FI56180B - N-(heteroarylmetyl)-7 alfa-acyl-6,14-endoeteno/endoetano-tetrahydronororipavin och -tebain, och deras hydreringsprodukter och syraadditonssalter samt foerfarande foer deras framstaellning - Google Patents

N-(heteroarylmetyl)-7 alfa-acyl-6,14-endoeteno/endoetano-tetrahydronororipavin och -tebain, och deras hydreringsprodukter och syraadditonssalter samt foerfarande foer deras framstaellning

Info

Publication number: FI56180B
Authority: FI; Finland
Prior art keywords: och; tetrahydronororipavin; syraadditonssalter; hydreringsprodukter; endoethane
Prior art date: 1972-06-19

Application number

FI1962/73A

Other languages

English (en)

Other versions

FI56180C (fi

Inventor

Adolf Langbein

Herbert Merz

Gerhard Walther

Klaus Stockhaus

Original Assignee

Boehringer Sohn Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-06-19

Filing date

1973-06-18

Publication date

1979-08-31

1973-06-18 Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim

1979-08-31 Publication of FI56180B publication Critical patent/FI56180B/fi

1979-12-10 Application granted granted Critical

1979-12-10 Publication of FI56180C publication Critical patent/FI56180C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FI1962/73A 1972-06-19 1973-06-18 N-(heteroarylmetyl)-7alfa-acyl-6,14-endoeteno/endoetano-tetrahydronororipavin och tebain och deras hydreringsprodukter och syraadditionssalter samt foerfarande foer deras framstaellning FI56180C (fi)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2229770A DE2229770A1 (de)	1972-06-19	1972-06-19	N-(heteroarylmethyl)-7alpha-acyl6,14-endoaethenotetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung

Publications (2)

Publication Number	Publication Date
FI56180B true FI56180B (fi)	1979-08-31
FI56180C FI56180C (fi)	1979-12-10

Family

ID=5848095

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI1962/73A FI56180C (fi)	1972-06-19	1973-06-18	N-(heteroarylmetyl)-7alfa-acyl-6,14-endoeteno/endoetano-tetrahydronororipavin och tebain och deras hydreringsprodukter och syraadditionssalter samt foerfarande foer deras framstaellning

Country Status (14)

Country	Link
US (1)	US3931187A (fi)
JP (1)	JPS5732073B2 (fi)
AT (6)	AT325217B (fi)
BE (1)	BE801083A (fi)
CH (6)	CH597233A5 (fi)
DE (1)	DE2229770A1 (fi)
DK (1)	DK140408C (fi)
ES (5)	ES416038A1 (fi)
FI (1)	FI56180C (fi)
FR (1)	FR2189054B1 (fi)
GB (1)	GB1430958A (fi)
NL (1)	NL7308482A (fi)
NO (1)	NO137998C (fi)
SE (1)	SE409035B (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62298530A (ja) *	1986-06-16	1987-12-25	Otsuka Pharmaceut Co Ltd	坐薬用医薬組成物
CA2256897C (en) *	1997-03-27	2006-10-03	Toray Industries, Inc.	Morphinan derivatives and medical uses
CA2802295C (en)	2010-06-11	2016-09-20	Rhodes Technologies	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
JP2013529595A (ja)	2010-06-11	2013-07-22	ローズテクノロジーズ	第３級アミンのｎ−脱アルキル化方法
US9315514B2 (en)	2012-08-27	2016-04-19	Rhodes Technologies	1,3-dioxanomorphides and 1,3-dioxanocodides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3474101A (en) *	1960-09-05	1969-10-21	Reckitt & Sons Ltd	Thebaine and oripavine derivatives
GB1223445A (en) *	1968-07-18	1971-02-24	Reckitt & Colmann Prod Ltd	Improvements in or relating to derivatives of morphine, their salts, and processes for their preparation
US3560505A (en) *	1969-05-15	1971-02-02	American Cyanamid Co	Substituted 7-(1-alkoxy - 1 - alken-1-yl)-7,8-dihydro-6-methoxy-6,14-endo- (etheno or ethano) codides and morphides
US3562279A (en) *	1969-05-15	1971-02-09	American Cyanamid Co	Substituted 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano)morphide - 7-ketones and n-cycloalkylmethyl - 7,8-dihydro - 6 - methoxy-6,14-endo(etheno or ethano) norcodide-7-ketones
DE2107989A1 (de) *	1971-02-19	1972-09-07	Boehringer Sohn Ingelheim	N-(Furyl-methy])-morphinane, deren Säureadditionssalze sowie Verfahren zu deren Herstellung

1972
- 1972-06-19 DE DE2229770A patent/DE2229770A1/de not_active Withdrawn
1973
- 1973-06-06 AT AT494273A patent/AT325217B/de not_active IP Right Cessation
- 1973-06-06 AT AT266074*7A patent/AT328626B/de not_active IP Right Cessation
- 1973-06-06 AT AT265974*7A patent/AT328097B/de not_active IP Right Cessation
- 1973-06-06 AT AT265774*7A patent/AT328625B/de not_active IP Right Cessation
- 1973-06-06 AT AT265674*7A patent/AT328095B/de not_active IP Right Cessation
- 1973-06-06 AT AT265874*7A patent/AT328096B/de not_active IP Right Cessation
- 1973-06-13 US US05/369,499 patent/US3931187A/en not_active Expired - Lifetime
- 1973-06-14 CH CH958477A patent/CH597233A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH958677A patent/CH597234A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH958577A patent/CH596212A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH958777A patent/CH599215A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH864473A patent/CH598260A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH958377A patent/CH599214A5/xx not_active IP Right Cessation
- 1973-06-18 DK DK336273A patent/DK140408C/da active
- 1973-06-18 BE BE132410A patent/BE801083A/xx unknown
- 1973-06-18 JP JP6863373A patent/JPS5732073B2/ja not_active Expired
- 1973-06-18 NO NO2519/73A patent/NO137998C/no unknown
- 1973-06-18 ES ES416038A patent/ES416038A1/es not_active Expired
- 1973-06-18 FI FI1962/73A patent/FI56180C/fi active
- 1973-06-18 SE SE7308565A patent/SE409035B/xx unknown
- 1973-06-18 GB GB2887073A patent/GB1430958A/en not_active Expired
- 1973-06-19 NL NL7308482A patent/NL7308482A/xx not_active Application Discontinuation
- 1973-06-19 FR FR7322247A patent/FR2189054B1/fr not_active Expired
1974
- 1974-03-15 ES ES424307A patent/ES424307A1/es not_active Expired
- 1974-03-15 ES ES424308A patent/ES424308A1/es not_active Expired
- 1974-03-15 ES ES424309A patent/ES424309A1/es not_active Expired
- 1974-03-15 ES ES424310A patent/ES424310A1/es not_active Expired

Also Published As

Publication number	Publication date
ES416038A1 (es)	1976-06-16
AT328097B (de)	1976-03-10
CH599214A5 (fi)	1978-05-12
AT328096B (de)	1976-03-10
US3931187A (en)	1976-01-06
FR2189054A1 (fi)	1974-01-25
AT328095B (de)	1976-03-10
GB1430958A (en)	1976-04-07
ES424309A1 (es)	1976-06-16
CH598260A5 (fi)	1978-04-28
ES424307A1 (es)	1976-07-01
DK140408B (da)	1979-08-20
AT325217B (de)	1975-10-10
JPS5732073B2 (fi)	1982-07-08
DK140408C (da)	1980-01-21
CH597234A5 (fi)	1978-03-31
CH596212A5 (fi)	1978-03-15
ATA265674A (de)	1975-05-15
AU5704773A (en)	1974-12-19
AT328626B (de)	1976-03-25
NO137998C (no)	1978-06-07
NL7308482A (fi)	1973-12-21
ES424310A1 (es)	1976-06-16
BE801083A (fr)	1973-12-18
NO137998B (no)	1978-02-27
FR2189054B1 (fi)	1976-12-31
CH599215A5 (fi)	1978-05-12
FI56180C (fi)	1979-12-10
ATA265974A (de)	1975-05-15
JPS4961188A (fi)	1974-06-13
AT328625B (de)	1976-03-25
DE2229770A1 (de)	1974-01-10
ES424308A1 (es)	1976-06-16
SE409035B (sv)	1979-07-23
CH597233A5 (fi)	1978-03-31
ATA265774A (de)	1975-06-15
ATA265874A (de)	1975-05-15

Publication	Publication Date	Title
NL175895C (nl)	1985-01-16	Laadbord.
NL170918B (nl)	1982-08-16	Rolveger.
NL162220C (nl)	1980-04-15	Elektrostatische fotokopieerinrichting.
NL7504492A (nl)	1976-10-19	Grondzuiger.
BE802531A (fr)	1974-01-21	D-6-methyl-ergolines 2,8-disubstitutuees
FI56180B (fi)	1979-08-31	N-(heteroarylmetyl)-7 alfa-acyl-6,14-endoeteno/endoetano-tetrahydronororipavin och -tebain, och deras hydreringsprodukter och syraadditonssalter samt foerfarande foer deras framstaellning
BE801271A (fr)	1973-12-21	N-(heteroarylmethyl)-6,14-endoetheno-7 alpha-hydroxyalcoyltetrahydronororipavines et -thebaines
CH550574A (de)	1974-06-28	Kehrgeraet.
NL154888B (nl)	1977-10-17	Oscillatorinrichting.
NL158618B (nl)	1978-11-15	Echolood.
CH547647A (de)	1974-04-11	Ski - bob.
CH555331A (de)	1974-10-31	Derives 3-hydrazonomethyles de rifamycine et leur preparation.
DK137215B (da)	1978-02-06	Dråbeflaske.
CH556782A (de)	1974-12-13	Schleppkreisfoerderer.
NL151200B (nl)	1976-10-15	Bandtransportinrichting.
NL152321B (nl)	1977-02-15	Grondzuiger.
NL168778C (nl)	1982-05-17	Laadbord.
NL150933B (nl)	1976-09-15	Bandtransportinrichting.
FI55709B (fi)	1979-05-31	Espagnolett foer doerrar foenster och liknande
BE788212A (fr)	1972-12-18	Porte-clefs.
FI793327A (fi)	1979-10-25	2,3-laegre alkylenpenam-3-karboksylsyraderivater och deras framstaellningsfoerfarande
ES185444Y (es)	1974-07-01	Dispositivo transportador.
ES177905Y (es)	1973-11-16	Boquilla.
ES187416Y (es)	1974-08-16	Boquilla de tobera.
ES179069Y (es)	1973-07-16	Dispositivo clasificador.