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FI946173A0 - Metoder för att förbättra läkemedelsupptagning med hjälp av modifierade saponiner - Google Patents

Metoder för att förbättra läkemedelsupptagning med hjälp av modifierade saponiner

Info

Publication number
FI946173A0
FI946173A0 FI946173A FI946173A FI946173A0 FI 946173 A0 FI946173 A0 FI 946173A0 FI 946173 A FI946173 A FI 946173A FI 946173 A FI946173 A FI 946173A FI 946173 A0 FI946173 A0 FI 946173A0
Authority
FI
Finland
Prior art keywords
efficacy
improving
drug delivery
modified saponins
saponins
Prior art date
Application number
FI946173A
Other languages
English (en)
Finnish (fi)
Other versions
FI946173A (sv
Inventor
Chrlotte A Kensil
Sean Soltysik
Dante J Marciani
Original Assignee
Cambridge Biotech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Biotech Corp filed Critical Cambridge Biotech Corp
Publication of FI946173A0 publication Critical patent/FI946173A0/sv
Publication of FI946173A publication Critical patent/FI946173A/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI946173A 1992-07-02 1994-12-30 Metoder för att förbättra läkemedelsupptagning med hjälp av modifierade saponiner FI946173A (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/906,870 US5273965A (en) 1992-07-02 1992-07-02 Methods for enhancing drug delivery with modified saponins
PCT/US1993/006348 WO1994001118A1 (en) 1992-07-02 1993-07-01 Methods for enhancing drug delivery with modified saponins

Publications (2)

Publication Number Publication Date
FI946173A0 true FI946173A0 (sv) 1994-12-30
FI946173A FI946173A (sv) 1995-02-15

Family

ID=25423119

Family Applications (1)

Application Number Title Priority Date Filing Date
FI946173A FI946173A (sv) 1992-07-02 1994-12-30 Metoder för att förbättra läkemedelsupptagning med hjälp av modifierade saponiner

Country Status (11)

Country Link
US (2) US5273965A (sv)
EP (1) EP0658111B1 (sv)
JP (1) JP3684370B2 (sv)
AU (1) AU687005B2 (sv)
BR (1) BR9306594A (sv)
CA (1) CA2139437A1 (sv)
DE (1) DE69326772T2 (sv)
FI (1) FI946173A (sv)
HU (1) HUT73814A (sv)
MX (1) MX9303977A (sv)
WO (1) WO1994001118A1 (sv)

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US5650398A (en) * 1992-07-02 1997-07-22 Cambridge Biotech Corporation Drug delivery enhancement via modified saponins
DK1155689T3 (da) 1993-07-19 2006-11-20 Angiotech Pharm Inc Antiangiogene stents og fremgangsmåder til fremstilling heraf
US5397778A (en) * 1994-02-25 1995-03-14 New England Deaconess Hospital Corporation Enteral formulations for treatment of inflammation and infection
AU1928295A (en) * 1994-02-25 1995-09-11 New England Deaconess Hospital Corporation Anti-inflammatory and infection protective effects of sesamin-based lignans
US5739118A (en) * 1994-04-01 1998-04-14 Apollon, Inc. Compositions and methods for delivery of genetic material
AUPM873294A0 (en) * 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
AU686891B2 (en) * 1994-10-12 1998-02-12 Iscotec A.B. Saponin preparations and use thereof in iscoms
US5962428A (en) * 1995-03-30 1999-10-05 Apollon, Inc. Compositions and methods for delivery of genetic material
AU773686B2 (en) * 1996-02-21 2004-06-03 Intarcia Therapeutics, Inc. Use of cell membrane permeants in the treatment of cellular proliferative diseases
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CN1245423A (zh) 1996-12-30 2000-02-23 巴特勒纪念研究院 采用吸入法治疗肿瘤的制剂和方法
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US6080725A (en) * 1997-05-20 2000-06-27 Galenica Pharmaceuticals, Inc. Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof
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ATE464907T1 (de) 1999-02-17 2010-05-15 Csl Ltd Immunogene komplexe und methoden in bezug auf diese
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US20040037809A1 (en) * 2002-06-28 2004-02-26 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of interferon beta
WO2004092329A2 (en) * 2003-04-08 2004-10-28 Galenica Pharmaceuticals, Inc. Semi-synthetic saponin analogs with carrier and immune stimulatory activities for dna and rna vaccines
AU2004274430A1 (en) 2003-09-12 2005-03-31 Antigenics, Inc. Vaccine for treatment and prevention of herpes simplex virus infection
US20050175623A1 (en) * 2004-02-10 2005-08-11 Zheng-Pin Wang Saponins as anticancer agent
DE602005021756D1 (de) * 2004-02-13 2010-07-22 Nod Pharmaceuticals Inc Partikel mit kern aus calciumphosphat-nanopartikeln, biomolekül und gallensäure, herstellungsverfahren und therapeutische verwendung
US7666914B2 (en) * 2004-06-03 2010-02-23 Richlin David M Topical preparation and method for transdermal delivery and localization of therapeutic agents
WO2006137069A2 (en) * 2005-06-22 2006-12-28 Ben Gurion University Of The Negev Research And Development Authority Balanites aegyptiaca saponins and uses thereof
WO2007092299A2 (en) * 2006-02-03 2007-08-16 Purdue Research Foundation Targeted conjugates and radiation
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EP2222328A4 (en) * 2007-11-15 2013-06-05 Endocyte Inc PROCESS FOR THE ADMINISTRATION OF CONJUGATES
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US9332776B1 (en) 2010-09-27 2016-05-10 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US8939388B1 (en) 2010-09-27 2015-01-27 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
EA201391183A1 (ru) 2011-02-15 2014-02-28 Иммьюн Дизайн Корп. Способы усиления иммуногенспецифических иммунных ответов при помощи векторных вакцин
US20130022728A1 (en) * 2011-03-04 2013-01-24 International Flavor & Fragrances Inc. Spray-Dried Compositions Capable of Retaining Volatile Compounds and Methods of Producing the Same
EP2680712B1 (en) 2011-03-04 2018-12-26 International Flavors & Fragrances Inc. Method for providing spray-dried compositions capable of retaining volatile compounds
SG194083A1 (en) 2011-04-08 2013-11-29 Immune Design Corp Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
WO2012149307A2 (en) 2011-04-27 2012-11-01 Immune Design Corp. Synthetic long peptide (slp)-based vaccines
AU2013262691B2 (en) 2012-05-16 2018-12-20 Immune Design Corp. Vaccines for HSV-2
US10195257B2 (en) * 2013-07-28 2019-02-05 Qantu Therapeutics, Inc. Vaccine formulations comprising quillaja desacylsaponins and beta amyloid peptides or tau protein to induce a Th2 immune response
CN105960241A (zh) 2014-01-21 2016-09-21 免疫设计公司 用于治疗过敏性病症的组合物
EP3104878B1 (en) 2014-02-14 2019-05-22 Immune Design Corp. Immunotherapy of cancer through combination of local and systemic immune stimulation
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Also Published As

Publication number Publication date
WO1994001118A1 (en) 1994-01-20
MX9303977A (es) 1994-04-29
FI946173A (sv) 1995-02-15
BR9306594A (pt) 1998-12-08
CA2139437A1 (en) 1994-01-20
DE69326772T2 (de) 2000-06-29
JPH07509440A (ja) 1995-10-19
HUT73814A (en) 1996-09-30
EP0658111A4 (en) 1996-02-07
US5443829A (en) 1995-08-22
EP0658111B1 (en) 1999-10-13
DE69326772D1 (de) 1999-11-18
HU9500001D0 (en) 1995-03-28
EP0658111A1 (en) 1995-06-21
JP3684370B2 (ja) 2005-08-17
AU687005B2 (en) 1998-02-19
US5273965A (en) 1993-12-28
AU4664993A (en) 1994-01-31

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