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ES8800161A1 - Procedimiento para la fabricacion de derivados quinolilglicinamidas - Google Patents

Procedimiento para la fabricacion de derivados quinolilglicinamidas

Info

Publication number
ES8800161A1
ES8800161A1 ES554305A ES554305A ES8800161A1 ES 8800161 A1 ES8800161 A1 ES 8800161A1 ES 554305 A ES554305 A ES 554305A ES 554305 A ES554305 A ES 554305A ES 8800161 A1 ES8800161 A1 ES 8800161A1
Authority
ES
Spain
Prior art keywords
psychotropes
quinolyl
preparation
pharmaceutical use
glycinamide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554305A
Other languages
English (en)
Other versions
ES554305A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8800161A1 publication Critical patent/ES8800161A1/es
Publication of ES554305A0 publication Critical patent/ES554305A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE QUINOLILGLICINAMIDAS, DE FORMULA (I), Y DE SUS SALS FISIOLOGICAMENTE COMPATIBLES. COMPRENDE LA REACCION DE CONDENSACION DE UN DERIVADO DE GLICINA DE FORMULA (II) CON UNA CLORO-4-QUINOLEINA, DE FORMULA (III), PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LA QUE X Y R1-R4 PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA COMPRENDIDA ENTRE 60GC Y 130GC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS ACTIVIDADES PSICOTROPICAS. *FORMULA* H
ES554305A 1985-05-06 1986-04-24 Procedimiento para la fabricacion de derivados quinolilglicinamidas Expired ES8800161A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8507247A FR2581382B1 (fr) 1985-05-06 1985-05-06 Derives n-(quinolyl) glycinamides, leur procede de preparation et leur application therapeutique en tant que psychotropes

Publications (2)

Publication Number Publication Date
ES8800161A1 true ES8800161A1 (es) 1987-11-16
ES554305A0 ES554305A0 (es) 1987-11-16

Family

ID=9319228

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554305A Expired ES8800161A1 (es) 1985-05-06 1986-04-24 Procedimiento para la fabricacion de derivados quinolilglicinamidas

Country Status (16)

Country Link
US (1) US4788188A (es)
EP (1) EP0205362B1 (es)
JP (1) JPH0739395B2 (es)
KR (1) KR860008982A (es)
AT (1) ATE48835T1 (es)
AU (1) AU582235B2 (es)
CA (1) CA1263957A (es)
DE (1) DE3667660D1 (es)
DK (1) DK204686A (es)
ES (1) ES8800161A1 (es)
FR (1) FR2581382B1 (es)
GR (1) GR861169B (es)
IL (1) IL78691A (es)
NZ (1) NZ216048A (es)
PT (1) PT82512B (es)
ZA (1) ZA863382B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8610980D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
DK273689A (da) * 1988-06-06 1989-12-07 Sanofi Sa 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler
FR2632305B1 (fr) * 1988-06-06 1992-05-15 Sanofi Sa Amino-4 aroyl-3 quinoleines et naphtyridines, leur procede de preparation et leur application en therapeutique
FR2632861B1 (fr) * 1988-06-15 1990-11-09 Sanofi Sa Derives d'amino-4 carboxy-3 quinoleines et naphtyridines, leur procede de preparation et leur application comme medicaments
FR2632639B1 (fr) * 1988-06-09 1990-10-05 Sanofi Sa Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent
US5493027A (en) * 1993-01-22 1996-02-20 Board Of Regents, The University Of Texas System Anticonvulsive agents and uses thereof
US5783700A (en) * 1997-07-03 1998-07-21 Nichols; Alfred C. Quinolic acid derivatives
DE19960924C2 (de) * 1999-12-17 2002-08-01 Therapeutics Gmbh G.O.T. Amphiphile Polyamine, deren Anwendungen
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CA2608144C (en) 2005-04-28 2012-11-13 Proteus Biomedical, Inc. Pharma-informatics system
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
ES2728225T3 (es) 2009-02-20 2019-10-23 2 Bbb Medicines B V Sistema de administración de fármacos a base de glutatión
CA2760945A1 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2456911A (en) * 1945-05-04 1948-12-21 Wyeth Corp Disubstituted acetamidyl derivatives of amino quinolines
US3470186A (en) * 1967-06-02 1969-09-30 American Cyanamid Co Substituted 4-anilino-3-quinolinecarboxylic acids and esters
GB1177548A (en) * 1967-11-28 1970-01-14 Ici Ltd Phenoxy-and Anilino-Alkanoic Acid Amides
FR8491M (es) * 1968-12-31 1973-07-27
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds

Also Published As

Publication number Publication date
PT82512B (pt) 1988-03-03
US4788188A (en) 1988-11-29
IL78691A0 (en) 1986-08-31
PT82512A (fr) 1986-06-01
IL78691A (en) 1989-09-28
DK204686D0 (da) 1986-05-02
GR861169B (en) 1986-09-01
KR860008982A (ko) 1986-12-19
JPS6226271A (ja) 1987-02-04
EP0205362A1 (fr) 1986-12-17
ATE48835T1 (de) 1990-01-15
FR2581382B1 (fr) 1987-06-26
DK204686A (da) 1986-11-07
JPH0739395B2 (ja) 1995-05-01
DE3667660D1 (de) 1990-01-25
AU582235B2 (en) 1989-03-16
CA1263957A (fr) 1989-12-19
AU5714286A (en) 1987-11-12
FR2581382A1 (fr) 1986-11-07
ES554305A0 (es) 1987-11-16
EP0205362B1 (fr) 1989-12-20
ZA863382B (en) 1987-01-28
NZ216048A (en) 1988-09-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303