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ES8605524A1 - Procedimiento para preparar tieno- y furo-(2,3-c)-pirroles - Google Patents

Procedimiento para preparar tieno- y furo-(2,3-c)-pirroles

Info

Publication number
ES8605524A1
ES8605524A1 ES547789A ES547789A ES8605524A1 ES 8605524 A1 ES8605524 A1 ES 8605524A1 ES 547789 A ES547789 A ES 547789A ES 547789 A ES547789 A ES 547789A ES 8605524 A1 ES8605524 A1 ES 8605524A1
Authority
ES
Spain
Prior art keywords
denotes
carbon atoms
denote
furo
thieno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES547789A
Other languages
English (en)
Other versions
ES547789A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA SAS, LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA SAS
Publication of ES8605524A1 publication Critical patent/ES8605524A1/es
Publication of ES547789A0 publication Critical patent/ES547789A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE TIENO- Y FURO-2,3-C-PIRROLES, DE FORMULA (I), EN LA QUE X1 Y X2 REPRESENTAN OXIGENO O AZUFRE; R2 REPRESENTA HIDROGENO O ALQUILO; R1 Y U PUEDEN SER VARIOS TIPOS DE RADICALES; Y M VALE 2 O 3. COMPRENDE LA REACCION DE UNA AMINA DE FORMULA (II), CON UN COMPUESTO DE UNA DE LAS FORMULAS (III), (IV), O (V); SEGUIDA DEL TRATAMIENTO DEL COMPUESTO ASI FORMADO CON UNA AMINA DE FORMULA R3NH2 O UNA HIDRAZINA DE FORMULA R4NHNH2, FORMULAS EN LAS QUE V ES NITROGENO O CH, W ES NO2 O CN, R3 PUEDE SER VARIOS RADICALES, R4 ES ALQUILO C1-3, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANTISECRETORAS Y ANTIULCEROSAS.
ES547789A 1984-10-12 1985-10-11 Procedimiento para preparar tieno- y furo-(2,3-c)-pirroles Expired ES8605524A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8415658A FR2571723B1 (fr) 1984-10-12 1984-10-12 Derives de thieno et furo-(2,3-c) pyrroles, procedes de preparation et medicaments les contenant

Publications (2)

Publication Number Publication Date
ES8605524A1 true ES8605524A1 (es) 1986-03-16
ES547789A0 ES547789A0 (es) 1986-03-16

Family

ID=9308598

Family Applications (1)

Application Number Title Priority Date Filing Date
ES547789A Expired ES8605524A1 (es) 1984-10-12 1985-10-11 Procedimiento para preparar tieno- y furo-(2,3-c)-pirroles

Country Status (19)

Country Link
EP (1) EP0180500A1 (es)
JP (1) JPS6197286A (es)
AU (1) AU593776B2 (es)
CA (1) CA1250847A (es)
CS (1) CS265211B2 (es)
DD (1) DD237662A5 (es)
DK (1) DK465685A (es)
ES (1) ES8605524A1 (es)
FR (1) FR2571723B1 (es)
HU (1) HU193827B (es)
IL (1) IL76619A (es)
IN (1) IN169684B (es)
MA (1) MA20543A1 (es)
NO (1) NO161917C (es)
OA (1) OA08119A (es)
PT (1) PT81282B (es)
SU (1) SU1329621A3 (es)
YU (1) YU162485A (es)
ZA (1) ZA857809B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60255756A (ja) * 1984-06-01 1985-12-17 Ikeda Mohandou:Kk アミノアルキルフエノキシ誘導体
FR2733750B1 (fr) * 1995-05-03 1997-06-13 Synthelabo Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique
DK1543011T3 (da) 2002-09-06 2006-08-07 Janssen Pharmaceutica Nv Thienopyrrolyl- og furanopyrrolylforbindelser og deres anvendelse som histamin H4-receptorligander
CN101186612B (zh) * 2006-11-15 2012-10-03 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
GB1601459A (en) * 1977-05-17 1981-10-28 Allen & Hanburys Ltd Aminoalkyl thiophene derivatives
US4390701A (en) * 1981-05-18 1983-06-28 Bristol-Myers Company 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses

Also Published As

Publication number Publication date
HUT40133A (en) 1986-11-28
OA08119A (fr) 1987-03-31
EP0180500A1 (fr) 1986-05-07
IN169684B (es) 1991-12-07
DK465685A (da) 1986-04-13
FR2571723A1 (fr) 1986-04-18
CS714485A2 (en) 1988-08-16
CS265211B2 (en) 1989-10-13
YU162485A (en) 1987-12-31
PT81282B (pt) 1988-02-17
NO161917C (no) 1989-10-11
PT81282A (fr) 1985-11-01
IL76619A (en) 1990-07-12
NO161917B (no) 1989-07-03
HU193827B (en) 1987-12-28
FR2571723B1 (fr) 1988-08-26
SU1329621A3 (ru) 1987-08-07
JPS6197286A (ja) 1986-05-15
AU4852885A (en) 1986-04-17
DD237662A5 (de) 1986-07-23
MA20543A1 (fr) 1986-07-01
ZA857809B (en) 1986-05-28
DK465685D0 (da) 1985-10-11
CA1250847A (fr) 1989-03-07
AU593776B2 (en) 1990-02-22
IL76619A0 (en) 1986-02-28
ES547789A0 (es) 1986-03-16
NO854051L (no) 1986-04-14

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