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ES8601999A1 - Clavulanic acid extraction - Google Patents

Clavulanic acid extraction

Info

Publication number
ES8601999A1
ES8601999A1 ES537158A ES537158A ES8601999A1 ES 8601999 A1 ES8601999 A1 ES 8601999A1 ES 537158 A ES537158 A ES 537158A ES 537158 A ES537158 A ES 537158A ES 8601999 A1 ES8601999 A1 ES 8601999A1
Authority
ES
Spain
Prior art keywords
acetone
clavulanic acid
adsorption
minutes
filtration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537158A
Other languages
Spanish (es)
Other versions
ES537158A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antibioticos SA
Original Assignee
Antibioticos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos SA filed Critical Antibioticos SA
Priority to ES537158A priority Critical patent/ES537158A0/en
Priority to MX8544U priority patent/MX7417E/en
Priority to NZ213963A priority patent/NZ213963A/en
Priority to AU49090/85A priority patent/AU600655B2/en
Priority to AR85302065A priority patent/AR245221A1/en
Priority to CN85108444A priority patent/CN1010415B/en
Priority to EG681/85A priority patent/EG17153A/en
Priority to IN855/MAS/85A priority patent/IN162768B/en
Priority to DE8585307783T priority patent/DE3583281D1/en
Priority to CA000494016A priority patent/CA1307223C/en
Priority to EP88115979A priority patent/EP0312813A3/en
Priority to JP60242586A priority patent/JPH0646949B2/en
Priority to AT85307783T priority patent/ATE64621T1/en
Priority to EP85307783A priority patent/EP0182522B1/en
Priority to IE269985A priority patent/IE58365B1/en
Publication of ES8601999A1 publication Critical patent/ES8601999A1/en
Publication of ES537158A0 publication Critical patent/ES537158A0/en
Priority to HK26696A priority patent/HK26696A/en
Granted legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The process comprises addition of a filtration coadjuvant to increase the flow in hot clavulanic acid fermentation stock. The filtrate impurities are improved by deproteinising at pH 40 or with acetone, followed by adsorption in ion exchange resins, for washing with NaCl soln. and elution of the acid salt. On using acetone, the stock is stirred 5-10 minutes and left to rest for 20 minutes, for elimination of the ppte. by centrifugation or filtration. The acetone is recovered by low-pressure distillation prior to the adsorption.
ES537158A 1984-10-27 1984-10-27 PROCEDURE TO IMPROVE THE EXTRACTION OF CLAVULANIC ACID Granted ES537158A0 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
ES537158A ES537158A0 (en) 1984-10-27 1984-10-27 PROCEDURE TO IMPROVE THE EXTRACTION OF CLAVULANIC ACID
MX8544U MX7417E (en) 1984-10-27 1985-10-25 METHOD FOR THE PREPARATION OF CLAVULANIC ACID AND ITS DERIVATIVES
NZ213963A NZ213963A (en) 1984-10-27 1985-10-25 Production of clavulanic acid
AU49090/85A AU600655B2 (en) 1984-10-27 1985-10-25 Preparation of clavulanic acid and its salts and esters
AR85302065A AR245221A1 (en) 1984-10-27 1985-10-25 A method for the production of clavulanic acid by fermenting s. clavuligerus.
CN85108444A CN1010415B (en) 1984-10-27 1985-10-26 Process of the preparation of clavulanic acid and its salts and esters
EG681/85A EG17153A (en) 1984-10-27 1985-10-27 Preparation of clavulanic acid and its salts and esters
CA000494016A CA1307223C (en) 1984-10-27 1985-10-28 Preparation of clavulanic acid and its salts and esters
DE8585307783T DE3583281D1 (en) 1984-10-27 1985-10-28 PRODUCTION OF CLAVULANIC ACID AND ITS SALTS AND ESTERS.
IN855/MAS/85A IN162768B (en) 1984-10-27 1985-10-28
EP88115979A EP0312813A3 (en) 1984-10-27 1985-10-28 Preparation of clavulanic acid and its salts and esters
JP60242586A JPH0646949B2 (en) 1984-10-27 1985-10-28 Clavulanic acid manufacturing method
AT85307783T ATE64621T1 (en) 1984-10-27 1985-10-28 PRODUCTION OF CLAVULAN ACID AND ITS SALTS AND ESTERS.
EP85307783A EP0182522B1 (en) 1984-10-27 1985-10-28 Preparation of clavulanic acid and its salts and esters
IE269985A IE58365B1 (en) 1984-10-27 1985-11-01 Preparation of clavulanic acid and its salts and esters
HK26696A HK26696A (en) 1984-10-27 1996-02-08 Preparation of clavulanic acid and its salts and esters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES537158A ES537158A0 (en) 1984-10-27 1984-10-27 PROCEDURE TO IMPROVE THE EXTRACTION OF CLAVULANIC ACID

Publications (2)

Publication Number Publication Date
ES8601999A1 true ES8601999A1 (en) 1985-12-01
ES537158A0 ES537158A0 (en) 1985-12-01

Family

ID=8488054

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537158A Granted ES537158A0 (en) 1984-10-27 1984-10-27 PROCEDURE TO IMPROVE THE EXTRACTION OF CLAVULANIC ACID

Country Status (1)

Country Link
ES (1) ES537158A0 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002022846A1 (en) * 2000-09-18 2002-03-21 Smithkline Beecham P.L.C. Process
CN108773924A (en) * 2018-05-03 2018-11-09 国药集团威奇达药业有限公司 The comprehensive recovering process of active ingredient in clavulanic acid extraction raffinate

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002022846A1 (en) * 2000-09-18 2002-03-21 Smithkline Beecham P.L.C. Process
CN108773924A (en) * 2018-05-03 2018-11-09 国药集团威奇达药业有限公司 The comprehensive recovering process of active ingredient in clavulanic acid extraction raffinate
CN108773924B (en) * 2018-05-03 2021-08-03 国药集团威奇达药业有限公司 Comprehensive recovery method of effective components in clavulanic acid extraction raffinate

Also Published As

Publication number Publication date
ES537158A0 (en) 1985-12-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050730