ES8705436A1 - Un procedimiento para la obtencion de derivados de bi- y triciclicosdde piridona - Google Patents
Un procedimiento para la obtencion de derivados de bi- y triciclicosdde piridonaInfo
- Publication number
- ES8705436A1 ES8705436A1 ES548532A ES548532A ES8705436A1 ES 8705436 A1 ES8705436 A1 ES 8705436A1 ES 548532 A ES548532 A ES 548532A ES 548532 A ES548532 A ES 548532A ES 8705436 A1 ES8705436 A1 ES 8705436A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- procedure
- piridona
- obtaining
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical class N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA OBTENER DERIVADOS BI- Y TRICICLICOS DE PIRIDONA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE UN DISOLVENTE INERTE, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES, SIENDO: Q1, CON EL ATOMO DE N2, UN GRUPO DE FORMULA (-N-CH2-CH2) O DE FORMULA (FN-CHFCH-); RA, FENILO, PIRIDILO Y OTROS; RB Y RC, H, HAL, TRIFLUOROMETILO Y OTROS; Y RKD Y RLD, CIANO, NITRO U OTROS. SE UTILIZAN COMO SEDANTES HIPNOTICOS Y ANSIOLITICOS.-
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH530484 | 1984-11-06 | ||
| CH383685 | 1985-09-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8705436A1 true ES8705436A1 (es) | 1987-05-01 |
| ES548532A0 ES548532A0 (es) | 1987-05-01 |
Family
ID=25693960
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES548532A Expired ES8705436A1 (es) | 1984-11-06 | 1985-11-05 | Un procedimiento para la obtencion de derivados de bi- y triciclicosdde piridona |
| ES554431A Expired ES8800936A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
| ES554432A Expired ES8800937A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
| ES554428A Expired ES8800934A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
| ES554429A Expired ES8800935A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
| ES554427A Expired ES8800933A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
| ES554426A Expired ES8800932A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
| ES554430A Expired ES8800939A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES554431A Expired ES8800936A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
| ES554432A Expired ES8800937A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
| ES554428A Expired ES8800934A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
| ES554429A Expired ES8800935A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
| ES554427A Expired ES8800933A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
| ES554426A Expired ES8800932A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
| ES554430A Expired ES8800939A1 (es) | 1984-11-06 | 1986-04-28 | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US4735940A (es) |
| EP (2) | EP0183994B1 (es) |
| JP (1) | JPH0692405B2 (es) |
| CN (1) | CN1016871B (es) |
| AR (1) | AR242579A1 (es) |
| AT (1) | ATE51232T1 (es) |
| AU (1) | AU584132B2 (es) |
| CA (1) | CA1277659C (es) |
| DE (2) | DE3587235D1 (es) |
| DK (1) | DK507685A (es) |
| DO (1) | DOP1985004378A (es) |
| ES (8) | ES8705436A1 (es) |
| FI (1) | FI89049C (es) |
| GB (1) | GB2169288B (es) |
| HU (1) | HU205353B (es) |
| IE (1) | IE58850B1 (es) |
| IL (1) | IL76894A (es) |
| IS (1) | IS1469B6 (es) |
| MC (1) | MC1707A1 (es) |
| MY (1) | MY103172A (es) |
| NO (1) | NO171914C (es) |
| PT (1) | PT81431B (es) |
| ZW (1) | ZW17385A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889848A (en) * | 1984-11-06 | 1989-12-26 | Hoffmann-La Roche Inc. | Tricyclic pyridine derivatives |
| NO162285C (no) * | 1984-11-23 | 1989-12-06 | Fujisawa Pharmaceutical Co | Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolizinon-derivater. |
| CA1317945C (en) * | 1985-12-13 | 1993-05-18 | Ulf Fischer | Tricyclic pyridazopyridone derivatives |
| EP0294599A3 (de) * | 1987-06-12 | 1990-05-09 | F. Hoffmann-La Roche Ag | Tricyclische Pyridonderivate |
| DE69123090D1 (de) * | 1990-07-06 | 1996-12-19 | Yoshitomi Pharmaceutical | Kondensierte Thiophenverbindungen und deren Verwendung |
| CA2058640A1 (en) * | 1991-01-25 | 1992-07-26 | Richard R. Scherschlicht | Tricyclic pyridone derivative |
| US5532240A (en) * | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
| FR2689129B1 (fr) * | 1992-03-27 | 1995-05-12 | Atochem Elf Sa | Nouveaux dérivés de l'acide 3-mercapto-2-thénoique et leurs procédés de préparation. |
| EP0650966A1 (de) * | 1993-10-28 | 1995-05-03 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung eines Benzo(a)chinolizinon-Derivates |
| US5869500A (en) * | 1996-12-13 | 1999-02-09 | Hoffmann-La Roche Inc. | Pyridone compounds useful in treating Alzheimer's disease |
| GB9708945D0 (en) * | 1997-05-01 | 1997-06-25 | Merck Sharp & Dohme | Therapeutic agents |
| GB0119828D0 (en) * | 2001-08-14 | 2001-10-10 | Merck Sharp & Dohme | Therapeutic agents |
| GB0119803D0 (en) * | 2001-08-14 | 2001-10-10 | Merck Sharp & Dohme | Therapeutic agents |
| KR101421745B1 (ko) | 2006-01-13 | 2014-07-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 코돈 최적화된 ｉｌ―15를 사용하는 백신 및 면역치료제, 및 그의 사용 방법 |
| AU2014306271A1 (en) | 2013-08-08 | 2016-03-24 | The Scripps Research Institute | A method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ191763A (en) * | 1978-10-13 | 1984-05-31 | Hoffmann La Roche | 7-beta-phenyl-quinolidines, intermediates and pharmaceutical compositions |
| EP0067565A1 (en) * | 1981-06-16 | 1982-12-22 | Beecham Group Plc | Pharmaceutically active compounds |
| GB8408292D0 (en) * | 1984-03-30 | 1984-05-10 | Fujisawa Pharmaceutical Co | Quinolizinone compound |
| GB8420602D0 (en) * | 1984-08-14 | 1984-09-19 | Wyeth John & Brother Ltd | Thienoquinolizines |
| NO162285C (no) * | 1984-11-23 | 1989-12-06 | Fujisawa Pharmaceutical Co | Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolizinon-derivater. |
| GB8509435D0 (en) * | 1985-04-12 | 1985-05-15 | Beecham Group Plc | Intermediates & process |
| AU582663B2 (en) * | 1985-08-10 | 1989-04-06 | John Wyeth & Brother Limited | Sulphonamides |
| US4686226A (en) * | 1985-09-03 | 1987-08-11 | Merck & Co., Inc. | Substituted benzo[b]furo- and benzo[b]thieno quinolizines |
-
1985
- 1985-10-02 ZW ZW173/85A patent/ZW17385A1/xx unknown
- 1985-10-10 CA CA000492742A patent/CA1277659C/en not_active Expired - Lifetime
- 1985-10-28 FI FI854211A patent/FI89049C/fi not_active IP Right Cessation
- 1985-10-31 DE DE8888117164T patent/DE3587235D1/de not_active Expired - Fee Related
- 1985-10-31 DE DE8585113864T patent/DE3576691D1/de not_active Expired - Lifetime
- 1985-10-31 US US06/793,511 patent/US4735940A/en not_active Expired - Fee Related
- 1985-10-31 EP EP85113864A patent/EP0183994B1/de not_active Expired - Lifetime
- 1985-10-31 EP EP88117164A patent/EP0318682B1/de not_active Expired - Lifetime
- 1985-10-31 AU AU49241/85A patent/AU584132B2/en not_active Ceased
- 1985-10-31 AT AT85113864T patent/ATE51232T1/de not_active IP Right Cessation
- 1985-10-31 IL IL76894A patent/IL76894A/xx not_active IP Right Cessation
- 1985-11-04 AR AR85302161A patent/AR242579A1/es active
- 1985-11-04 CN CN85108120A patent/CN1016871B/zh not_active Expired
- 1985-11-04 HU HU854211A patent/HU205353B/hu not_active IP Right Cessation
- 1985-11-04 DK DK507685A patent/DK507685A/da not_active Application Discontinuation
- 1985-11-04 MC MC851800A patent/MC1707A1/xx unknown
- 1985-11-05 NO NO854404A patent/NO171914C/no unknown
- 1985-11-05 JP JP60246439A patent/JPH0692405B2/ja not_active Expired - Lifetime
- 1985-11-05 PT PT81431A patent/PT81431B/pt not_active IP Right Cessation
- 1985-11-05 IS IS3054A patent/IS1469B6/is unknown
- 1985-11-05 IE IE275185A patent/IE58850B1/en not_active IP Right Cessation
- 1985-11-05 DO DO1985004378A patent/DOP1985004378A/es unknown
- 1985-11-05 ES ES548532A patent/ES8705436A1/es not_active Expired
- 1985-11-05 GB GB8527196A patent/GB2169288B/en not_active Expired
-
1986
- 1986-04-28 ES ES554431A patent/ES8800936A1/es not_active Expired
- 1986-04-28 ES ES554432A patent/ES8800937A1/es not_active Expired
- 1986-04-28 ES ES554428A patent/ES8800934A1/es not_active Expired
- 1986-04-28 ES ES554429A patent/ES8800935A1/es not_active Expired
- 1986-04-28 ES ES554427A patent/ES8800933A1/es not_active Expired
- 1986-04-28 ES ES554426A patent/ES8800932A1/es not_active Expired
- 1986-04-28 ES ES554430A patent/ES8800939A1/es not_active Expired
-
1987
- 1987-09-07 MY MYPI87001572A patent/MY103172A/en unknown
-
1989
- 1989-10-16 US US07/422,397 patent/US5036066A/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20041004 |