[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES8605820A1 - Procedimiento de sintesis en fase liquida y por fragmentos para los hgrf 1-44 y hgrf 1-40. - Google Patents

Procedimiento de sintesis en fase liquida y por fragmentos para los hgrf 1-44 y hgrf 1-40.

Info

Publication number
ES8605820A1
ES8605820A1 ES544987A ES544987A ES8605820A1 ES 8605820 A1 ES8605820 A1 ES 8605820A1 ES 544987 A ES544987 A ES 544987A ES 544987 A ES544987 A ES 544987A ES 8605820 A1 ES8605820 A1 ES 8605820A1
Authority
ES
Spain
Prior art keywords
hgrf
called
frag
ment
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544987A
Other languages
English (en)
Other versions
ES544987A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8605820A1 publication Critical patent/ES8605820A1/es
Publication of ES544987A0 publication Critical patent/ES544987A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Manufacture And Refinement Of Metals (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

PROCEDIMIENTO PARA LA SINTESIS DE LOS HGRF 1-44 Y HGRF 1-40, EN FASE LIQUIDA Y POR FRAGMENTOS. CONSISTE EN ACOPLAR UNO DESPUES DE OTRO, Y EN EL ORDEN DE LA SECUENCIA DEL GRF, LOS FRAGMENTOS ADECUADOS PARA OBTENER EL PEPTIDO K1HGRF(20-44) O EL PEPTIDO CORRESPONDIENTE CON LA SECUENCIA (20-40); Y POR OTRA PARTE LOS FRAGMENTOS ADECUADOS PARA OBTENER EL PEPTIDO JHGRF(5-19); ACOPLAR ENTRE SI LOS PEPTIDOS J Y K1 Y ACOPLAR EL PEPTIDO ASI OBTENIDO CON EL PEPTIDO H-TYR-ALA-ASP-ALA-OH. LAS FUNCIONES ACIDAS Y AMINA ESTAN PROTEGIDAS, Y AL FINAL DE LA SECUENCIA TODOS LOS GRUPOS PROTECTORES SON ELIMINADOS POR HIDROLISIS. ESTOS COMPUESTOS TIENEN APLICACIONES PARA EL TRATAMIENTO DEL ENANISMO Y DE LOS RETRASOS EN EL CRECIMIENTO, EN PEDIATRIA, PARA EL CRECIMIENTO GANADERO Y EL AUMENTO DE LA LACTACION.
ES544987A 1984-07-10 1985-07-09 Procedimiento de sintesis en fase liquida y por fragmentos para los hgrf 1-44 y hgrf 1-40. Expired ES8605820A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8410965A FR2567524B1 (fr) 1984-07-10 1984-07-10 Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires

Publications (2)

Publication Number Publication Date
ES8605820A1 true ES8605820A1 (es) 1986-04-01
ES544987A0 ES544987A0 (es) 1986-04-01

Family

ID=9305984

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544987A Expired ES8605820A1 (es) 1984-07-10 1985-07-09 Procedimiento de sintesis en fase liquida y por fragmentos para los hgrf 1-44 y hgrf 1-40.

Country Status (15)

Country Link
US (2) US4707541A (es)
EP (1) EP0171315B1 (es)
JP (1) JPS6136299A (es)
AT (1) ATE40141T1 (es)
AU (2) AU4457085A (es)
CA (1) CA1254349A (es)
DE (1) DE3567659D1 (es)
DK (1) DK311385A (es)
ES (1) ES8605820A1 (es)
FR (1) FR2567524B1 (es)
GR (1) GR851703B (es)
IL (1) IL75732A (es)
NZ (1) NZ212696A (es)
PT (1) PT80788B (es)
ZA (1) ZA855188B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6393796A (ja) * 1986-10-09 1988-04-25 Shin Etsu Chem Co Ltd ペプチド合成の脱保護基用薬剤
IT1226552B (it) * 1988-07-29 1991-01-24 Ellem Ind Farmaceutica Peptidi immunostimolanti.
KR0173119B1 (ko) * 1989-04-26 1999-02-01 닐 에이. 밴스로우 선형 소마토스타틴 유사체
GB8912837D0 (en) * 1989-06-03 1989-07-19 Coopers Animal Health Biologically active molecules
EP0639981A4 (en) * 1992-05-08 1995-06-28 Univ Jefferson ANALOGS OF THE IGF FACTOR (01/18/94).
GB9211668D0 (en) * 1992-06-02 1992-07-15 Nycomed Bioreg As Peptide compounds
US5550212A (en) * 1993-12-17 1996-08-27 The Administrators Of The Tulane Educational Fund Analogues of hGH-RH(1-29)NH2 having antagonistic activity
DK0770091T3 (da) * 1994-05-12 2000-08-14 Imre Mezo Forbindelser til ophævelse af lægmiddelresistens
GB9502540D0 (en) * 1995-02-09 1995-03-29 Zeneca Ltd Compounds
SE9903291D0 (sv) * 1999-09-15 1999-09-15 Astra Ab New process
ATE410437T1 (de) * 2003-12-31 2008-10-15 Hoffmann La Roche Verfahren und systeme zur rückgewinnung von peptiden

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4415558A (en) * 1981-06-08 1983-11-15 The Salk Institute For Biological Studies CRF And analogs
US4517181A (en) * 1982-09-15 1985-05-14 The Salk Institute For Biological Studies Mammalian PGRF
NZ204456A (en) * 1982-06-16 1987-05-29 Salk Inst For Biological Studi Synthetic pancreatic growth-hormone releasing factor
US4563352A (en) * 1982-10-04 1986-01-07 The Salk Institute For Biological Studies Human pancreatic GRF
US4529595A (en) * 1983-01-13 1985-07-16 The Salk Institute For Biological Studies GRF Analogs
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
US4581168A (en) * 1983-02-21 1986-04-08 Sanofi Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides
US4489163A (en) * 1983-04-14 1984-12-18 The Salk Institute For Biological Studies rCRF and analogs
US4549986A (en) * 1983-12-23 1985-10-29 The Salk Institute For Biological Studies Human CGRP

Also Published As

Publication number Publication date
IL75732A (en) 1990-02-09
GR851703B (es) 1985-11-26
CA1254349A (en) 1989-05-16
NZ212696A (en) 1989-05-29
PT80788A (fr) 1985-08-01
PT80788B (fr) 1987-01-12
US4707541A (en) 1987-11-17
ZA855188B (en) 1986-03-26
FR2567524A1 (fr) 1986-01-17
DK311385D0 (da) 1985-07-08
AU4457085A (en) 1986-01-16
JPS6136299A (ja) 1986-02-20
IL75732A0 (en) 1985-11-29
EP0171315B1 (fr) 1989-01-18
ATE40141T1 (de) 1989-02-15
ES544987A0 (es) 1986-04-01
EP0171315A1 (fr) 1986-02-12
FR2567524B1 (fr) 1987-11-27
DK311385A (da) 1986-01-11
AU4978790A (en) 1990-08-30
US4797469A (en) 1989-01-10
DE3567659D1 (en) 1989-02-23

Similar Documents

Publication Publication Date Title
ES8605820A1 (es) Procedimiento de sintesis en fase liquida y por fragmentos para los hgrf 1-44 y hgrf 1-40.
AU544231B2 (en) Double mixed refrigerant liquefaction process for natural gas
OA07829A (en) Dual mixed refrigerant natural gas liquefaction.
ES8609483A1 (es) Un procedimiento para producir un precursor de insulina
AU3457584A (en) Dual mixed refrigerant natural gas lique-faction with stages compression
GB2156046B (en) Reed valve for refrigeration compressor
AU2585884A (en) Double loop antenna
AU2746084A (en) Liquefying (natural) gas with at least two refrigerants in cascade
GB8623151D0 (en) 2-oxo-(1(substituted sulfonyl)amino)-carbonyl)azetidines
AU8790782A (en) Elliptical suturing cuff
EP0334244A3 (en) Bradykinin antagonist peptides
EP0155786A3 (en) New peptide, and production and use thereof
IL63108A0 (en) Methods and compositions for preparing peptides
AU7408887A (en) Peptides influencing diuresis and natriuresis, a process for their preparation, agents containing them, and their use
CA2133834A1 (en) Process for preparing modified proteins
AU582416B2 (en) Polypeptide secretion-causing vector, microorganisms transformed by said vector, and process for preparing polypeptide using said microorganisms
GB2139202B (en) Sulphur cements, sulphur concretes, their preparation and use
KR840006328A (ko) 펩티드의 제조방법
AU2891184A (en) Meta-and para-isopropenyl-alpha, alpha-dimethyl benzylamine
AU8639182A (en) Sewn loop pin seam having flat monofilament yarn
GB2207132B (en) 2-oxo-1-(((substituted sulfonyl)amino)-carbonyl)azetidines
GB2206348B (en) 2-oxo-1(((substituted sulfonyl)amino)-carbonyl)azetidines
HUT50880A (en) Process for producing kedarcidin and pharmaceutical compositions comprising same
GB1308809A (en) D-analogs of secretin
JPS6437645A (en) Interface switching system