FI82598B - Cosmetic compositions intended for external use - Google Patents

Description

1 82598

Cosmetic compositions for external use

The invention relates to cosmetic compositions for use in body care which promote cell and skin regeneration, optimize the biological processes taking place in skin cells and in particular improve the function of the cellular enzyme system.

The object of the invention is to make it possible to refresh and protect the cells and skin of the body by means of natural substances. According to the invention, this object is achieved by treating proteins suitably prepared from blood or blood plasma with inorganic substances present as trace elements in the body or in natural, natural, lake, marine, mineral or medicinal waters, and by transforming the resulting materials into various cosmetic body protective compositions.

It is known that trace elements are components of many different enzymes and have a decisive effect on the function of a living organism. Lack of trace elements, e.g. copper, iron or zinc, leads to a decrease in cell activity; thus, cellular respiration, red blood cell formation, brain tissue, lung, and nervous system may be destroyed. Although the primary role of the cosmetic effect 25 is in the beauty care of the skin, it can be stated that the function and health of different parts of the body should not be considered in isolation, as all organs and tissues of the body interact with each other.

30 Disorders caused by a lack of trace elements have a general effect on the body and therefore also on the condition of the skin, which attracts the viewer's attention the most. The skin is a very highly differentiated organ and its proper impact has a decisive effect on a person’s aesthetic appearance.

35 In many cases, the elimination of interferences due to trace element deficiencies is not a simple matter.

2 82598 because the absorption of salts of trace elements, e.g. ferrous sulphate, in a form in which it takes part sufficiently in physiological processes, is not in itself satisfactory.

According to the current knowledge, trace elements can fulfill their function in an organism, e.g. in skin cells, only when they are connected to the so-called to a carrier molecule that transfers these elements to the site of action and thus allows for incorporation into a suitable enzyme. In general, such carrier molecules are proteins derived in part from the blood or plasma, respectively. At present, the exact mechanism of this method is not known, however, it is thought that the combination of a trace element with a protein is crucial in a multi-step event.

15 Of the trace elements of known importance, zinc, copper, iron, cobalt, manganese, silicon and magnesium, etc. are essential for the skin. Thus, 20% of the zinc content in the human body is found in the skin. Zinc plays an important role in skin protein synthesis. Copper plays a major role in the structural development of collagen and elastin in addition to its well-known effect on blood counting. When these trace elements are not present in sufficient amounts, the solubility of collagen and elastin increases and their function is deficient. Manganese and magnesium are involved in many enzymatic reactions, e.g., collagen synthesis, however, their effects on the activity of enzymes that regulate nucleic acid metabolism are also significant. Silicon plays an important role in the structural development of both collagen and cartilage tissues. In addition to the trace elements mentioned above, many other substances, such as selenium as well as sulfur, sulfides, vanadium and nickel, are also important. Virtually all inorganic substances are important for the optimal functioning of a living cell 35, which is not surprising given that all of these substances were present in the primordial sea when life occurred.

3,82598

It is known that an inorganic substance, trace element or ion can undergo active transfer by binding to a carrier protein on the other side (outside) of the cell membrane where the carrier-substrate complex is formed. This complex crosses the membrane, then the carrier protein leaves the substrate on the other side of the membrane and returns to the surface of the membrane. Such carrier proteins include plasma proteins, transferrin, alpha-microglobins, transmangin, nickel plasminins, etc. The number and nature of these substances are not currently well known, but their existence and significance are well established.

There are cosmetics that contain trace elements, as well as cosmetic compositions that utilize a variety of proteins known to provide various types of activities, e.g., hydration ability, etc. However, trace elements cannot advantageously be absorbed through the skin from an aqueous medium as such or as common organic complexes. Thus, the skin reacts with inconsistent and widely fragmented results to drug baths and mineral water treatments, or is even ineffective, although balneologists may expect a clear, beneficial effect of these baths and mineral waters based on the quality and amount of inorganic salts contained in these waters. It is known that the compositions of medicinal and mineral waters used for decades and centuries have hardly changed and that the composition of seawater can be considered stable under natural conditions. Nevertheless, the usefulness of these waters varies and they are even inactive in patients who often suffer from similar skin disorders. Because the composition of mineral waters, which contain the majority of the trace elements needed by the skin and body, is stable, the reasons for these 35 extreme results should be found in the individual characteristics of the patients. Probably the reason for the different results is that 4,82598 carrier molecules that transfer trace elements are not always available. Trace elements, inorganic salts and ions as such cannot sufficiently diffuse freely through the skin into living organisms and cells and cannot bind to enzymes; this is done only by carrier molecules. These carriers can specifically transfer only one specific trace element to the site of action; such carriers are present in the blood.

U.S. Patent No. 4,177,261 discloses a pharmaceutical composition comprising albumin-deprived calf blood extract and quinine, bradykinin or kallidin. The composition is intended for stimulating blood circulation and healing wounds. The product of the present invention, on the other hand, contains pro-15 proteins, i.e. it is not a deprotenized product. The product according to the invention also does not have any circulatory stimulating effect.

The invention thus relates to cosmetic compositions for external use, characterized in that they comprise (a) proteins derived from animal blood or animal plasma, (b) mineral water, fruit or vegetable extract or wine, optionally enriched by the addition of 25 0.001 to 2 mg of mineral salts with Au as the mineral,

Ag, Pt, Cr, Fe, Mn, Mg, Mo, Co, Cu, B, Zn, Ni or Ca, per 100 ml of mineral water, fruit or vegetable extract or wine, and (c) known carriers and additives, Wherein the composition comprising components (a) and (b) is prepared by treating component (a) with component (b) by either (i) swelling component (a) in component (b) or (ii) mixing component (a) with component (b), optionally at an elevated temperature of 35, and thus obtained, containing components (a) and (b)

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5,82598 The product is formulated into a cosmetic composition in a conventional manner using known carriers and additives.

It has been found that compositions are obtained which have 5 very significant activities for skin care, hair quality improvement, hair follicle refreshment and alleviation of skin disorders caused by skin disorders and detergents.

By treating trace elements in the blood, e.g. plasma proteins-10 and mineral waters or plant extracts (fruit or vegetable extracts), cosmetic substances with an excellent and surprising effect can be prepared, as described, for example, in Example 6. Animal experiments were performed on this composition. are unusual for the cosmetic industry, but are suitable as evidence that the cosmetic agents of the invention have advantageous and surprising activities. The results for these experiments are summarized in Table 1. The study was performed on 20 H.C. Stoerk et al. as described (A. J. Path. 30, 616 [1947]).

The effect of the ointment described in Example 6 was studied using the adjuvant arthritis test performed on Long-Evans rats in order to detect a measurable effect on rat arthritis with a cosmetic agent containing medicinal water or substances derived therefrom. For better comparison, the rats used in the experiment were treated with an ointment containing 1 or 5% phenylbutazone, which is currently known as one of the best anti-arthritic agents. Arthritis was induced by injecting "Ravenal" (Mycobacterium tuberculosista at a concentration of 0.2 mg / kg, 0.1 ml per paw, in paraffin oil suspension) into the right hind paw of the rat. The animal's left hind paw and both forepaws were treated with ointment once daily for three 6,82598 weeks, i.e., 16 times during the experiment. Evaluation was performed based on the change in volume of the left hind paw. (The spread of arthritis was indicated by swelling of the leg joints). On day 21, in addition to the change in volume of the left hind paw 5, the use of the tibia as well as the physical condition of the animal compared to controls were also considered. (This provided information on the mobility of arthritic rats.)

In the experiments in question, each cream was applied to Koskelo but 12 rats were used for the study. The averages of the experimental results are summarized in Table 1. It is clear from the results shown in Table 1 that the ointment described in Example 6 has a stronger effect than the ointment containing 1% phenylbutazone because it was as effective as the ointment containing 5% phenylbutazone. The ointment described in Example 6, although used only once daily, prevented degenerative changes in the joints and improved walking and movement. Both the physical condition and the ability of the animals to move were good. This experiment, although not cosmetic in nature, provides satisfactory, indirect evidence of the surprising effect of the composition of the invention, despite the fact that its mechanism of action is clearly different from that of phenylbutazone. These 25 experiments can be considered crucial in the fact that plasma proteins treated with trace elements play a crucial role in the migration of skin cells and elements necessary for optimal conditions of physiological events into skin cells and into the body. This beneficial effect is thought to be due to the proteins used as active ingredients which have been prepared from the blood and treated with trace elements, natural waters, mineral and medicinal waters and / or inorganic substances and which are included in the cosmetic compositions according to the invention.

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The cosmetic preparations according to the invention are very useful in the treatment and rejuvenation of the skin.

Using the medicinal waters of Harkäny and Hfeviz - as described in Examples 20 and 22, promotes hair follicle refreshment and reduces hair oiliness.

The composition described in Example 24 promotes the recovery of sunburned skin and has a beneficial effect on 10 milder household burns.

The beneficial effect of the compositions according to the invention is increased when water of the compositions according to the invention is used as a fraction in addition to or instead of medicated mixtures of plant extracts and / or vegetable juices and medicated waters, or mixtures of natural waters and / or extracts or solutions enriched with trace elements.

The compositions of the invention and embodiments of the invention are illustrated in the following examples.

20 Example 1

A mixture of 137.5 g of white petrolatum, 82.5 g of cetyl alcohol, 27.5 g of paraffin oil and 27.5 g of Tween 60® is heated to 80 ° C to form a fat fraction of the composition. Meanwhile, 10 g of bovine plasma protein is swollen in 200 ml of Harkäny's medicinal water and the mixture is preheated at 112 ° C for 90 minutes. After treatment with medicated water, the protein is cooled to 60 ° C and mixed with a fat fraction maintained at 80 ° C-30 ° C. After homogenization, a further 600 ml of Harkäny medicinal water heated to 70 ° C are added to the hot mixture and the whole mixture is stirred until it has cooled. A cream with an excellent moisturizing and skin refreshing (soothing) effect is obtained.

35 Example 2

The procedure described in Example 1 is followed, except that 1 mg of gold (III) trichloride is added to the plasma 9 82598 protein before or after the heat treatment.

Example 3

The procedure described in Example 1 or 2 is followed, except that Hajduszoboszlo 5 medicated water is used as the aqueous fraction.

Example 4

The procedure described in Example 1 or 2 is followed, except that Paräd's medicinal water is used as the aqueous fraction.

Example 5 The procedure described in Examples 1 to 4 is followed, except that the plasma protein is treated before heat treatment with 200 ml of medicinal water containing 1 mg of gold (III) trichloride, 0.5 g of silver nitrate, 0.1 mg of chromium chloride, 2 mg of ferrous sulphate, 1 mg of manganese (2) chloride, 1 mg of ammonium molybdate, 0,5 mg of copper sulphate, 1 mg of zinc chloride, 0,5 mg of cobalt (3) chloride, 0,2 mg of boric acid and 0,2 mg of nickel (2) ) sulphate.

Example 6

The procedure described in Example 1 is followed, except that the plasma protein is treated with 200 ml of medicated water from the Lukäcs Spa (Budapest) to which 1 mg of ferrous sulphate, 1 mg of copper sulphate, 0.5 mg of nickel (2) have been added. sulphate, 1 mg of zinc sulphate and 0.5 mg of cobalt (3) chloride.

25 Example 7

The procedure described in Examples 1-6 is followed, except that water from the Karlsbad hot spring is used as the aqueous fraction of the composition.

Example 8 30 The procedure described in Examples 1-7 is followed, except that the natural water of Lake Balaton is used as the water fraction.

Example 9

The procedure described in Example 1 is followed, except that plasma protein 35, preheated with 200 ml of distilled water and 600 ml of seawater, using e.g. Aegean sea water, is used to prepare the ointment.

10 82598

Example 10

The procedure described in Examples 1 to 6 is followed, except that in addition to 200 ml, medicinal water is used for the treatment of plasma protein to prepare an ointment.

Example 11

The procedure described in Example 1 is followed, except that the plasma protein is treated with medicinal water in the presence of 2 mg of zinc sulphate.

10 Example 12

The procedure described in Example 1 is followed, except that water containing 5 [mu] g of copper, 5 [mu] g of iron, 10 [mu] g of zinc, 2 [mu] g of cobalt, 1 [mu] g of nickel, 20 [mu] g of magnesium and 20 [mu] g of magnesium) and 20 [mu] g of 15 calcium.

Example 13

The procedure described in Example 1 is followed, except that carrot juice is used as the aqueous fraction.

Example 14 The procedure described in Examples 1 to 6 is followed, except that wine made from grapes is used as the aqueous fraction.

Example 15

The procedure described in Examples 1 to 6 is followed, except that cider is neutralized with sodium hydrogen carbonate.

Example 16

The procedure described in Examples 1 to 6 is followed, except that fruit juice is used as the aqueous fraction, e.g.

30 apple juice.

Example 17 80 ml of water and 2 g of sodium carbonate are added to any pig blood, then the mixture is kept at 120 ° C for one hour. The material obtained is filtered and 700 ml of Harkäny's medicinal water are added to the filtrate. The obtained water fraction is used for the preparation of an ointment in a known manner, which gives an excellent, moisturizing and skin refreshing (soothing) cosmetic substance.

Example 18 2 g of sodium bicarbonate, 50 ml of aqueous ka-5 momilla extract and 600 ml of Heviz medicinal water are added to 100 ml of sheep plasma. The mixture is stirred at 20 ° C for one hour, then applied to a body cream in a known manner.

Example 19 The procedure described in Example 1 is followed, except that Harkäny, Ha jduszoboszlo and Heviz medicinal waters are used as the water fraction in a 1: 1: 1 mixture instead of Harkäny.

Example 20 Plasma protein prepared from 10 g of piglet blood is treated with 200 ml of Heviz medicinal water at 120 ° C for one hour. To the resulting solution is added 300 ml of Heviz natural water, the mixture is filled into 2 ml ampoules and sterilized after sealing. This ampoule-containing composition is suitable for soothing the skin by manual massage or iontophoresis.

Example 21 2 mg of ferrous sulphate, 1 mg of zinc sulphate and an extract prepared from 1 g of chamomile with 20 ml of hot water are added to 100 ml of native bovine plasma. The mixture is heated to 80 ° C with vigorous stirring to give a gel-like substance which has a highly moisturizing and skin refreshing (soothing) effect.

30 Example 22

The procedure described in Example 20 or or 21 is followed, except that a mixture containing Harkäny and Hajduszoboszlo medicinal water in a ratio of 1: 1 is used instead of Heviz medicinal water.

35 Example 23

To the plasma protein powder prepared from 10 g of bovine blood is added 200 ml of Harkäny medicinal water, which has been kept at 70 ° C, and the mixture is heated at 112 ° C for 90 minutes. After cooling, Harkäny natural medicinal water, 30 g of Alfozide KT-25, 80 g of Zalabetaine, 570 g of sodium 5-lauryl ether sulphate, 20 g of Alfid-D-11®, 2 g of Alphasepticr (preservative), 10 g of polyethylene glycol M are added to the mixture. -200 ^ and 10 ml of 96% ethanol to give a refreshing, skin rejuvenating bath foam.

Example 24 Plasma protein prepared from 10 g of porcine blood is treated with 200 ml of Harkäny medicinal water at 120 ° C for one hour, then 125 ml of Harkäny medicinal water and 125 ml of Lukäcs bath (Budapest) are added to the resulting solution. medicinal water. This mixture is supplemented with 15 suitable preservatives and is used in the form of a spray to alleviate sunburn skin injuries.

Example 25

Plasma protein prepared from 10 g of rabbit blood is treated with 200 ml of Hajduszoboszlö medicament at 112 ° C for 90 minutes, then 300 ml of Balf medicated water and 50 ml of seawater are added to the hot solution. 92 g of Alfozide KT-2, 75 g of Zala-betaine, 190 g of sodium lauryl ether sulphate, 10 g of Alfid-D-lr and 2 g of Alphasept are then added to the mixture to give an excellent hair shampoo which promotes hair follicle rejuvenation and continuous hair growth.

Example 26

Plasma protein powder prepared from 10 g of bovine blood is swollen with 200 ml of Har-30 running water while stirring and kept at 112 ° C for one hour. To the resulting solution is added 300 ml of Harkäny medicinal water containing 0.2 g of ferrous sulfate, 0.2 mg of zinc sulfate, 0.2 mg of copper sulfate, 0.1 mg of nickel (2) sulfate and 0.1 mg of cobalt (3) chloro-35 dia . The resulting mixture is filled into ampoules with a volume of 2 ml and heat sterilized. This composition is an excellent inhibitor of hair oiling when rubbed

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i3 82598 it on the hair as well as on the scalp and promotes hair follicles refresh. The composition also prevents sebum leakage in the hair.

Example 27

Plasma protein prepared from 10 g of porcine blood 5 is dissolved by treatment with 100 ml of Hajdus-zoboszlo medicinal water and 100 ml of Harkäny medicinal water at 120 ° C. To this solution is added a melt containing 100 g of cetyl alcohol, 101 g of isopropyl myristate, 220 g of 70% sorbitol, 60 g of cosmetic stearin, 10 140 g of cosmetic petrolatum oil, 2 g of glutaraldehyde, 39.2 g of cosmetic lanolin, 20 g of propylene glycol g of product Nipagi The mixture is made up to 1 100 ml with Hajduszoboszlo medicinal water kept at 60 ° C and 5 g of potassium hydroxide and mixed until it has cooled. This composition is very useful as a hand protection balm, e.g. to relieve skin rash caused by detergents.

Example 28 800 g of soap powder are dissolved in 2 liters of distilled water at 80 ° C, then 200 g of sodium lauryl ether sulphate, a 5% 120 ° C plasma protein solution prepared from bovine blood, 200 ml of Harkäny's medicinal water and 500 ml are added. glycerol, 8 g of Nipagiri® and perfume and stir until the mixture has cooled. This gives an excellent cream soap which prevents damage to the skin and is particularly suitable for keeping inflamed skin clean.

Example 29 142 g of stearin are saponified with 28.5 g of potassium hydroxide in 500 ml of distilled water at 80 ° C, then a solution of 10 g of plasma protein in 200 ml of Heviz medicinal water at 160 ° C is prepared, also 200 g of sodium lauryl ether sulfate, 100 g of glycerol, 3 g of Nipagin d * preservative and mixed until the mixture is cooled. This provides an excellent cleanser that prevents skin damage (inflammation) and dehydration.

i4 82598

Example 30

To a melt prepared from 25 g of cetyl alcohol, 12 g of petrolatum, 2.5 g of Tween 60® and 5 g of glycerol at 72 ° C is added a 1-5% plasma protein solution, prepared in 6 ml of Höviz medicinal water at 120 ° C and 5 ml of ethanol. The mixture is colored and flavored as desired to give a lip care agent that reduces dryness of the lips.

10 Example 31

The salt mixture obtained by evaporating 0.5 g of Harkäny's medicinal water is mixed with 200 ml of distilled water, plasma protein prepared from 10 g of bovine blood plasma is added, and the resulting mixture is heat-treated at 121 ° C for two hours. The material thus obtained is used for the preparation of an ointment according to Example 1.

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Claims (3)

Cosmetic compositions for external use, characterized in that they comprise 5 (a) proteins derived from animal blood or animal plasma, (b) mineral water, fruit or vegetable extract or wine, optionally enriched by the addition of 0.001 to 2 mg of mineral salts with the mineral Au, 10 Ag, Pt, Cr, Fe, Mn, Mg, Mo, Co, Cu, B, Zn, Ni or Ca, per 100 ml of mineral water, fruit or vegetable extract or wine, and (c) known carriers and additives wherein the composition comprising components (a) and (b) is prepared by treating component (a) with component (b) by either (i) swelling component (a) in component (b) or (ii) mixing component (a) with component (b) , optionally at an elevated temperature, and the product thus obtained containing components (a) and (b) is formulated into a cosmetic composition in a conventional manner using known carriers and additives. ie 82598 Cosmetic composition for use in the manufacture of beverages, in which case 5, mg of mineral salt from the mineral Au, Ag, Pt, 10 Cr, Fe, Mn, Mg, Mo, Co, Cu, B, Zn, Ni or Ca, per 100 ml of mineral wool, fruct- or green extract or vin, and (c) kärda bärare och tillsatsämnen, varvid kompos-sitionen som other components (a) and (b) of the genome are derived from component (a) of component (b) antennas (i) genome is derived from component (a) component i (b) or (ii) genome bland Component (a) with component (b), optionally having a temperature of the invention, and having the same product as component 20 (a) and (b) formulating an cosmetic composition in accordance with the conventional provisions of the genome och tillsatsämnen.