ES8501393A1 - Procedimiento para preparar nuevos 4-hidroxi-2h-1,2-benzotiazin-3-carboxamida-1,1-dioxidos - Google Patents
Procedimiento para preparar nuevos 4-hidroxi-2h-1,2-benzotiazin-3-carboxamida-1,1-dioxidosInfo
- Publication number
- ES8501393A1 ES8501393A1 ES526332A ES526332A ES8501393A1 ES 8501393 A1 ES8501393 A1 ES 8501393A1 ES 526332 A ES526332 A ES 526332A ES 526332 A ES526332 A ES 526332A ES 8501393 A1 ES8501393 A1 ES 8501393A1
- Authority
- ES
- Spain
- Prior art keywords
- benzothiazine
- dioxides
- carboxamide
- hydroxy
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR NUEVOS 4-HIDROXI-2H-1,2-BENZOTIAZIN-3-CARBOXAMIDO-1,1-DIOXIDOS.CONSISTE EN HACER REACCIONAR UN DERIVADO DE ACIDO 4-HIDROXI-2H-1,2-BENZOTIAZIN-1,1-DIOXIDO-3-CARBOXILICO DE FORMULA (III) CON 2 AMINO-6-CLORO-PIRAZINA DE FORMULA (III), PARA OBTENER NUEVOS 4-HIDROXI-2H-1,2-BENZOTIAZIN-3-CARBOXAMIDO-1,1-DIOXIDOS DE FORMULA (I) Y SUS SALES FISIOLOGICAMENTE ACEPTABLES CON BASES ORGANICAS E INORGANICAS. DONDE: R1 SIGNIFICA H, UN GRUPO METILO O METOXI O UN ATOMO DE FLUOR O CLORO; R2 SIGNIFICA H, O UN GRUPO METILO, ETILO O N-PROPILO Y X SIGNIFICA UN GRUPO INTERCAMBIABLE NUCLEOFILICAMENTE, COMO UN GRUPO ALCOXI DE C 1 A 8, UN GRUPO FENILALCOXI DE C 7 A 10 Y OTROS. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO INDIFERENTE Y A TEMPERATURA ENTRE 20 Y 200JC.SE UTILIZA COMO ANTIBIOTICO POR SU GRAN EFECTO ANTITROMBOTICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823237473 DE3237473A1 (de) | 1982-10-09 | 1982-10-09 | Neue 4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung, ihre verwendung und diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8501393A1 true ES8501393A1 (es) | 1984-11-16 |
| ES526332A0 ES526332A0 (es) | 1984-11-16 |
Family
ID=6175330
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526332A Granted ES526332A0 (es) | 1982-10-09 | 1983-10-07 | Procedimiento para preparar nuevos 4-hidroxi-2h-1,2-benzotiazin-3-carboxamida-1,1-dioxidos |
| ES531402A Expired ES8502115A1 (es) | 1982-10-09 | 1984-04-09 | Procedimiento para preparar nuevos 4-hidroxi-2h-1, 2-benzotiazin-3-carboxamido-1, 1-dioxidos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES531402A Expired ES8502115A1 (es) | 1982-10-09 | 1984-04-09 | Procedimiento para preparar nuevos 4-hidroxi-2h-1, 2-benzotiazin-3-carboxamido-1, 1-dioxidos |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4533664A (es) |
| EP (1) | EP0106214B1 (es) |
| JP (1) | JPS5988482A (es) |
| KR (1) | KR840006634A (es) |
| AT (1) | ATE16807T1 (es) |
| AU (1) | AU1998683A (es) |
| CA (1) | CA1207767A (es) |
| CS (1) | CS236896B2 (es) |
| DD (1) | DD215549A5 (es) |
| DE (2) | DE3237473A1 (es) |
| DK (1) | DK460783A (es) |
| ES (2) | ES526332A0 (es) |
| FI (1) | FI833566A (es) |
| GB (1) | GB2128190B (es) |
| GR (1) | GR79010B (es) |
| HU (1) | HU190169B (es) |
| IL (1) | IL69931A (es) |
| NO (1) | NO833665L (es) |
| NZ (1) | NZ205891A (es) |
| PH (1) | PH20402A (es) |
| PL (1) | PL139147B1 (es) |
| PT (1) | PT77466B (es) |
| SU (1) | SU1148565A3 (es) |
| ZA (1) | ZA837500B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3435843A1 (de) * | 1984-09-29 | 1986-04-03 | Gödecke AG, 1000 Berlin | Antirheumatisch wirksame suppositorien |
| US5599811A (en) * | 1995-02-21 | 1997-02-04 | Warner-Lambert Company | Benzothiazine dioxides as endothelin antagonists |
| WO2023154412A1 (en) * | 2022-02-12 | 2023-08-17 | Miralogx Llc | Anti-inflammatory compounds, pharmaceutical compositions, and treatment methods |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
| US3891637A (en) * | 1974-10-01 | 1975-06-24 | Pfizer | Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides |
| DE2756113A1 (de) * | 1977-12-16 | 1979-06-21 | Thomae Gmbh Dr K | Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
-
1982
- 1982-10-09 DE DE19823237473 patent/DE3237473A1/de not_active Withdrawn
-
1983
- 1983-09-24 AT AT83109512T patent/ATE16807T1/de not_active IP Right Cessation
- 1983-09-24 DE DE8383109512T patent/DE3361437D1/de not_active Expired
- 1983-09-24 EP EP83109512A patent/EP0106214B1/de not_active Expired
- 1983-09-30 US US06/537,592 patent/US4533664A/en not_active Expired - Fee Related
- 1983-10-03 FI FI833566A patent/FI833566A/fi not_active Application Discontinuation
- 1983-10-04 PH PH29650A patent/PH20402A/en unknown
- 1983-10-05 GR GR72624A patent/GR79010B/el unknown
- 1983-10-05 SU SU833654490A patent/SU1148565A3/ru active
- 1983-10-06 DK DK460783A patent/DK460783A/da not_active Application Discontinuation
- 1983-10-06 DD DD83255478A patent/DD215549A5/de unknown
- 1983-10-07 NZ NZ205891A patent/NZ205891A/en unknown
- 1983-10-07 NO NO833665A patent/NO833665L/no unknown
- 1983-10-07 CA CA000438617A patent/CA1207767A/en not_active Expired
- 1983-10-07 GB GB08326876A patent/GB2128190B/en not_active Expired
- 1983-10-07 AU AU19986/83A patent/AU1998683A/en not_active Abandoned
- 1983-10-07 PT PT77466A patent/PT77466B/pt unknown
- 1983-10-07 JP JP58188284A patent/JPS5988482A/ja active Pending
- 1983-10-07 IL IL69931A patent/IL69931A/xx unknown
- 1983-10-07 CS CS837378A patent/CS236896B2/cs unknown
- 1983-10-07 HU HU833482A patent/HU190169B/hu unknown
- 1983-10-07 ZA ZA837500A patent/ZA837500B/xx unknown
- 1983-10-07 PL PL1983244080A patent/PL139147B1/pl unknown
- 1983-10-07 ES ES526332A patent/ES526332A0/es active Granted
- 1983-10-08 KR KR1019830004772A patent/KR840006634A/ko not_active Application Discontinuation
-
1984
- 1984-04-09 ES ES531402A patent/ES8502115A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| PH20402A (en) | 1986-12-12 |
| PT77466B (de) | 1986-05-07 |
| DK460783A (da) | 1984-04-10 |
| NZ205891A (en) | 1986-02-21 |
| KR840006634A (ko) | 1984-12-01 |
| IL69931A (en) | 1987-03-31 |
| HUT34472A (en) | 1985-03-28 |
| FI833566A (fi) | 1984-04-10 |
| EP0106214A1 (de) | 1984-04-25 |
| US4533664A (en) | 1985-08-06 |
| IL69931A0 (en) | 1984-01-31 |
| GB2128190A (en) | 1984-04-26 |
| GB2128190B (en) | 1986-07-02 |
| GR79010B (es) | 1984-10-02 |
| ATE16807T1 (de) | 1985-12-15 |
| PT77466A (de) | 1983-11-01 |
| SU1148565A3 (ru) | 1985-03-30 |
| EP0106214B1 (de) | 1985-12-04 |
| CA1207767A (en) | 1986-07-15 |
| DK460783D0 (da) | 1983-10-06 |
| PL139147B1 (en) | 1986-12-31 |
| FI833566A0 (fi) | 1983-10-03 |
| DD215549A5 (de) | 1984-11-14 |
| PL244080A1 (en) | 1985-01-16 |
| GB8326876D0 (en) | 1983-11-09 |
| HU190169B (en) | 1986-08-28 |
| ES531402A0 (es) | 1984-12-16 |
| ES526332A0 (es) | 1984-11-16 |
| ES8502115A1 (es) | 1984-12-16 |
| ZA837500B (en) | 1985-06-26 |
| NO833665L (no) | 1984-04-10 |
| DE3361437D1 (en) | 1986-01-16 |
| JPS5988482A (ja) | 1984-05-22 |
| CS236896B2 (en) | 1985-05-15 |
| AU1998683A (en) | 1984-04-12 |
| DE3237473A1 (de) | 1984-04-12 |
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