FI49497C - Process for the preparation of therapeutically active 1-phenoxy-2-3-alkylaminopropanes. - Google Patents

Process for the preparation of therapeutically active 1-phenoxy-2-3-alkylaminopropanes.

Info

Publication number: FI49497C
Authority: FI; Finland
Prior art keywords: alkylaminopropanes; phenoxy; preparation; therapeutically active; therapeutically
Prior art date: 1967-12-13

Application number

FI683535A

Other languages

Finnish (fi)

Swedish (sv)

Other versions

FI49497B (en

Inventor

Herbert Koeppe

Werner Kummer

Helmut Staehle

Karl Zeile

Albrecht Engelhardt

Original Assignee

Boehringer Sohn Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1967-12-13

Filing date

1968-12-11

Publication date

1975-07-10

1968-12-11 Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim

1975-04-01 Application granted granted Critical

1975-04-01 Publication of FI49497B publication Critical patent/FI49497B/fi

1975-07-10 Publication of FI49497C publication Critical patent/FI49497C/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FI683535A 1967-12-13 1968-12-11 Process for the preparation of therapeutically active 1-phenoxy-2-3-alkylaminopropanes. FI49497C (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE1643262A DE1643262C3 (en)	1967-12-13	1967-12-13	i-Phenoxy ^ -hydroxy-S-alklyaminopropane, process for their preparation and medicaments containing these compounds

Publications (2)

Publication Number	Publication Date
FI49497B FI49497B (en)	1975-04-01
FI49497C true FI49497C (en)	1975-07-10

Family

ID=5684274

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI683535A FI49497C (en)	1967-12-13	1968-12-11	Process for the preparation of therapeutically active 1-phenoxy-2-3-alkylaminopropanes.

Country Status (21)

Country	Link
US (1)	US3872147A (en)
JP (1)	JPS5220457B1 (en)
AT (13)	AT292679B (en)
BE (1)	BE725490A (en)
BG (9)	BG17298A3 (en)
BR (1)	BR6804840D0 (en)
CA (1)	CA954528A (en)
CH (2)	CH556816A (en)
DE (1)	DE1643262C3 (en)
DK (1)	DK131029B (en)
ES (11)	ES361189A1 (en)
FI (1)	FI49497C (en)
FR (2)	FR1596100A (en)
GB (1)	GB1260866A (en)
HU (1)	HU162734B (en)
IE (1)	IE32758B1 (en)
IL (1)	IL31266A (en)
NL (3)	NL146709B (en)
PH (1)	PH9266A (en)
SE (1)	SE367396B (en)
YU (12)	YU33949B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3541130A (en) *	1967-02-06	1970-11-17	Boehringer Sohn Ingelheim	1-(cyanophenoxy)-2-hydroxy-3-tert.-butylamine propanes
US4086272A (en) *	1970-07-18	1978-04-25	Pfizer Inc.	Phenyl-alkanolamine, alkylamine and alpha-aminoalkyl ketone derivatives as heart stimulants
US3998874A (en) *	1971-03-23	1976-12-21	Gist-Brocades N.V.	Phenylene di-ethers
US4038414A (en) *	1972-06-08	1977-07-26	Ciba-Geigy Corporation	Amines and processes for their manufacture
US4084002A (en) *	1973-02-28	1978-04-11	Boehringer Ingelheim Gmbh	Pharmaceutical compositions containing a 1-phenoxy-2-hydroxy-3-alkynylamino-propane and method of use
DE2309887C2 (en) *	1973-02-28	1983-11-10	C.H. Boehringer Sohn, 6507 Ingelheim	1-aryloxy-2-hydroxy-3-alkynylaminopropane derivatives and their physiologically acceptable acid addition salts, pharmaceutical preparations and manufacturing processes for the compounds
US4161530A (en) *	1975-01-06	1979-07-17	Ciba-Geigy Corporation	Pharmaceutical combination preparations as hypnotics
US4094991A (en) *	1975-06-17	1978-06-13	Nippon Shinyaku Co., Ltd.	Substituted n-(carboxymethyl)-3-aminopropan-2-ol derivatives
US4243681A (en) *	1977-10-11	1981-01-06	Mead Johnson & Company	Alkylthiophenoxypropanolamines and pharmaceutical compositions and uses thereof
DE2839475A1 (en) *	1978-09-11	1980-03-20	Dolorgiet Arzneimittelfabrik	ISOPROPYLAMINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME
EP0025331B1 (en) *	1979-09-06	1983-03-02	Beecham Group Plc	Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them
JPS56142262A (en)	1980-04-08	1981-11-06	Nippon Shinyaku Co Ltd	Piperazine derivative
US4387103A (en) *	1980-11-28	1983-06-07	American Hospital Supply Corporation	Method for treatment or prophylaxis of cardiac disorders
US4593119A (en) *	1980-11-28	1986-06-03	American Hospital Supply Corporation	Method for treatment or prophylaxis of cardiac disorders
US4405642A (en) *	1980-11-28	1983-09-20	American Hospital Supply Corporation	Method for treatment or prophylaxis of cardiac disorders
US4396629A (en) *	1980-12-29	1983-08-02	Sterling Drug Inc.	Compositions, processes and method
DE3131527A1 (en) *	1981-08-08	1983-02-24	Kali-Chemie Pharma Gmbh, 3000 Hannover	1-PHENYL-2-AMINOCARBONYLINDOL COMPOUNDS AND METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
WO1985004580A1 (en) *	1984-04-09	1985-10-24	American Hospital Supply Corporation	Pharmaceutical composition and method for treatment or prophylaxis of cardiac disorders
US4652584A (en) *	1984-07-13	1987-03-24	Mcneilab, Inc.	Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension
US4665094A (en) *	1985-08-29	1987-05-12	Merck & Co., Inc.	Oculoselective beta-blockers for treatment of elevated intraocular pressure
ES2011255B3 (en) *	1985-12-24	1990-01-01	Merck & Co Inc	SELECTIVE BETA LOCKERS FOR EYES.
US4945182A (en) *	1985-12-24	1990-07-31	Merck & Co., Inc.	Oculoselective beta-blockers
US5480908A (en) *	1993-12-13	1996-01-02	American Cyanamid Company	β3 -adrenergic agents benzodioxole dicarboxylates and their use in pharmaceutical compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3459782A (en) *	1963-08-26	1969-08-05	Boehringer Sohn Ingelheim	1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes

1967
- 1967-12-13 DE DE1643262A patent/DE1643262C3/en not_active Expired
1968
- 1968-04-03 BG BG012150A patent/BG17298A3/en unknown
- 1968-04-30 BG BG012149A patent/BG17297A3/en unknown
- 1968-12-07 ES ES361189A patent/ES361189A1/en not_active Expired
- 1968-12-10 CH CH848471A patent/CH556816A/en not_active IP Right Cessation
- 1968-12-10 CH CH1843568A patent/CH532015A/en not_active IP Right Cessation
- 1968-12-11 NL NL686817768A patent/NL146709B/en not_active IP Right Cessation
- 1968-12-11 PH PH9832*UA patent/PH9266A/en unknown
- 1968-12-11 FI FI683535A patent/FI49497C/en active
- 1968-12-12 SE SE17070/68A patent/SE367396B/xx unknown
- 1968-12-12 DK DK608568AA patent/DK131029B/en not_active IP Right Cessation
- 1968-12-12 JP JP43091282A patent/JPS5220457B1/ja active Pending
- 1968-12-12 CA CA037,721A patent/CA954528A/en not_active Expired
- 1968-12-12 YU YU2949/68A patent/YU33949B/en unknown
- 1968-12-13 AT AT880170A patent/AT292679B/en active
- 1968-12-13 AT AT880070A patent/AT292678B/en not_active IP Right Cessation
- 1968-12-13 BR BR204840/68A patent/BR6804840D0/en unknown
- 1968-12-13 AT AT879570A patent/AT292674B/en active
- 1968-12-13 AT AT879370A patent/AT292673B/en active
- 1968-12-13 BG BG011231A patent/BG16329A3/en unknown
- 1968-12-13 HU HUBO1162A patent/HU162734B/hu unknown
- 1968-12-13 GB GB59518/68A patent/GB1260866A/en not_active Expired
- 1968-12-13 BG BG012146A patent/BG19135A3/en unknown
- 1968-12-13 IE IE1519/68A patent/IE32758B1/en unknown
- 1968-12-13 AT AT879770A patent/AT292676B/en active
- 1968-12-13 IL IL31266A patent/IL31266A/en unknown
- 1968-12-13 AT AT879970A patent/AT298459B/en not_active IP Right Cessation
- 1968-12-13 AT AT879870A patent/AT292677B/en active
- 1968-12-13 AT AT1216668A patent/AT292670B/en not_active IP Right Cessation
- 1968-12-13 AT AT595771A patent/AT298463B/en not_active IP Right Cessation
- 1968-12-13 AT AT880270A patent/AT292680B/en active
- 1968-12-13 AT AT879670A patent/AT292675B/en not_active IP Right Cessation
- 1968-12-13 FR FR1596100D patent/FR1596100A/fr not_active Expired
- 1968-12-13 BE BE725490D patent/BE725490A/xx not_active IP Right Cessation
- 1968-12-13 AT AT879470A patent/AT294799B/en not_active IP Right Cessation
1969
- 1969-03-13 FR FR183279A patent/FR8328M/fr not_active Expired
- 1969-04-30 BG BG012145A patent/BG16445A3/en unknown
- 1969-04-30 BG BG012143A patent/BG16330A3/en unknown
- 1969-04-30 BG BG012148A patent/BG16332A3/en unknown
- 1969-04-30 BG BG012147A patent/BG16331A3/en unknown
- 1969-04-30 BG BG012144A patent/BG16444A3/en unknown
1970
- 1970-01-15 ES ES375449A patent/ES375449A1/en not_active Expired
- 1970-01-15 ES ES375450A patent/ES375450A1/en not_active Expired
- 1970-01-15 ES ES375451A patent/ES375451A1/en not_active Expired
- 1970-01-15 ES ES375447A patent/ES375447A1/en not_active Expired
- 1970-01-15 ES ES375448A patent/ES375448A1/en not_active Expired
- 1970-01-15 ES ES375453A patent/ES375453A1/en not_active Expired
- 1970-01-15 ES ES375445A patent/ES375445A1/en not_active Expired
- 1970-01-15 ES ES375446A patent/ES375446A1/en not_active Expired
- 1970-01-15 ES ES375444A patent/ES375444A1/en not_active Expired
- 1970-01-15 ES ES375452A patent/ES375452A1/en not_active Expired
- 1970-12-13 AT AT08803/70A patent/AT292681B/en active
1971
- 1971-12-02 US US204316A patent/US3872147A/en not_active Expired - Lifetime
1974
- 1974-09-03 YU YU2380/74A patent/YU33854B/en unknown
- 1974-09-03 YU YU2384/74A patent/YU33948B/en unknown
- 1974-09-03 YU YU2383/74A patent/YU33856B/en unknown
- 1974-09-03 YU YU2377/74A patent/YU33947B/en unknown
- 1974-09-03 YU YU2376/74A patent/YU33773B/en unknown
- 1974-09-03 YU YU2378/74A patent/YU33852B/en unknown
- 1974-09-03 YU YU2375/74A patent/YU33946B/en unknown
- 1974-09-03 YU YU2382/74A patent/YU33855B/en unknown
- 1974-09-03 YU YU2374/74A patent/YU33851B/en unknown
- 1974-09-03 YU YU2381/74A patent/YU33774B/en unknown
- 1974-09-03 YU YU2379/74A patent/YU33853B/en unknown
1975
- 1975-02-14 NL NL757501794A patent/NL151354B/en not_active IP Right Cessation
- 1975-02-14 NL NL7501792A patent/NL7501792A/en unknown

Also Published As

Publication number	Publication date
YU33949B (en)	1978-09-08
YU33851B (en)	1978-06-30
YU33855B (en)	1978-06-30
YU238474A (en)	1978-02-28
YU33774B (en)	1978-05-15
DK131029C (en)	1975-10-06
ES375444A1 (en)	1972-05-01
GB1260866A (en)	1972-01-19
ES375447A1 (en)	1972-05-01
ES375449A1 (en)	1972-05-01
YU238374A (en)	1977-12-31
DE1643262B2 (en)	1974-11-07
BG17298A3 (en)	1973-07-25
ES375452A1 (en)	1972-05-16
AT292675B (en)	1971-09-10
DK131029B (en)	1975-05-20
AT292673B (en)	1971-09-10
YU33946B (en)	1978-09-08
SE367396B (en)	1974-05-27
YU33853B (en)	1978-06-30
ES361189A1 (en)	1970-08-16
YU238274A (en)	1977-12-31
US3872147A (en)	1975-03-18
NL7501794A (en)	1975-05-30
CA954528A (en)	1974-09-10
AT292670B (en)	1971-09-10
YU33854B (en)	1978-06-30
NL7501792A (en)	1975-05-30
IE32758L (en)	1969-06-13
CH532015A (en)	1972-12-31
NL6817768A (en)	1969-06-17
JPS5220457B1 (en)	1977-06-03
ES375448A1 (en)	1972-05-01
BG16332A3 (en)	1972-08-20
YU238174A (en)	1977-10-31
YU294968A (en)	1978-02-28
IL31266A0 (en)	1969-02-27
AT292679B (en)	1971-09-10
AT292680B (en)	1971-09-10
BG16331A3 (en)	1972-08-20
FI49497B (en)	1975-04-01
DE1643262A1 (en)	1972-04-20
BG19135A3 (en)	1975-04-30
FR8328M (en)	1970-12-07
YU237474A (en)	1977-12-31
ES375450A1 (en)	1972-05-01
ES375445A1 (en)	1972-05-16
PH9266A (en)	1975-07-30
BG16444A3 (en)	1972-11-20
YU33948B (en)	1978-09-08
ES375453A1 (en)	1972-05-16
NL146709B (en)	1975-08-15
YU33856B (en)	1978-06-30
AT292678B (en)	1971-09-10
YU33773B (en)	1978-05-15
AT292676B (en)	1971-09-10
YU33852B (en)	1978-06-30
AT292681B (en)	1971-08-15
YU33947B (en)	1978-09-08
IE32758B1 (en)	1973-11-28
YU237674A (en)	1977-10-31
BE725490A (en)	1969-06-13
AT294799B (en)	1971-12-10
BG16330A3 (en)	1972-08-20
AT298463B (en)	1972-05-10
YU237574A (en)	1978-02-28
BG16329A3 (en)	1972-08-20
CH556816A (en)	1974-12-13
YU238074A (en)	1977-12-31
YU237874A (en)	1977-12-31
FR1596100A (en)	1970-06-15
BG17297A3 (en)	1973-07-25
AT292674B (en)	1971-09-10
AT292677B (en)	1971-09-10
ES375446A1 (en)	1972-05-01
IL31266A (en)	1974-09-10
YU237774A (en)	1978-02-28
DE1643262C3 (en)	1975-06-26
BR6804840D0 (en)	1973-03-08
ES375451A1 (en)	1972-05-01
HU162734B (en)	1973-04-28
YU237974A (en)	1977-12-31
BG16445A3 (en)	1972-11-20
NL151354B (en)	1976-11-15
AT298459B (en)	1972-05-10

Publication	Publication Date	Title
DK128353B (en)	1974-04-16	Analogous process for the preparation of therapeutically active bis-chromones.
FI42712C (en)	1970-10-12	Process for the preparation of therapeutically active biphenylalkane derivatives
FI49957C (en)	1975-11-10	Process for the preparation of therapeutically active oxime ethers i.
FI49497C (en)	1975-07-10	Process for the preparation of therapeutically active 1-phenoxy-2-3-alkylaminopropanes.
FI48727C (en)	1974-12-10	Process for the preparation of acetylguanidines.
FI50707C (en)	1976-06-10	Process for the preparation of new pharmacologically active hydroxycyclohexylamines.
FI49720C (en)	1975-09-10	Process for the preparation of therapeutically active 2-methyl-3-carboxylic acid amidoquinoxaline di-N-oxides (1,4).
FI52857C (en)	1977-12-12	Process for the preparation of therapeutically active amidoximes.
FI45551C (en)	1972-07-10	Process for the preparation of therapeutically useful dehydroepiandro osterone monanthate.
DK117635B (en)	1970-05-19	Analogous process for the preparation of therapeutically active 3- (piperazinoalkyl) -pyrazoles.
FI49718C (en)	1975-09-10	Process for the preparation of therapeutically active 2-halomethyl-3-carboxylic acid amidoquinoxaline di-N-oxides- (1,4).
FI51175C (en)	1976-11-10	Process for the preparation of indanylthiocarbamates for therapeutic use.
FI49032C (en)	1975-03-10	Process for the preparation of therapeutically active 7-nitro-8-hydroxyquinoline esters.
FI50420C (en)	1976-03-10	Process for the preparation of therapeutically active 4-pyrimidinyl-1,4-dihydropyridine derivatives
FI47189C (en)	1973-10-10	Process for the preparation of therapeutically active d-lysergic acid-N-phenylpiperazides.
FI48576C (en)	1974-11-11	Process for the preparation of therapeutically active alpha-fluoromalic acid derivatives.
FI46066C (en)	1972-12-11	Analogous process for the preparation of therapeutically active N, N-dimethylamino-ethyl-14beta-hydroxy-5beta-pregn-20-ene-21-carboxylates.
FI48190C (en)	1974-07-10	Process for the preparation of therapeutically active 10alpha-methoxy-9,10-dihydroergoline derivatives
FI50879C (en)	1976-08-10	Process for the preparation of therapeutically active substituted 3-aminoacylamino-thiophenes.
FI48841C (en)	1975-01-10	Process for the preparation of pharmacologically active 5-nitro-2-furfurylideneaminooxazolidinones.
FI45553C (en)	1972-07-10	Method for the preparation of therapeutically useful 16-thio-substituted 9beta, 10a lfa-pregnenes
FI47661C (en)	1974-02-11	Process for the preparation of therapeutically active benzofuran derivatives.
FI47651C (en)	1974-02-11	Process for the preparation of nitrous oxide.
FI49722C (en)	1975-09-10	Process for the preparation of therapeutically active 3-carboxylic acid amidoquinoxaline-di-N-oxides- (1,4).
DK122763B (en)	1972-04-10	Analogous process for the preparation of therapeutically active 1,2α-methylene-4-pregnene-3,20-dione derivatives.