1988-09-26 Pharmacia Ab Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
US4582865A (en) * 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
SE8501022L (sv) * 1985-03-01 1986-09-02 Pharmacia Ab Format alster och forfarande for dess framstellning
US4774093A (en) * 1985-06-25 1988-09-27 Fmc Corporation Polysaccharide compositions, preparation and uses

Also Published As

Publication number Publication date
FI94357C (sv) 1995-08-25
AU2482588A (en) 1989-04-17
US4937270A (en) 1990-06-26
NO309001B1 (no) 2000-11-27
CA1332235C (en) 1994-10-04
FI901330A0 (sv) 1990-03-16
ATE138940T1 (de) 1996-06-15
DE3855351D1 (de) 1996-07-11
NO301770B1 (no) 1997-12-08
NO901229D0 (no) 1990-03-16
EP0397652A4 (en) 1991-04-03
JPH03502704A (ja) 1991-06-20
EP0397652A1 (en) 1990-11-22
NO942763D0 (no) 1994-07-22
DK68990D0 (da) 1990-03-16
DE3855351T2 (de) 1996-10-10
NO901229L (no) 1990-03-16
JP2670996B2 (ja) 1997-10-29
JPH09183804A (ja) 1997-07-15
EP0397652B1 (en) 1996-06-05
AU606230B2 (en) 1991-01-31
DK68990A (da) 1990-05-17
JP2684208B2 (ja) 1997-12-03
NO942763L (no) 1990-03-16
WO1989002445A1 (en) 1989-03-23

Similar Documents

Publication Publication Date Title
FI94357B (sv) Förfarande för framställning av i vatten olösliga hyaluronsyragel och -membran
US5017229A (en) Water insoluble derivatives of hyaluronic acid
US6174999B1 (en) Water insoluble derivatives of polyanionic polysaccharides
US5527893A (en) Water insoluble derivatives of polyanionic polysaccharides
US6030958A (en) Water insoluble derivatives of hyaluronic acid
US6235726B1 (en) Water insoluble derivatives of polyanionic polysaccharides
US6610669B1 (en) Water insoluble derivatives of polyanionic polysaccharides
ITFI20000020A1 (it) Gel di acido ialuronico cross-linked con l-amminoacidi o l-amminoesteri bifunzionali
JP2670996C (sv)

Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: GENZYME CORPORATION

MA Patent expired