FI101881B1 - Process for the preparation of 3-aminopyridazine derivatives useful as ligands of acetylcholine-like receptors - Google Patents

Process for the preparation of 3-aminopyridazine derivatives useful as ligands of acetylcholine-like receptors

Info

Publication number: FI101881B1
Authority: FI; Finland
Prior art keywords: acetylcholine; ligands; receptors; preparation; derivatives useful
Prior art date: 1989-11-17

Application number

FI905663A

Other languages

Finnish (fi)

Swedish (sv)

Other versions

FI905663A0 (en

FI905663A (en

FI101881B (en

Inventor

Robert Boigegrain

Roger Brodin

Jean Paul Kan

Dominique Olliero

Camille Georges Wermuth

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-17

Filing date

1990-11-15

Publication date

1998-09-15

1989-11-17 Priority claimed from FR8915137A external-priority patent/FR2654727B1/en

1990-11-15 Application filed by Sanofi Sa filed Critical Sanofi Sa

1990-11-15 Publication of FI905663A0 publication Critical patent/FI905663A0/en

1991-05-18 Publication of FI905663A publication Critical patent/FI905663A/en

1992-06-29 Priority to MX9203714A priority Critical patent/MX9203714A/en

1998-09-15 Application granted granted Critical

1998-09-15 Publication of FI101881B1 publication Critical patent/FI101881B1/en

1998-09-15 Publication of FI101881B publication Critical patent/FI101881B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FI905663A 1989-11-17 1990-11-15 A process for the preparation of 3-aminopyridazine derivatives useful as ligands for acetylcholine-like receptors FI101881B (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
MX9203714A MX9203714A (en)	1989-11-17	1992-06-29	DERIVATIVES OF PIRIDAZINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
FR8915137		1989-11-17
FR8915137A FR2654727B1 (en)	1989-11-17	1989-11-17	PYRIDAZINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
FR9007533		1990-06-15
FR909007533A FR2663326B2 (en)	1989-11-17	1990-06-15	PYRIDAZINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.

Publications (4)

Publication Number	Publication Date
FI905663A0 FI905663A0 (en)	1990-11-15
FI905663A FI905663A (en)	1991-05-18
FI101881B1 true FI101881B1 (en)	1998-09-15
FI101881B FI101881B (en)	1998-09-15

Family

ID=26227673

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI905663A FI101881B (en)	1989-11-17	1990-11-15	A process for the preparation of 3-aminopyridazine derivatives useful as ligands for acetylcholine-like receptors

Country Status (21)

Country	Link
EP (1)	EP0429344B1 (en)
JP (1)	JPH03170465A (en)
KR (1)	KR0164599B1 (en)
AR (1)	AR247557A1 (en)
AT (1)	ATE143010T1 (en)
AU (1)	AU639043B2 (en)
CA (1)	CA2030133A1 (en)
DE (1)	DE69028602T2 (en)
DK (1)	DK0429344T3 (en)
ES (1)	ES2094146T3 (en)
FI (1)	FI101881B (en)
FR (1)	FR2663326B2 (en)
GR (1)	GR3021933T3 (en)
HK (1)	HK1000597A1 (en)
HU (2)	HU207852B (en)
IE (1)	IE75697B1 (en)
IL (1)	IL96384A (en)
LV (1)	LV11972B (en)
NO (1)	NO178967C (en)
NZ (1)	NZ236107A (en)
PT (1)	PT95902B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2665442B1 (en) *	1990-07-31	1992-12-04	Sanofi Sa	ALKYL-6 PYRIDAZINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
FR2676444B1 (en) *	1991-05-16	1995-03-10	Sanofi Elf	NOVEL AMINO-3 PYRIDAZINE DERIVATIVES ACTIVE IN THE CENTRAL NERVOUS SYSTEM, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
KR100443893B1 (en) *	1996-01-15	2004-10-15	얀센 파마슈티카 엔.브이.	Angiogenesis inhibitor pyridazine amine
DK1042293T3 (en) *	1997-12-19	2008-07-14	Amgen Inc	Substituted pyridine and pyridazine compounds and their pharmaceutical use
US6528529B1 (en)	1998-03-31	2003-03-04	Acadia Pharmaceuticals Inc.	Compounds with activity on muscarinic receptors
JP2004532628A (en)	2001-03-23	2004-10-28	アドバンスドバイオニュートリション	Transporting disease control in aquaculture and agriculture using microorganisms containing bioactive proteins
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
US7678363B2 (en)	2005-08-26	2010-03-16	Braincells Inc	Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
WO2007066601A1 (en)	2005-12-07	2007-06-14	Sumitomo Chemical Company, Limited	Pyridazine compound and use thereof
FR2904314A1 (en) *	2006-07-26	2008-02-01	Centre Nat Rech Scient	LINEAR PYRIDAZINIC AND PYRROLIC COMPOUNDS, METHODS OF OBTAINING AND APPLICATIONS
WO2011133920A1 (en)	2010-04-23	2011-10-27	Cytokinetics, Inc.	Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (en)	2010-04-23	2012-08-08	Cytokinetics Inc	AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME
AR081626A1 (en) *	2010-04-23	2012-10-10	Cytokinetics Inc	AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS
AR119731A1 (en)	2019-05-17	2022-01-05	Novartis Ag	NLRP3 INFLAMASOME INHIBITORS
CN115279739A (en) *	2020-03-27	2022-11-01	安斯泰来制药株式会社	Substituted pyridazine compounds
WO2022166890A1 (en) *	2021-02-08	2022-08-11	南京明德新药研发有限公司	Substituted pyridazine phenol derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2510998B1 (en) *	1981-08-07	1986-01-10	Sanofi Sa	NOVEL AMINO DERIVATIVES OF PYRIDAZINE, PROCESS FOR THEIR PREPARATION AND DRINKING ACTS THEREOF
FR2540113A1 (en) *	1983-01-27	1984-08-03	Sanofi Sa	PYRIDAZINE DERIVATIVE ACIDS ACTIVE ON THE CENTRAL NERVOUS SYSTEM
DE3629929A1 (en) *	1986-09-03	1988-03-10	Thomae Gmbh Dr K	NEW SULFONAMIDO-AETHYL COMPOUNDS, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
PT93060B (en) *	1989-02-07	1995-12-29	Sanofi Sa	METHOD FOR OBTAINING PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2642648B1 (en) *	1989-02-07	1991-06-21	Sanofi Sa	USE OF ALKYL-5 PYRIDAZINE DERIVATIVES AS ACTIVE MEDICAMENTS ON THE CHOLINERGIC SYSTEM

1990
- 1990-06-15 FR FR909007533A patent/FR2663326B2/en not_active Expired - Lifetime
- 1990-11-15 PT PT95902A patent/PT95902B/en not_active IP Right Cessation
- 1990-11-15 FI FI905663A patent/FI101881B/en not_active IP Right Cessation
- 1990-11-16 DK DK90403239.8T patent/DK0429344T3/da active
- 1990-11-16 ES ES90403239T patent/ES2094146T3/en not_active Expired - Lifetime
- 1990-11-16 CA CA002030133A patent/CA2030133A1/en active Granted
- 1990-11-16 DE DE69028602T patent/DE69028602T2/en not_active Expired - Fee Related
- 1990-11-16 AU AU66672/90A patent/AU639043B2/en not_active Ceased
- 1990-11-16 AT AT90403239T patent/ATE143010T1/en not_active IP Right Cessation
- 1990-11-16 IE IE414590A patent/IE75697B1/en not_active IP Right Cessation
- 1990-11-16 NO NO904984A patent/NO178967C/en unknown
- 1990-11-16 AR AR90318401A patent/AR247557A1/en active
- 1990-11-16 EP EP90403239A patent/EP0429344B1/en not_active Expired - Lifetime
- 1990-11-16 HU HU907178A patent/HU207852B/en not_active IP Right Cessation
- 1990-11-16 JP JP2312597A patent/JPH03170465A/en active Pending
- 1990-11-16 NZ NZ236107A patent/NZ236107A/en unknown
- 1990-11-17 KR KR1019900018663A patent/KR0164599B1/en not_active IP Right Cessation
- 1990-11-18 IL IL9638490A patent/IL96384A/en not_active IP Right Cessation
1995
- 1995-06-27 HU HU95P/P00450P patent/HU211351A9/en unknown
1996
- 1996-12-06 GR GR960403344T patent/GR3021933T3/en unknown
1997
- 1997-09-10 LV LVP-97-165A patent/LV11972B/en unknown
- 1997-11-10 HK HK97102147A patent/HK1000597A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH03170465A (en)	1991-07-24
FI905663A0 (en)	1990-11-15
DE69028602D1 (en)	1996-10-24
PT95902B (en)	1998-01-30
EP0429344A1 (en)	1991-05-29
NO178967C (en)	1996-07-10
IL96384A (en)	1995-10-31
HUT56078A (en)	1991-07-29
EP0429344B1 (en)	1996-09-18
FI905663A (en)	1991-05-18
PT95902A (en)	1991-09-13
AU6667290A (en)	1991-05-23
CA2030133C (en)	1991-05-18
ES2094146T3 (en)	1997-01-16
CA2030133A1 (en)	1991-05-18
GR3021933T3 (en)	1997-03-31
AU639043B2 (en)	1993-07-15
HU907178D0 (en)	1991-05-28
FR2663326B2 (en)	1992-10-16
NZ236107A (en)	1992-10-28
IE904145A1 (en)	1991-05-22
HK1000597A1 (en)	1998-04-09
IL96384A0 (en)	1991-08-16
HU211351A9 (en)	1995-11-28
AR247557A1 (en)	1995-01-31
HU207852B (en)	1993-06-28
LV11972A (en)	1998-02-20
NO904984L (en)	1991-05-21
KR0164599B1 (en)	1999-01-15
NO904984D0 (en)	1990-11-16
FI101881B (en)	1998-09-15
LV11972B (en)	1998-04-20
KR910009672A (en)	1991-06-28
NO178967B (en)	1996-04-01
DE69028602T2 (en)	1997-04-03
ATE143010T1 (en)	1996-10-15
DK0429344T3 (en)	1997-03-03
IE75697B1 (en)	1997-09-10
FR2663326A2 (en)	1991-12-20

Publication	Publication Date	Title
FI891021A0 (en)	1989-03-03	Process for the preparation of 1,2,4-triazole derivatives useful as a drug
FI890282A (en)	1989-07-21	Process for the Preparation of Therapeutically Useful 23,24-Dide Hydro-25-Hydroxy Ciferol Derivatives
FI103050B1 (en)	1999-04-15	Process for the preparation of a composition containing N, O-sulfated heparosans
FI881103A (en)	1988-09-19	Process for the preparation of benzoxazole derivatives as antidiabetic agents
FI881978A0 (en)	1988-04-27	Process for the preparation of a pharmaceutical composition containing eperison
NO900830D0 (en)	1990-02-21	PROCEDURE FOR THE PREPARATION OF PIPERIDE COMPOUNDS.
FI101881B1 (en)	1998-09-15	Process for the preparation of 3-aminopyridazine derivatives useful as ligands of acetylcholine-like receptors
NO890269D0 (en)	1989-01-20	PROCEDURE FOR THE PREPARATION OF 1,4-DISUBSTITUTED-PIPERIDINYL COMPOUNDS.
KR950010075B1 (en)	1995-09-06	Process for the preparation of 1,2,3,6-tetrahydro-5-nitro-pyrimidine derivatives
FI104171B1 (en)	1999-11-30	Process for the preparation of mono-N-alkylated polyazamacrocyclic compounds
FI902316A0 (en)	1990-05-09	Process for the preparation of therapeutically-substituted dihydropyrrolizine compounds
NO892204D0 (en)	1989-05-31	PROCEDURE FOR THE PREPARATION OF IMIDAZOKINOXALIN COMPOUNDS.
DK0417680T3 (en)	1993-04-19	Process for the preparation of 1,1,1,2-tetrafluoroethane
FI93107B (en)	1994-11-15	Process for the preparation of 2-imino-6-polyfluoroalkoxybenzothiazole derivatives useful as a drug
IS3589A7 (en)	1990-12-23	Process for the preparation of the compound Indenoindoles I
FI895662A0 (en)	1989-11-27	Process for the preparation of 3,4-difluoro-substituted benzene
FI901606A0 (en)	1990-03-30	Process for the preparation of sulfonyl derivatives of thieno-trizolidodiazepines
FI973644A (en)	1997-09-09	New process for the preparation of 2,3-dihydrobenzofuranol derivatives
FI900145A0 (en)	1990-01-11	Process for the Preparation of Pharmaceutically Useful 1,1-Dioxocephem-4-Carbothiol Acid Derivatives
NO841965L (en)	1984-11-19	PROCEDURE FOR PREPARING 1,8-DIHYDROXY-10-ACYL-9-ANTRON DERIVATIVES
FI891111A0 (en)	1989-03-08	Process for the preparation of 1,4-dihydropyridine derivatives
FI943833A (en)	1994-08-19	Process for the preparation of 2,3,5,6-tetrachloropyridine
FI892144A0 (en)	1989-05-04	Process for the preparation of 5-C-hydroxymethylaldohexose-based compounds
NO903666D0 (en)	1990-08-21	PROCEDURE FOR THE PREPARATION OF PYRROLOKINOL COMPOUNDS.
NO900969D0 (en)	1990-03-01	PROCEDURE FOR THE PREPARATION OF ANILIN DERIVATIVES.

Legal Events

Date	Code	Title	Description
1990-11-15	FG	Patent granted	Owner name: SANOFI
2004-08-31	MM	Patent lapsed	Owner name: SANOFI