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ES8605760A1 - (Omega-(diethylamino)-alkoxy)-alpha-(ethyl)-benzhydrol derivatives, their acid addition salts and quaternary salts, process for their preparation and medicines containing these compounds. - Google Patents

(Omega-(diethylamino)-alkoxy)-alpha-(ethyl)-benzhydrol derivatives, their acid addition salts and quaternary salts, process for their preparation and medicines containing these compounds.

Info

Publication number
ES8605760A1
ES8605760A1 ES543785A ES543785A ES8605760A1 ES 8605760 A1 ES8605760 A1 ES 8605760A1 ES 543785 A ES543785 A ES 543785A ES 543785 A ES543785 A ES 543785A ES 8605760 A1 ES8605760 A1 ES 8605760A1
Authority
ES
Spain
Prior art keywords
alkoxy
acid addition
compounds
preparation
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543785A
Other languages
Spanish (es)
Other versions
ES543785A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES8605760A1 publication Critical patent/ES8605760A1/en
Publication of ES543785A0 publication Critical patent/ES543785A0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention relates to the preparation of new diethylaminoalkoxybenzhydrol derivatives of the formula (I) < IMAGE > (I) wherein R1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms, R2 is halogen, trihalomethyl, or alkoxy having from one to 4 carbon atoms, and n is 1, 2, 3 or 4, and acid addition and quaternary ammonium salts thereof. According to another aspect of the invention, there are provided new compounds of the formula (I), and acid addition and quaternary salts thereof. The compounds can be used for the treatment of acute ethanolic intoxication and depression syndromes. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.
ES543785A 1982-12-28 1985-06-01 (Omega-(diethylamino)-alkoxy)-alpha-(ethyl)-benzhydrol derivatives, their acid addition salts and quaternary salts, process for their preparation and medicines containing these compounds. Expired ES8605760A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU824182A HU187204B (en) 1982-12-28 1982-12-28 Process for producing new diethyl-amino-alkoxy-benzhydrol derivatives, acid additional salts, and quaternary salts and pharmaceutical compositions contatining them

Publications (2)

Publication Number Publication Date
ES8605760A1 true ES8605760A1 (en) 1986-04-01
ES543785A0 ES543785A0 (en) 1986-04-01

Family

ID=10967233

Family Applications (3)

Application Number Title Priority Date Filing Date
ES528452A Expired ES8600202A1 (en) 1982-12-28 1983-12-27 (Omega-(diethylamino)-alkoxy)-alpha-(ethyl)-benzhydrol derivatives, their acid addition salts and quaternary salts, process for their preparation and medicines containing these compounds.
ES543786A Granted ES543786A0 (en) 1982-12-28 1985-06-01 PROCEDURE FOR THE PREPARATION OF NEW A-ETILBEN-ZOL DERIVATIVES WITH A SUBSTITUTED DIETHYLAMINOALCOXY GROUP AND ITS ADDITIONAL SALTS ACIDIC AND QUATERNARY AMMONICS
ES543785A Expired ES8605760A1 (en) 1982-12-28 1985-06-01 (Omega-(diethylamino)-alkoxy)-alpha-(ethyl)-benzhydrol derivatives, their acid addition salts and quaternary salts, process for their preparation and medicines containing these compounds.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES528452A Expired ES8600202A1 (en) 1982-12-28 1983-12-27 (Omega-(diethylamino)-alkoxy)-alpha-(ethyl)-benzhydrol derivatives, their acid addition salts and quaternary salts, process for their preparation and medicines containing these compounds.
ES543786A Granted ES543786A0 (en) 1982-12-28 1985-06-01 PROCEDURE FOR THE PREPARATION OF NEW A-ETILBEN-ZOL DERIVATIVES WITH A SUBSTITUTED DIETHYLAMINOALCOXY GROUP AND ITS ADDITIONAL SALTS ACIDIC AND QUATERNARY AMMONICS

Country Status (14)

Country Link
US (1) US4605672A (en)
EP (1) EP0115080B1 (en)
JP (1) JPS59130842A (en)
AT (1) ATE19236T1 (en)
AU (2) AU557898B2 (en)
CA (1) CA1220225A (en)
DE (1) DE3363105D1 (en)
DK (1) DK163144C (en)
ES (3) ES8600202A1 (en)
FI (1) FI78458C (en)
GR (1) GR78772B (en)
HU (1) HU187204B (en)
IL (1) IL70550A (en)
ZA (1) ZA839613B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3262353D1 (en) * 1981-12-14 1985-03-28 Sandoz Ag N,n-disubstituted alkenamides and phenylalkenamides, processes for their production and their use as pharmaceuticals
AU589967B2 (en) * 1985-06-11 1989-10-26 Warner-Lambert Company Improved process for the manufacture of diphenhydramine
DK368687A (en) * 1986-11-21 1988-05-22 Cheminova As AMINOALCYLED HYDROXY COMPOUNDS AND THEIR USE AS FUNGICIDES
CA2016738A1 (en) * 1989-06-08 1990-12-08 Philippe Guerry Substituted aminoalkylbenzene derivatives
US5214046A (en) * 1989-07-27 1993-05-25 Hoffmann-La Roche Inc. Substituted aminoalkoxybenzene anti-fungicidal compositions and use
CA2020888A1 (en) * 1989-07-27 1991-01-28 Philippe Guerry Substituted aminoalkoxybenzene derivatives
GB9303210D0 (en) * 1993-02-17 1993-03-31 Univ Manitoba Cancer treatment
DE10225692A1 (en) * 2002-06-10 2003-12-24 Zimmer Ag Process for the production of caprolactam from waste containing polyamide
DE10333539A1 (en) * 2003-07-23 2005-02-24 Zimmer Ag Process for the purification of caprolactam from waste containing polyamide by means of UV irradiation
DE10333538B4 (en) * 2003-07-23 2008-04-10 Lurgi Zimmer Gmbh Process for the treatment of polyamide-containing waste with the recycling of the Depolymerisationsrückstandes
EP1754769A1 (en) 2005-08-16 2007-02-21 Research Institute of Petroleum Continuous catalyst /wax separation method
US7858825B2 (en) * 2007-02-15 2010-12-28 Colorado State University Research Foundation Acid and base stable diphenylmethanol derivatives and methods of use
PL2892540T3 (en) * 2012-09-06 2018-12-31 Mcpharma Biotech Inc. Treatment of diarrhea and post-weaning diarrhea with resistant potato starch
WO2023106973A1 (en) * 2021-12-10 2023-06-15 Общество С Ограниченной Ответственностью "Валента-Интеллект" Novel hepatoprotective agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3075014A (en) * 1960-06-14 1963-01-22 Richardson Merrell Inc Basic substituted alkoxy diphenylalkanols, diphenylalkenes and diphenylalkanes
US3927128A (en) * 1971-01-18 1975-12-16 Hoffmann La Roche Tricyclic amines and processes for the preparation thereof
HU168432B (en) * 1973-08-15 1976-04-28
US4094908A (en) * 1973-08-15 1978-06-13 Richter Gedeon Vegyeszeti Gyar Rt. Alpha-substituted benzhydrol derivatives
US4024282A (en) * 1975-11-25 1977-05-17 Mitsubishi Chemical Industries Ltd. Pharmaceutically active 2-(3-alkylaminopropoxy)diphenylmethanes

Also Published As

Publication number Publication date
IL70550A0 (en) 1984-03-30
FI834790A0 (en) 1983-12-27
JPS59130842A (en) 1984-07-27
AU2290783A (en) 1984-07-05
DK163144B (en) 1992-01-27
ES528452A0 (en) 1985-10-01
ES8600202A1 (en) 1985-10-01
DK602283A (en) 1984-06-29
ATE19236T1 (en) 1986-05-15
FI78458C (en) 1989-08-10
AU557898B2 (en) 1987-01-15
FI78458B (en) 1989-04-28
DK602283D0 (en) 1983-12-27
ES543785A0 (en) 1986-04-01
ZA839613B (en) 1985-02-27
JPH0159263B2 (en) 1989-12-15
IL70550A (en) 1986-11-30
ES8603810A1 (en) 1986-01-01
GR78772B (en) 1984-10-02
FI834790A (en) 1984-06-29
US4605672A (en) 1986-08-12
HU187204B (en) 1985-11-28
AU557954B2 (en) 1987-01-15
EP0115080B1 (en) 1986-04-16
AU2290583A (en) 1984-07-05
DE3363105D1 (en) 1986-05-22
EP0115080A1 (en) 1984-08-08
DK163144C (en) 1992-06-22
CA1220225A (en) 1987-04-07
ES543786A0 (en) 1986-01-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401