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ES8802388A1 - Substituted azabicycloheptanes, their use, pharmaceutical compositions comprising them and process for the preparation of the compounds. - Google Patents

Substituted azabicycloheptanes, their use, pharmaceutical compositions comprising them and process for the preparation of the compounds.

Info

Publication number
ES8802388A1
ES8802388A1 ES557122A ES557122A ES8802388A1 ES 8802388 A1 ES8802388 A1 ES 8802388A1 ES 557122 A ES557122 A ES 557122A ES 557122 A ES557122 A ES 557122A ES 8802388 A1 ES8802388 A1 ES 8802388A1
Authority
ES
Spain
Prior art keywords
represents hydrogen
compounds
substituted
lower alkyl
azabicycloheptanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557122A
Other languages
Spanish (es)
Other versions
ES557122A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8802388A1 publication Critical patent/ES8802388A1/en
Publication of ES557122A0 publication Critical patent/ES557122A0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)

Abstract

1-phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula < IMAGE > (I) in which R1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R2 represents hydrogen, lower alkyl, sulpho or acyl, R3 represents hydrogen or lower alkyl and R4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by -N(R2)(R3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.
ES557122A 1984-06-20 1986-10-01 Substituted azabicycloheptanes, their use, pharmaceutical compositions comprising them and process for the preparation of the compounds. Expired ES8802388A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH298784 1984-06-20

Publications (2)

Publication Number Publication Date
ES8802388A1 true ES8802388A1 (en) 1988-05-16
ES557122A0 ES557122A0 (en) 1988-05-16

Family

ID=4246108

Family Applications (4)

Application Number Title Priority Date Filing Date
ES544319A Expired ES8801261A1 (en) 1984-06-20 1985-06-18 Substituted azabicycloheptanes, their use, pharmaceutical compositions comprising them and process for the preparation of the compounds.
ES557122A Expired ES8802388A1 (en) 1984-06-20 1986-10-01 Substituted azabicycloheptanes, their use, pharmaceutical compositions comprising them and process for the preparation of the compounds.
ES557123A Expired ES8801278A1 (en) 1984-06-20 1986-10-01 Substituted azabicycloheptanes, their use, pharmaceutical compositions comprising them and process for the preparation of the compounds.
ES557121A Expired ES8801214A1 (en) 1984-06-20 1986-10-01 Substituted azabicycloheptanes, their use, pharmaceutical compositions comprising them and process for the preparation of the compounds.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES544319A Expired ES8801261A1 (en) 1984-06-20 1985-06-18 Substituted azabicycloheptanes, their use, pharmaceutical compositions comprising them and process for the preparation of the compounds.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557123A Expired ES8801278A1 (en) 1984-06-20 1986-10-01 Substituted azabicycloheptanes, their use, pharmaceutical compositions comprising them and process for the preparation of the compounds.
ES557121A Expired ES8801214A1 (en) 1984-06-20 1986-10-01 Substituted azabicycloheptanes, their use, pharmaceutical compositions comprising them and process for the preparation of the compounds.

Country Status (20)

Country Link
US (3) US4677129A (en)
EP (1) EP0166692B1 (en)
JP (1) JPH0625127B2 (en)
KR (1) KR920005494B1 (en)
AT (1) ATE54446T1 (en)
AU (1) AU584098B2 (en)
DD (2) DD234419A5 (en)
DE (1) DE3578608D1 (en)
DK (1) DK164052C (en)
ES (4) ES8801261A1 (en)
FI (1) FI83214C (en)
GR (1) GR851498B (en)
HU (2) HU194180B (en)
IE (1) IE58069B1 (en)
IL (1) IL75545A0 (en)
NO (1) NO166444C (en)
NZ (1) NZ212482A (en)
PH (1) PH21957A (en)
PT (1) PT80659B (en)
ZA (1) ZA854613B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0114033B1 (en) * 1982-12-21 1988-10-12 Ciba-Geigy Ag Substituted azabicycloalkanes, their use, pharmaceutical preparations containing these compounds and process for preparing these compounds
ATE54446T1 (en) * 1984-06-20 1990-07-15 Ciba Geigy Ag SUBSTITUTED AZABICYCLOHEPTANS, THEIR USE, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF THESE COMPOUNDS.
US4883877A (en) * 1987-11-13 1989-11-28 Ciba-Geigy Corporation Azabicycloheptanes and process for their preparation
DE3843481A1 (en) * 1988-12-23 1990-06-28 Boehringer Ingelheim Kg SUBSTITUTED 3-AZABICYCLO / 3.1.1 / HEPTANESE, THEIR PREPARATION AND THEIR USE
CH683151A5 (en) * 1991-04-24 1994-01-31 Ciba Geigy Ag Contraception in female primates without affecting the menstrual cycle.
DE69230566T2 (en) 1991-05-14 2000-06-15 Seiko Epson Corp., Tokio/Tokyo Imaging device

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE548074A (en) *
US2673205A (en) * 1951-02-13 1954-03-23 Ciba Pharm Prod Inc 3-disubstituted dioxopiperidines and the manufacture thereof
DE1088957B (en) * 1955-07-18 1960-09-15 Ciba Geigy Process for the preparation of ª ‡ - (p-Amino-phenyl) -ª ‡ -alkyl-glutarimides
US2848455A (en) * 1955-07-18 1958-08-19 Ciba Pharm Prod Inc Alpha-(p-amino-phenyl)-alpha-lower alkyl glutarimides
GB1015618A (en) * 1962-04-10 1966-01-05 Aspro Nicholas Ltd Glutarimide therapeutic compositions
DE1299617B (en) * 1965-01-13 1969-07-24 Degussa Process for the manufacture of finely divided precipitated silica
US4231935A (en) * 1975-07-31 1980-11-04 American Cyanamid Company 1-Phenyl-3-azabicyclo[3.1.0]hexanes
US4131611A (en) * 1975-07-31 1978-12-26 American Cyanamid Company Azabicyclohexanes
US4435419A (en) * 1981-07-01 1984-03-06 American Cyanamid Company Method of treating depression using azabicyclohexanes
EP0114033B1 (en) * 1982-12-21 1988-10-12 Ciba-Geigy Ag Substituted azabicycloalkanes, their use, pharmaceutical preparations containing these compounds and process for preparing these compounds
ATE54446T1 (en) * 1984-06-20 1990-07-15 Ciba Geigy Ag SUBSTITUTED AZABICYCLOHEPTANS, THEIR USE, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF THESE COMPOUNDS.

Also Published As

Publication number Publication date
NO852478L (en) 1985-12-23
FI83214B (en) 1991-02-28
ES544319A0 (en) 1987-12-16
ES8801214A1 (en) 1988-01-01
PT80659B (en) 1987-05-04
ES8801261A1 (en) 1987-12-16
DK277485A (en) 1985-12-21
IL75545A0 (en) 1985-10-31
KR860000265A (en) 1986-01-27
NO166444B (en) 1991-04-15
IE58069B1 (en) 1993-06-30
HUT38346A (en) 1986-05-28
ATE54446T1 (en) 1990-07-15
HU192231B (en) 1987-05-28
FI83214C (en) 1991-06-10
PT80659A (en) 1985-07-01
FI852429L (en) 1985-12-21
DD234419A5 (en) 1986-04-02
DK164052B (en) 1992-05-04
JPS6112666A (en) 1986-01-21
EP0166692B1 (en) 1990-07-11
PH21957A (en) 1988-04-15
AU584098B2 (en) 1989-05-18
NO166444C (en) 1991-08-07
HU194180B (en) 1988-01-28
KR920005494B1 (en) 1992-07-06
JPH0625127B2 (en) 1994-04-06
ES557123A0 (en) 1987-12-16
DK164052C (en) 1992-09-28
DK277485D0 (en) 1985-06-19
DE3578608D1 (en) 1990-08-16
EP0166692A2 (en) 1986-01-02
ES557121A0 (en) 1988-01-01
FI852429A0 (en) 1985-06-19
AU4385885A (en) 1986-01-02
ES8801278A1 (en) 1987-12-16
DD245871A5 (en) 1987-05-20
IE851519L (en) 1985-12-20
ZA854613B (en) 1986-02-26
GR851498B (en) 1985-11-25
US4764640A (en) 1988-08-16
ES557122A0 (en) 1988-05-16
EP0166692A3 (en) 1986-11-12
NZ212482A (en) 1988-08-30
US4677129A (en) 1987-06-30
US4857660A (en) 1989-08-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401