ES8603880A1 - Eburnane carboxylic acid derivative, manufacture and medicinal composition - Google Patents
Eburnane carboxylic acid derivative, manufacture and medicinal compositionInfo
- Publication number
- ES8603880A1 ES8603880A1 ES545116A ES545116A ES8603880A1 ES 8603880 A1 ES8603880 A1 ES 8603880A1 ES 545116 A ES545116 A ES 545116A ES 545116 A ES545116 A ES 545116A ES 8603880 A1 ES8603880 A1 ES 8603880A1
- Authority
- ES
- Spain
- Prior art keywords
- opt
- prods
- eburnane
- carboxylic acid
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Fats And Perfumes (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
(A) 9- or 11-Amino-eburnane-carboxylic acid derivs. of formula (I) and their optical isomers and salts are new. R = NH2, NHCOR1 or NHSO2R2 in the 9 or 11 posn. R1 = H or opt. substd. 1-10C aliphatic hydrocarbyl, 3-8C cycloaliphatic hydrocarbyl, 6-14C aryl or heteroaryl R2 = opt. substd. 1-10C aliphatic hydrocarbyl or 6-14C aryl R3 = H or opt. substd. 1-10C aliphatic hydrocarbyl, 3-8C cycloaliphatic hydrocarbyl or 6-14C aryl A = OH B = H or A+B = direct bond provided that R3 is not Me when (a) R = NH2 or (b) R = 11-acetamido, A = OH and B = H. (B) Prodn. of eburnane-carboxylic acid derivs., 11-acetamido-vincamine or 9- or 11-amino-apovincamine is effected by: (a) acylating a cpd. (I) where R3 = Me or where R3 = H and A+B = bond, opt. after hydrolysis, excluding acetylation when R4 = Me, A = OH and B = H, opt. followed by (i) esterificn. or transesterificn. of prods. where R = NHCOR1 or NHSO2R2, (ii) hydrolysis of prods. where R = NHCOR1 or NHSO2R2, A = OH, B = H and R3 is other than H, and/or (iii) dehydration of prods. where A = OH and B = H (b) esterifying or transesterifying a cpd. (I) where R3 = Me or R3 = H and A+B bond, opt. followed by (i) hydrolysis of prods. where R = NH2, A = OH, B = H and R3 is other than H, (ii) dehydration of prods. where A = OH and B = H, and/or (iii) acylation of prods. where R = NH2 and R3 is as defined in (A) or is Me or (c) reducing cpds. of formula (I) where R = NO2, opt. followed by reactions as defined in (a)(i) and/or (a)(ii) or in (b)(i) and/or (a)(iii) or in (b)(ii) and/or (b)(iii). (C) Medicaments contg. cpds. (I) as defined in (A) and/or 11-acetamido-vincamine are new.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU842703A HU191694B (en) | 1984-07-11 | 1984-07-11 | Process for production of new derivatives of amineburnan carbonic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8603880A1 true ES8603880A1 (en) | 1986-01-01 |
| ES545116A0 ES545116A0 (en) | 1986-01-01 |
Family
ID=10960716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES545116A Granted ES545116A0 (en) | 1984-07-11 | 1985-07-11 | PROCEDURE FOR THE PREPARATION OF NEW RACEOMIC AND OPTICALLY ACTIVE DERIVATIVES OF ACID 9- AND 11-AMINOEBURNANO-CARBOXYLIC |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS6150981A (en) |
| KR (1) | KR860001111A (en) |
| AU (1) | AU577393B2 (en) |
| CS (1) | CS255889B2 (en) |
| DD (1) | DD235646A5 (en) |
| DK (1) | DK317985A (en) |
| ES (1) | ES545116A0 (en) |
| FI (1) | FI852750L (en) |
| GR (1) | GR851723B (en) |
| HU (1) | HU191694B (en) |
| IL (1) | IL75775A0 (en) |
| NO (1) | NO852795L (en) |
| NZ (1) | NZ212713A (en) |
| PL (1) | PL254496A1 (en) |
| PT (1) | PT80799B (en) |
| SU (1) | SU1428200A3 (en) |
| YU (1) | YU115385A (en) |
| ZA (1) | ZA855245B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU191938B (en) * | 1984-07-11 | 1987-04-28 | Andras Vedres | Process for production of new derivatives of 9 and 11 nitro-apovincamin acid |
| HU191693B (en) * | 1984-07-11 | 1987-03-30 | Richter Gedeon Vegyeszet | Process for production of derivatives of 9-or-11 substituated apovincamin acid |
| FR2623501B1 (en) * | 1987-11-19 | 1990-03-16 | Roussel Uclaf | NOVEL SUBSTITUTED DERIVATIVES OF 20.21-DINOREBURNAMENINE, THEIR PREPARATION PROCESS AND THE NOVEL INTERMEDIATES THUS OBTAINED, THEIR APPLICATION AS DRUGS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| CA2238488A1 (en) * | 1994-07-07 | 1997-06-05 | Hiroyoshi Hidaka | Apovincaminic acid derivatives and drugs containing the same |
| BR112017016819B1 (en) * | 2015-02-04 | 2022-12-13 | Harbin Pharmaceutical Group Co., Ltd. General Pharmaceutical Factory | DIAZA-BENZOFLUORANTHRENE COMPOUNDS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU191938B (en) * | 1984-07-11 | 1987-04-28 | Andras Vedres | Process for production of new derivatives of 9 and 11 nitro-apovincamin acid |
-
1984
- 1984-07-11 HU HU842703A patent/HU191694B/en not_active IP Right Cessation
-
1985
- 1985-07-10 AU AU44770/85A patent/AU577393B2/en not_active Ceased
- 1985-07-11 YU YU01153/85A patent/YU115385A/en unknown
- 1985-07-11 GR GR851723A patent/GR851723B/el unknown
- 1985-07-11 PL PL25449685A patent/PL254496A1/en unknown
- 1985-07-11 IL IL75775A patent/IL75775A0/en unknown
- 1985-07-11 ZA ZA855245A patent/ZA855245B/en unknown
- 1985-07-11 NZ NZ212713A patent/NZ212713A/en unknown
- 1985-07-11 DK DK317985A patent/DK317985A/en not_active Application Discontinuation
- 1985-07-11 SU SU853923279A patent/SU1428200A3/en active
- 1985-07-11 PT PT80799A patent/PT80799B/en unknown
- 1985-07-11 ES ES545116A patent/ES545116A0/en active Granted
- 1985-07-11 DD DD85278517A patent/DD235646A5/en not_active IP Right Cessation
- 1985-07-11 CS CS855186A patent/CS255889B2/en unknown
- 1985-07-11 NO NO852795A patent/NO852795L/en unknown
- 1985-07-11 FI FI852750A patent/FI852750L/en not_active Application Discontinuation
- 1985-07-11 JP JP60151430A patent/JPS6150981A/en active Pending
- 1985-07-11 KR KR1019850004954A patent/KR860001111A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU4477085A (en) | 1986-01-16 |
| NZ212713A (en) | 1988-03-30 |
| DK317985A (en) | 1986-01-12 |
| KR860001111A (en) | 1986-02-22 |
| NO852795L (en) | 1986-01-13 |
| IL75775A0 (en) | 1985-11-29 |
| PT80799B (en) | 1987-01-12 |
| DK317985D0 (en) | 1985-07-11 |
| YU115385A (en) | 1988-04-30 |
| DD235646A5 (en) | 1986-05-14 |
| HU191694B (en) | 1987-03-30 |
| SU1428200A3 (en) | 1988-09-30 |
| ES545116A0 (en) | 1986-01-01 |
| CS255889B2 (en) | 1988-03-15 |
| HUT38101A (en) | 1986-04-28 |
| ZA855245B (en) | 1986-02-26 |
| FI852750L (en) | 1986-01-12 |
| GR851723B (en) | 1986-02-28 |
| AU577393B2 (en) | 1988-09-22 |
| JPS6150981A (en) | 1986-03-13 |
| PT80799A (en) | 1985-08-01 |
| PL254496A1 (en) | 1988-07-21 |
| FI852750A0 (en) | 1985-07-11 |
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