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ES8801783A1 - Phenethanolamine derivatives - Google Patents

Phenethanolamine derivatives

Info

Publication number
ES8801783A1
ES8801783A1 ES552097A ES552097A ES8801783A1 ES 8801783 A1 ES8801783 A1 ES 8801783A1 ES 552097 A ES552097 A ES 552097A ES 552097 A ES552097 A ES 552097A ES 8801783 A1 ES8801783 A1 ES 8801783A1
Authority
ES
Spain
Prior art keywords
compounds
image
general formula
hydrogen atom
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552097A
Other languages
Spanish (es)
Other versions
ES552097A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8801783A1 publication Critical patent/ES8801783A1/en
Publication of ES552097A0 publication Critical patent/ES552097A0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compounds of the general formula (I> < IMAGE > (wherein R represents a hydrogen atom or a straight chain C1-3 alkyl group and n is 1 or 2, and physiologically acceptable acid addition salts, solvates and metabolically labile esters thereof) of use in the treatment of heart failure, cardiogenic shock or ischaemic heart disease. Also disclosed are compounds of general formula (XV> < IMAGE > (wherein n is 1 or 2, R<2>, R<3>, R<4> and R<5> each represent a hydrogen atom or a protecting group and R<8> represents a carboxyl group, or a salt or C1-5 alkyl ester thereof) which are of value as intermediates.
ES552097A 1984-08-09 1986-02-17 Phenethanolamine derivatives Expired ES8801783A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848420303A GB8420303D0 (en) 1984-08-09 1984-08-09 Chemical compounds

Publications (2)

Publication Number Publication Date
ES8801783A1 true ES8801783A1 (en) 1988-02-16
ES552097A0 ES552097A0 (en) 1988-02-16

Family

ID=10565130

Family Applications (5)

Application Number Title Priority Date Filing Date
ES546010A Expired ES8703829A1 (en) 1984-08-09 1985-08-08 Phenethanolamine derivatives
ES552097A Expired ES8801783A1 (en) 1984-08-09 1986-02-17 Phenethanolamine derivatives
ES557415A Expired ES8802488A1 (en) 1984-08-09 1987-02-16 Phenethanolamine derivatives
ES557414A Expired ES8802487A1 (en) 1984-08-09 1987-02-16 Phenethanolamine derivatives
ES557416A Expired ES8801784A1 (en) 1984-08-09 1987-02-16 Phenethanolamine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES546010A Expired ES8703829A1 (en) 1984-08-09 1985-08-08 Phenethanolamine derivatives

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES557415A Expired ES8802488A1 (en) 1984-08-09 1987-02-16 Phenethanolamine derivatives
ES557414A Expired ES8802487A1 (en) 1984-08-09 1987-02-16 Phenethanolamine derivatives
ES557416A Expired ES8801784A1 (en) 1984-08-09 1987-02-16 Phenethanolamine derivatives

Country Status (24)

Country Link
JP (1) JPS6183154A (en)
KR (1) KR860001783A (en)
AU (1) AU4590885A (en)
BE (1) BE903041A (en)
CH (1) CH667870A5 (en)
DE (1) DE3528700A1 (en)
DK (1) DK364185A (en)
ES (5) ES8703829A1 (en)
FI (1) FI853057L (en)
FR (1) FR2568874B1 (en)
GB (2) GB8420303D0 (en)
GR (1) GR851949B (en)
HU (1) HU196171B (en)
IL (1) IL76062A (en)
IT (1) IT1184685B (en)
LU (1) LU86038A1 (en)
MY (1) MY102187A (en)
NL (1) NL8502212A (en)
NO (1) NO853151L (en)
NZ (1) NZ213055A (en)
PH (1) PH21664A (en)
PT (1) PT80936B (en)
SE (1) SE8503763L (en)
ZA (1) ZA856021B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1165845A (en) * 1955-05-28 1958-10-29 Philips Nv Secondary amines bearing substituents and their preparation
EP0021636B1 (en) * 1979-06-16 1982-12-01 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions

Also Published As

Publication number Publication date
IL76062A0 (en) 1985-12-31
ES557414A0 (en) 1988-07-01
MY102187A (en) 1992-04-30
FI853057L (en) 1986-02-10
GB8520111D0 (en) 1985-09-18
ES8802487A1 (en) 1988-07-01
IT1184685B (en) 1987-10-28
NL8502212A (en) 1986-03-03
NZ213055A (en) 1988-11-29
FR2568874A1 (en) 1986-02-14
IL76062A (en) 1989-07-31
SE8503763D0 (en) 1985-08-09
GB8420303D0 (en) 1984-09-12
GB2162845A (en) 1986-02-12
FI853057A0 (en) 1985-08-09
HUT39149A (en) 1986-08-28
NO853151L (en) 1986-02-10
ZA856021B (en) 1986-05-28
CH667870A5 (en) 1988-11-15
GB2162845B (en) 1988-06-08
KR860001783A (en) 1986-03-22
BE903041A (en) 1986-02-10
LU86038A1 (en) 1986-09-11
SE8503763L (en) 1986-02-10
ES552097A0 (en) 1988-02-16
DK364185A (en) 1986-02-10
ES557416A0 (en) 1988-02-16
PT80936A (en) 1985-09-01
ES8703829A1 (en) 1987-03-01
ES8802488A1 (en) 1988-07-01
DE3528700A1 (en) 1986-03-06
DK364185D0 (en) 1985-08-09
ES8801784A1 (en) 1988-02-16
JPS6183154A (en) 1986-04-26
AU4590885A (en) 1986-02-13
ES557415A0 (en) 1988-07-01
IT8548467A0 (en) 1985-08-09
PT80936B (en) 1987-06-02
GR851949B (en) 1985-12-11
HU196171B (en) 1988-10-28
FR2568874B1 (en) 1988-09-09
ES546010A0 (en) 1987-03-01
PH21664A (en) 1988-01-13

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