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ES8505948A1 - Un derivado de amida. - Google Patents

Un derivado de amida.

Info

Publication number
ES8505948A1
ES8505948A1 ES524253A ES524253A ES8505948A1 ES 8505948 A1 ES8505948 A1 ES 8505948A1 ES 524253 A ES524253 A ES 524253A ES 524253 A ES524253 A ES 524253A ES 8505948 A1 ES8505948 A1 ES 8505948A1
Authority
ES
Spain
Prior art keywords
aryl
hydrogen
alkyl
bears
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524253A
Other languages
English (en)
Other versions
ES524253A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES8505948A1 publication Critical patent/ES8505948A1/es
Publication of ES524253A0 publication Critical patent/ES524253A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE AMIDAS.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN DISOLVENTE ALCOHOLICO Y EN PRESENCIA DE AGENTES REDUCTORES COMO NI RANEY O CIANOBOROHIDRUROSODICO, PARA OBTENER LOS DERIVADOS DE AMIDA DE FORMULA (I) Y SUS SALES. SIENDO: R1, ARILO O RADICALHETEROCICLICO Y OTROS; A1, ALQUILENO DE C 1 A 5 O ENLACE DIRECTO; X, -CH2- O -OR11COR12-; R2, H, ALQUILO Y OTROS; R3, H, ALQUILO DE HASTA C 5, SUSTITUIDO POR HAL, OH-, AMINO Y OTROS; R4 FENILO O ALQUILFENILO; R5, R6, R16, H; R11 Y R12 IGUALES O DIFERENTES, ALQUILO DE HASTA C 5; A2 ALQUILENO DE C 1 A 4 Y N, 0 O 1.SE UTILIZAN COMO INHIBIDORES DE ENZIMA DE CONVERSION DE ANGIOTENSINA (ACE).
ES524253A 1982-07-19 1983-07-19 Un derivado de amida. Granted ES524253A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8220879 1982-07-19

Publications (2)

Publication Number Publication Date
ES8505948A1 true ES8505948A1 (es) 1985-06-16
ES524253A0 ES524253A0 (es) 1985-06-16

Family

ID=10531769

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524253A Granted ES524253A0 (es) 1982-07-19 1983-07-19 Un derivado de amida.

Country Status (14)

Country Link
US (1) US4533656A (es)
EP (1) EP0099709A3 (es)
JP (1) JPS5951248A (es)
AU (1) AU560285B2 (es)
CA (1) CA1246550A (es)
DK (1) DK329483D0 (es)
ES (1) ES524253A0 (es)
FI (1) FI832610A (es)
GR (1) GR78630B (es)
IL (1) IL69247A0 (es)
NO (1) NO832601L (es)
NZ (1) NZ204936A (es)
PT (1) PT77047B (es)
ZA (1) ZA835046B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8422165D0 (en) * 1984-09-01 1984-10-03 Wellcome Found Compounds
FR2573765B1 (fr) * 1984-11-23 1988-06-10 Solvay Procede pour la synthese de peptides
GB8728561D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
GB8728560D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
WO2006007586A1 (en) * 2004-07-01 2006-01-19 Science & Technology Corporation @ Unm Organocatalysts and methods of use in chemical synthesis
JP2007182419A (ja) * 2005-12-07 2007-07-19 Tokyo Univ Of Science プロリン誘導体及び光学活性アンチ選択性増強触媒
WO2009039181A2 (en) 2007-09-17 2009-03-26 State Of Oregon Acting By & Through The State Board Of Higher Education On Behalf Of Or. State Univ. Sulfonamide-based organocatalysts and method for their use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4296110A (en) * 1980-10-28 1981-10-20 E. I. Du Pont De Nemours And Company Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
US4820729A (en) * 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids
AU9173582A (en) * 1982-01-05 1983-07-14 Fujisawa Pharmaceutical Co., Ltd. N-acyl peptide

Also Published As

Publication number Publication date
NO832601L (no) 1984-01-20
ZA835046B (en) 1984-06-27
ES524253A0 (es) 1985-06-16
PT77047B (en) 1986-01-24
JPS5951248A (ja) 1984-03-24
AU560285B2 (en) 1987-04-02
NZ204936A (en) 1986-02-21
EP0099709A3 (en) 1985-11-13
CA1246550A (en) 1988-12-13
FI832610A (fi) 1984-01-20
US4533656A (en) 1985-08-06
IL69247A0 (en) 1983-11-30
GR78630B (es) 1984-09-27
DK329483D0 (da) 1983-07-18
AU1667083A (en) 1984-01-26
FI832610A0 (fi) 1983-07-18
EP0099709A2 (en) 1984-02-01
PT77047A (en) 1983-08-01

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