FI114792B - Menetelmä terapeuttisesti aktiivisten N-fenyylialkyyli-substituoitujen alfa-aminokarboksamidi-johdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti aktiivisten N-fenyylialkyyli-substituoitujen alfa-aminokarboksamidi-johdannaisten valmistamiseksi Download PDF

Info

Publication number: FI114792B
Authority: FI; Finland
Prior art keywords: formula; oxybenzyl; amino; compound; aminopropionamide
Prior art date: 1989-05-25

Application number

FI910354A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI910354A0 (fi

Inventor

Philippe Dostert

Romeo Roncucci

Mario Varasi

Paolo Pevarello

Alberto Bonsignori

Franco Heidempergher

Original Assignee

Newron Pharm Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-25

Filing date

1991-01-23

Publication date

2004-12-31

1989-05-25 Priority claimed from GB898912071A external-priority patent/GB8912071D0/en

1990-04-04 Priority claimed from GB909007567A external-priority patent/GB9007567D0/en

1991-01-23 Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa

1991-01-23 Publication of FI910354A0 publication Critical patent/FI910354A0/fi

2004-12-31 Application granted granted Critical

2004-12-31 Publication of FI114792B publication Critical patent/FI114792B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/02—Monothiocarboxylic acids
- C07C327/04—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C327/06—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Pyridine Compounds (AREA)
Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Plural Heterocyclic Compounds (AREA)

FI910354A 1989-05-25 1991-01-23 Menetelmä terapeuttisesti aktiivisten N-fenyylialkyyli-substituoitujen alfa-aminokarboksamidi-johdannaisten valmistamiseksi FI114792B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB8912071		1989-05-25
GB898912071A GB8912071D0 (en)	1989-05-25	1989-05-25	N-phenylalkyl substituted-alpha-amino carboxamide derivatives and process for their preparation
GB909007567A GB9007567D0 (en)	1990-04-04	1990-04-04	New n-substituted alpha-amino carboxamide derivatives and process for their preparation
GB9007567		1990-04-04
EP9000841		1990-05-25
PCT/EP1990/000841 WO1990014334A1 (en)	1989-05-25	1990-05-25	N-PHENYLALKYL SUBSTITUTED α-AMINO CARBOXAMIDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION

Publications (2)

Publication Number	Publication Date
FI910354A0 FI910354A0 (fi)	1991-01-23
FI114792B true FI114792B (fi)	2004-12-31

Family

ID=26295400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI910354A FI114792B (fi)	1989-05-25	1991-01-23	Menetelmä terapeuttisesti aktiivisten N-fenyylialkyyli-substituoitujen alfa-aminokarboksamidi-johdannaisten valmistamiseksi

Country Status (23)

Country	Link
US (3)	US5236957A (da)
EP (2)	EP0400495B1 (da)
JP (1)	JP2771328B2 (da)
KR (1)	KR0179661B1 (da)
CN (1)	CN1027588C (da)
AT (1)	ATE96775T1 (da)
AU (1)	AU645752B2 (da)
CA (1)	CA2033190C (da)
CZ (1)	CZ281420B6 (da)
DE (1)	DE69004337T2 (da)
DK (1)	DK0400495T3 (da)
ES (1)	ES2062174T3 (da)
FI (1)	FI114792B (da)
HU (2)	HUT55348A (da)
IE (1)	IE63934B1 (da)
IL (1)	IL94466A (da)
MY (1)	MY105618A (da)
NO (1)	NO179944C (da)
NZ (1)	NZ233785A (da)
PT (1)	PT94160B (da)
RU (1)	RU2097371C1 (da)
WO (1)	WO1990014334A1 (da)
YU (1)	YU48322B (da)

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US20050281752A1 (en) *	1997-10-01	2005-12-22	Dugger Harry A Iii	Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
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US20040213842A1 (en)	2003-01-30	2004-10-28	Dynogen Pharmaceuticals, Inc.	Methods of treating gastrointestinal tract disorders using sodium channel modulators
AR044007A1 (es)	2003-04-11	2005-08-24	Newron Pharmaceuticals Inc	Metodos para el tratamiento de la enfermedad de parkinson
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WO2006001463A1 (ja)	2004-06-23	2006-01-05	Ono Pharmaceutical Co., Ltd.	Ｓ１ｐ受容体結合能を有する化合物およびその用途
RS51411B (en) *	2004-09-10	2011-02-28	Newron Pharmaceuticals S.P.A.	USE (R) - (HALOBENZYLOXY) BENZYLAMINO-PROPANAMIDE AS SELECTIVE MODULATORS OF SODIUM AND / OR CALCIUM CHANNELS
TW200730494A (en)	2005-10-10	2007-08-16	Glaxo Group Ltd	Novel compounds
TW200728258A (en)	2005-10-10	2007-08-01	Glaxo Group Ltd	Novel compounds
ATE472529T1 (de) *	2005-10-10	2010-07-15	Glaxo Group Ltd	Prolinamidderivate als natriumkanalmodulatoren
BRPI0620239B8 (pt)	2005-12-22	2021-05-25	Newron Pharm Spa	derivados de 2-feniletilamino.
EP1870097A1 (en) *	2006-06-15	2007-12-26	Newron Pharmaceuticals S.p.A.	Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
EP2474521B1 (en)	2006-06-19	2016-08-10	Newron Pharmaceuticals S.p.A.	High purity degree 2-[4-(3- and 2-fluorobenzyloxy)benzylamino]propanamides for use as medicaments and pharmaceutical formulations containing them
CN101495185A (zh) *	2006-07-28	2009-07-29	爱尔康研究有限公司	用于治疗外层视网膜病症的单胺氧化酶抑制剂
KR100868353B1 (ko) *	2007-03-08	2008-11-12	한국화학연구원	도파민 ｄ4 수용체 길항제인 신규 피페라지닐프로필피라졸유도체, 이의 제조방법 및 이를 포함하는 약학적 조성물
GB0706630D0 (en) *	2007-04-04	2007-05-16	Glaxo Group Ltd	Novel compounds
LT2155663T (lt)	2007-06-15	2018-02-12	Newron Pharmaceuticals S.P.A.	Pakeisti 2-[2-(fenil)etilamino]alkanamidų dariniai ir jų, kaip natrio ir (arba) kalcio kanalų moduliatorių, panaudojimas
CN104523668B (zh) *	2007-12-11	2020-06-09	纽朗制药有限公司	高纯度的2-[4-(3-或2-氟苄氧基)苄氨基]丙酰胺类及其用途
EP2222290B1 (en)	2007-12-19	2021-06-16	Newron Pharmaceuticals S.p.A.	Alpha-aminoamide derivatives for the treatment of psychiatric disorders
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BR112012027623B1 (pt)	2010-04-27	2021-07-06	Newron Pharmaceuticals S.P.A.	Processo para a produção de sais de ralfinamida metanossulfonato ou seus renantiômeros, forma pseudopolimorfa de hemi-hidrato cristalino h do sal de metanossulfonato de ralfinamida, ou seu r-enantiômero, seu uso e formulação farmacêutica que o compreende
KR101679568B1 (ko)	2014-10-02	2016-11-28	한국과학기술연구원	알파-아미노아미드 유도체 화합물 및 이를 포함하는 약학적 조성물
ES2774800T3 (es)	2014-10-02	2020-07-22	Megabiowood Co Ltd	Compuesto derivado de alfa-aminoamida y composición farmacéutica que contiene el mismo
WO2016102967A1 (en)	2014-12-23	2016-06-30	Convergence Pharmaceuticals Limited	Process for preparing alpha-carboxamide pyrrolidine derivatives
JP2018521021A (ja)	2015-06-11	2018-08-02	バジリア・ファルマスーチカ・インターナショナル・アーゲーＢａｓｉｌｅａＰｈａｒｍａｃｅｕｔｉｃａＩｎｔｅｒｎａｔｉｏｎａｌＡｇ	排出ポンプ阻害剤及びその治療的使用
CN105061245A (zh) *	2015-08-25	2015-11-18	成都维恒医药科技有限公司	一种高纯度沙芬酰胺的制备方法
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WO2019205147A1 (zh) *	2018-04-28	2019-10-31	上海璃道医药科技有限公司	包含苯并含氧脂肪环结构的氨基乙酰胺类化合物及其用途
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1990
- 1990-05-22 IL IL9446690A patent/IL94466A/en not_active IP Right Cessation
- 1990-05-23 NZ NZ233785A patent/NZ233785A/xx unknown
- 1990-05-23 CZ CS902520A patent/CZ281420B6/cs not_active IP Right Cessation
- 1990-05-24 IE IE187890A patent/IE63934B1/en not_active IP Right Cessation
- 1990-05-24 MY MYPI90000843A patent/MY105618A/en unknown
- 1990-05-24 YU YU102290A patent/YU48322B/sh unknown
- 1990-05-25 CN CN90103800A patent/CN1027588C/zh not_active Expired - Lifetime
- 1990-05-25 EP EP90109950A patent/EP0400495B1/en not_active Expired - Lifetime
- 1990-05-25 AT AT90109950T patent/ATE96775T1/de not_active IP Right Cessation
- 1990-05-25 DK DK90109950.7T patent/DK0400495T3/da active
- 1990-05-25 KR KR1019910700086A patent/KR0179661B1/ko not_active IP Right Cessation
- 1990-05-25 JP JP2507938A patent/JP2771328B2/ja not_active Expired - Lifetime
- 1990-05-25 RU SU925011522A patent/RU2097371C1/ru active
- 1990-05-25 AU AU57299/90A patent/AU645752B2/en not_active Expired
- 1990-05-25 ES ES90109950T patent/ES2062174T3/es not_active Expired - Lifetime
- 1990-05-25 CA CA002033190A patent/CA2033190C/en not_active Expired - Lifetime
- 1990-05-25 HU HU905133A patent/HUT55348A/hu unknown
- 1990-05-25 PT PT94160A patent/PT94160B/pt not_active IP Right Cessation
- 1990-05-25 EP EP90908218A patent/EP0426816A1/en active Pending
- 1990-05-25 WO PCT/EP1990/000841 patent/WO1990014334A1/en active IP Right Grant
- 1990-05-25 DE DE90109950T patent/DE69004337T2/de not_active Expired - Lifetime
- 1990-05-25 US US07/646,596 patent/US5236957A/en not_active Expired - Lifetime
1991
- 1991-01-23 NO NO910270A patent/NO179944C/no not_active IP Right Cessation
- 1991-01-23 FI FI910354A patent/FI114792B/fi active
1993
- 1993-05-25 US US08/065,888 patent/US5391577A/en not_active Expired - Lifetime
1994
- 1994-11-17 US US08/343,853 patent/US5502079A/en not_active Expired - Lifetime
1995
- 1995-06-30 HU HU95P/P00703P patent/HU211550A9/hu unknown

Also Published As

Publication number	Publication date
KR0179661B1 (ko)	1999-05-15
JP2771328B2 (ja)	1998-07-02
AU645752B2 (en)	1994-01-27
DK0400495T3 (da)	1993-12-06
YU48322B (sh)	1998-05-15
HU211550A9 (en)	1995-12-28
NO179944C (no)	1997-01-15
CA2033190A1 (en)	1990-11-26
CN1027588C (zh)	1995-02-08
IL94466A (en)	1995-01-24
EP0400495A1 (en)	1990-12-05
US5391577A (en)	1995-02-21
NZ233785A (en)	1992-12-23
IE63934B1 (en)	1995-06-28
IE901878L (en)	1990-11-25
MY105618A (en)	1994-11-30
US5502079A (en)	1996-03-26
EP0400495B1 (en)	1993-11-03
FI910354A0 (fi)	1991-01-23
CN1047496A (zh)	1990-12-05
ES2062174T3 (es)	1994-12-16
JPH04500215A (ja)	1992-01-16
HU905133D0 (en)	1991-04-29
EP0426816A1 (en)	1991-05-15
PT94160A (pt)	1991-01-08
CA2033190C (en)	2003-04-08
CZ252090A3 (en)	1996-06-12
YU102290A (sh)	1992-07-20
NO179944B (no)	1996-10-07
DE69004337D1 (de)	1993-12-09
AU5729990A (en)	1990-12-18
NO910270D0 (no)	1991-01-23
ATE96775T1 (de)	1993-11-15
WO1990014334A1 (en)	1990-11-29
RU2097371C1 (ru)	1997-11-27
PT94160B (pt)	1997-04-30
DE69004337T2 (de)	1994-02-24
CZ281420B6 (cs)	1996-09-11
IL94466A0 (en)	1991-03-10
HUT55348A (en)	1991-05-28
KR920701131A (ko)	1992-08-11
US5236957A (en)	1993-08-17
NO910270L (no)	1991-01-23

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FR2896798A1 (fr)	2007-08-03	Derives de sulfonamides, leur preparation et leur application en therapeutique
US5446066A (en)	1995-08-29	Substituted (arylalkoxybenzyl)aminopropanamide derivatives and process for their preparation
US5840764A (en)	1998-11-24	Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones
JPH11509848A (ja)	1999-08-31	Ｎ−（４−置換−ベンジル）−２−アミノラクタム誘導体
US5449692A (en)	1995-09-12	Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
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KR20010033998A (ko)	2001-04-25	신경학적 질병 치료용 1,4-디아자시클로헵탄 유도체
FR2717473A1 (fr)	1995-09-22	Dérivés de cyclopropylacétonitrile, leur préparation et leur application comme médicaments.
FR2663329A1 (fr)	1991-12-20	Composes aromatiques amines, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688218A1 (fr)	1993-09-10	Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
IE914126A1 (en)	1992-06-03	Imidazol-2-yl derivatives of substituted bicyclic compounds¹and process for their preparation
FR2654100A1 (fr)	1991-05-10	Arylalkylenediamines, procede pour leur preparation et compositions pharmaceutiques les contenant.
IE841261L (en)	1985-11-21	2-aminotetralins.

Legal Events

Date	Code	Title	Description
1997-01-20	GB	Transfer or assigment of application	Owner name: PHARMACIA & UPJOHN S,P.A.