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FI810948L - Nytt foerfarande foer framstaellning av kefalosporinantibiotika och i detta foerfarande anvaendbara nya mellanprodukter och framstaellning av dem - Google Patents

Nytt foerfarande foer framstaellning av kefalosporinantibiotika och i detta foerfarande anvaendbara nya mellanprodukter och framstaellning av dem

Info

Publication number
FI810948L
FI810948L FI810948A FI810948A FI810948L FI 810948 L FI810948 L FI 810948L FI 810948 A FI810948 A FI 810948A FI 810948 A FI810948 A FI 810948A FI 810948 L FI810948 L FI 810948L
Authority
FI
Finland
Prior art keywords
och
framstaellning
foerfarande
kefalosporinantibiotika
anvaendbara
Prior art date
Application number
FI810948A
Other languages
English (en)
Other versions
FI74019C (fi
FI74019B (fi
Inventor
Gerd Ascher
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Publication of FI810948L publication Critical patent/FI810948L/fi
Priority to FI864119A priority Critical patent/FI864119A/fi
Application granted granted Critical
Publication of FI74019B publication Critical patent/FI74019B/fi
Publication of FI74019C publication Critical patent/FI74019C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06—Acylation of 7-aminocephalosporanic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI810948A 1980-03-28 1981-03-27 Foerfarande foer framstaellning av 7 -acylamino-3-substitueradmetyl-3-cefem-4-karboxylsyraderivat. FI74019C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI864119A FI864119A (fi) 1980-03-28 1986-10-13 Nytt foerfarande foer framstaellning av syn-isomerer och vid framstaellning av kefalosporinantibiotika anvaendbara nya mellanprodukter.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT168080 1980-03-28
AT168080 1980-03-28

Publications (3)

Publication Number Publication Date
FI810948L true FI810948L (fi) 1981-09-29
FI74019B FI74019B (fi) 1987-08-31
FI74019C FI74019C (fi) 1987-12-10

Family

ID=3518666

Family Applications (1)

Application Number Title Priority Date Filing Date
FI810948A FI74019C (fi) 1980-03-28 1981-03-27 Foerfarande foer framstaellning av 7 -acylamino-3-substitueradmetyl-3-cefem-4-karboxylsyraderivat.

Country Status (19)

Country Link
US (2) US4767852A (fi)
EP (1) EP0037380B1 (fi)
JP (2) JPS56152488A (fi)
AU (2) AU6885981A (fi)
CA (1) CA1172627A (fi)
CY (1) CY1365A (fi)
DE (1) DE3165922D1 (fi)
DK (2) DK163243C (fi)
ES (2) ES500792A0 (fi)
FI (1) FI74019C (fi)
HK (1) HK80687A (fi)
IE (1) IE51831B1 (fi)
IL (1) IL62506A (fi)
NZ (2) NZ206261A (fi)
PH (1) PH17071A (fi)
PT (1) PT72736B (fi)
SG (1) SG35287G (fi)
YU (2) YU43764B (fi)
ZA (1) ZA812083B (fi)

Families Citing this family (52)

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EP0096297B1 (de) * 1982-06-03 1988-06-15 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von 1-Sulfo-2-oxoazetidinderivaten
DK162718C (da) * 1982-09-30 1992-05-11 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af 7-substitueret-3-vinyl-3-cephemforbindelser
US4652651A (en) * 1983-05-31 1987-03-24 Hoffmann-La Roche Inc. Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
IT8448798A0 (it) * 1983-09-12 1984-09-05 Biochemie Gmbh Procedimento per la preparazione di antibiotici del tipo cefalosporina
JPS6064986A (ja) * 1983-09-20 1985-04-13 Toyama Chem Co Ltd セファロスポリン類の製造法
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
AT392792B (de) * 1984-03-23 1991-06-10 Toyama Chemical Co Ltd Verfahren zur herstellung von cephalosporinderivaten
AR243192A1 (es) * 1984-03-23 1993-07-30 Toyama Chemical Co Ltd Procedimiento de preparacion de una cefalosporina y de un intermediario para su preparacion.
EP0156771A3 (en) * 1984-03-29 1986-03-19 Biochemie Gesellschaft M.B.H. Cephalosporins
EP0312844B1 (de) * 1984-04-10 1994-06-22 Biochemie Gesellschaft M.B.H. Cephalosporinzwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung
AT382149B (de) * 1984-04-10 1987-01-12 Biochemie Gmbh Verfahren zur herstellung von syn-isomeren von thioessigsaeureestern
DE3587866D1 (de) * 1984-04-10 1994-07-28 Biochemie Gmbh Cephalosporinzwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung.
GB2161476B (en) * 1984-05-25 1988-01-27 Toyama Chemical Co Ltd 2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4675398A (en) * 1985-08-16 1987-06-23 E. R. Squibb & Sons, Inc. Copper-mediated oximation reaction
ATE77378T1 (de) * 1986-02-07 1992-07-15 Hoffmann La Roche Verfahren zur herstellung von carbonsaeureamiden.
US5359057A (en) * 1986-02-07 1994-10-25 Hoffmann-La Roche Inc. Acylation of amines
GB8614710D0 (en) * 1986-06-17 1986-07-23 Ici Plc Process
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
YU44630B (en) * 1987-06-11 1990-10-31 Krka Process for preparing 6-/d(-)-alpha(4-ethyl-2,3-dioxo-1-piperazincarboxamido)-phenylacetamido/phenicilanic acid
IT1234385B (it) * 1989-05-23 1992-05-18 Sbd Synthetic And Biolog Devel Procedimento migliorato per la produzione di una sostanza antibiotica appartenente al gruppo delle cefalosporine
KR950014571B1 (ko) * 1991-11-18 1995-12-08 제일제당주식회사 세펨 유도체의 제조방법
AT398764B (de) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat
AT399877B (de) * 1992-02-20 1995-08-25 Biochemie Gmbh Neues verfahren zur herstellung von ceftriaxon
KR970006247B1 (en) * 1992-09-28 1997-04-25 Lg Chemical Ltd Novel benzothiazole derivatives and process for preparing the same
JPH08142052A (ja) * 1994-11-18 1996-06-04 Fuji Car Mfg Co Ltd 減容押出成形機
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim
KR100197788B1 (ko) * 1995-06-30 1999-06-15 김충환 세펨 유도체의 제조방법
IN181459B (fi) * 1995-12-26 1998-06-20 Lupin Lab Ltd
IN184690B (fi) * 1996-03-18 2000-09-23 Ranbaxy Lab Ltd
AU690482B2 (en) * 1996-03-18 1998-04-23 Ranbaxy Laboratories Limited Process for producing cephalosporin antibiotics
KR100361829B1 (ko) * 1997-04-16 2005-08-17 주식회사 엘지생명과학 반응성 유기산 유도체로 부터 세프트리악손을 제조하는 방법
KR100361828B1 (ko) * 1997-04-16 2005-08-12 주식회사 엘지생명과학 반응성 유기산 유도체로 부터 세포탁심을 제조하는방법
IT1295935B1 (it) 1997-10-30 1999-05-28 Acs Dobfar Spa Derivati aminotiazolici utili nella preparazione di antibiotici b -lattamici
AU7224300A (en) 1999-05-07 2000-11-21 Ranbaxy Laboratories Limited Process for the preparation of cefpodoxime acid
US6388070B1 (en) * 2001-01-05 2002-05-14 Orchid Chemicals & Pharmaceuticals Ltd. Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
WO2003004477A1 (en) * 2001-06-14 2003-01-16 Orchid Chemicals & Pharmaceuticals Limited 1,3,4-oxadiazol-2-yl thioesters and their use for acylating 7-aminocephalosporins
US6610845B1 (en) 2002-01-04 2003-08-26 Orchid Chemicals & Pharmaceuticals Limited, India Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
WO2003099826A1 (en) * 2002-05-23 2003-12-04 Orchid Chemicals And Pharmaceuticals Limited A new process for the preparation of cefditoren using the thioester of thiazolylacetic acid
US20040002600A1 (en) * 2002-06-20 2004-01-01 Orchid Chemicals And Pharmaceuticals Limited Process for the conversion of penam ring system to cepham ring system
US7847093B2 (en) * 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
DE602004028111D1 (de) 2003-04-16 2010-08-26 Sandoz Ag Verfahren zur herstellung von cefepim
WO2004111059A1 (en) * 2003-06-19 2004-12-23 Orchid Chemicals & Pharmaceuticals Ltd A process for the preparation of a cephalosporin antibiotic
WO2005003141A2 (en) * 2003-07-04 2005-01-13 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefditoren
EP1704153A2 (en) * 2004-01-16 2006-09-27 Wockhardt Limited Improved process for the production of cefotaxime sodium
CN100448856C (zh) * 2006-06-26 2009-01-07 山东金城医药化工股份有限公司 一种催化合成ae-活性酯的工艺
CN101418015B (zh) * 2007-10-24 2011-04-27 山东轩竹医药科技有限公司 头孢曲松磷酰化衍生物
US9139597B2 (en) 2009-05-25 2015-09-22 Sandoz Ag Method for the production of ceftobiprole medocaril
KR101139431B1 (ko) * 2011-05-30 2012-04-27 (주)비씨월드제약 이매티닙 염기의 신규한 제조방법

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JPS4823401B1 (fi) * 1969-11-19 1973-07-13
US3659237A (en) * 1971-03-30 1972-04-25 Westinghouse Electric Corp Contactor
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
JPS5936891B2 (ja) * 1977-12-09 1984-09-06 武田薬品工業株式会社 保護基の脱離方法
DE2758000A1 (de) * 1977-12-24 1979-07-05 Hoechst Ag Verfahren zur herstellung von penicillinen und cephalosporinen
EP0004570B1 (en) * 1978-03-09 1982-04-14 Asahi Kasei Kogyo Kabushiki Kaisha Thiol esters, process for their preparation, pharmaceutical compositions containing them and a process for preparing cephalosporin compounds using the same
JPS6058239B2 (ja) * 1978-07-20 1985-12-19 山之内製薬株式会社 新規セフアロスポリン誘導体
US4220761A (en) * 1978-09-12 1980-09-02 Fujisawa Pharmaceutical Co., Ltd. 7-[Substituted oximinoacetamido]-3-[hydroxy alkyltetrazolo]cephalosporin derivatives
FI800381A (fi) * 1979-02-16 1980-08-17 Sandoz Ag Nya kefalosporinderivat deras framstaellning och anvaendning som antimikrobiella aemnen
CA1145744A (fr) * 1979-05-23 1983-05-03 Daniel Farge Thiovinyl-3 cephalosporines, leur preparation et les compositions qui les contiennent
NL8100539A (nl) * 1980-02-12 1981-09-01 Rhone Poulenc Ind Nieuwe thiolesters, de bereiding daarvan en hun gebruik bij syntheses.
EP0137227B1 (en) * 1980-09-02 1987-12-16 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of cephalosporin derivatives using novel thioesters
CH648038A5 (de) * 1981-01-19 1985-02-28 Sandoz Ag 7-((carboxymethoxyimino)-1h-pyrazol-3-yl-acetyl)amino-3-desacetoxy-3-(1-methyl-1h-tetrazol-5-yl-thio)cephalosporansaeure und salze, verfahren zur herstellung und verwendung.
EP0115770B2 (en) * 1983-01-07 1996-06-19 Takeda Chemical Industries, Ltd. Thiazole Derivatives
US4652651A (en) * 1983-05-31 1987-03-24 Hoffmann-La Roche Inc. Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage

Also Published As

Publication number Publication date
ZA812083B (en) 1982-11-24
IE51831B1 (en) 1987-04-15
DK138781A (da) 1981-09-29
AU6885981A (en) 1981-10-01
NZ206261A (en) 1984-07-31
ES8205228A1 (es) 1982-06-01
CA1172627A (en) 1984-08-14
DE3165922D1 (en) 1984-10-18
EP0037380A3 (en) 1981-12-02
PH17071A (en) 1984-05-24
PT72736B (en) 1982-07-13
IL62506A0 (en) 1981-05-20
US5003073A (en) 1991-03-26
ES8307007A1 (es) 1983-06-16
YU43179B (en) 1989-04-30
PT72736A (en) 1981-04-01
IL62506A (en) 1986-01-31
DK163243B (da) 1992-02-10
ES500792A0 (es) 1982-06-01
YU122783A (en) 1986-12-31
FI74019C (fi) 1987-12-10
YU79881A (en) 1983-12-31
DK163243C (da) 1992-06-29
JPH0313237B2 (fi) 1991-02-22
YU43764B (en) 1989-12-31
IE810697L (en) 1981-09-28
US4767852A (en) 1988-08-30
EP0037380B1 (en) 1984-09-12
FI74019B (fi) 1987-08-31
JPS56152488A (en) 1981-11-26
SG35287G (en) 1988-05-20
JPH02177A (ja) 1990-01-05
NZ196642A (en) 1984-07-31
CY1365A (en) 1987-08-07
ES509957A0 (es) 1983-06-16
DK157291D0 (da) 1991-09-06
DK157291A (da) 1991-09-06
AU550168B1 (en) 1986-03-06
DK167680B1 (da) 1993-12-06
HK80687A (en) 1987-11-06
EP0037380A2 (en) 1981-10-07
JPH0567632B2 (fi) 1993-09-27

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Legal Events

Date Code Title Description
MA Patent expired

Owner name: BIOCHEMIE GESELLSCHAFT M.B.H