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FI933629A - ANTAGONISPEPTIDER TILL HORMON SOM FRIGOER LUTEINISERANDE HORMON (LHRH) - Google Patents

ANTAGONISPEPTIDER TILL HORMON SOM FRIGOER LUTEINISERANDE HORMON (LHRH) Download PDF

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Publication number
FI933629A
FI933629A FI933629A FI933629A FI933629A FI 933629 A FI933629 A FI 933629A FI 933629 A FI933629 A FI 933629A FI 933629 A FI933629 A FI 933629A FI 933629 A FI933629 A FI 933629A
Authority
FI
Finland
Prior art keywords
hormon
phe
nal
lhrh
pro
Prior art date
Application number
FI933629A
Other languages
Finnish (fi)
Other versions
FI101884B (en
FI101884B1 (en
FI933629A0 (en
Inventor
Andrew V Schally
Sandor Bajusz
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/074,126 external-priority patent/US4800191A/en
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of FI933629A publication Critical patent/FI933629A/en
Publication of FI933629A0 publication Critical patent/FI933629A0/en
Application granted granted Critical
Publication of FI101884B publication Critical patent/FI101884B/en
Publication of FI101884B1 publication Critical patent/FI101884B1/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to novel peptides of the formula X- R1-R2-R3-Ser-Tyr-R6-Leu-Arg-Pro-R10-NH2 in which X is an acyl group which has been obtained from straight or branched chains of aliphatic or alicyclic carboxylic acids which contain 1-7 carbon atoms, or a carbamoyl group, R1 is D- or L-Pro, D- or L-δ3-Pro, D-Phe, D-Phe(4-Hl), D-Ser, D-Thr, D-Ala, D-Nal(1) or D Nal(2), R2 is D-Phe or D-Phe(4-Hl), R3 is D-Trp, D-Phe, D Pal(3), D-Nal(1) or D-Nal(2), R6 is D-Cit, D-Hci, DCit(Q) or D-Hci(Q) and R10 is Gly or D-Ala, with Hl being fluorine, chlorine or bromine, and Q being C1-3-alkyl, or a physiologically acceptable addition salt thereof. The peptides are LHRH antagonists and can be used, for example, for preventing ovulation.
FI933629A 1987-07-17 1993-08-17 Peptides which are antagonists of luteinizing hormone releasing hormone (LHRH) FI101884B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/074,126 US4800191A (en) 1987-07-17 1987-07-17 LHRH antagonists
US7412687 1987-07-17
FI883388 1988-07-15
FI883388A FI91075C (en) 1987-07-17 1988-07-15 Process for the preparation of novel therapeutically useful peptides

Publications (4)

Publication Number Publication Date
FI933629A true FI933629A (en) 1993-08-17
FI933629A0 FI933629A0 (en) 1993-08-17
FI101884B FI101884B (en) 1998-09-15
FI101884B1 FI101884B1 (en) 1998-09-15

Family

ID=26158395

Family Applications (1)

Application Number Title Priority Date Filing Date
FI933629A FI101884B1 (en) 1987-07-17 1993-08-17 Peptides which are antagonists of luteinizing hormone releasing hormone (LHRH)

Country Status (1)

Country Link
FI (1) FI101884B1 (en)

Also Published As

Publication number Publication date
FI101884B (en) 1998-09-15
FI101884B1 (en) 1998-09-15
FI933629A0 (en) 1993-08-17

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Legal Events

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SPCG Supplementary protection certificate granted

Spc suppl protection certif: L178

Extension date: 20130714