US5266331A
(en)
*
|
1991-11-27 |
1993-11-30 |
Euroceltique, S.A. |
Controlled release oxycodone compositions
|
US5478577A
(en)
*
|
1993-11-23 |
1995-12-26 |
Euroceltique, S.A. |
Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
|
US5968551A
(en)
*
|
1991-12-24 |
1999-10-19 |
Purdue Pharma L.P. |
Orally administrable opioid formulations having extended duration of effect
|
US5958459A
(en)
*
|
1991-12-24 |
1999-09-28 |
Purdue Pharma L.P. |
Opioid formulations having extended controlled released
|
US20080075781A1
(en)
*
|
1992-11-25 |
2008-03-27 |
Purdue Pharma Lp |
Controlled release oxycodone compositions
|
NZ260408A
(en)
|
1993-05-10 |
1996-05-28 |
Euro Celtique Sa |
Controlled release preparation comprising tramadol
|
US20070275062A1
(en)
*
|
1993-06-18 |
2007-11-29 |
Benjamin Oshlack |
Controlled release oxycodone compositions
|
US7740881B1
(en)
|
1993-07-01 |
2010-06-22 |
Purdue Pharma Lp |
Method of treating humans with opioid formulations having extended controlled release
|
IL110014A
(en)
*
|
1993-07-01 |
1999-11-30 |
Euro Celtique Sa |
Solid controlled-release oral dosage forms of opioid analgesics
|
US5879705A
(en)
*
|
1993-07-27 |
1999-03-09 |
Euro-Celtique S.A. |
Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
|
KR100354702B1
(ko)
|
1993-11-23 |
2002-12-28 |
유로-셀티크 소시에떼 아노뉨 |
약학조성물의제조방법및서방형조성물
|
US5891471A
(en)
|
1993-11-23 |
1999-04-06 |
Euro-Celtique, S.A. |
Pharmaceutical multiparticulates
|
US5843480A
(en)
|
1994-03-14 |
1998-12-01 |
Euro-Celtique, S.A. |
Controlled release diamorphine formulation
|
GB9422154D0
(en)
|
1994-11-03 |
1994-12-21 |
Euro Celtique Sa |
Pharmaceutical compositions and method of producing the same
|
US5965161A
(en)
|
1994-11-04 |
1999-10-12 |
Euro-Celtique, S.A. |
Extruded multi-particulates
|
DE19530575A1
(de)
*
|
1995-08-19 |
1997-02-20 |
Gruenenthal Gmbh |
Schnell zerfallende Arzneiform von Tramadol oder einem Tramadolsalz
|
GB9519363D0
(en)
|
1995-09-22 |
1995-11-22 |
Euro Celtique Sa |
Pharmaceutical formulation
|
EP0888111B1
(en)
*
|
1996-03-08 |
2003-05-21 |
Nycomed Danmark A/S |
Modified release multiple-units dosage composition
|
DE19712398A1
(de)
*
|
1997-03-25 |
1998-10-01 |
Gruenenthal Gmbh |
Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel
|
PT1009387E
(pt)
*
|
1997-07-02 |
2006-08-31 |
Euro Celtique Sa |
Formulacoes estabilizadas de libertacao controlada de tramadol
|
US6156342A
(en)
*
|
1998-05-26 |
2000-12-05 |
Andex Pharmaceuticals, Inc. |
Controlled release oral dosage form
|
DE29818454U1
(de)
*
|
1998-10-15 |
1999-01-14 |
Euroceltique S.A., Luxemburg/Luxembourg |
Opioid-Analgetikum
|
US6806294B2
(en)
|
1998-10-15 |
2004-10-19 |
Euro-Celtique S.A. |
Opioid analgesic
|
WO2000040205A2
(en)
*
|
1999-01-05 |
2000-07-13 |
Copley Pharmaceutical Inc. |
Sustained release formulation with reduced moisture sensitivity
|
DE19901692C2
(de)
*
|
1999-01-18 |
2002-06-20 |
Gruenenthal Gmbh |
Verfahren zur Herstellung von Pellets mit einem Gehalt von bis zu 90 Gew.% eines pharmazeutischen Wirkstoffes
|
DE19918325A1
(de)
|
1999-04-22 |
2000-10-26 |
Euro Celtique Sa |
Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
|
JP2003508430A
(ja)
*
|
1999-08-31 |
2003-03-04 |
グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング |
トラマドールサッカリナートを含有する徐放性投薬形
|
JP4806507B2
(ja)
|
1999-10-29 |
2011-11-02 |
ユーロ−セルティーク エス.エイ. |
制御放出ヒドロコドン処方
|
US10179130B2
(en)
|
1999-10-29 |
2019-01-15 |
Purdue Pharma L.P. |
Controlled release hydrocodone formulations
|
SK285128B6
(sk)
*
|
1999-12-28 |
2006-07-07 |
Zentiva, A. S. |
Liečivý prípravok s riadeným uvoľňovaním obsahujúci tramadol hydrochlorid a spôsob jeho prípravy
|
DE60105243T2
(de)
*
|
2000-09-22 |
2005-11-24 |
Smb Technology |
Oral anzuwendende tramadolhaltige Teilchen zur einmal täglichen Verabreichung
|
BR0115382A
(pt)
|
2000-10-30 |
2003-09-16 |
Euro Celtique Sa |
Formulações para liberação controlada de hidrocodona, método de produzir analgesia efetiva, processo de preparação de uma forma farmacêutica de um sólido oral de liberação controlada, liberação controlada da forma farmacêutica oral e uso da forma farmacêutica
|
DE10108122A1
(de)
|
2001-02-21 |
2002-10-02 |
Gruenenthal Gmbh |
Arzneimittel auf Basis von Tramadol
|
CA2758923A1
(en)
*
|
2001-03-16 |
2002-09-26 |
Dmi Biosciences, Inc. |
Use of tramadol to delay ejaculation
|
UA81224C2
(uk)
|
2001-05-02 |
2007-12-25 |
Euro Celtic S A |
Дозована форма оксикодону та її застосування
|
US20110104214A1
(en)
|
2004-04-15 |
2011-05-05 |
Purdue Pharma L.P. |
Once-a-day oxycodone formulations
|
PE20030527A1
(es)
*
|
2001-10-24 |
2003-07-26 |
Gruenenthal Chemie |
Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen
|
US8128957B1
(en)
|
2002-02-21 |
2012-03-06 |
Valeant International (Barbados) Srl |
Modified release compositions of at least one form of tramadol
|
US20060099249A1
(en)
*
|
2002-02-21 |
2006-05-11 |
Pawan Seth |
Modified release formulations of at least one form of tramadol
|
EP1485078B1
(en)
*
|
2002-03-15 |
2012-09-26 |
Cypress Bioscience, Inc. |
Milnacipran for the treatment of irritable bowel syndrome
|
WO2003080031A1
(en)
*
|
2002-03-22 |
2003-10-02 |
Cilag Ag |
Sustained release formulation of tramadol
|
DE10224108A1
(de)
*
|
2002-05-29 |
2004-01-29 |
Grünenthal GmbH |
1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol enthaltendes Arzneimiitel mit verzögerter Wirkstofffreisetzung
|
US7410965B2
(en)
|
2002-05-29 |
2008-08-12 |
Gruenenthal Gmbh |
Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol
|
US7776314B2
(en)
|
2002-06-17 |
2010-08-17 |
Grunenthal Gmbh |
Abuse-proofed dosage system
|
US20050020613A1
(en)
*
|
2002-09-20 |
2005-01-27 |
Alpharma, Inc. |
Sustained release opioid formulations and method of use
|
US20040132826A1
(en)
*
|
2002-10-25 |
2004-07-08 |
Collegium Pharmaceutical, Inc. |
Modified release compositions of milnacipran
|
TWI319713B
(en)
|
2002-10-25 |
2010-01-21 |
|
Sustained-release tramadol formulations with 24-hour efficacy
|
US20060003004A1
(en)
*
|
2002-10-25 |
2006-01-05 |
Collegium Pharmaceutical, Inc. |
Pulsatile release compositions of milnacipran
|
US8487002B2
(en)
|
2002-10-25 |
2013-07-16 |
Paladin Labs Inc. |
Controlled-release compositions
|
US20040228830A1
(en)
*
|
2003-01-28 |
2004-11-18 |
Collegium Pharmaceutical, Inc. |
Multiparticulate compositions of milnacipran for oral administration
|
DE10333835A1
(de)
*
|
2003-07-24 |
2005-03-10 |
Gruenenthal Gmbh |
6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung
|
DE10361596A1
(de)
*
|
2003-12-24 |
2005-09-29 |
Grünenthal GmbH |
Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
|
DE102004032051A1
(de)
*
|
2004-07-01 |
2006-01-19 |
Grünenthal GmbH |
Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
|
AU2004264666B2
(en)
*
|
2003-08-06 |
2009-10-15 |
Gruenenthal Gmbh |
Abuse-proofed dosage form
|
US20070048228A1
(en)
|
2003-08-06 |
2007-03-01 |
Elisabeth Arkenau-Maric |
Abuse-proofed dosage form
|
DE102005005446A1
(de)
*
|
2005-02-04 |
2006-08-10 |
Grünenthal GmbH |
Bruchfeste Darreichungsformen mit retardierter Freisetzung
|
US8075872B2
(en)
*
|
2003-08-06 |
2011-12-13 |
Gruenenthal Gmbh |
Abuse-proofed dosage form
|
DE102004020220A1
(de)
*
|
2004-04-22 |
2005-11-10 |
Grünenthal GmbH |
Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
|
DE10336400A1
(de)
|
2003-08-06 |
2005-03-24 |
Grünenthal GmbH |
Gegen Missbrauch gesicherte Darreichungsform
|
US20060172006A1
(en)
*
|
2003-10-10 |
2006-08-03 |
Vincent Lenaerts |
Sustained-release tramadol formulations with 24-hour clinical efficacy
|
US20050089558A1
(en)
*
|
2003-10-28 |
2005-04-28 |
Alamo Pharmaceuticals, Llc |
Compositions and methods for the co-formulation and administration of tramadol and propoxyphene
|
DE102004032049A1
(de)
|
2004-07-01 |
2006-01-19 |
Grünenthal GmbH |
Gegen Missbrauch gesicherte, orale Darreichungsform
|
DE102004032103A1
(de)
*
|
2004-07-01 |
2006-01-19 |
Grünenthal GmbH |
Gegen Missbrauch gesicherte, orale Darreichungsform
|
DE102005005449A1
(de)
|
2005-02-04 |
2006-08-10 |
Grünenthal GmbH |
Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
|
AU2006269225B2
(en)
*
|
2005-07-07 |
2011-10-06 |
Farnam Companies, Inc. |
Sustained release pharmaceutical compositions for highly water soluble drugs
|
JP5269595B2
(ja)
|
2005-09-09 |
2013-08-21 |
アンジェリーニ ラボファーム リミテッド ライアビリティ カンパニー |
1日1回投与用トラゾドン組成物
|
US20090104266A1
(en)
*
|
2005-09-15 |
2009-04-23 |
Tobias Jung |
3-(2-dimethylaminomethylcy clohexyl)phenol retard formulation
|
US8691272B2
(en)
*
|
2005-12-30 |
2014-04-08 |
Intelgenx Corp. |
Multilayer tablet
|
US20070190141A1
(en)
*
|
2006-02-16 |
2007-08-16 |
Aaron Dely |
Extended release opiate composition
|
US20080075770A1
(en)
*
|
2006-07-21 |
2008-03-27 |
Vaughn Jason M |
Hydrophilic abuse deterrent delivery system
|
DE102006044694A1
(de)
*
|
2006-09-22 |
2008-03-27 |
Krewel Meuselbach Gmbh |
Perorale feste Schmerzmittelzubereitung
|
NZ579169A
(en)
*
|
2007-02-12 |
2012-05-25 |
Dmi Biosciences Inc |
Treatment of comorbid premature ejaculation and erectile dysfunction using tramadol and a phosphodiesterase (pde) inhibitor
|
MX2009008511A
(es)
*
|
2007-02-12 |
2010-01-20 |
Dmi Biosciences Inc |
Reduccion de efectos secundarios de tramadol.
|
DE102007011485A1
(de)
*
|
2007-03-07 |
2008-09-11 |
Grünenthal GmbH |
Darreichungsform mit erschwertem Missbrauch
|
EP2203166B1
(en)
*
|
2007-10-16 |
2015-05-06 |
Paladin Labs Inc. |
Bilayer composition for the sustained release of acetaminophen and tramadol
|
BRPI0821732A2
(pt)
|
2007-12-17 |
2015-06-16 |
Labopharm Inc |
Formulações de liberação controlada , forma de dosagem sólida, e, uso da formulação de liberação controlada
|
WO2009092601A1
(en)
|
2008-01-25 |
2009-07-30 |
Grünenthal GmbH |
Pharmaceutical dosage form
|
EP2273983B1
(en)
*
|
2008-05-09 |
2016-07-20 |
Grünenthal GmbH |
Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
|
US20100003322A1
(en)
*
|
2008-07-03 |
2010-01-07 |
Lai Felix S |
Enteric coated hydrophobic matrix formulation
|
AU2009327312A1
(en)
|
2008-12-16 |
2011-08-04 |
Labopharm Europe Limited |
Misuse preventative, controlled release formulation
|
CN102573805A
(zh)
|
2009-07-22 |
2012-07-11 |
格吕伦塔尔有限公司 |
热熔挤出的控制释放剂型
|
RU2015138422A
(ru)
|
2009-07-22 |
2018-12-25 |
Грюненталь Гмбх |
Стабильная при окислении, прочная на излом лекарственная форма
|
US10610528B2
(en)
|
2009-12-08 |
2020-04-07 |
Intelgenx Corp. |
Solid oral film dosage forms and methods for making same
|
US20110136815A1
(en)
*
|
2009-12-08 |
2011-06-09 |
Horst Zerbe |
Solid oral film dosage forms and methods for making same
|
ES2606227T3
(es)
*
|
2010-02-03 |
2017-03-23 |
Grünenthal GmbH |
Preparación de una composición farmacéutica en polvo mediante una extrusora
|
KR20130030261A
(ko)
|
2010-05-10 |
2013-03-26 |
유로-셀티큐 에스.에이. |
활성제-무함유 과립 및 그를 포함하는 정제의 제조
|
EP2590636A1
(en)
|
2010-07-06 |
2013-05-15 |
Grünenthal GmbH |
Novel gastro- retentive dosage forms comprising a gaba analog and an opioid
|
AR082862A1
(es)
|
2010-09-02 |
2013-01-16 |
Gruenenthal Gmbh |
Forma de dosificacion resistente a alteracion que comprende un polimero anionico
|
JP5925779B2
(ja)
|
2010-09-02 |
2016-05-25 |
グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング |
無機塩を含む不正使用抵抗性剤形
|
US20120202838A1
(en)
*
|
2010-11-04 |
2012-08-09 |
Abbott Laboratories |
Drug formulations
|
PT2736497T
(pt)
|
2011-07-29 |
2017-11-30 |
Gruenenthal Gmbh |
Comprimido resistente a adulteração proporcionando libertação imediata de fármaco
|
CN103841964A
(zh)
|
2011-07-29 |
2014-06-04 |
格吕伦塔尔有限公司 |
提供药物立即释放的抗破碎片剂
|
WO2013127831A1
(en)
|
2012-02-28 |
2013-09-06 |
Grünenthal GmbH |
Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
|
DK2838512T3
(en)
|
2012-04-18 |
2018-11-19 |
Gruenenthal Gmbh |
MANIPULATED AND DOSAGE DUMPED PHARMACEUTICAL DOSAGE FORM
|
US10064945B2
(en)
|
2012-05-11 |
2018-09-04 |
Gruenenthal Gmbh |
Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
|
US10154966B2
(en)
|
2013-05-29 |
2018-12-18 |
Grünenthal GmbH |
Tamper-resistant dosage form containing one or more particles
|
MX2015016254A
(es)
|
2013-05-29 |
2016-04-20 |
Gruenenthal Gmbh |
Forma de dosificacion resistente al uso indebido con perfil de liberacion bimodal.
|
JP6449871B2
(ja)
|
2013-07-12 |
2019-01-09 |
グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング |
エチレン−酢酸ビニルポリマーを含有する改変防止剤形
|
WO2015078891A1
(en)
|
2013-11-26 |
2015-06-04 |
Farmaceutici Formenti S.P.A. |
Preparation of a powdery pharmaceutical composition by means of cryo-milling
|
EP3142646A1
(en)
|
2014-05-12 |
2017-03-22 |
Grünenthal GmbH |
Tamper resistant immediate release capsule formulation comprising tapentadol
|
WO2015181059A1
(en)
|
2014-05-26 |
2015-12-03 |
Grünenthal GmbH |
Multiparticles safeguarded against ethanolic dose-dumping
|
BR112017021475A2
(pt)
|
2015-04-24 |
2018-07-10 |
Gruenenthal Gmbh |
forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
|
EP3346991A1
(en)
|
2015-09-10 |
2018-07-18 |
Grünenthal GmbH |
Protecting oral overdose with abuse deterrent immediate release formulations
|