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ES8801624A1 - Procedimiento para preparar disulfuros heterociclicos - Google Patents

Procedimiento para preparar disulfuros heterociclicos

Info

Publication number
ES8801624A1
ES8801624A1 ES557614A ES557614A ES8801624A1 ES 8801624 A1 ES8801624 A1 ES 8801624A1 ES 557614 A ES557614 A ES 557614A ES 557614 A ES557614 A ES 557614A ES 8801624 A1 ES8801624 A1 ES 8801624A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical preparations
preparations containing
heterocyclic disulfides
disulfides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557614A
Other languages
English (en)
Other versions
ES557614A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES557614A0 publication Critical patent/ES557614A0/es
Publication of ES8801624A1 publication Critical patent/ES8801624A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DISULFUROS HETEROCICLICOS, DE FORMULA GENERAL (I). CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE HETK REPRESENTA UN HETEROCICLO DE 5 MIEMBROS, EVENTUALMENTE SUSTITUIDO, CON UN ATOMO DE AZUFRE Y CON 1 A 2 ATOMOS DE NITROGENO O CON 1 A 3 ATOMOS DE NITROGENO, PUDIENDO ESTOS HETEROCICLOS TAMBIEN ESTAR CONDENSADOS CON BENZO; Y X REPRESENTA UN GRUPO REACTIVO, FACILMENTE SEPARABLE, CON ME2S2, REPRESENTANDO ME UN METAL ALCALINO. DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA DE INMUNIDAD.
ES557614A 1985-03-12 1987-07-07 Procedimiento para preparar disulfuros heterociclicos Expired ES8801624A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853508666 DE3508666A1 (de) 1985-03-12 1985-03-12 Heterocyclische disulfide und ihre anwendung als immunmodulatoren

Publications (2)

Publication Number Publication Date
ES557614A0 ES557614A0 (es) 1988-02-16
ES8801624A1 true ES8801624A1 (es) 1988-02-16

Family

ID=6264871

Family Applications (3)

Application Number Title Priority Date Filing Date
ES552840A Expired ES8801506A1 (es) 1985-03-12 1986-03-10 Procedimiento para preparar disulfuros heterociclicos
ES557614A Expired ES8801624A1 (es) 1985-03-12 1987-07-07 Procedimiento para preparar disulfuros heterociclicos
ES557615A Expired ES8801625A1 (es) 1985-03-12 1987-07-07 Procedimiento para preparar disulfuros heterociclicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES552840A Expired ES8801506A1 (es) 1985-03-12 1986-03-10 Procedimiento para preparar disulfuros heterociclicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557615A Expired ES8801625A1 (es) 1985-03-12 1987-07-07 Procedimiento para preparar disulfuros heterociclicos

Country Status (19)

Country Link
EP (1) EP0194571B1 (es)
JP (1) JPH0751572B2 (es)
KR (1) KR940001773B1 (es)
AR (1) AR245113A1 (es)
AT (1) ATE58293T1 (es)
AU (1) AU594943B2 (es)
DE (2) DE3508666A1 (es)
DK (1) DK165181C (es)
ES (3) ES8801506A1 (es)
FI (1) FI860980A (es)
GR (1) GR860649B (es)
HU (1) HU201742B (es)
IE (1) IE58729B1 (es)
IL (1) IL78091A (es)
NO (1) NO168357C (es)
NZ (1) NZ215424A (es)
PH (1) PH22275A (es)
PT (1) PT82166B (es)
ZA (1) ZA861780B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3915094A1 (de) 1989-05-09 1991-01-10 Hoechst Ag Verfahren zur herstellung von 2-mercapto-4-methyl-1,3-thiazol-5-yl-essigsaeure und deren ester
TW252112B (es) * 1993-08-19 1995-07-21 Pfizer
DE10055219A1 (de) 2000-11-08 2002-05-29 Bayer Ag Verfahren zur Herstellung von Dithiazolyldisulfiden
US8163776B2 (en) 2001-01-10 2012-04-24 Grassetti Family Trust Method of immunomodulation using thione-forming disulfides
DE102005004472A1 (de) * 2005-01-31 2006-08-10 Rhein Chemie Rheinau Gmbh Verfahren zur Herstellung von Bis-DMTD

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5680M (es) * 1966-08-19 1968-01-08
IL36587A (en) * 1970-05-05 1977-10-31 Grassetti D Compositions containing pyridine derivatives and their use in a method of modifying cellular surface reactions
US4378364A (en) * 1970-05-05 1983-03-29 Grassetti Davide R Postoperative treatment of carcinoma patients
GB1365943A (en) * 1970-09-16 1974-09-04 Gaf Corp Metalworking additive and composition and process for making the same
GB1327467A (en) * 1970-10-12 1973-08-22 Merck & Co Inc Pharmaceutical compositions for inhibiting indoleamine- n-methyl transferase
FR2403798A1 (fr) * 1977-09-22 1979-04-20 Rorer Inc William H Compositions synergiques a base de disulfure de bis(2-pyridyl-1-oxyde et leur utilisation pour leur activite anti-inflammatoire
US4152439A (en) * 1978-01-12 1979-05-01 Davide R. Grassetti Stimulant and antidepressant agents
DE2944225A1 (de) * 1979-11-02 1981-05-07 Akzo Gmbh, 5600 Wuppertal Verfahren zur herstellung von dithiazoldisulfiden
US4451471A (en) * 1981-03-18 1984-05-29 Ciba-Geigy Corporation Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same
DE3118128A1 (de) * 1981-05-07 1982-12-02 Bayer Ag, 5090 Leverkusen Verwendung von disulfiden als lipoxygenasehemmer und diese enthaltende arzneimittel
EP0077630B1 (en) * 1981-10-21 1985-04-17 Beecham Group Plc Topical antimicrobial compositions
HU193951B (en) * 1985-03-11 1987-12-28 Richter Gedeon Vegyeszet Process for producing new sulfur-containing 5-substituted benzimidazol derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
GR860649B (en) 1986-07-11
ATE58293T1 (de) 1990-11-15
KR940001773B1 (ko) 1994-03-05
FI860980A0 (fi) 1986-03-10
AU5460586A (en) 1986-10-16
NZ215424A (en) 1989-04-26
EP0194571A1 (de) 1986-09-17
ES8801506A1 (es) 1988-01-16
KR860007246A (ko) 1986-10-10
ES557615A0 (es) 1988-02-16
IL78091A (en) 1990-04-29
DE3675561D1 (de) 1990-12-20
PH22275A (en) 1988-07-14
JPS61207331A (ja) 1986-09-13
DE3508666A1 (de) 1986-09-18
JPH0751572B2 (ja) 1995-06-05
FI860980A (fi) 1986-09-13
IE860630L (en) 1986-09-12
ES552840A0 (es) 1988-01-16
AR245113A1 (es) 1993-12-30
IE58729B1 (en) 1993-11-03
NO168357B (no) 1991-11-04
PT82166A (de) 1986-04-01
DK108786A (da) 1986-09-13
HU201742B (en) 1990-12-28
ZA861780B (en) 1986-10-29
DK165181B (da) 1992-10-19
ES557614A0 (es) 1988-02-16
ES8801625A1 (es) 1988-02-16
AU594943B2 (en) 1990-03-22
PT82166B (pt) 1988-07-29
IL78091A0 (en) 1986-07-31
DK108786D0 (da) 1986-03-10
NO168357C (no) 1992-02-12
EP0194571B1 (de) 1990-11-14
NO860908L (no) 1986-09-15
DK165181C (da) 1993-03-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301