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ES8700851A1 - Procedimiento para la obtencion de acido alquil-1- ciclopropil-1, 4-dihidro-4-oxo-3-quinolincarboxilico. - Google Patents

Procedimiento para la obtencion de acido alquil-1- ciclopropil-1, 4-dihidro-4-oxo-3-quinolincarboxilico.

Info

Publication number
ES8700851A1
ES8700851A1 ES548843A ES548843A ES8700851A1 ES 8700851 A1 ES8700851 A1 ES 8700851A1 ES 548843 A ES548843 A ES 548843A ES 548843 A ES548843 A ES 548843A ES 8700851 A1 ES8700851 A1 ES 8700851A1
Authority
ES
Spain
Prior art keywords
alkyl
cyclopropyl
dihydro
oxo
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548843A
Other languages
English (en)
Other versions
ES548843A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8700851A1 publication Critical patent/ES8700851A1/es
Publication of ES548843A0 publication Critical patent/ES548843A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS DE FORMULA (I) Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN LA REACCION DE UN ACIDO DE FORMULA (II) CON CLORURO DE TIONILO, PARA FORMAR EL CORRESPONDIENTE CLORURO DE ACIDO; ACILACION DEL MALONATO DE ETILO CON ESTE CLORURO DE ACIDO, EN PRESENCIA DE METILATO DE MAGNESIO; SAPONIFICACION PARCIAL Y DESCARBOXILACION DEL ESTER DEL ACIDO AROILMALONICO OBTENIDO, CON ACIDO SULFURICO O P-TOLUENSULFONICO EN MEDI ACUOSO; REACCION CON O-FORMIATO DE TRIETILO/ANHIDRIDO ACETICO, SEGUIDA DE TRATAMIENTO CON CICLOPROPILAMINA Y CICLACION A 60JC A 300JC; Y SAPONIFICACION DEL PRODUCTO FORMADO PARA DAR EL COMPUESTO DE FORMULA (I), EN LAS QUE X1, X2, X3 Y X4 PUEDEN SER VARIOS RADICALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIBACTERIANOS.
ES548843A 1984-11-15 1985-11-13 Procedimiento para la obtencion de acido alquil-1- ciclopropil-1, 4-dihidro-4-oxo-3-quinolincarboxilico. Expired ES8700851A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843441788 DE3441788A1 (de) 1984-11-15 1984-11-15 Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Publications (2)

Publication Number Publication Date
ES8700851A1 true ES8700851A1 (es) 1986-11-16
ES548843A0 ES548843A0 (es) 1986-11-16

Family

ID=6250391

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548843A Expired ES8700851A1 (es) 1984-11-15 1985-11-13 Procedimiento para la obtencion de acido alquil-1- ciclopropil-1, 4-dihidro-4-oxo-3-quinolincarboxilico.

Country Status (14)

Country Link
US (1) US4762844A (es)
EP (1) EP0181588A3 (es)
JP (1) JPS61122272A (es)
KR (1) KR870000784B1 (es)
AU (1) AU572702B2 (es)
BR (1) BR8505734A (es)
CA (1) CA1260478A (es)
CS (1) CS252835B2 (es)
DE (1) DE3441788A1 (es)
ES (1) ES8700851A1 (es)
FI (1) FI854466A (es)
HU (1) HU194178B (es)
PL (1) PL145639B1 (es)
ZA (1) ZA858733B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
AU576272B2 (en) * 1984-11-13 1988-08-18 Kyorin Pharmaceutical Co. Ltd. Quinolone carboxylic acid derivates
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
DE3615767A1 (de) * 1986-05-10 1987-11-12 Bayer Ag Verfahren zur herstellung von 4-hydroxy-chinolin-3-carbonsaeuren
US5591744A (en) * 1987-04-16 1997-01-07 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US5290934A (en) * 1987-04-16 1994-03-01 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
DE3724466A1 (de) * 1987-07-24 1989-02-02 Bayer Ag Verfahren zur herstellung von chinoloncarbonsaeuren
US4929613A (en) * 1987-08-26 1990-05-29 Warner-Lambert Company Antibacterial agents
DE3811341A1 (de) * 1987-10-09 1989-04-27 Bayer Ag In 7-stellung c-verknuepfte chinolon- und 1,8-naphthyridin-4-on-carbonsaeure und ein verfahren zu ihrer herstellung
EP0342849A3 (en) * 1988-05-19 1990-03-14 Pfizer Inc. Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters
US5233091A (en) * 1988-06-21 1993-08-03 Pfizer Inc. 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
US5039682A (en) * 1988-06-21 1991-08-13 Pfizer Inc. 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
US5103040A (en) * 1988-06-21 1992-04-07 Pfizer Inc. 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and intermediates therefor
US5104868A (en) * 1988-06-21 1992-04-14 Pfizer Inc. Tricyclic derivatives of 7-substituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acids and esters
JP2915068B2 (ja) * 1990-05-07 1999-07-05 岩城製薬株式会社 ジヒドロフラノン誘導体の製造方法
DE4301246A1 (de) * 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
DE69933660T2 (de) * 1998-04-06 2007-08-23 Toyama Chemical Co. Ltd. Chinoloncarbonsäurederivate oder deren salze
DE10108750A1 (de) * 2001-02-23 2002-09-05 Bayer Ag Verbessertes Verfahren zur Herstellung von Fluorchinoloncarbonsäuren
KR100519158B1 (ko) * 2002-12-21 2005-10-06 주식회사유한양행 퀴놀론 카르복실레이트 유도체의 제조방법
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
EP2755942A2 (en) 2011-09-15 2014-07-23 Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University Therapeutic compounds
WO2015109318A2 (en) 2014-01-17 2015-07-23 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Therapeutic methods
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof
JP7282332B2 (ja) * 2017-10-25 2023-05-29 学校法人順天堂 リアノジン受容体阻害薬
CN113968787A (zh) * 2020-07-24 2022-01-25 广东东阳光药业有限公司 一种制备5-氟-4-甲基-2-硝基苯甲酸的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7101049A (es) * 1970-01-28 1971-07-30
DE2246503A1 (de) * 1972-09-22 1974-04-04 Boehringer Mannheim Gmbh 7,8-dimethylchinolon-3-carbonsaeurederivate
JPS604820B2 (ja) * 1979-02-26 1985-02-06 大塚製薬株式会社 キノリンカルボン酸誘導体
JPS5653656A (en) * 1979-10-05 1981-05-13 Tanabe Seiyaku Co Ltd Quinoline derivative and its preparation
DE3248507A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
US4623650A (en) * 1984-12-06 1986-11-18 Pfizer Inc. Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

Also Published As

Publication number Publication date
KR870000784B1 (ko) 1987-04-18
DE3441788A1 (de) 1986-05-15
JPS61122272A (ja) 1986-06-10
FI854466A (fi) 1986-05-16
HU194178B (en) 1988-01-28
AU572702B2 (en) 1988-05-12
PL145639B1 (en) 1988-10-31
PL256260A1 (en) 1986-12-30
HUT40422A (en) 1986-12-28
EP0181588A3 (de) 1989-02-01
AU4917785A (en) 1986-05-22
CS252835B2 (en) 1987-10-15
CA1260478A (en) 1989-09-26
KR860004026A (ko) 1986-06-16
EP0181588A2 (de) 1986-05-21
ZA858733B (en) 1986-07-30
ES548843A0 (es) 1986-11-16
FI854466A0 (fi) 1985-11-13
US4762844A (en) 1988-08-09
BR8505734A (pt) 1986-08-12
CS813285A2 (en) 1987-03-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303