ES8707489A1 - Un procedimiento para preparar un derivado de carbaciclina - Google Patents
Un procedimiento para preparar un derivado de carbaciclinaInfo
- Publication number
- ES8707489A1 ES8707489A1 ES553166A ES553166A ES8707489A1 ES 8707489 A1 ES8707489 A1 ES 8707489A1 ES 553166 A ES553166 A ES 553166A ES 553166 A ES553166 A ES 553166A ES 8707489 A1 ES8707489 A1 ES 8707489A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- hydrogen atom
- carbacyclin derivatives
- methyl
- carbacyclin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XZFRIPGNUQRGPI-WLPVIMDJSA-N Carbacyclin Chemical class C1\C(=C\CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WLPVIMDJSA-N 0.000 title abstract 2
- -1 4-pentenyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004975 3-butenyl group Chemical group C(CC=C)* 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
- C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
- C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
- C07C13/36—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with a bicyclo ring system containing five carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE CARBACICLINA, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), CON UN REACTIVO WITTIG DE FORMULA GENERAL (III), EN LAS QUE R1 SIGNIFICA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO DE 1 A 10 ATOMOS DE CARBONO; R2 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO METILO; R3 ES UN GRUPO 3-BUTENILO; R4 Y R5 REPRESENTAN CADA UNO DE ELLOS UN ATOMO DE HIDROGENO O UN GRUPO PROTECTOR DE HIDROXILO; Y R7 REPRESENTA UN GRUPO ALQUILO C1-4. DICHA REACCION SE EFECTUA EN UN DISOLVENTE INERTE TAL COMO EL ETER, UN HIDROCARBURO AROMATICO O UN SULFOXIDO. DE APLICACION EN MEDICINA POR SU ACTIVIDAD ANTIULCEROSA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5530585 | 1985-03-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8707489A1 true ES8707489A1 (es) | 1987-08-01 |
ES553166A0 ES553166A0 (es) | 1987-08-01 |
Family
ID=12994853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES553166A Expired ES8707489A1 (es) | 1985-03-19 | 1986-03-19 | Un procedimiento para preparar un derivado de carbaciclina |
Country Status (8)
Country | Link |
---|---|
US (1) | US4757087A (es) |
EP (1) | EP0195668B1 (es) |
JP (1) | JPS6216A (es) |
KR (1) | KR890003841B1 (es) |
AT (1) | ATE63537T1 (es) |
CA (1) | CA1251202A (es) |
DE (1) | DE3679224D1 (es) |
ES (1) | ES8707489A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4576102A (en) * | 1983-09-02 | 1986-03-18 | Waste-Tech Services, Inc. | Removal of tramp material from fluid bed vessels |
US4553487A (en) * | 1983-09-02 | 1985-11-19 | Waste-Tech Services, Inc. | Removal of tramp material from fluid bed vessels |
DE3608088C2 (de) * | 1986-03-07 | 1995-11-16 | Schering Ag | Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5495552A (en) * | 1978-01-06 | 1979-07-28 | Sankyo Co Ltd | Prostacyline derivative and its preparation |
GB2038333B (en) * | 1978-01-26 | 1982-10-06 | Erba Farmitalia | 12 -formyl- (20 12)octanor-9-deoxy-9 -methylene pgi derivatives |
US4238414A (en) * | 1978-02-13 | 1980-12-09 | The Upjohn Company | 2-Decarboxy-2-aminomethyl-6a-carba-PGI2 compounds |
DE2845770A1 (de) * | 1978-10-19 | 1980-04-30 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
US4338457A (en) * | 1980-02-28 | 1982-07-06 | The Upjohn Company | Composition and process |
US4628110A (en) * | 1982-02-16 | 1986-12-09 | The Upjohn Company | Novel 9-substituted carbacyclin analogs |
-
1986
- 1986-03-18 JP JP61059996A patent/JPS6216A/ja active Granted
- 1986-03-18 US US06/840,920 patent/US4757087A/en not_active Expired - Fee Related
- 1986-03-19 AT AT86302037T patent/ATE63537T1/de not_active IP Right Cessation
- 1986-03-19 CA CA000504492A patent/CA1251202A/en not_active Expired
- 1986-03-19 ES ES553166A patent/ES8707489A1/es not_active Expired
- 1986-03-19 EP EP86302037A patent/EP0195668B1/en not_active Expired - Lifetime
- 1986-03-19 KR KR1019860002033A patent/KR890003841B1/ko not_active IP Right Cessation
- 1986-03-19 DE DE8686302037T patent/DE3679224D1/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE3679224D1 (de) | 1991-06-20 |
EP0195668B1 (en) | 1991-05-15 |
US4757087A (en) | 1988-07-12 |
EP0195668A2 (en) | 1986-09-24 |
CA1251202A (en) | 1989-03-14 |
KR890003841B1 (ko) | 1989-10-05 |
JPH0584295B2 (es) | 1993-12-01 |
EP0195668A3 (en) | 1987-09-30 |
ES553166A0 (es) | 1987-08-01 |
JPS6216A (ja) | 1987-01-06 |
KR860007280A (ko) | 1986-10-10 |
ATE63537T1 (de) | 1991-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU556348B2 (en) | 5,6,7-trinor-4,8-inter-m-phenylene prostaglandin i2 derivatives | |
ES8605506A1 (es) | Procedimiento para preparar derivados de piperidina | |
NO860424L (no) | Fremgangsmaate ved fremstilling av 6-thioxanthinderivater. | |
WO1988000042A1 (en) | New 5-alkoxy-2,4-diamino-alkyl benzols, and hair tinting means using them | |
ES8503667A1 (es) | Un procedimiento para la preparacion de nuevos derivados de 2-oxo-imidazolina. | |
IE820401L (en) | N-£4-(indolyl)-piperidino-alkyl|-benzimidazolines | |
AU553840B2 (en) | Octahydrobenzo(f)quinoline compounds | |
ES8304567A1 (es) | "un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida". | |
ES8505518A1 (es) | Procedimiento para preparar derivados de aminoacidos | |
IE790630L (en) | 2, 6-dialkoxybenzamido-pyrrolidines. | |
ES481551A1 (es) | Procedimiento de preparacion de nuevos compuestos bis (ari- loxicarboxilicos). | |
DE3266845D1 (en) | Hydrocortisone derivatives, their preparation and their utilization | |
IE790996L (en) | Phenylaminothiophene derivatives | |
ES8707489A1 (es) | Un procedimiento para preparar un derivado de carbaciclina | |
ATE29721T1 (de) | 5-(4-vinyl- oder 4-ethynylbenzoyl)-1,2-dihydro-3h-pyrrolo-(1,2-a -pyrrol-1-carbosaeure und deren derivate. | |
ES8401761A1 (es) | Un procedimiento para la preparacion de derivados de 1-(3,4,5-trimetoxicinamoil)-4-aminocarboniletil-piperazina sustituidos. | |
AU559732B2 (en) | Di-and-tetrahydroguinolylacetic acid esters | |
IE811212L (en) | Substituted phenoxy-aminopropanol derivatives | |
AU557880B2 (en) | Method for modulating the immune response with dibenzocycloheptenylidenes | |
GB1509853A (en) | 4-amino-3-hydroxy-6-nitrobenzo-pyrans | |
NO855383L (no) | Fremgangsmaate for fremstilling av piperazin-derivater. | |
ES8504772A1 (es) | Un procedimiento para preparar un compuesto de 7-(4-piridil)-1,8-naftiridina. | |
ES459705A1 (es) | Procedimiento para la preparacion de derivados de hidracina-piridacina. | |
IE790924L (en) | 1,3-benzodioxin derivatives | |
IE41906L (en) | But-2-enoanilides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19971001 |